MA51037A - Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4 - Google Patents

Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4

Info

Publication number
MA51037A
MA51037A MA051037A MA51037A MA51037A MA 51037 A MA51037 A MA 51037A MA 051037 A MA051037 A MA 051037A MA 51037 A MA51037 A MA 51037A MA 51037 A MA51037 A MA 51037A
Authority
MA
Morocco
Prior art keywords
acetylcholin
muscarinic
receptor
positive allosteric
allosteric modulators
Prior art date
Application number
MA051037A
Other languages
English (en)
Inventor
P Jeffrey Conn
Darren W Engers
Julie L Engers
Craig W Lindsley
Original Assignee
Univ Vanderbilt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt
Publication of MA51037A publication Critical patent/MA51037A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MA051037A 2017-12-05 2018-12-05 Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4 MA51037A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762594849P 2017-12-05 2017-12-05

Publications (1)

Publication Number Publication Date
MA51037A true MA51037A (fr) 2021-03-17

Family

ID=64902428

Family Applications (2)

Application Number Title Priority Date Filing Date
MA051038A MA51038A (fr) 2017-12-05 2018-12-05 Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4
MA051037A MA51037A (fr) 2017-12-05 2018-12-05 Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA051038A MA51038A (fr) 2017-12-05 2018-12-05 Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4

Country Status (8)

Country Link
US (1) US10736898B2 (fr)
EP (1) EP3720860A1 (fr)
JP (1) JP2021505580A (fr)
CN (1) CN111433212A (fr)
AR (1) AR114153A1 (fr)
MA (2) MA51038A (fr)
TW (1) TW201930311A (fr)
WO (1) WO2019113179A1 (fr)

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5594001A (en) 1993-04-08 1997-01-14 The Dupont Merck Pharmaceutical Company Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
US5654307A (en) 1994-01-25 1997-08-05 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US20020168761A1 (en) 2000-01-24 2002-11-14 Gour Barbara J. Peptidomimetic modulators of cell adhesion
US6608053B2 (en) 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
ATE330633T1 (de) 2000-07-27 2006-07-15 Pharmacia Corp Epoxy-steroidaler aldosteronantagonist und beta- adrenergischer antagonist-kombinationstherapie zur behandlung von kongestivem herzversagen
US7291733B2 (en) 2003-10-10 2007-11-06 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted tricyclic heterocycles and their uses
US20090099165A1 (en) 2003-10-14 2009-04-16 Arizona Board Of Regents On Behalf Of The University Of Arizona Protein Kinase Inhibitors
PT1678166E (pt) 2003-10-14 2009-10-30 Supergen Inc Inibidores de proteína-quinase
AR049300A1 (es) 2004-06-15 2006-07-12 Schering Corp Compuestos triciclicos antagonistas de mglur1 como agentes terapeuticos
EP1619196A1 (fr) 2004-07-23 2006-01-25 Curacyte Discovery GmbH Pyrido[3',2':4,5]thieno[3,2-d]pyrimidines et Pyrido[3',2':4,5]furo[3,2-d]-pyrimidines substitués comme inhibiteurs de PDA-4 et/ou libération de TNF-alpha
ES2341559T3 (es) 2004-07-23 2010-06-22 The Medicines Company (Leipzig) Gmbh Pirido(3',2':4,5)tieno(3,2-d)pirimidinas y pirido(3',2':4,5)furo(3,2-d)pirimidinas sustituidas para su utilizacion como inhibidores de la liberacion de pda-4 y/o tnf-alfa.
PT1807434E (pt) 2004-10-25 2010-09-22 Lilly Co Eli Tienopiridinas a título de potenciadores alostéricos do receptor muscarínicom4
ES2259892B1 (es) 2004-11-30 2007-11-01 Laboratorios Almirall S.A. Nuevos derivados de piridotienopirimidina.
ES2259891B1 (es) 2004-11-30 2007-11-01 Laboratorios Almirall S.A. Nuevos derivados de piridotienopirimidina.
WO2006138418A2 (fr) 2005-06-14 2006-12-28 President And Fellows Of Harvard College Amelioration de la performance cognitive avec des activateurs de sirtuine
AR059901A1 (es) 2006-03-20 2008-05-07 Bayer Pharmaceuticals Corp Compuestos de tetrahidropiridotienopirimidina utiles para tratar o prevenir trastornos proliferativos celulares.
US20080021063A1 (en) 2006-07-18 2008-01-24 Kazantsev Aleksey G Compositions and methods for modulating sirtuin activity
US7547781B2 (en) 2006-09-11 2009-06-16 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
CN110551105B (zh) 2006-12-29 2022-10-18 里格尔制药公司 用作axl抑制剂的取代三唑
US20090105240A1 (en) 2007-10-17 2009-04-23 Tomas Mustelin Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same
WO2009151569A2 (fr) 2008-06-09 2009-12-17 Combinatorx, Incorporated Agonistes des récepteurs bêta-adrénergiques utilisables pour le traitement des troubles prolifératifs des lymphocytes b
ES2534326T3 (es) 2009-08-20 2015-04-21 Karus Therapeutics Limited Compuestos tricíclicos heterocíclicos como inhibidores de la fosfoinositida 3-cinasa
US20110178107A1 (en) 2010-01-20 2011-07-21 Taigen Biotechnology Co., Ltd. Hcv protease inhibitors
WO2012131297A1 (fr) * 2011-03-28 2012-10-04 Jonathan Bayldon Baell Dérivés de pyrido[3',2':4,5]thiéno[3,2-d]pyrimidin-4-ylamine et leur utilisation thérapeutique
US9056876B2 (en) 2011-09-16 2015-06-16 Vanderbilt University Substituted 1H-pyrazolo[3′,4′,4,5]thieno[2,3-b]pyridin-3-amine analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
US20130116241A1 (en) 2011-11-09 2013-05-09 Abbvie Inc. Novel inhibitor compounds of phosphodiesterase type 10a
US9353121B2 (en) 2011-12-21 2016-05-31 The Regents Of The University Of Colorado, A Body Corporate Anti-cancer compounds targeting Ral GTPases and methods of using the same
US8697888B2 (en) 2012-01-06 2014-04-15 Vanderbilt University Substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs as antagonists of muscarinic acetylcholine M1 receptors
WO2013126856A1 (fr) 2012-02-23 2013-08-29 Vanderbilt University Analogues de 5-aminothiéno[2,3-c]pyridazine-6-carboxamide substitués en tant que modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4
EP2872144A4 (fr) * 2012-07-11 2015-12-02 Nimbus Iris Inc Inhibiteurs d'irak et leurs utilisations
US9056875B2 (en) 2012-08-31 2015-06-16 Vanderbilt University Substituted pyrazolo[3′,4′:4,5]thieno[2,3-C]pyridazin-3-amine analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
WO2015027214A1 (fr) 2013-08-23 2015-02-26 Vanderbilt University Analogues de thiéno[2,3-c]pyridazine-6-carboxamide substitués utilisés en tant que modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4
US20160200733A1 (en) 2013-08-23 2016-07-14 Vanderbilt University Substituted thieno[2,3-b]pyridine-2-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m4
WO2015200619A1 (fr) 2014-06-26 2015-12-30 Rodin Therapeutics, Inc. Inhibiteurs d'histone désacétylase
MA45463A (fr) 2016-06-22 2019-05-01 Univ Vanderbilt Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4
EP3534901B1 (fr) 2016-11-07 2022-06-22 Vanderbilt University Modulateurs allostériques positifs du récepteur muscarinique à l'acétylcholine m4
JP7099725B2 (ja) 2016-11-07 2022-07-12 ヴァンダービルト ユニヴァーシティ ムスカリン性アセチルコリンレセプターｍ４のポジティブアロステリック調節因子
MA46899A (fr) 2016-11-07 2021-04-14 Univ Vanderbilt Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4

Also Published As

Publication number Publication date
WO2019113179A1 (fr) 2019-06-13
MA51038A (fr) 2020-10-14
US10736898B2 (en) 2020-08-11
EP3720860A1 (fr) 2020-10-14
CN111433212A (zh) 2020-07-17
TW201930311A (zh) 2019-08-01
JP2021505580A (ja) 2021-02-18
US20190167688A1 (en) 2019-06-06
AR114153A1 (es) 2020-07-29

Similar Documents

Publication Publication Date Title
MA45463A (fr) Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4
MA44253A (fr) Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m1
IL273924A (en) Muscarinic acetylcholine M4 receptor antagonists
IL274369A (en) Combined pressure pathway modulators
DK3452448T3 (da) Modulatorer af den integrerede stressvej
MA43756A (fr) Modulateurs allostériques des récepteurs nicotiniques de l'acétylcholine
IL274405A (en) Combined pressure pathway modulators
IL274368A (en) Combined pressure pathway modulators
MA47127A (fr) Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4
MA46899A (fr) Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4
MA46722A (fr) Modulateurs allostériques positifs du récepteur muscarinique à l'acétylcholine m4
MA47126A (fr) Modulateurs allostériques positifs du récepteur muscarinique à l'acétylcholine m4
IL274367A (en) Combined pressure pathway modulators
IL264951B (en) Positive allosteric modulators of the m1 muscarinic receptor
ZA202105774B (en) Novel modulators of the 5-hydroxytryptamine receptor 7 and their method of use
IL274062A (en) Muscarinic acetylcholine M4 receptor antagonists
EP3393472A4 (fr) Modulateurs allostériques de type 3-(1h-pyrazol-4-yl)pyridine du récepteur muscarinique m4 d'acétylcholine
BR112017026561A2 (pt) moduladores alostéricos positivos do receptor muscarínico m2
IL271805A (en) M4 muscarinic acetylcholine receptor antagonists
EP3697781C0 (fr) Antagonistes du récepteur muscarinique de l'acétylcholine m4
MA52555A (fr) Modulateurs du récepteur des oestrogènes
MA52482A (fr) Modulateurs allostériques de spiropipéridine des récepteurs nicotiniques de l'acétylcholine
MA49564A (fr) Modulateurs thérapeutiques du mode inverse de l'atp synthase
MA51036A (fr) Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4
HUE036698T2 (hu) Mérõeszközök regisztrálása az interneten keresztül