MD1180Z - Способ стимулирования формирования условных рефлексов в период снижения функций - Google Patents
Способ стимулирования формирования условных рефлексов в период снижения функций Download PDFInfo
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- MD1180Z MD1180Z MDS20170030A MDS20170030A MD1180Z MD 1180 Z MD1180 Z MD 1180Z MD S20170030 A MDS20170030 A MD S20170030A MD S20170030 A MDS20170030 A MD S20170030A MD 1180 Z MD1180 Z MD 1180Z
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- formation
- conditioned
- period
- stimulating
- conditioned reflexes
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- 238000000034 method Methods 0.000 title claims abstract description 13
- 230000004936 stimulating effect Effects 0.000 title claims abstract description 9
- 230000006870 function Effects 0.000 title claims description 6
- 239000002028 Biomass Substances 0.000 claims abstract description 18
- 241000187438 Streptomyces fradiae Species 0.000 claims abstract description 12
- 239000002207 metabolite Substances 0.000 claims abstract description 12
- 230000037396 body weight Effects 0.000 claims abstract description 5
- 230000003292 diminished effect Effects 0.000 claims description 4
- 235000013373 food additive Nutrition 0.000 claims description 2
- 239000002778 food additive Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 abstract description 2
- 235000015872 dietary supplement Nutrition 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 description 19
- 241000700159 Rattus Species 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 235000013305 food Nutrition 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 6
- 238000011835 investigation Methods 0.000 description 6
- 241000187747 Streptomyces Species 0.000 description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 241000700157 Rattus norvegicus Species 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 239000004471 Glycine Substances 0.000 description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
- 229930182558 Sterol Natural products 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 235000003704 aspartic acid Nutrition 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 230000008717 functional decline Effects 0.000 description 2
- 235000013922 glutamic acid Nutrition 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 150000003432 sterols Chemical class 0.000 description 2
- 235000003702 sterols Nutrition 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 241000946786 Kitasatospora purpeofusca Species 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- 241001494960 Streptomyces griseoflavus Species 0.000 description 1
- 241000946871 Streptomyces massasporeus Species 0.000 description 1
- 241001137869 Streptomyces nitrosporeus Species 0.000 description 1
- 241001655322 Streptomycetales Species 0.000 description 1
- 230000037328 acute stress Effects 0.000 description 1
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- 230000003078 antioxidant effect Effects 0.000 description 1
- 150000001510 aspartic acids Chemical class 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 150000002307 glutamic acids Chemical class 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000004112 neuroprotection Effects 0.000 description 1
- 230000000324 neuroprotective effect Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
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Abstract
Изобретение относится к экспериментальной физиологии, экспериментальной медицине и фармакологии, в частности к способам стимулирования формирования условных рефлексов в период снижения функций.Согласно изобретению, способ включает введение в качестве пищевой добавки метаболитов биомассы штамма Streptomyces fradiae CNMN-Ac-11, в дозе 250 мг/кг массы тела в сутки, в течение 90 суток до формирования и в период формирования условных рефлексов.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDS20170030A MD1180Z (ru) | 2017-03-02 | 2017-03-02 | Способ стимулирования формирования условных рефлексов в период снижения функций |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDS20170030A MD1180Z (ru) | 2017-03-02 | 2017-03-02 | Способ стимулирования формирования условных рефлексов в период снижения функций |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD1180Y MD1180Y (ru) | 2017-08-31 |
| MD1180Z true MD1180Z (ru) | 2018-03-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDS20170030A MD1180Z (ru) | 2017-03-02 | 2017-03-02 | Способ стимулирования формирования условных рефлексов в период снижения функций |
Country Status (1)
| Country | Link |
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| MD (1) | MD1180Z (ru) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1069631A3 (ru) * | 1980-07-02 | 1984-01-23 | Эли Лилли Энд Компани (Фирма) | Способ получени тилактона и штамм @ @ @ 12188 дл его получени |
| SU1645300A1 (ru) * | 1988-12-06 | 1991-04-30 | Научно-Исследовательский Конструкторско-Технологический Институт Биологически Активных Веществ | Штамм SтRертомYсеS FRaDIae - продуцент рестриктазы SFR I |
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2017
- 2017-03-02 MD MDS20170030A patent/MD1180Z/ru not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1069631A3 (ru) * | 1980-07-02 | 1984-01-23 | Эли Лилли Энд Компани (Фирма) | Способ получени тилактона и штамм @ @ @ 12188 дл его получени |
| SU1645300A1 (ru) * | 1988-12-06 | 1991-04-30 | Научно-Исследовательский Конструкторско-Технологический Институт Биологически Активных Веществ | Штамм SтRертомYсеS FRaDIae - продуцент рестриктазы SFR I |
Non-Patent Citations (4)
| Title |
|---|
| Kim W.G. et al. Benzastatins H and I, new benzastatin derivatives with neuronal cell protecting activity from Streptomyces nitrosporeus. In: J. Antibiotics, 2001, vol. 54, р. 513-516 * |
| Shin-Ya K. et al. A novel neuronal cell protecting substance mescengricin produced by Streptomyces griseoflavus. In: J. Asian Natural Products Research, 2000, vol. 2, p. 121-132 * |
| Shin-Ya K. et al. Novel neuronal cell protecting substances, aestivophoenins A and B, produced by Streptomyces purpeofuscus. In: J. Antibiotics, 1995, vol. 48, is. 11, р. 1378-1381 * |
| Шептицкий В.А., Братухина А.А., Бурцева С.А. Условнорефлекторная деятельность белых крыс при длительном потреблении биопрепаратов на основе метаболитов Streptomyces massasporeus. In: Buletinul AŞM. Ştiinţele vieţii, 2007, nr. 2 (302), p. 7-12 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD1180Y (ru) | 2017-08-31 |
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