MD248C2 - Method of preparation of derivatives of 7-(2-(2-aminothiarolyl-4)-2-alkoxyiminoacetamido)-3-thiomethyl-3 cefem-4-carbonic acid in the form of sin-isomers. - Google Patents

Method of preparation of derivatives of 7-(2-(2-aminothiarolyl-4)-2-alkoxyiminoacetamido)-3-thiomethyl-3 cefem-4-carbonic acid in the form of sin-isomers.

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Publication number
MD248C2
MD248C2 MD94-0278A MD940278A MD248C2 MD 248 C2 MD248 C2 MD 248C2 MD 940278 A MD940278 A MD 940278A MD 248 C2 MD248 C2 MD 248C2
Authority
MD
Moldova
Prior art keywords
derivatives
aminothiarolyl
alkoxyiminoacetamido
cefem
thiomethyl
Prior art date
Application number
MD94-0278A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD248B1 (en
Inventor
Rene Heymes
Andre Lutz
Original Assignee
Roussel Uclaf, Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7608690A external-priority patent/FR2345153A1/en
Application filed by Roussel Uclaf, Societe Anonyme filed Critical Roussel Uclaf, Societe Anonyme
Publication of MD248B1 publication Critical patent/MD248B1/en
Publication of MD248C2 publication Critical patent/MD248C2/en

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  • Cephalosporin Compounds (AREA)

Abstract

The invention relates to the method of antibiotics of cefalosporine group, namely derivatives of 7-[2-(2-aminothiarolyl-4)-2-alkoxyiminoacetamido] -3-thiomethyl-3 cefem-4-carbonic acid of general formula (I)in the form of sin-isomers, where A- atom of hydrogen or alkalimetal, R1 - acetyl, 2-methyl-1,3,4-thiadiarolyl or 1-methyltetrarolyl, R2-C1-C4 alkyl.The purpose of invention is to synthesize the new derivatives of cefalosporine that extend arsenal of remedies action on living organism.The method is realized by interaction of compound of the formula (II)where R2 has above indicated means and obtaining product at the necessity is treated by the acidic hydrolysis agent.The final product is separated in the form of the free acid or salt of alkalimetal.
MD94-0278A 1976-03-25 1994-09-08 Method of preparation of derivatives of 7-(2-(2-aminothiarolyl-4)-2-alkoxyiminoacetamido)-3-thiomethyl-3 cefem-4-carbonic acid in the form of sin-isomers. MD248C2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR7608690A FR2345153A1 (en) 1976-03-25 1976-03-25 NEW ALCOYLOXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
SU772462904A SU791246A3 (en) 1976-03-25 1977-03-23 Method of preparing derivatives of 7-/2-(2-aminothiazolyl-4)-2-alkoxyiminoacetamido/-3-cephem-4-carboxylic acid
SU782584103A SU795482A3 (en) 1976-03-25 1978-02-27 Method of preparing 7-/2-(2-aminothiazolyl-4)-2-alkoxyiminoacetamido/-3-thiomethyl-3-cephem-4-carboxylic acid derivatives in the form of sin-isomers

Publications (2)

Publication Number Publication Date
MD248B1 MD248B1 (en) 1995-07-31
MD248C2 true MD248C2 (en) 1995-12-31

Family

ID=27250604

Family Applications (1)

Application Number Title Priority Date Filing Date
MD94-0278A MD248C2 (en) 1976-03-25 1994-09-08 Method of preparation of derivatives of 7-(2-(2-aminothiarolyl-4)-2-alkoxyiminoacetamido)-3-thiomethyl-3 cefem-4-carbonic acid in the form of sin-isomers.

Country Status (1)

Country Link
MD (1) MD248C2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941781A (en) * 1971-12-23 1976-03-02 Eli Lilly And Company Preparation of 3-alkylthiomethyl cephalosporins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941781A (en) * 1971-12-23 1976-03-02 Eli Lilly And Company Preparation of 3-alkylthiomethyl cephalosporins

Also Published As

Publication number Publication date
MD248B1 (en) 1995-07-31

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