MD114C2 - Procedeu de obţinere a fenilalchilaminelor sau a sărurilor acestora care pot fi utilizate în farmaceutică - Google Patents
Procedeu de obţinere a fenilalchilaminelor sau a sărurilor acestora care pot fi utilizate în farmaceuticăInfo
- Publication number
- MD114C2 MD114C2 MD94-0140A MD940140A MD114C2 MD 114 C2 MD114 C2 MD 114C2 MD 940140 A MD940140 A MD 940140A MD 114 C2 MD114 C2 MD 114C2
- Authority
- MD
- Moldova
- Prior art keywords
- alkyl
- inferior
- phenyl
- substances
- phenylalkylamines
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- 239000000126 substance Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 230000001988 toxicity Effects 0.000 abstract 2
- 231100000419 toxicity Toxicity 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 229910000761 Aluminium amalgam Inorganic materials 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- GRWZHXKQBITJKP-UHFFFAOYSA-L dithionite(2-) Chemical compound [O-]S(=O)S([O-])=O GRWZHXKQBITJKP-UHFFFAOYSA-L 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Invenţia se referă la fenilalchilamine, în speţă la obţinerea compuşilor cu formula generală C6 H6-CH2-CHR1-NHR2, în care R1 este un n- sau izo-C2-C8-alchil, fenil-C7-C10-alchil, ciclo-C3-C8-alchil, fenil; R2 este un n- sau izoalchil inferior, halogeno-alchil inferior sau hidroxialchil inferior, C1-C4-alcoxipropilfenil, C3-C8-cicloalchil, R1 şi R2 conţinând împreună C5-C13, iar când R1 este etil, R2 nu este izobutil; aceşti compuşi posedând proprietăţi antidepresante, ceea ce se poate utiliza în medicină. Scopul invenţiei este de a crea substanţe din această clasă, mai active şi cu nivel redus de toxicitate. Sinteza se efectuează prin reacţia aminei cu formula NH2-R2 cu o cetonă cu formula C6H6-CH2-CR1 -O cu reducerea ulterioară prin hidrogen, în prezenţa paladiului sau nichelului Raney, sau utilizând pentru hidrogenare hidrura complexă a unui metal, ditionitul de sodiu, sau amalgamul de aluminiu. Produsul final se separă sub forma unei baze sau a unei sări uilizabile în farmaceutică. Noile substanţe au un nuvel de toxicitate redus, sunt mult mai active decât substanţele cunoscute, fără a inhiba monoaminooxidaza.Revendicări:1.Tabele: 11.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU864101A HU207280B (en) | 1986-09-25 | 1986-09-25 | Process for producing new phenyl-alkyl-amines and pharmaceutical compositions containing them |
| PCT/HU1987/000040 WO1988002254A1 (en) | 1986-09-25 | 1987-09-25 | New psychostimulant agent |
| SU884355858A SU1746882A3 (ru) | 1986-09-25 | 1988-05-24 | Способ получени фенилалкиламинов или их фармакологически приемлемых солей |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD114C2 true MD114C2 (ro) | 1995-05-31 |
| MD114B1 MD114B1 (ro) | 1995-12-31 |
Family
ID=26317736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD940140A MD114B1 (ro) | 1986-09-25 | 1994-04-21 | Procedeu de obtinere a fenilalchilaminelor sau a sarurilor acestora care pot fi ultizate in farmecutica |
Country Status (3)
| Country | Link |
|---|---|
| LT (1) | LT2581B (ro) |
| LV (1) | LV5226A3 (ro) |
| MD (1) | MD114B1 (ro) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD459Z (ro) * | 2010-02-05 | 2012-07-31 | Дину СПИНЕЙ | Instalaţie energetică eoliană verticală în caturi |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3117160A (en) * | 1961-07-27 | 1964-01-07 | Pfizer & Co C | Aralkylamines |
| US3485926A (en) * | 1959-03-18 | 1969-12-23 | Hoffmann La Roche | Alpha-methylphenethylamino anorectic compositions and use |
-
1993
- 1993-06-08 LV LV930485A patent/LV5226A3/xx unknown
- 1993-06-12 LT LTRP653A patent/LT2581B/xx not_active IP Right Cessation
-
1994
- 1994-04-21 MD MD940140A patent/MD114B1/ro active IP Right Grant
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3485926A (en) * | 1959-03-18 | 1969-12-23 | Hoffmann La Roche | Alpha-methylphenethylamino anorectic compositions and use |
| US3117160A (en) * | 1961-07-27 | 1964-01-07 | Pfizer & Co C | Aralkylamines |
Non-Patent Citations (1)
| Title |
|---|
| Brevet nr. 4025624, US, Int.Cl5. A 61 K 31/17, 1977. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD459Z (ro) * | 2010-02-05 | 2012-07-31 | Дину СПИНЕЙ | Instalaţie energetică eoliană verticală în caturi |
Also Published As
| Publication number | Publication date |
|---|---|
| LV5226A3 (lv) | 1993-10-10 |
| MD114B1 (ro) | 1995-12-31 |
| LT2581B (lt) | 1994-03-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20070924 |