MC1694A1 - Composes bicycliques - Google Patents

Composes bicycliques

Info

Publication number
MC1694A1
MC1694A1 MC851791A MC1791A MC1694A1 MC 1694 A1 MC1694 A1 MC 1694A1 MC 851791 A MC851791 A MC 851791A MC 1791 A MC1791 A MC 1791A MC 1694 A1 MC1694 A1 MC 1694A1
Authority
MC
Monaco
Prior art keywords
bicyclic compounds
bicyclic
compounds
Prior art date
Application number
MC851791A
Other languages
English (en)
French (fr)
Inventor
Cedric Hassall
Geoffrey Lawton
Sally Redshaw
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848421493A external-priority patent/GB8421493D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC1694A1 publication Critical patent/MC1694A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
MC851791A 1984-08-24 1985-08-21 Composes bicycliques MC1694A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848421493A GB8421493D0 (en) 1984-08-24 1984-08-24 Bicyclic compounds
GB858513541A GB8513541D0 (en) 1984-08-24 1985-05-29 Bicyclic compounds

Publications (1)

Publication Number Publication Date
MC1694A1 true MC1694A1 (fr) 1986-07-18

Family

ID=26288155

Family Applications (1)

Application Number Title Priority Date Filing Date
MC851791A MC1694A1 (fr) 1984-08-24 1985-08-21 Composes bicycliques

Country Status (14)

Country Link
US (4) US4692438A (es)
EP (1) EP0172552A3 (es)
AU (1) AU583843B2 (es)
CS (1) CS255893B2 (es)
DK (1) DK384385A (es)
ES (3) ES8700258A1 (es)
FI (1) FI853174L (es)
HU (1) HU193446B (es)
IL (1) IL76133A (es)
MC (1) MC1694A1 (es)
NO (1) NO161914C (es)
NZ (1) NZ213130A (es)
PH (1) PH21749A (es)
PT (1) PT81015B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
EP0534363B1 (en) * 1991-09-27 1997-07-09 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
EP0625987B1 (en) * 1992-02-14 1998-04-01 Merrell Pharmaceuticals Inc. Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
DE69325904T2 (de) * 1992-05-15 1999-12-09 Merrell Pharmaceuticals Inc., Cincinnati MERCAPTOACETYLAMIDE VON PYRIDAZO[1,2-a][1,2]-DIAZEPIN -DERIVATEN ALS EUKEPHALINASE UND ACE-INHIBITOREN
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
WO1994010193A1 (en) * 1992-10-30 1994-05-11 Merrell Dow Pharmaceuticals Inc. Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace
WO1994022440A1 (en) * 1993-03-29 1994-10-13 Smithkline Beecham Corporation Bicyclic compounds which inhibit platelet aggregation
WO1995021839A1 (en) * 1994-02-14 1995-08-17 Merrell Pharmaceuticals Inc. Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
DE69516128T2 (de) * 1994-02-14 2000-12-21 Merrell Pharmaceuticals Inc., Cincinnati Mercaptoacetylamid-1,3,4,5-tetrahydrobenzo(c)azepin-3-ein disulfidderivate als enkephalinase und ace inhibitoren
HUT76479A (en) * 1994-02-14 1997-09-29 Merrell Pharma Inc Novel fused benzazepinone derivatives, process for preparation thereof and pharmaceutical composition containing them
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
CN1069317C (zh) * 1994-02-14 2001-08-08 默里尔药物公司 用作脑啡肽酶抑制剂的新的1,2－二氢化茚－2－巯基乙酰胺二硫化物衍生物
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
US6013645A (en) * 1994-03-24 2000-01-11 Hoechst Marion Roussel, Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives
EP0751783B1 (en) * 1994-03-24 2000-02-02 Merrell Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic use of aminoacetylmercapto derivatives
US6177565B1 (en) * 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
US6703500B2 (en) 1998-08-19 2004-03-09 Vertex Pharmaceuticals, Incorporated Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
US6559304B1 (en) 1998-08-19 2003-05-06 Vertex Pharmaceuticals Incorporated Method for synthesizing caspase inhibitors
EP1280780B1 (en) * 2000-05-04 2005-11-30 Vertex Pharmaceuticals Incorporated Asymmetric synthesis of piperazic acid and derivatives thereof
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
EA016837B1 (ru) * 2008-07-25 2012-07-30 Чулуун Энхболд Способ обогащения и транспортировки твердого топлива на тепловую электростанцию
US20110313035A1 (en) * 2009-12-16 2011-12-22 Hetero Research Foundation Polymorphs of darunavir
ES2595235T3 (es) 2010-05-20 2016-12-28 Hetero Research Foundation Sal clorhidrato cristalina de darunavir

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308094A (en) * 1977-02-02 1981-12-29 Sanyo Electric Co., Ltd. Diaphragm for speaker and method of producing same
IL60617A0 (en) * 1979-07-23 1980-09-16 Sparamedica Ag Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them
DE3062972D1 (en) * 1979-09-19 1983-06-09 Hoffmann La Roche Pyridazopyridazine derivatives, processes for their preparation and pharmaceutical compositions containing these pyridazopyridazine derivatives
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity

Also Published As

Publication number Publication date
US4826980A (en) 1989-05-02
CS255893B2 (en) 1988-03-15
AU583843B2 (en) 1989-05-11
US4785093A (en) 1988-11-15
AU4641585A (en) 1986-02-27
EP0172552A2 (de) 1986-02-26
CS592885A2 (en) 1987-07-16
FI853174A0 (fi) 1985-08-19
NO161914C (no) 1989-10-11
HUT38644A (en) 1986-06-30
US4762924A (en) 1988-08-09
NO161914B (no) 1989-07-03
US4692438A (en) 1987-09-08
ES8700258A1 (es) 1986-10-01
ES552397A0 (es) 1987-05-01
PH21749A (en) 1988-02-18
NZ213130A (en) 1988-05-30
PT81015A (en) 1985-09-01
DK384385A (da) 1986-02-25
ES8705444A1 (es) 1987-05-01
ES546360A0 (es) 1986-10-01
FI853174L (fi) 1986-02-25
ES552398A0 (es) 1987-05-01
NO853336L (no) 1986-02-25
PT81015B (en) 1987-08-24
DK384385D0 (da) 1985-08-23
HU193446B (en) 1987-10-28
IL76133A (en) 1989-12-15
ES8705443A1 (es) 1987-05-01
EP0172552A3 (de) 1989-01-11
IL76133A0 (en) 1985-12-31

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