MA50116B2 - Agent d'absorption transdermique comprenant du donépézil pour le traitement de la démence - Google Patents
Agent d'absorption transdermique comprenant du donépézil pour le traitement de la démenceInfo
- Publication number
- MA50116B2 MA50116B2 MA50116A MA50116A MA50116B2 MA 50116 B2 MA50116 B2 MA 50116B2 MA 50116 A MA50116 A MA 50116A MA 50116 A MA50116 A MA 50116A MA 50116 B2 MA50116 B2 MA 50116B2
- Authority
- MA
- Morocco
- Prior art keywords
- treatment
- dementia
- transdermal absorption
- absorption agent
- donepezil
- Prior art date
Links
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 title abstract 6
- 206010012289 Dementia Diseases 0.000 title abstract 4
- 238000010521 absorption reaction Methods 0.000 title abstract 4
- 229960003530 donepezil Drugs 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- GHHURQMJLARIDK-UHFFFAOYSA-N 2-hydroxypropyl octanoate Chemical compound CCCCCCCC(=O)OCC(C)O GHHURQMJLARIDK-UHFFFAOYSA-N 0.000 abstract 1
- 206010040880 Skin irritation Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 abstract 1
- 230000036556 skin irritation Effects 0.000 abstract 1
- 231100000475 skin irritation Toxicity 0.000 abstract 1
- 231100000245 skin permeability Toxicity 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D7/00—Producing flat articles, e.g. films or sheets
- B29D7/01—Films or sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2071/00—Use of polyethers, e.g. PEEK, i.e. polyether-etherketone or PEK, i.e. polyetherketone or derivatives thereof, as moulding material
- B29K2071/02—Polyalkylene oxides, e.g. PEO, i.e. polyethylene oxide, or derivatives thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/753—Medical equipment; Accessories therefor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne un agent d'absorption transdermique comprenant du donépézil pour le traitement de la démence et, plus particulièrement, un agent d'absorption transdermique pour le traitement de la démence, l'agent comprenant : (a) le donépézil en tant que principe actif ; (b) le monocaprylate de propylène glycol en tant que solubilisant ; et (c) un copolymère séquencé de styrène-isoprène-styrène en tant que matériau de base adhésif. L'agent d'absorption transdermique pour le traitement de la démence selon la présente invention entraîne une faible irritation cutanée et simultanément présente une excellente perméabilité cutanée.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020170180647A KR102024996B1 (ko) | 2017-12-27 | 2017-12-27 | 도네페질을 함유하는 치매 치료용 경피흡수제제 |
PCT/KR2018/013439 WO2019132229A1 (fr) | 2017-12-27 | 2018-11-07 | Agent d'absorption transdermique comprenant du donépézil pour le traitement de la démence |
Publications (2)
Publication Number | Publication Date |
---|---|
MA50116A1 MA50116A1 (fr) | 2021-09-30 |
MA50116B2 true MA50116B2 (fr) | 2023-03-31 |
Family
ID=67067659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA50116A MA50116B2 (fr) | 2017-12-27 | 2018-11-07 | Agent d'absorption transdermique comprenant du donépézil pour le traitement de la démence |
Country Status (13)
Country | Link |
---|---|
US (1) | US11992562B2 (fr) |
EP (1) | EP3733168A4 (fr) |
JP (1) | JP7170728B2 (fr) |
KR (1) | KR102024996B1 (fr) |
CN (1) | CN111542311B (fr) |
AU (1) | AU2018395643B2 (fr) |
BR (1) | BR112020013187A2 (fr) |
CA (1) | CA3087156C (fr) |
CL (1) | CL2020001738A1 (fr) |
MA (1) | MA50116B2 (fr) |
MX (1) | MX2020006645A (fr) |
WO (1) | WO2019132229A1 (fr) |
ZA (1) | ZA202004530B (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102218593B1 (ko) * | 2020-05-13 | 2021-02-22 | 동아에스티 주식회사 | 안정성이 향상된 도네페질 함유 경피 흡수제제 |
KR102489860B1 (ko) * | 2021-09-02 | 2023-01-19 | 동아에스티 주식회사 | 메만틴 에난트산염을 포함하는 치매 치료용 경피흡수 제제 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6193993B1 (en) * | 1998-03-03 | 2001-02-27 | Eisai Co., Ltd. | Suppository containing an antidementia medicament |
JP3987655B2 (ja) | 1998-03-03 | 2007-10-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗痴呆薬を含有した経皮適用製剤又は坐剤 |
US20040258741A1 (en) * | 2001-10-17 | 2004-12-23 | Takaaki Terahara | Percutaneous absorption preparations |
DE10159120B4 (de) * | 2001-12-01 | 2006-08-17 | Lts Lohmann Therapie-Systeme Ag | Steroidhormonhaltige transdermale therapeutische Systeme enthaltend Propylenglycolmonocaprylat und seine Verwendung |
ATE413166T1 (de) | 2004-11-22 | 2008-11-15 | Hisamitsu Pharmaceutical Co | Transdermales pflaster enthaltend einen schmelzpunktsenkenden hilfsstoff |
US20080131491A1 (en) * | 2006-12-01 | 2008-06-05 | Akinori Hanatani | Percutaneously absorbable preparation |
KR101454362B1 (ko) * | 2008-03-24 | 2014-10-23 | 아이큐어 주식회사 | 도네페질을 유효성분으로 함유하는 치매 치료용경피흡수제제 |
US20090291127A1 (en) * | 2008-05-21 | 2009-11-26 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
JP2012504163A (ja) | 2008-09-30 | 2012-02-16 | テイコク ファーマ ユーエスエー インコーポレーテッド | 経皮持続送達ドネペジル組成物および該組成物を使用する方法 |
WO2011034323A2 (fr) | 2009-09-16 | 2011-03-24 | Samyang Corporation | Système de distribution transdermique, son procédé de fabrication, et procédé de distribution transdermique utilisant le système |
RU2545696C2 (ru) * | 2009-10-21 | 2015-04-10 | Тейкоку Сейяку Ко., Лтд. | Трансдермально абсорбируемый состав, содержащий донепезил |
KR101292768B1 (ko) * | 2010-04-23 | 2013-08-05 | 아이큐어 주식회사 | 경피 흡수 제제 |
WO2011136288A1 (fr) | 2010-04-28 | 2011-11-03 | 久光製薬株式会社 | Préparation contenant du donépézil absorbable par voie transdermique |
JPWO2012029097A1 (ja) | 2010-09-03 | 2013-10-28 | 株式会社 ケイ・エム トランスダーム | 経皮吸収製剤 |
JP6089339B2 (ja) | 2011-09-08 | 2017-03-08 | 株式会社 ケイ・エム トランスダーム | 経皮吸収製剤 |
KR101239150B1 (ko) | 2012-02-28 | 2013-03-06 | 에스케이케미칼주식회사 | 도네페질-함유 경피흡수제제 및 그의 제조방법 |
KR101485822B1 (ko) | 2014-01-22 | 2015-01-23 | 주식회사 대웅제약 | 도네페질 또는 그의 염을 함유하는 경피흡수제제 |
WO2015127280A1 (fr) * | 2014-02-20 | 2015-08-27 | Nal Pharmaceuticals, Ltd. | Système d'administration transdermique de médicament, contenant du donépézil |
RU2713207C2 (ru) * | 2014-12-18 | 2020-02-04 | Айкьюре Фармасьютикал Инк. | Трансдермальная композиция, содержащая донепезил в качестве активного ингредиента |
JP7285790B2 (ja) | 2018-01-22 | 2023-06-02 | 株式会社カネカ | 皮膚貼付用粘着シート |
-
2017
- 2017-12-27 KR KR1020170180647A patent/KR102024996B1/ko active IP Right Grant
-
2018
- 2018-11-07 CN CN201880084013.8A patent/CN111542311B/zh active Active
- 2018-11-07 MX MX2020006645A patent/MX2020006645A/es unknown
- 2018-11-07 JP JP2020536165A patent/JP7170728B2/ja active Active
- 2018-11-07 CA CA3087156A patent/CA3087156C/fr active Active
- 2018-11-07 AU AU2018395643A patent/AU2018395643B2/en active Active
- 2018-11-07 EP EP18896586.7A patent/EP3733168A4/fr active Pending
- 2018-11-07 MA MA50116A patent/MA50116B2/fr unknown
- 2018-11-07 BR BR112020013187-3A patent/BR112020013187A2/pt unknown
- 2018-11-07 US US16/957,774 patent/US11992562B2/en active Active
- 2018-11-07 WO PCT/KR2018/013439 patent/WO2019132229A1/fr active Application Filing
-
2020
- 2020-06-25 CL CL2020001738A patent/CL2020001738A1/es unknown
- 2020-07-22 ZA ZA2020/04530A patent/ZA202004530B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2019132229A1 (fr) | 2019-07-04 |
CN111542311B (zh) | 2023-07-14 |
ZA202004530B (en) | 2021-09-29 |
JP2021508713A (ja) | 2021-03-11 |
CN111542311A (zh) | 2020-08-14 |
AU2018395643B2 (en) | 2023-02-16 |
US11992562B2 (en) | 2024-05-28 |
EP3733168A1 (fr) | 2020-11-04 |
KR20190078893A (ko) | 2019-07-05 |
JP7170728B2 (ja) | 2022-11-14 |
CL2020001738A1 (es) | 2020-11-06 |
RU2020123498A (ru) | 2022-01-27 |
MX2020006645A (es) | 2020-11-06 |
CA3087156A1 (fr) | 2019-07-04 |
CA3087156C (fr) | 2023-08-01 |
EP3733168A4 (fr) | 2021-09-08 |
RU2020123498A3 (fr) | 2022-01-27 |
BR112020013187A2 (pt) | 2020-12-01 |
MA50116A1 (fr) | 2021-09-30 |
AU2018395643A1 (en) | 2020-07-02 |
KR102024996B1 (ko) | 2019-09-25 |
US20210059956A1 (en) | 2021-03-04 |
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