DK384385A - Bicycliske forbindelser - Google Patents
Bicycliske forbindelser Download PDFInfo
- Publication number
- DK384385A DK384385A DK384385A DK384385A DK384385A DK 384385 A DK384385 A DK 384385A DK 384385 A DK384385 A DK 384385A DK 384385 A DK384385 A DK 384385A DK 384385 A DK384385 A DK 384385A
- Authority
- DK
- Denmark
- Prior art keywords
- bicyclic
- relations
- bicyclic relations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848421493A GB8421493D0 (en) | 1984-08-24 | 1984-08-24 | Bicyclic compounds |
GB858513541A GB8513541D0 (en) | 1984-08-24 | 1985-05-29 | Bicyclic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DK384385D0 DK384385D0 (da) | 1985-08-23 |
DK384385A true DK384385A (da) | 1986-02-25 |
Family
ID=26288155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK384385A DK384385A (da) | 1984-08-24 | 1985-08-23 | Bicycliske forbindelser |
Country Status (14)
Country | Link |
---|---|
US (4) | US4692438A (es) |
EP (1) | EP0172552A3 (es) |
AU (1) | AU583843B2 (es) |
CS (1) | CS255893B2 (es) |
DK (1) | DK384385A (es) |
ES (3) | ES8700258A1 (es) |
FI (1) | FI853174L (es) |
HU (1) | HU193446B (es) |
IL (1) | IL76133A (es) |
MC (1) | MC1694A1 (es) |
NO (1) | NO161914C (es) |
NZ (1) | NZ213130A (es) |
PH (1) | PH21749A (es) |
PT (1) | PT81015B (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4692438A (en) * | 1984-08-24 | 1987-09-08 | Hoffmann-La Roche Inc. | Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity |
ZW11586A1 (en) * | 1985-07-01 | 1987-12-30 | Hoffmann La Roche | Bicyclic compounds |
GB8629875D0 (en) * | 1986-12-15 | 1987-01-28 | Hoffmann La Roche | Pyridazodiazepine derivatives |
US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
US5308841A (en) * | 1990-12-21 | 1994-05-03 | Merrell Dow Pharmaceuticals Inc. | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
EP0534363B1 (en) * | 1991-09-27 | 1997-07-09 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
NZ246811A (en) * | 1992-02-14 | 1996-02-27 | Merrell Dow Pharma | N-[pyrido (and oxazino and thiazino) benzazepine] 1-benzyl-1-(heterocyclyl(alkyl)carbonylthio) acetamide derivatives and pharmaceutical compositions |
DE69325904T2 (de) * | 1992-05-15 | 1999-12-09 | Merrell Pharma Inc | MERCAPTOACETYLAMIDE VON PYRIDAZO[1,2-a][1,2]-DIAZEPIN -DERIVATEN ALS EUKEPHALINASE UND ACE-INHIBITOREN |
US5420271A (en) * | 1992-08-24 | 1995-05-30 | Merrell Dow Pharmaceuticals, Inc. | 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
WO1994010193A1 (en) * | 1992-10-30 | 1994-05-11 | Merrell Dow Pharmaceuticals Inc. | Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace |
WO1994022440A1 (en) * | 1993-03-29 | 1994-10-13 | Smithkline Beecham Corporation | Bicyclic compounds which inhibit platelet aggregation |
PT745081E (pt) * | 1994-02-14 | 2002-04-29 | Merrell Pharma Inc | Derivados de dissulfureto de inda-2-mercaptoacetilamida uteis como inibidores da encefalinase |
DK0750631T3 (da) * | 1994-02-14 | 2000-10-23 | Merrell Pharma Inc | Mercaptoacetylamido-1,3,4,5-tetrahydrobenzo[c]azepin-3-ondisulfidderivater som enkephalinase- og ACE-inhibitorer |
US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
CA2183320C (en) * | 1994-02-14 | 1999-10-26 | Gary A. Flynn | Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
EP0746566A1 (en) * | 1994-02-14 | 1996-12-11 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
ATE246927T1 (de) * | 1994-03-24 | 2003-08-15 | Merrell Pharma Inc | Cholesterin senkende mercaptoacetylamiddisulfidderivate |
JPH09510476A (ja) * | 1994-03-24 | 1997-10-21 | メリル・フアーマシユウテイカルズ・インコーポレイテツド | 低コレステロール血性、抗アテローム性動脈硬化性および低トリグリセライド血性のアミノアセチルメルカプト誘導体 |
US6177565B1 (en) * | 1998-08-19 | 2001-01-23 | Vertex Pharmaceuticals Inc. | Process for synthesizing piperazic acid |
US6559304B1 (en) | 1998-08-19 | 2003-05-06 | Vertex Pharmaceuticals Incorporated | Method for synthesizing caspase inhibitors |
US6703500B2 (en) | 1998-08-19 | 2004-03-09 | Vertex Pharmaceuticals, Incorporated | Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors |
DE60115419T2 (de) | 2000-05-04 | 2006-08-17 | Vertex Pharmaceuticals Inc., Cambridge | Assymetrische synthese von piperazinsäure und ihre derivate |
GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
CN102131587B (zh) * | 2008-07-25 | 2014-08-13 | C·恩克博德 | 固体燃料选矿并向热电厂运输的方法 |
PT2513116E (pt) * | 2009-12-16 | 2015-10-14 | Hetero Research Foundation | Polimorfos de darunavir |
ES2595235T3 (es) | 2010-05-20 | 2016-12-28 | Hetero Research Foundation | Sal clorhidrato cristalina de darunavir |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4308094A (en) * | 1977-02-02 | 1981-12-29 | Sanyo Electric Co., Ltd. | Diaphragm for speaker and method of producing same |
IL60617A0 (en) * | 1979-07-23 | 1980-09-16 | Sparamedica Ag | Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them |
DE3062972D1 (en) * | 1979-09-19 | 1983-06-09 | Hoffmann La Roche | Pyridazopyridazine derivatives, processes for their preparation and pharmaceutical compositions containing these pyridazopyridazine derivatives |
EP0042100A1 (de) * | 1980-06-13 | 1981-12-23 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel |
GB2128984B (en) * | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
US4692438A (en) * | 1984-08-24 | 1987-09-08 | Hoffmann-La Roche Inc. | Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity |
-
1985
- 1985-08-12 US US06/764,372 patent/US4692438A/en not_active Expired - Fee Related
- 1985-08-15 CS CS855928A patent/CS255893B2/cs unknown
- 1985-08-16 NZ NZ213130A patent/NZ213130A/en unknown
- 1985-08-19 EP EP85110370A patent/EP0172552A3/de not_active Withdrawn
- 1985-08-19 AU AU46415/85A patent/AU583843B2/en not_active Ceased
- 1985-08-19 IL IL76133A patent/IL76133A/xx unknown
- 1985-08-19 FI FI853174A patent/FI853174L/fi not_active Application Discontinuation
- 1985-08-21 MC MC851791A patent/MC1694A1/xx unknown
- 1985-08-21 HU HU853187A patent/HU193446B/hu not_active IP Right Cessation
- 1985-08-21 PH PH32671A patent/PH21749A/en unknown
- 1985-08-23 PT PT81015A patent/PT81015B/pt unknown
- 1985-08-23 DK DK384385A patent/DK384385A/da not_active Application Discontinuation
- 1985-08-23 ES ES546360A patent/ES8700258A1/es not_active Expired
- 1985-08-23 NO NO853336A patent/NO161914C/no unknown
-
1986
- 1986-02-17 ES ES552397A patent/ES8705443A1/es not_active Expired
- 1986-02-17 ES ES552398A patent/ES8705444A1/es not_active Expired
-
1987
- 1987-05-11 US US07/048,172 patent/US4785093A/en not_active Expired - Fee Related
- 1987-06-15 US US07/062,033 patent/US4762924A/en not_active Expired - Fee Related
-
1988
- 1988-07-12 US US07/217,805 patent/US4826980A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HUT38644A (en) | 1986-06-30 |
US4785093A (en) | 1988-11-15 |
EP0172552A3 (de) | 1989-01-11 |
CS592885A2 (en) | 1987-07-16 |
NZ213130A (en) | 1988-05-30 |
PT81015A (en) | 1985-09-01 |
NO161914B (no) | 1989-07-03 |
US4826980A (en) | 1989-05-02 |
FI853174L (fi) | 1986-02-25 |
ES552397A0 (es) | 1987-05-01 |
US4692438A (en) | 1987-09-08 |
CS255893B2 (en) | 1988-03-15 |
ES552398A0 (es) | 1987-05-01 |
AU4641585A (en) | 1986-02-27 |
EP0172552A2 (de) | 1986-02-26 |
ES8705443A1 (es) | 1987-05-01 |
FI853174A0 (fi) | 1985-08-19 |
IL76133A0 (en) | 1985-12-31 |
ES8700258A1 (es) | 1986-10-01 |
MC1694A1 (fr) | 1986-07-18 |
HU193446B (en) | 1987-10-28 |
PT81015B (en) | 1987-08-24 |
DK384385D0 (da) | 1985-08-23 |
NO161914C (no) | 1989-10-11 |
PH21749A (en) | 1988-02-18 |
IL76133A (en) | 1989-12-15 |
US4762924A (en) | 1988-08-09 |
ES8705444A1 (es) | 1987-05-01 |
ES546360A0 (es) | 1986-10-01 |
NO853336L (no) | 1986-02-25 |
AU583843B2 (en) | 1989-05-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |