MA48971B1 - Tétrahydrate de ligand h3, son procédé de préparation et compositions pharmaceutiques le comprenant - Google Patents

Tétrahydrate de ligand h3, son procédé de préparation et compositions pharmaceutiques le comprenant

Info

Publication number
MA48971B1
MA48971B1 MA48971A MA48971A MA48971B1 MA 48971 B1 MA48971 B1 MA 48971B1 MA 48971 A MA48971 A MA 48971A MA 48971 A MA48971 A MA 48971A MA 48971 B1 MA48971 B1 MA 48971B1
Authority
MA
Morocco
Prior art keywords
tetrahydrate
ligand
pharmaceutical compositions
preparation process
preparation
Prior art date
Application number
MA48971A
Other languages
English (en)
Other versions
MA48971A (fr
Inventor
Jean-Charles Schwartz
Jeanne-Marie Lecomte
Marc Capet
Original Assignee
Bioprojet Soc Civ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioprojet Soc Civ filed Critical Bioprojet Soc Civ
Publication of MA48971A publication Critical patent/MA48971A/fr
Publication of MA48971B1 publication Critical patent/MA48971B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La présente invention concerne la forme tétrahydrate du composé : (3s)-4-{4-[3-(3-méthylpipéridin-1-yl)propoxy]phényl}pyridine 1-oxide, dichlorhydrate, son procédé de préparation et ses utilisations thérapeutiques.
MA48971A 2017-03-21 2018-03-20 Tétrahydrate de ligand h3, son procédé de préparation et compositions pharmaceutiques le comprenant MA48971B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17305310.9A EP3378858A1 (fr) 2017-03-21 2017-03-21 Tétrahydrate de ligand h3, son procédé de préparation et compositions pharmaceutiques le comprenant
PCT/EP2018/056999 WO2018172344A1 (fr) 2017-03-21 2018-03-20 Tétrahydrate de ligand h3, son procédé de préparation et compositions pharmaceutiques les comprenant

Publications (2)

Publication Number Publication Date
MA48971A MA48971A (fr) 2020-02-05
MA48971B1 true MA48971B1 (fr) 2021-03-31

Family

ID=58488932

Family Applications (1)

Application Number Title Priority Date Filing Date
MA48971A MA48971B1 (fr) 2017-03-21 2018-03-20 Tétrahydrate de ligand h3, son procédé de préparation et compositions pharmaceutiques le comprenant

Country Status (21)

Country Link
US (1) US11078183B2 (fr)
EP (2) EP3378858A1 (fr)
JP (1) JP7235671B2 (fr)
KR (1) KR102608265B1 (fr)
CN (1) CN110891948B (fr)
AU (1) AU2018238260B2 (fr)
BR (1) BR112019019643A2 (fr)
CA (1) CA3056490A1 (fr)
CY (1) CY1124114T1 (fr)
DK (1) DK3601252T3 (fr)
ES (1) ES2868024T3 (fr)
HR (1) HRP20210312T1 (fr)
HU (1) HUE053710T2 (fr)
IL (1) IL269360B2 (fr)
LT (1) LT3601252T (fr)
MA (1) MA48971B1 (fr)
PL (1) PL3601252T3 (fr)
PT (1) PT3601252T (fr)
RS (1) RS61511B1 (fr)
WO (1) WO2018172344A1 (fr)
ZA (1) ZA201906202B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3378477A1 (fr) * 2017-03-21 2018-09-26 BIOPROJET Pharma Nouvelles utilisations thérapeutiques de ligands h3

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101060971B1 (ko) * 2002-05-14 2011-09-01 제노바 리미티드 안트라닐산 유도체 수화물의 제조 방법
EP1820797A4 (fr) 2004-12-01 2009-10-28 Banyu Pharma Co Ltd Derive substitue de pyridone
EP1717235A3 (fr) 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidines and -pyrrolidines et leur utilisation comme ligands du récepteur histaminique H3
MX345145B (es) 2011-12-08 2017-01-17 Taisho Pharmaceutical Co Ltd Derivado de fenilpirrol.
US20150045553A1 (en) 2011-12-27 2015-02-12 Taisho Pharmaceutical Co., Ltd Phenyltriazole derivative
EP3378477A1 (fr) * 2017-03-21 2018-09-26 BIOPROJET Pharma Nouvelles utilisations thérapeutiques de ligands h3
DK3598975T3 (da) * 2018-07-27 2020-11-02 Bioprojet Soc Civ Hidtil ukendte kombinationer af en H3-antagonist og en noradrenalin-genoptagelseshæmmer, og de terapeutiske anvendelser deraf

Also Published As

Publication number Publication date
EP3378858A1 (fr) 2018-09-26
CN110891948B (zh) 2022-11-11
ZA201906202B (en) 2020-10-28
JP2020511507A (ja) 2020-04-16
CA3056490A1 (fr) 2018-09-27
RS61511B1 (sr) 2021-03-31
CY1124114T1 (el) 2022-05-27
IL269360B (en) 2022-10-01
IL269360A (en) 2019-11-28
RU2019129432A3 (fr) 2021-07-01
IL269360B2 (en) 2023-02-01
DK3601252T3 (da) 2021-03-08
US20200024256A1 (en) 2020-01-23
EP3601252B1 (fr) 2021-02-17
JP7235671B2 (ja) 2023-03-08
AU2018238260B2 (en) 2021-07-22
PL3601252T3 (pl) 2021-08-02
US11078183B2 (en) 2021-08-03
HUE053710T2 (hu) 2021-07-28
ES2868024T3 (es) 2021-10-21
PT3601252T (pt) 2021-03-31
EP3601252A1 (fr) 2020-02-05
HRP20210312T1 (hr) 2021-04-02
KR102608265B1 (ko) 2023-11-30
MA48971A (fr) 2020-02-05
KR20200008995A (ko) 2020-01-29
CN110891948A (zh) 2020-03-17
BR112019019643A2 (pt) 2020-04-14
AU2018238260A1 (en) 2019-10-10
WO2018172344A1 (fr) 2018-09-27
RU2019129432A (ru) 2021-03-18
LT3601252T (lt) 2021-04-26

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MA48971B1 (fr) Tétrahydrate de ligand h3, son procédé de préparation et compositions pharmaceutiques le comprenant