MA56113A - Formes solides de (6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-3-[(3s,4s)-4-amino-3-méthyl-2-oxa-8-azaspiro [4,5]décan-8-yl]-5-méthylpyrazin-2-yl)méthanol, un inhibiteur de shp2 - Google Patents
Formes solides de (6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-3-[(3s,4s)-4-amino-3-méthyl-2-oxa-8-azaspiro [4,5]décan-8-yl]-5-méthylpyrazin-2-yl)méthanol, un inhibiteur de shp2Info
- Publication number
- MA56113A MA56113A MA056113A MA56113A MA56113A MA 56113 A MA56113 A MA 56113A MA 056113 A MA056113 A MA 056113A MA 56113 A MA56113 A MA 56113A MA 56113 A MA56113 A MA 56113A
- Authority
- MA
- Morocco
- Prior art keywords
- amino
- methylpyrazin
- decan
- azaspiro
- chloropyridin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962858837P | 2019-06-07 | 2019-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA56113A true MA56113A (fr) | 2022-04-13 |
Family
ID=71787182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA056113A MA56113A (fr) | 2019-06-07 | 2020-06-04 | Formes solides de (6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-3-[(3s,4s)-4-amino-3-méthyl-2-oxa-8-azaspiro [4,5]décan-8-yl]-5-méthylpyrazin-2-yl)méthanol, un inhibiteur de shp2 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11220501B2 (fr) |
| EP (1) | EP3980128A1 (fr) |
| JP (1) | JP2022534788A (fr) |
| KR (1) | KR20220019017A (fr) |
| CN (2) | CN115141205A (fr) |
| AU (1) | AU2020288631A1 (fr) |
| BR (1) | BR112021022635A2 (fr) |
| CA (1) | CA3142430A1 (fr) |
| IL (1) | IL288568A (fr) |
| MA (1) | MA56113A (fr) |
| MX (1) | MX2021014855A (fr) |
| SG (1) | SG11202112461QA (fr) |
| TW (1) | TW202112785A (fr) |
| WO (1) | WO2020247643A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200051684A (ko) | 2017-09-07 | 2020-05-13 | 레볼루션 메디슨즈, 인크. | 암 치료를 위한 shp2 억제제 조성물 및 방법 |
| KR20220019017A (ko) | 2019-06-07 | 2022-02-15 | 레볼루션 메디슨즈, 인크. | ｛6-[(2-아미노-3-클로로피리딘-4-일)설파닐]-3-[(3s,4s)-4-아미노-3-메틸-2-옥사-8-아자스피로[4.5]데칸-8-일]-5-메틸피라진-2-일｝메탄올의 고체 형태인 shp2 저해제 |
| TW202313041A (zh) | 2021-06-09 | 2023-04-01 | 瑞士商諾華公司 | 包含達拉菲尼、曲美替尼和shp2抑制劑之三重藥物組合 |
| TW202317100A (zh) | 2021-06-23 | 2023-05-01 | 瑞士商諾華公司 | 包含ｋｒａｓ ｇ１２ｃ抑制劑的藥物組合及其用於治療癌症之用途 |
| EP4395769A1 (fr) | 2021-09-01 | 2024-07-10 | Novartis AG | Combinaisons pharmaceutiques comprenant un inhibiteur de tead et leurs utilisations pour le traitement de cancers |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5262564A (en) | 1992-10-30 | 1993-11-16 | Octamer, Inc. | Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents |
| IL264186B1 (en) * | 2016-07-12 | 2024-04-01 | Revolution Medicines Inc | 2,5-dimutomers of 3-methylpyrazines and 2,5,6-dimutomers of 3-methylpyrazines as allosteric SHP2 inhibitors |
| KR20200051684A (ko) | 2017-09-07 | 2020-05-13 | 레볼루션 메디슨즈, 인크. | 암 치료를 위한 shp2 억제제 조성물 및 방법 |
| IL277783B2 (en) | 2018-04-10 | 2024-07-01 | Revolution Medicines Inc | SHP2 inhibitory compositions, methods for treating cancer and methods for identifying a subject with SHP2 mutations |
| KR20220019017A (ko) | 2019-06-07 | 2022-02-15 | 레볼루션 메디슨즈, 인크. | ｛6-[(2-아미노-3-클로로피리딘-4-일)설파닐]-3-[(3s,4s)-4-아미노-3-메틸-2-옥사-8-아자스피로[4.5]데칸-8-일]-5-메틸피라진-2-일｝메탄올의 고체 형태인 shp2 저해제 |
-
2020
- 2020-06-04 KR KR1020227000184A patent/KR20220019017A/ko unknown
- 2020-06-04 BR BR112021022635A patent/BR112021022635A2/pt unknown
- 2020-06-04 JP JP2021571896A patent/JP2022534788A/ja active Pending
- 2020-06-04 CN CN202210564150.XA patent/CN115141205A/zh active Pending
- 2020-06-04 CN CN202080054905.0A patent/CN114190090A/zh active Pending
- 2020-06-04 TW TW109118750A patent/TW202112785A/zh unknown
- 2020-06-04 SG SG11202112461QA patent/SG11202112461QA/en unknown
- 2020-06-04 EP EP20746488.4A patent/EP3980128A1/fr active Pending
- 2020-06-04 MX MX2021014855A patent/MX2021014855A/es unknown
- 2020-06-04 MA MA056113A patent/MA56113A/fr unknown
- 2020-06-04 CA CA3142430A patent/CA3142430A1/fr active Pending
- 2020-06-04 WO PCT/US2020/036137 patent/WO2020247643A1/fr active Application Filing
- 2020-06-04 AU AU2020288631A patent/AU2020288631A1/en not_active Abandoned
-
2021
- 2021-02-26 US US17/187,504 patent/US11220501B2/en active Active
- 2021-11-29 US US17/537,113 patent/US20220298159A1/en active Pending
- 2021-12-01 IL IL288568A patent/IL288568A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020288631A1 (en) | 2021-12-09 |
| BR112021022635A2 (pt) | 2022-01-04 |
| CN114190090A (zh) | 2022-03-15 |
| KR20220019017A (ko) | 2022-02-15 |
| MX2021014855A (es) | 2022-01-18 |
| WO2020247643A1 (fr) | 2020-12-10 |
| US20210253574A1 (en) | 2021-08-19 |
| JP2022534788A (ja) | 2022-08-03 |
| US11220501B2 (en) | 2022-01-11 |
| EP3980128A1 (fr) | 2022-04-13 |
| CN115141205A (zh) | 2022-10-04 |
| TW202112785A (zh) | 2021-04-01 |
| SG11202112461QA (en) | 2021-12-30 |
| US20220298159A1 (en) | 2022-09-22 |
| IL288568A (en) | 2022-02-01 |
| CA3142430A1 (fr) | 2020-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA56113A (fr) | Formes solides de (6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-3-[(3s,4s)-4-amino-3-méthyl-2-oxa-8-azaspiro [4,5]décan-8-yl]-5-méthylpyrazin-2-yl)méthanol, un inhibiteur de shp2 | |
| CL2022000027A1 (es) | Compuestos antagonistas de pcsk9. (divisional de solicitud 202003257). | |
| EA201992235A1 (ru) | Синтез ингибитора mcl-1 | |
| WO2016168682A3 (fr) | Inhibiteur de bromodomaine | |
| AU2015293541B2 (en) | Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof | |
| EA201890749A1 (ru) | ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ (ACC) И ИХ ПРИМЕНЕНИЕ | |
| CA3010752A1 (fr) | Inhibiteurs de l'interaction proteine/proteine pd-1/pd-l1 | |
| MA55716A (fr) | Inhibiteurs de dihydroorotate déshydrogénase | |
| EP3931827A4 (fr) | Détermination d'entrée pour un moteur de traitement vocal | |
| BR112013016982A2 (pt) | formas polimórficas de ácido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acético e usos destes | |
| MA51897A (fr) | Procédés d'utilisation de dérivés de benzotriazole trisubstitués | |
| MA54695A (fr) | Inhibiteurs de dihydroorotate déshydrogénase | |
| MD3762368T2 (ro) | Compuși diol aminopirazină ca inhibitori ai PI3K-Y | |
| EA201991700A1 (ru) | Селективные ингибиторы jak1 | |
| EP3822276A4 (fr) | Composé hétérocyclique utilisé en tant qu'inhibiteur de trk | |
| BR112022008365A2 (pt) | Inibidores de cd73 | |
| DK3789906T3 (da) | Bestemmelse af modulstørrelsen for en optisk kode | |
| MA54907A (fr) | Inhibiteurs de phosphoinositide 3-kinase topiques | |
| DE602006019710D1 (de) | Magnesiumsalze von hmg-coa-reduktase-hemmern | |
| EA202190537A1 (ru) | Способ улавливания кислотных сульфидных соединений | |
| EP3882788A4 (fr) | Procédé de recherche de contenus ayant la même voix que la voix d'un locuteur cible, et appareil pour l'exécuter | |
| EP3886909A4 (fr) | Composés d'excipients destinés au traitement de protéines | |
| MA46039B1 (fr) | Dérivé de triazolopyrazinone utile en tant qu'inhibiteur de pde1 humain | |
| EP3982959A4 (fr) | Nouveaux composés de tétrahydroquinoléine substitués en tant qu'inhibiteurs de l'indoléamine 2,3-dioxygénase (ido) | |
| EA201891430A1 (ru) | Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений |