MA33758B1 - Polypeptides anti-tnfr1 stables, domaines variables de l'anticorps, et antagonistes - Google Patents
Polypeptides anti-tnfr1 stables, domaines variables de l'anticorps, et antagonistesInfo
- Publication number
- MA33758B1 MA33758B1 MA34878A MA34878A MA33758B1 MA 33758 B1 MA33758 B1 MA 33758B1 MA 34878 A MA34878 A MA 34878A MA 34878 A MA34878 A MA 34878A MA 33758 B1 MA33758 B1 MA 33758B1
- Authority
- MA
- Morocco
- Prior art keywords
- antagonists
- antibody
- tnfr1
- stable anti
- polypeptides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Cette invention concerne des domaines variables uniques de l'anticorps anti-TNFR1 stable à l'entreposage (d Abs), des antagonistes et des ligands multispécifiques, ainsi que des méthodes et des utilisations de ceux-ci. Les polypeptides anti-TNFR1, les domaines variables uniques de l'anticorps (d Abs), les antagonistes et les ligands multispécifiques sont utiles pour le traitement et/ou la prévention d'une maladie inflammatoire, telle que la BPCO, ainsi que pour l'administration par voie pulmonaire ou orale ou l'acheminement au poumon ou au tractus gastro-intestinal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25523509P | 2009-10-27 | 2009-10-27 | |
PCT/EP2010/066046 WO2011051217A1 (fr) | 2009-10-27 | 2010-10-25 | Polypeptides anti-tnfr1 stables, domaines variables de l'anticorps, et antagonistes |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33758B1 true MA33758B1 (fr) | 2012-11-01 |
Family
ID=43382391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34878A MA33758B1 (fr) | 2009-10-27 | 2012-05-18 | Polypeptides anti-tnfr1 stables, domaines variables de l'anticorps, et antagonistes |
Country Status (26)
Country | Link |
---|---|
US (1) | US20150210767A1 (fr) |
EP (1) | EP2493504B1 (fr) |
JP (1) | JP2013507978A (fr) |
KR (1) | KR20120101417A (fr) |
CN (1) | CN102686239B (fr) |
AR (1) | AR078763A1 (fr) |
AU (1) | AU2010311640B2 (fr) |
BR (1) | BR112012010114A2 (fr) |
CA (1) | CA2777312A1 (fr) |
CL (1) | CL2012001055A1 (fr) |
CO (1) | CO6612254A2 (fr) |
CR (1) | CR20120197A (fr) |
DO (1) | DOP2012000113A (fr) |
EA (1) | EA022898B1 (fr) |
ES (1) | ES2552177T3 (fr) |
IL (1) | IL218860A0 (fr) |
MA (1) | MA33758B1 (fr) |
MX (1) | MX2012005024A (fr) |
NZ (1) | NZ599114A (fr) |
PE (1) | PE20121564A1 (fr) |
SG (1) | SG10201500274TA (fr) |
TW (1) | TW201125877A (fr) |
UA (1) | UA107200C2 (fr) |
UY (1) | UY32969A (fr) |
WO (1) | WO2011051217A1 (fr) |
ZA (1) | ZA201203052B (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010094720A2 (fr) * | 2009-02-19 | 2010-08-26 | Glaxo Group Limited | Polypeptides, domaines variables d'anticorps, et antagonistes améliorés, tous étant des anti-tnfr1 |
WO2012172070A1 (fr) * | 2011-06-17 | 2012-12-20 | Glaxo Group Limited | Antagonistes du récepteur 1 du facteur de nécrose tumorale |
CA2897345A1 (fr) * | 2013-01-31 | 2014-08-07 | Glaxo Group Limited | Procede de production de proteine |
WO2015104322A1 (fr) | 2014-01-09 | 2015-07-16 | Glaxosmithkline Intellectual Property Development Limited | Traitement de maladies inflammatoires avec des antagonistes anti-tnfr1 non compétitifs |
JP6784775B2 (ja) * | 2016-04-05 | 2020-11-11 | ウニヴェルズィテート シュトゥットガルト | huTNFR1相互作用の一価阻害剤 |
IL300930A (en) | 2020-08-27 | 2023-04-01 | Enosi Therapeutics Corp | Methods and compositions for the treatment of autoimmune diseases and cancer |
WO2022117569A1 (fr) | 2020-12-02 | 2022-06-09 | Oncurious Nv | Anticorps antagoniste de ccr8 en combinaison avec un anticorps agoniste du récepteur bêta de la lymphotoxine en thérapie contre le cancer |
CN114699533B (zh) * | 2022-05-06 | 2023-05-09 | 郑州大学 | 一种核酸适配体和多肽交联的双靶点复合核酸纳米药物制备方法与应用 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
JP3095168B2 (ja) | 1988-02-05 | 2000-10-03 | エル. モリソン,シェリー | ドメイン‐変性不変部を有する抗体 |
DE68927933T2 (de) | 1988-09-02 | 1997-08-14 | Dyax Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
ATE92107T1 (de) | 1989-04-29 | 1993-08-15 | Delta Biotechnology Ltd | N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen. |
US5977307A (en) | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
WO1994026087A2 (fr) | 1993-05-14 | 1994-11-24 | Connor Kim C O | Production de proteines de recombinaison, culture de cellules d'insectes et procede s'y rapportant |
WO1994029351A2 (fr) | 1993-06-16 | 1994-12-22 | Celltech Limited | Anticorps |
AU736836B2 (en) | 1997-07-07 | 2001-08-02 | Medical Research Council | In vitro sorting method |
IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
EP1263788A2 (fr) | 2000-02-11 | 2002-12-11 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Identification d'un nouveau domaine dans la famille des recepteurs du facteur de necrose tumorale mediant l'assemblage et la fonction du recepteur de pre-ligand |
WO2003002609A2 (fr) | 2001-06-28 | 2003-01-09 | Domantis Limited | Ligand |
WO2003076567A2 (fr) | 2002-03-05 | 2003-09-18 | Eli Lilly And Company | Proteines hybrides g-csf heterologues |
US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
US20060002935A1 (en) * | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
CN1678634A (zh) | 2002-06-28 | 2005-10-05 | 多曼蒂斯有限公司 | 免疫球蛋白单个变体抗原结合区及其特异性构建体 |
CA2505326A1 (fr) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Procede d'administration de polypeptides therapeutiques et polypeptides associes |
EP1578801A2 (fr) | 2002-12-27 | 2005-09-28 | Domantis Limited | Anticorps a domaine unique ayant une double specificite pour un ligand et son recepteur |
GB0230203D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
EP1627062A1 (fr) | 2003-05-14 | 2006-02-22 | Domantis Limited | Procede de recuperation de polypeptides qui se deplient de facon reversible a partir d'un repertoire de polypeptides |
ES2315664T3 (es) | 2003-06-30 | 2009-04-01 | Domantis Limited | Anticuerpos de dominio unico (dab) pegilados. |
PL1729795T3 (pl) | 2004-02-09 | 2016-08-31 | Human Genome Sciences Inc | Białka fuzyjne albuminy |
CN101084014A (zh) * | 2004-10-08 | 2007-12-05 | 杜门蒂斯有限公司 | 抗肿瘤坏死因子受体1的单域抗体及其使用方法 |
GB0521621D0 (en) | 2005-10-24 | 2005-11-30 | Domantis Ltd | Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases |
GB0724331D0 (en) | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
CA2688434A1 (fr) | 2007-06-06 | 2008-12-11 | Domantis Limited | Polypeptides, domaines variables d'anticorps et antagonistes |
WO2010094720A2 (fr) * | 2009-02-19 | 2010-08-26 | Glaxo Group Limited | Polypeptides, domaines variables d'anticorps, et antagonistes améliorés, tous étant des anti-tnfr1 |
EP3330287B1 (fr) * | 2009-02-19 | 2019-12-18 | Glaxo Group Limited | Variants de liaison anti-albumine sérique améliorés |
-
2010
- 2010-10-25 ES ES10774177.9T patent/ES2552177T3/es active Active
- 2010-10-25 MX MX2012005024A patent/MX2012005024A/es not_active Application Discontinuation
- 2010-10-25 NZ NZ599114A patent/NZ599114A/en not_active IP Right Cessation
- 2010-10-25 TW TW099136369A patent/TW201125877A/zh unknown
- 2010-10-25 PE PE2012000560A patent/PE20121564A1/es not_active Application Discontinuation
- 2010-10-25 CN CN201080059618.5A patent/CN102686239B/zh not_active Expired - Fee Related
- 2010-10-25 JP JP2012535767A patent/JP2013507978A/ja active Pending
- 2010-10-25 UY UY0001032969A patent/UY32969A/es not_active Application Discontinuation
- 2010-10-25 AU AU2010311640A patent/AU2010311640B2/en not_active Ceased
- 2010-10-25 EA EA201290172A patent/EA022898B1/ru not_active IP Right Cessation
- 2010-10-25 EP EP10774177.9A patent/EP2493504B1/fr active Active
- 2010-10-25 WO PCT/EP2010/066046 patent/WO2011051217A1/fr active Application Filing
- 2010-10-25 CA CA2777312A patent/CA2777312A1/fr not_active Abandoned
- 2010-10-25 UA UAA201204796A patent/UA107200C2/uk unknown
- 2010-10-25 AR ARP100103911A patent/AR078763A1/es unknown
- 2010-10-25 KR KR1020127013723A patent/KR20120101417A/ko not_active Application Discontinuation
- 2010-10-25 SG SG10201500274TA patent/SG10201500274TA/en unknown
- 2010-10-25 BR BR112012010114A patent/BR112012010114A2/pt not_active IP Right Cessation
-
2012
- 2012-03-27 IL IL218860A patent/IL218860A0/en unknown
- 2012-03-29 CO CO12053463A patent/CO6612254A2/es unknown
- 2012-04-18 DO DO2012000113A patent/DOP2012000113A/es unknown
- 2012-04-23 CR CR20120197A patent/CR20120197A/es unknown
- 2012-04-25 CL CL2012001055A patent/CL2012001055A1/es unknown
- 2012-04-25 ZA ZA2012/03052A patent/ZA201203052B/en unknown
- 2012-05-18 MA MA34878A patent/MA33758B1/fr unknown
-
2015
- 2015-04-09 US US14/682,176 patent/US20150210767A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AR078763A1 (es) | 2011-11-30 |
ES2552177T3 (es) | 2015-11-26 |
AU2010311640B2 (en) | 2015-01-29 |
CN102686239B (zh) | 2016-02-03 |
KR20120101417A (ko) | 2012-09-13 |
UA107200C2 (uk) | 2014-12-10 |
AU2010311640A1 (en) | 2012-05-10 |
CA2777312A1 (fr) | 2011-05-05 |
EA022898B1 (ru) | 2016-03-31 |
WO2011051217A1 (fr) | 2011-05-05 |
EP2493504A1 (fr) | 2012-09-05 |
ZA201203052B (en) | 2013-09-25 |
CR20120197A (es) | 2012-06-22 |
EA201290172A1 (ru) | 2013-04-30 |
CO6612254A2 (es) | 2013-02-01 |
UY32969A (es) | 2011-05-31 |
BR112012010114A2 (pt) | 2017-08-08 |
CL2012001055A1 (es) | 2012-10-05 |
EP2493504B1 (fr) | 2015-10-07 |
TW201125877A (en) | 2011-08-01 |
IL218860A0 (en) | 2012-06-28 |
DOP2012000113A (es) | 2012-08-15 |
NZ599114A (en) | 2014-09-26 |
US20150210767A1 (en) | 2015-07-30 |
JP2013507978A (ja) | 2013-03-07 |
MX2012005024A (es) | 2012-09-07 |
PE20121564A1 (es) | 2012-11-29 |
CN102686239A (zh) | 2012-09-19 |
SG10201500274TA (en) | 2015-03-30 |
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