ES8801242A1 - Un procedimiento para la preparacion de metanosulfonatos de dioxolano. - Google Patents

Un procedimiento para la preparacion de metanosulfonatos de dioxolano.

Info

Publication number
ES8801242A1
ES8801242A1 ES553874A ES553874A ES8801242A1 ES 8801242 A1 ES8801242 A1 ES 8801242A1 ES 553874 A ES553874 A ES 553874A ES 553874 A ES553874 A ES 553874A ES 8801242 A1 ES8801242 A1 ES 8801242A1
Authority
ES
Spain
Prior art keywords
sulfamates
anticonvulsant
dioxolane
methane
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553874A
Other languages
English (en)
Other versions
ES553874A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McNeilab Inc filed Critical McNeilab Inc
Publication of ES8801242A1 publication Critical patent/ES8801242A1/es
Publication of ES553874A0 publication Critical patent/ES553874A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE METANOSULFAMATOS DE DIOXOLANO, DE FORMULA GENERAL (I). CONSISTE EN HACER REACCIONAR UN ALCOHOL DE FORMULA GENERAL (II), EN LA QUE R1 Y R2 SON ALQUILO O TOMADOS JUNTOS SE UNEN FORMANDO UN ANILLO DE CICLOALQUILO, CON UN CLORURO SULFAMATO DE FORMULA GENERAL (III), EN PRESENCIA DE UNA BASE TAL COMO T-BUTOXIDO POTASICO O HIDRURO DE SODIO A UNA TEMPERATURA COMPRENDIDA ENTRE C20 Y 25 GRADOS, Y EN PRESENCIA DE UN DISOLVENTE, TAL COMO TOLUENO, TETRAHIDROFURANO O DIMETILFORMAMIDA. DE APLICACION EN COMPOSICIONES FARMACEUTICAS UTILIZADAS EN EL TRATAMIENTO DE ENFERMEDADES TALES COMO LA EPILEPSIA Y DEL GLAUCOMA.
ES553874A 1985-04-12 1986-04-10 Un procedimiento para la preparacion de metanosulfonatos de dioxolano. Expired ES8801242A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/722,869 US4591601A (en) 1985-04-12 1985-04-12 Anticonvulsant dioxolane methane sulfamates

Publications (2)

Publication Number Publication Date
ES8801242A1 true ES8801242A1 (es) 1988-01-01
ES553874A0 ES553874A0 (es) 1988-01-01

Family

ID=24903753

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553874A Expired ES8801242A1 (es) 1985-04-12 1986-04-10 Un procedimiento para la preparacion de metanosulfonatos de dioxolano.

Country Status (9)

Country Link
US (1) US4591601A (es)
EP (1) EP0198686A3 (es)
JP (1) JPS61263973A (es)
AU (1) AU579463B2 (es)
CA (1) CA1252109A (es)
DK (1) DK167586A (es)
ES (1) ES8801242A1 (es)
GR (1) GR860953B (es)
ZA (1) ZA862744B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792569A (en) * 1987-08-27 1988-12-20 Mcneilab, Inc. Anticonvulsant phenethyl sulfamates
US5194446A (en) * 1989-06-12 1993-03-16 A. H. Robins Company, Incorporated Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals
US5273993A (en) * 1989-06-12 1993-12-28 A. H. Robins Company, Incorporated Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals
US5192785A (en) * 1989-09-03 1993-03-09 A. H. Robins Company, Incorporated Sulfamates as antiglaucoma agents
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
US6011024A (en) 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
US6903084B2 (en) 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
US5242942A (en) * 1992-04-28 1993-09-07 Mcneilab, Inc. Anticonvulsant fructopyranose cyclic sulfites and sulfates
IL140861A (en) * 1998-07-15 2004-06-01 Bristol Myers Squibb Co Dioxolane pentanoic acid and processes for the preparation thereof
US7335650B2 (en) * 2000-01-14 2008-02-26 Sterix Limited Composition
US7422775B2 (en) * 2005-05-17 2008-09-09 Applied Materials, Inc. Process for low temperature plasma deposition of an optical absorption layer and high speed optical annealing
US20090318520A1 (en) 2008-06-20 2009-12-24 Afecta Pharmaceuticals Drive Use of isoindoles for the treatment of neurobehavioral disorders
WO2013187727A1 (en) 2012-06-15 2013-12-19 Bio-Pharm Solutions Co., Ltd. Phenylalkyl sulfamate compound and muscle relaxant composition comprising the same
ES2706184T3 (es) 2013-12-12 2019-03-27 Bio Pharm Solutions Co Ltd Compuesto derivado de sulfamato para su uso en la prevención o el tratamiento de la epilepsia
CN105979942B (zh) 2013-12-12 2018-12-07 比皮艾思药物研发有限公司 用于治疗或缓解疼痛的氨基磺酸酯衍生物
KR101792998B1 (ko) 2013-12-12 2017-11-02 (주)바이오팜솔루션즈 통증을 치료 또는 완화하기 위한 설파메이트 유도체 화합물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3058981A (en) * 1958-11-14 1962-10-16 Richardson Merrell Inc 2-methyl-2-nonyl-4-hydroxymethyl-1, 3-dioxolane and carbamates thereof
DE1131226B (de) * 1958-12-24 1962-06-14 Riedel De Haeen Ag Verfahren zur Herstellung der Carbaminsaeureester von 4-Oxymethyl-1,3-dioxolanen
BE622353A (es) * 1961-09-15
US3948953A (en) * 1969-08-05 1976-04-06 Texaco Inc. Dioxolane derivatives having surfactant properties
US3997585A (en) * 1974-12-30 1976-12-14 Ortho Pharmaceutical Corporation Aliphatic sulfamates
IL59407A (en) * 1979-03-06 1983-12-30 Sanofi Sa Di-n-propylacetic acid diesters of glycerol,their preparation and pharmaceutical compositions containing them
JPS57197258A (en) * 1981-05-29 1982-12-03 Taiho Yakuhin Kogyo Kk Sulfonic ester derivative and its preparation

Also Published As

Publication number Publication date
US4591601A (en) 1986-05-27
AU5601086A (en) 1986-10-16
EP0198686A2 (en) 1986-10-22
EP0198686A3 (en) 1987-10-21
CA1252109A (en) 1989-04-04
GR860953B (en) 1986-08-06
ES553874A0 (es) 1988-01-01
DK167586A (da) 1986-10-13
JPS61263973A (ja) 1986-11-21
DK167586D0 (da) 1986-04-11
AU579463B2 (en) 1988-11-24
ZA862744B (en) 1987-11-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603