MA38010A1 - Dérivés d'éthynyl utilisés en tant que modulateurs de l'activité des récepteurs mglur5 - Google Patents
Dérivés d'éthynyl utilisés en tant que modulateurs de l'activité des récepteurs mglur5Info
- Publication number
- MA38010A1 MA38010A1 MA38010A MA38010A MA38010A1 MA 38010 A1 MA38010 A1 MA 38010A1 MA 38010 A MA38010 A MA 38010A MA 38010 A MA38010 A MA 38010A MA 38010 A1 MA38010 A1 MA 38010A1
- Authority
- MA
- Morocco
- Prior art keywords
- modulators
- receptor activity
- derivatives used
- mglur5 receptor
- ethynyl derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention concerne des dérivés d'éthynyl de formule (i), dans laquelle y représente n ou ch, r
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12188943 | 2012-10-18 | ||
| PCT/EP2013/071476 WO2014060384A1 (fr) | 2012-10-18 | 2013-10-15 | Dérivés d'éthynyl utilisés en tant que modulateurs de l'activité des récepteurs mglur5 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA38010A1 true MA38010A1 (fr) | 2016-01-29 |
| MA38010B1 MA38010B1 (fr) | 2016-10-31 |
Family
ID=47049068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA38010A MA38010B1 (fr) | 2012-10-18 | 2015-04-17 | Dérivés d'éthynyl utilisés en tant que modulateurs de l'activité des récepteurs mglur5 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9359301B2 (fr) |
| EP (1) | EP2909178B1 (fr) |
| JP (1) | JP6263542B2 (fr) |
| KR (1) | KR20150070102A (fr) |
| CN (1) | CN104603110B (fr) |
| AR (1) | AR093029A1 (fr) |
| AU (1) | AU2013331782B2 (fr) |
| BR (1) | BR112015002320A2 (fr) |
| CA (1) | CA2879489A1 (fr) |
| CL (1) | CL2015000890A1 (fr) |
| CR (1) | CR20150158A (fr) |
| EA (1) | EA026941B1 (fr) |
| ES (1) | ES2599507T3 (fr) |
| HK (1) | HK1206715A1 (fr) |
| IL (1) | IL237217A (fr) |
| MA (1) | MA38010B1 (fr) |
| MX (1) | MX2015002823A (fr) |
| MY (1) | MY171517A (fr) |
| NZ (1) | NZ703537A (fr) |
| PE (1) | PE20150733A1 (fr) |
| PH (1) | PH12015500346B1 (fr) |
| SG (1) | SG11201500729SA (fr) |
| TW (1) | TWI504593B (fr) |
| UA (1) | UA114008C2 (fr) |
| WO (1) | WO2014060384A1 (fr) |
| ZA (1) | ZA201500343B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016273751B2 (en) * | 2015-06-03 | 2020-04-02 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
| JP6761821B2 (ja) | 2015-07-15 | 2020-09-30 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 代謝性グルタミン酸受容体モジュレーターとしてのエチニル誘導体 |
| EA201891948A1 (ru) | 2016-03-30 | 2019-04-30 | Синнтаксис Аб | Отрицательные аллостерические модуляторы метаботропного глутаматного рецептора 5 для применения в лечении зрелых повреждений головного мозга |
| SG11201811829QA (en) | 2016-07-18 | 2019-02-27 | Hoffmann La Roche | Ethynyl derivatives |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4536518A (en) * | 1979-11-01 | 1985-08-20 | Pfizer Inc. | Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine |
| US7531529B2 (en) * | 2003-06-05 | 2009-05-12 | Roche Palo Alto Llc | Imidazole derivatives |
| UA80888C2 (en) * | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
| US8853392B2 (en) * | 2007-06-03 | 2014-10-07 | Vanderbilt University | Benzamide mGluR5 positive allosteric modulators and methods of making and using same |
| US20100273772A1 (en) * | 2009-04-23 | 2010-10-28 | Wyeth Llc | Bisaryl Alkynylamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (MGLUR5) |
| US8389536B2 (en) * | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
| US8586581B2 (en) * | 2009-12-17 | 2013-11-19 | Hoffmann-La Roche Inc | Ethynyl compounds useful for treatment of CNS disorders |
| US8772300B2 (en) * | 2011-04-19 | 2014-07-08 | Hoffmann-La Roche Inc. | Phenyl or pyridinyl-ethynyl derivatives |
| KR101554803B1 (ko) * | 2011-04-26 | 2015-09-21 | 에프. 호프만-라 로슈 아게 | Mglur5의 양성 알로스테릭 조절체로서 에틴일 유도체 |
| WO2013049255A1 (fr) * | 2011-09-26 | 2013-04-04 | Vanderbilt University | Analogues de 5-(prop-1-yn-1-yl)picolinamide substitué comme modulateurs allostériques des récepteurs de mglur5 |
| UA110862C2 (uk) * | 2011-10-07 | 2016-02-25 | Ф. Хоффманн-Ля Рош Аг | Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5 |
| UA110995C2 (uk) * | 2011-10-07 | 2016-03-10 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні як модулятори метаботропного глутаматного рецептора |
| PE20150184A1 (es) * | 2012-07-17 | 2015-02-13 | Hoffmann La Roche | Derivados de ariletinilo |
| UA113223C2 (xx) * | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
| DK2900659T3 (en) * | 2012-09-27 | 2016-10-03 | Hoffmann La Roche | ARYLETHYNYL DERIVATIVES |
| EP2909180B1 (fr) * | 2012-10-18 | 2016-10-05 | F. Hoffmann-La Roche AG | Dérivés d'éthynyle comme modulateurs de l'activité des récepteurs mglur5 |
| KR101656634B1 (ko) * | 2012-10-18 | 2016-09-09 | 에프. 호프만-라 로슈 아게 | mGluR5 수용체 활성의 조절제로서 에틴일 유도체 |
-
2013
- 2013-10-15 CA CA2879489A patent/CA2879489A1/fr not_active Abandoned
- 2013-10-15 MY MYPI2015000250A patent/MY171517A/en unknown
- 2013-10-15 CN CN201380046124.7A patent/CN104603110B/zh active Active
- 2013-10-15 WO PCT/EP2013/071476 patent/WO2014060384A1/fr active Application Filing
- 2013-10-15 PE PE2015000287A patent/PE20150733A1/es not_active Application Discontinuation
- 2013-10-15 SG SG11201500729SA patent/SG11201500729SA/en unknown
- 2013-10-15 KR KR1020157006701A patent/KR20150070102A/ko active IP Right Grant
- 2013-10-15 JP JP2015537217A patent/JP6263542B2/ja active Active
- 2013-10-15 EP EP13776507.9A patent/EP2909178B1/fr active Active
- 2013-10-15 EA EA201590676A patent/EA026941B1/ru not_active IP Right Cessation
- 2013-10-15 UA UAA201504679A patent/UA114008C2/uk unknown
- 2013-10-15 AU AU2013331782A patent/AU2013331782B2/en not_active Ceased
- 2013-10-15 ES ES13776507.9T patent/ES2599507T3/es active Active
- 2013-10-15 NZ NZ703537A patent/NZ703537A/en not_active IP Right Cessation
- 2013-10-15 MX MX2015002823A patent/MX2015002823A/es unknown
- 2013-10-15 BR BR112015002320A patent/BR112015002320A2/pt not_active Application Discontinuation
- 2013-10-16 AR ARP130103749A patent/AR093029A1/es unknown
- 2013-10-17 TW TW102137559A patent/TWI504593B/zh not_active IP Right Cessation
-
2015
- 2015-01-16 ZA ZA2015/00343A patent/ZA201500343B/en unknown
- 2015-02-12 IL IL237217A patent/IL237217A/en not_active IP Right Cessation
- 2015-02-17 PH PH12015500346A patent/PH12015500346B1/en unknown
- 2015-03-20 CR CR20150158A patent/CR20150158A/es unknown
- 2015-04-09 CL CL2015000890A patent/CL2015000890A1/es unknown
- 2015-04-17 MA MA38010A patent/MA38010B1/fr unknown
- 2015-04-17 US US14/689,387 patent/US9359301B2/en active Active
- 2015-07-27 HK HK15107144.3A patent/HK1206715A1/zh unknown
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