MD227C2 - Method of 7-(2-(2-aminothiazolyl-4)-2-oxyiminoacetamido)-3-acetoxymethyl-3-cefem-4-carbonic acid preparation in the form of sin-isomers - Google Patents
Method of 7-(2-(2-aminothiazolyl-4)-2-oxyiminoacetamido)-3-acetoxymethyl-3-cefem-4-carbonic acid preparation in the form of sin-isomersInfo
- Publication number
- MD227C2 MD227C2 MD94-0268A MD940268A MD227C2 MD 227 C2 MD227 C2 MD 227C2 MD 940268 A MD940268 A MD 940268A MD 227 C2 MD227 C2 MD 227C2
- Authority
- MD
- Moldova
- Prior art keywords
- sin
- acid
- isomers
- oxyiminoacetamido
- aminothiazolyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 4
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal salt Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
The invention relates to the preparation of new cefalosporinic class antibiotics especially of 7-[2-(2-aminothiazolyl-4)-2-oxyiminoacetamido]-3-acetoxymethyl-3-cefem-4-carbonic acid derivatives of general formulain the form of sin-isomers that can be applied as medicines.The purpose of the invention is obtaining of new cefalosporinic compounds extending the arsenal of remedies influenced on live organism.The method is realized by interaction of 7-aminocefalosporanic acid of formulawith acid of general formulain the form of sin-isomers wherein R1-C1-C4-alkyl, C2-C4-alkenyl or protected group such as trityl or with its functional derivative in the solvent medium in the presence of base from temperature of (-30)°C up to temperature of environment.The obtaining acid of formulain the form of sin-isomer, wherein R1 and R2 have indicated means, in the case of necessity is treated by thiourea and/or is undergone the acid hydrolysis.The final product is separated in the form of free acid or in the form of alkali metal salt or organic amin.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7601834A FR2346014A1 (en) | 1976-01-23 | 1976-01-23 | Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activity |
| FR7617743A FR2361893A2 (en) | 1976-01-23 | 1976-06-11 | Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activity |
| FR7625051A FR2361894A2 (en) | 1976-01-23 | 1976-08-18 | Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activity |
| SU772439818A SU822754A3 (en) | 1976-01-23 | 1977-01-18 | Method of preparing derivatives of 7-/-2-(2-aminothiazolyl-4)-2-oxyiminoacetamido/3-acetoxymethyl-3-cephem-4-carboxylic acid in the form of sin-isomers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD227B1 MD227B1 (en) | 1995-06-30 |
| MD227C2 true MD227C2 (en) | 1995-11-30 |
Family
ID=27446323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0268A MD227C2 (en) | 1976-01-23 | 1994-09-08 | Method of 7-(2-(2-aminothiazolyl-4)-2-oxyiminoacetamido)-3-acetoxymethyl-3-cefem-4-carbonic acid preparation in the form of sin-isomers |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD227C2 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3891635A (en) * | 1970-11-06 | 1975-06-24 | Koninklijke Gist Spiritus | 7-{8 3-(Phenyl)-isoxazol-5-yl{9 acetamido-cephalosporanic acids |
-
1994
- 1994-09-08 MD MD94-0268A patent/MD227C2/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3891635A (en) * | 1970-11-06 | 1975-06-24 | Koninklijke Gist Spiritus | 7-{8 3-(Phenyl)-isoxazol-5-yl{9 acetamido-cephalosporanic acids |
Also Published As
| Publication number | Publication date |
|---|---|
| MD227B1 (en) | 1995-06-30 |
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