MA53271A - Polypeptides fhbp méningococciques modifiés - Google Patents

Polypeptides fhbp méningococciques modifiés

Info

Publication number
MA53271A
MA53271A MA053271A MA53271A MA53271A MA 53271 A MA53271 A MA 53271A MA 053271 A MA053271 A MA 053271A MA 53271 A MA53271 A MA 53271A MA 53271 A MA53271 A MA 53271A
Authority
MA
Morocco
Prior art keywords
meningococcal fhbp
fhbp polypeptides
modified meningococcal
modified
polypeptides
Prior art date
Application number
MA053271A
Other languages
English (en)
Inventor
Maria Scarselli
Daniele Veggi
Original Assignee
Glaxosmithkline Biologicals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
Publication of MA53271A publication Critical patent/MA53271A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MA053271A 2018-08-09 2019-08-09 Polypeptides fhbp méningococciques modifiés MA53271A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18188321.6A EP3607967A1 (fr) 2018-08-09 2018-08-09 Polypeptides modifiés du méningocoque fhbp

Publications (1)

Publication Number Publication Date
MA53271A true MA53271A (fr) 2021-11-17

Family

ID=63371487

Family Applications (1)

Application Number Title Priority Date Filing Date
MA053271A MA53271A (fr) 2018-08-09 2019-08-09 Polypeptides fhbp méningococciques modifiés

Country Status (14)

Country Link
US (3) US11708394B2 (fr)
EP (2) EP3607967A1 (fr)
JP (2) JP7271654B2 (fr)
KR (1) KR102677445B1 (fr)
CN (1) CN112566657B (fr)
AU (1) AU2019318120B2 (fr)
BR (1) BR112021000988A2 (fr)
CA (1) CA3108355A1 (fr)
EA (1) EA202190184A1 (fr)
IL (1) IL280189B2 (fr)
MA (1) MA53271A (fr)
MX (1) MX2021001610A (fr)
SG (1) SG11202100482UA (fr)
WO (1) WO2020030782A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017001417B1 (pt) * 2014-07-23 2023-11-07 Children's Hospital & Research Center At Oakland Variantes da proteína de ligação ao fator h (fhbp), composição imunogênica e uso de uma fhbp variante referência cruzada
MX2021010555A (es) 2019-03-08 2022-04-06 Glaxosmithkline Biologicals Sa Derivados carbocíclicos y derivados conjugados de los mismos y su uso en vacunas.
GB202013262D0 (en) * 2020-08-25 2020-10-07 Glaxosmithkline Biologicals Sa Vaccine Composition
CN114681601B (zh) * 2020-12-31 2025-08-19 基础治疗有限公司 脑膜炎奈瑟氏球菌疫苗及其应用
TW202245836A (zh) 2021-02-19 2022-12-01 美商賽諾菲巴斯德公司 重組ｂ型腦膜炎球菌疫苗
GB202115077D0 (en) 2021-10-21 2021-12-08 Glaxosmithkline Biologicals Sa Assay
GB202115151D0 (en) 2021-10-21 2021-12-08 Glaxosmithkline Biologicals Sa Methods
GB202208093D0 (en) * 2022-06-01 2022-07-13 Glaxosmithkline Biologicals Sa Immunogenic composition
GB202208089D0 (en) * 2022-06-01 2022-07-13 Glaxosmithkline Biologicals Sa Immunogenic composition
TW202423477A (zh) 2022-08-03 2024-06-16 美商賽諾菲巴斯德公司 針對腦膜炎奈瑟氏菌b的含佐劑免疫原性組成物
CN117264031B (zh) * 2023-11-03 2024-01-30 烟台派诺生物技术有限公司 一种B群脑膜炎奈瑟菌fHBP重组蛋白及其应用
CN118240723B (zh) * 2024-05-29 2024-08-23 上海羽冠生物技术有限公司 一种通过发酵产生细菌外膜囊泡的方法

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4057685A (en) 1972-02-02 1977-11-08 Abbott Laboratories Chemically modified endotoxin immunizing agent
DE2848965A1 (de) 1978-11-11 1980-05-22 Behringwerke Ag Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine
US4356170A (en) 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4673574A (en) 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4459286A (en) 1983-01-31 1984-07-10 Merck & Co., Inc. Coupled H. influenzae type B vaccine
US4663160A (en) 1983-03-14 1987-05-05 Miles Laboratories, Inc. Vaccines for gram-negative bacteria
US4761283A (en) 1983-07-05 1988-08-02 The University Of Rochester Immunogenic conjugates
US4695624A (en) 1984-05-10 1987-09-22 Merck & Co., Inc. Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
US4882317A (en) 1984-05-10 1989-11-21 Merck & Co., Inc. Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency
US4808700A (en) 1984-07-09 1989-02-28 Praxis Biologics, Inc. Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
IT1187753B (it) 1985-07-05 1987-12-23 Sclavo Spa Coniugati glicoproteici ad attivita' immunogenica trivalente
NL8802046A (nl) 1988-08-18 1990-03-16 Gen Electric Polymeermengsel met polyester en alkaansulfonaat, daaruit gevormde voorwerpen.
DE3841091A1 (de) 1988-12-07 1990-06-13 Behringwerke Ag Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung
CA2006700A1 (fr) 1989-01-17 1990-07-17 Antonello Pessi Peptides synthetiques et leur utilisation comme porteurs universels pour la preparation de conjugats immunogenes convenant a la mise au point de vaccins synthetiques
AU651949B2 (en) 1989-07-14 1994-08-11 American Cyanamid Company Cytokine and hormone carriers for conjugate vaccines
IT1237764B (it) 1989-11-10 1993-06-17 Eniricerche Spa Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
SE466259B (sv) 1990-05-31 1992-01-20 Arne Forsgren Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
ATE128628T1 (de) 1990-08-13 1995-10-15 American Cyanamid Co Faser-hemagglutinin von bordetella pertussis als träger für konjugierten impfstoff.
IT1262896B (it) 1992-03-06 1996-07-22 Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini.
IL102687A (en) 1992-07-30 1997-06-10 Yeda Res & Dev Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
EP0720485B1 (fr) 1993-09-22 2003-11-19 Henry M. Jackson Foundation For The Advancement Of Military Medicine Procede permettant d'activer un glucide soluble a l'aide de nouveaux reactifs cyanylants pour produire des structures immunogenes
US6180111B1 (en) 1995-05-18 2001-01-30 University Of Maryland Vaccine delivery system
GB9711964D0 (en) 1997-06-09 1997-08-06 Medical Res Council Live attenuated vaccines
GB9713156D0 (en) 1997-06-20 1997-08-27 Microbiological Res Authority Vaccines
CN1263510C (zh) 1998-08-19 2006-07-12 巴克斯特健康护理股份有限公司 多糖－蛋白质缀合物或寡糖－蛋白质缀合物、其制备方法及其应用
WO2000033882A1 (fr) 1998-12-04 2000-06-15 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Conjugue vaccinal vi-repa pour l'immunisation contre la salmonella typhi
WO2000061761A2 (fr) 1999-04-09 2000-10-19 Techlab, Inc. Support proteique recombinant de la toxine a pour vaccins conjugues polysaccharides
GB9918319D0 (en) 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
WO2001034642A2 (fr) 1999-11-12 2001-05-17 University Of Iowa Research Foundation Commande de la synthese de membrane de neisseria
ES2588917T3 (es) 2000-01-17 2016-11-07 Glaxosmithkline Biologicals Sa Vacuna de VME suplementada contra meningococo
GB0007432D0 (en) 2000-03-27 2000-05-17 Microbiological Res Authority Proteins for use as carriers in conjugate vaccines
NO20002828D0 (no) 2000-06-02 2000-06-02 Statens Inst For Folkehelse Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav
MXPA03000822A (es) 2000-07-27 2004-11-01 Childrens Hosp & Res Ct Oak Vacunas para proteccion de espectro amplio contra enfermedades causadas por neisseria meningitidis.
GB0103170D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
US7939087B2 (en) 2000-10-27 2011-05-10 Novartis Vaccines And Diagnostics, Inc. Nucleic acids and proteins from Streptococcus groups A & B
GB0103171D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
AU2002309706A1 (en) 2001-05-11 2002-11-25 Aventis Pasteur, Inc. Novel meningitis conjugate vaccine
CN100350972C (zh) 2001-07-26 2007-11-28 启龙股份公司 含有铝佐剂和组氨酸的疫苗
CN1674933B (zh) 2002-08-02 2012-09-26 葛兰素史密丝克莱恩生物有限公司 疫苗组合物
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
CA2506318C (fr) 2002-11-15 2011-07-12 Chiron Srl Proteines de surface inattendues sur le meningocoque
GB0316560D0 (en) 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
CN101107007B (zh) 2005-01-27 2011-08-17 奥克兰儿童医院及研究中心 对脑膜炎奈瑟球菌所致疾病具有广谱保护作用的gna1870囊泡疫苗
EP2208999B1 (fr) 2005-09-05 2014-08-27 GlaxoSmithKline Biologicals SA Essai d'activité bactéricide sérique pour des antisérums spécifiques de n. méningitidis
GB0819633D0 (en) 2008-10-25 2008-12-03 Isis Innovation Composition
GB0917003D0 (en) 2009-09-28 2009-11-11 Novartis Vaccines Inst For Global Health Srl Purification of bacterial vesicles
CA2779816A1 (fr) * 2009-10-27 2011-05-05 Novartis Ag Polypeptides fhbp meningococciques modifies
TR201802933T4 (tr) * 2010-03-30 2018-03-21 Childrens Hospital & Res Center At Oakland Özellikleri değiştirilmiş faktör h bağlama proteinleri (fhbp) ve bunların kullanım yöntemi.
CA2846290A1 (fr) 2011-08-31 2013-03-07 Children's Hospital & Research Center Oakland Sequences concues par ingenierie pour faciliter l'expression d'antigenes dans des neisseria et procedes d'utilisation
MX2014008988A (es) 2012-02-02 2014-08-27 Novartis Ag Promotores para aumento de expresion de proteinas en meningococo.
CN106661092B (zh) * 2014-02-28 2021-07-06 葛兰素史密丝克莱恩生物有限公司 修饰的脑膜炎球菌fHbp多肽
MX2017000776A (es) * 2014-07-17 2017-05-04 Glaxosmithkline Biologicals Sa Polipeptidos fhbp meningococicos modificados.
AU2015289193A1 (en) * 2014-07-17 2017-02-02 Glaxosmithkline Biologicals S.A. Meningococcus vaccines
BR112017001417B1 (pt) 2014-07-23 2023-11-07 Children's Hospital & Research Center At Oakland Variantes da proteína de ligação ao fator h (fhbp), composição imunogênica e uso de uma fhbp variante referência cruzada

Also Published As

Publication number Publication date
SG11202100482UA (en) 2021-02-25
WO2020030782A1 (fr) 2020-02-13
AU2019318120B2 (en) 2024-03-14
AU2019318120A1 (en) 2021-02-11
EA202190184A1 (ru) 2021-05-14
JP7271654B2 (ja) 2023-05-11
JP2021533748A (ja) 2021-12-09
IL280189B1 (en) 2025-01-01
CN112566657A (zh) 2021-03-26
EP3607967A1 (fr) 2020-02-12
MX2021001610A (es) 2021-04-19
KR102677445B1 (ko) 2024-06-20
US20240132550A1 (en) 2024-04-25
US20250250307A1 (en) 2025-08-07
JP2023061971A (ja) 2023-05-02
IL280189B2 (en) 2025-05-01
KR20210041594A (ko) 2021-04-15
US20210277069A1 (en) 2021-09-09
BR112021000988A2 (pt) 2021-04-27
EP3833388A1 (fr) 2021-06-16
CA3108355A1 (fr) 2020-02-13
US11708394B2 (en) 2023-07-25
US20240228551A9 (en) 2024-07-11
US12312384B2 (en) 2025-05-27
CN112566657B (zh) 2025-03-14
IL280189A (en) 2021-03-01

Similar Documents

Publication Publication Date Title
ES1323411Y (es) Cierre
HUE058687T2 (hu) Azonnali elõkészítés
IL280189A (en) Modified meningococcal FHBP polypeptides
EP3555124C0 (fr) Tcr nyeso
DK4177504T3 (da) Forbindelse
LT3110442T (lt) Modifikuoti meningokokinio fhbp polipeptidai
EP3781060A4 (fr) Cryosonde
EP3802565A4 (fr) Polypeptides
HUE061610T2 (hu) Készítmény
EP3784463A4 (fr) Fluorosulfones
EP3899155A4 (fr) Raccord amélioré
EP3745904C0 (fr) Poignée de bâton
EP4014818A4 (fr) Mélangeur
EP4014814A4 (fr) Mélangeur
EP3898177C0 (fr) Configuration de moule
EP3830105A4 (fr) Polypeptides immunogènes chimériques
EP3721129C0 (fr) Cryosphère
EP4046552A4 (fr) Mélangeur
EP4014815A4 (fr) Mélangeur
DK3587968T3 (da) Fluidsystem
EP3742947A4 (fr) Mixeur
DK3752258T3 (da) Trampolin
EP4014816A4 (fr) Mélangeur
EP3843921C0 (fr) Joint rotatif
EP3828490A4 (fr) Raccord