MA31991B1 - Anticorps contre le virus de la grippe et procedes pour leur utilisation - Google Patents

Anticorps contre le virus de la grippe et procedes pour leur utilisation

Info

Publication number
MA31991B1
MA31991B1 MA32976A MA32976A MA31991B1 MA 31991 B1 MA31991 B1 MA 31991B1 MA 32976 A MA32976 A MA 32976A MA 32976 A MA32976 A MA 32976A MA 31991 B1 MA31991 B1 MA 31991B1
Authority
MA
Morocco
Prior art keywords
methods
influenza
influenza virus
virus antibodies
relates
Prior art date
Application number
MA32976A
Other languages
Arabic (ar)
English (en)
Inventor
Robert C Liddington
Wayne A Marasco
Jianhua Sui
Original Assignee
Dana Farber Cancer Inst Inc
Burnham Inst Medical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc, Burnham Inst Medical Research filed Critical Dana Farber Cancer Inst Inc
Publication of MA31991B1 publication Critical patent/MA31991B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)

Abstract

L'invention concerne des anticorps humains scfv et des anticorps monoclonaux qui neutralisent le virus de la grippe. L'invention concerne également des procédés de traitement et/ou de prévention d'une maladie ou d'un trouble associé à la grippe, comme la grippe aviaire. L'invention concerne également des procédés de vaccination d'un patient contre la grippe. Des procédés de diagnostic de maladies ou de troubles liés à la grippe et des procédés pour détecter la présence de la grippe dans un échantillon sont également décrits.
MA32976A 2007-12-06 2010-07-01 Anticorps contre le virus de la grippe et procedes pour leur utilisation MA31991B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US572507P 2007-12-06 2007-12-06
US9159908P 2008-08-25 2008-08-25
PCT/US2008/085876 WO2009079259A2 (fr) 2007-12-06 2008-12-08 Anticorps contre le virus de la grippe et procédés pour leur utilisation

Publications (1)

Publication Number Publication Date
MA31991B1 true MA31991B1 (fr) 2011-01-03

Family

ID=40796093

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32976A MA31991B1 (fr) 2007-12-06 2010-07-01 Anticorps contre le virus de la grippe et procedes pour leur utilisation

Country Status (18)

Country Link
US (3) US20110038935A1 (fr)
EP (3) EP3524619A1 (fr)
JP (5) JP6149213B2 (fr)
KR (1) KR20100115346A (fr)
CN (1) CN101970483A (fr)
AU (1) AU2008338691B2 (fr)
BR (1) BRPI0819971A2 (fr)
CA (1) CA2708221C (fr)
CO (1) CO6331300A2 (fr)
CR (1) CR11553A (fr)
EC (1) ECSP10010322A (fr)
IL (1) IL206156A0 (fr)
MA (1) MA31991B1 (fr)
MX (1) MX2010006148A (fr)
NZ (1) NZ586611A (fr)
RU (1) RU2010127156A (fr)
WO (1) WO2009079259A2 (fr)
ZA (1) ZA201004478B (fr)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2132312B1 (fr) 2007-03-27 2016-01-27 Sea Lane Biotechnologies,llc. Constructions et bibliothèques comprenant des séquences de chaînes légères de substitution d'anticorps
MX2010006148A (es) * 2007-12-06 2011-02-23 Dana Farber Cancer Inst Inc Anti-cuerpos contra el virus de la influenza y metodos de uso de los mismos.
WO2009121004A2 (fr) 2008-03-28 2009-10-01 Sea Lane Biotechnologies, Llc Molécules neutralisantes d'antigènes viraux
CA2736799A1 (fr) * 2008-08-25 2010-03-11 Burnham Institute For Medical Research Epitope conserve d'hemagglutinine, anticorps contre l'epitope et procedes d'utilisation
JP5396111B2 (ja) * 2009-03-12 2014-01-22 学校法人慶應義塾 インフルエンザ治療／予防薬
CA2787099A1 (fr) 2009-03-30 2010-10-14 Anice C. Lowen Polypeptides d'hemagglutinine du virus de l'influenza renfermant des domaines souches, vaccins et utilisations associees
WO2010130636A1 (fr) * 2009-05-11 2010-11-18 Crucell Holland B.V. Molécules de liaison humaines pouvant neutraliser le virus de la grippe h3n2 et leurs utilisations
CN102482345A (zh) * 2009-05-13 2012-05-30 航道生物技术有限责任公司 针对流感病毒的中和分子
AU2010254136B2 (en) 2009-05-26 2016-09-29 Mount Sinai School Of Medicine Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof
ES2802623T3 (es) * 2010-01-27 2021-01-20 Massachusetts Inst Technology Agentes polipeptídicos técnicamente diseñados para la neutralización dirigida de amplio espectro de la gripe
US9701723B2 (en) 2010-02-18 2017-07-11 Icahn School Of Medicine At Mount Sinai Vaccines for use in the prophylaxis and treatment of influenza virus disease
US9573991B2 (en) * 2010-03-08 2017-02-21 Celltrion, Inc. Human monoclonal antibodies derived from human B cells and having neutralizing activity against influenza A viruses
CN102939103A (zh) * 2010-03-30 2013-02-20 西奈山医学院 流感病毒疫苗及其应用
JP6050747B2 (ja) * 2010-06-17 2016-12-21 トレリス バイオサイエンス リミテッド ライアビリティー カンパニー インフルエンザ受動免疫化に有用な抗体
WO2012018907A2 (fr) * 2010-08-03 2012-02-09 University Of Washington Through Its Center For Commercialization Polypeptides pour traitement et/ou limitation d'infection par la grippe
US8900590B2 (en) * 2010-08-12 2014-12-02 Theraclone Sciences, Inc. Anti-hemagglutinin antibody compositions and methods of use thereof
US9534042B2 (en) 2010-09-03 2017-01-03 Fujita Health University Influenza virus-neutralizing antibody and screening method therefor
CA2827301A1 (fr) * 2011-02-14 2012-08-23 Theraclone Sciences, Inc. Compositions et methodes de therapie et de diagnostic de la grippe
RU2491338C2 (ru) * 2011-06-30 2013-08-27 Федеральное государственное бюджетное учреждение "Научно-исследовательский Институт гриппа" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "НИИ гриппа" Минздравсоцразвития России) Применение моноклональных антител для идентификации ямагатской или викторианской эволюционных линий вируса гриппа типа в, штамм гибридомы 4н7 для получения моноклональных антител, предназначенных для определения вирусов гриппа в ямагатской ветви, штамм гибридомы в/4н1 для получения моноклональных антител, предназначенных для определения вирусов гриппа в викторианской ветви
EP2736928B1 (fr) 2011-07-28 2019-01-09 i2 Pharmaceuticals, Inc. Proteines "sur"-liantes dirigees contre erbb3
US9512202B2 (en) 2011-08-27 2016-12-06 University Of Zurich Multi-strain-reactive antibodies for therapy and diagnosis of influenza
KR20140068205A (ko) 2011-09-20 2014-06-05 마운트 시나이 스쿨 오브 메디슨 인플루엔자 바이러스 백신 및 이의 용도
CN104302321A (zh) 2011-12-05 2015-01-21 特瑞利斯生物科学有限责任公司 可用于被动流感免疫的抗体
EP2793940B1 (fr) 2011-12-22 2018-11-14 i2 Pharmaceuticals, Inc. Protéines substitutives de liaison
WO2013169377A1 (fr) * 2012-05-10 2013-11-14 Massachusetts Institute Of Technology Agents convenant à la neutralisation de la grippe
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
CN103592436A (zh) * 2012-08-15 2014-02-19 华中农业大学 一种甲型h1亚型流感病毒抗体阻断elisa试剂盒及应用
CN103665153B (zh) * 2012-09-14 2016-03-16 中国科学院上海生命科学研究院 一种抗流感病毒广谱中和性的中和分子1e1
KR20150104117A (ko) 2012-12-18 2015-09-14 이칸 스쿨 오브 메디슨 엣 마운트 시나이 인플루엔자 바이러스 백신 및 그의 용도
WO2014159960A1 (fr) 2013-03-14 2014-10-02 Icahn School Of Medicine At Mount Sinai Anticorps contre l'hémagglutinine du virus de la grippe et utilisations correspondantes
CN105209071A (zh) * 2013-03-14 2015-12-30 抗非特公司 用于提高疗效的基于鼻内递送中和抗体的组合物和方法
KR20140118682A (ko) 2013-03-29 2014-10-08 (주)셀트리온 2 이상의 인플루엔자 ａ 바이러스 중화 결합 분자를 포함하는 조성물
WO2015020913A2 (fr) * 2013-08-03 2015-02-12 Marshall Christopher Patrick Protéines d'hémagglutinine de la grippe et méthodes associées
WO2015031268A1 (fr) * 2013-08-26 2015-03-05 Arizona Board Of Regents On Behalf Of Arizona State University Corps de synthèse à affinité élevée pour la grippe
EP3070167A4 (fr) * 2013-11-06 2017-06-07 Osaka University Anticorps présentant une large activité neutralisante contre le virus de la grippe a de groupe 1
US10639370B2 (en) 2014-02-04 2020-05-05 Contrafect Corporation Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof
KR102344390B1 (ko) 2014-02-04 2021-12-28 콘트라펙트 코포레이션 수동 인플루엔자 면역화에 유용한 항체, 및 이의 사용을 위한 조성물, 조합 및 방법
AU2015231164B2 (en) 2014-03-19 2020-04-09 Dana-Farber Cancer Institute, Inc. Immunogenetic restriction on elicitation of antibodies
WO2015186721A1 (fr) * 2014-06-03 2015-12-10 国立研究開発法人農業・食品産業技術総合研究機構 Anticorps ou fragment d'anticorps comprenant une région variable de celui-ci, polypeptide antigénique et utilisations de ceux-ci
CN105301249A (zh) * 2014-07-24 2016-02-03 江苏维赛科技生物发展有限公司 金刚烷胺药物残留快速检测试纸条
CN105301248A (zh) * 2014-07-24 2016-02-03 江苏维赛科技生物发展有限公司 金刚烷胺快速时间分辨荧光免疫层析定量检测试纸条
TWI702229B (zh) 2014-12-19 2020-08-21 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
IL320860A (en) 2014-12-19 2025-07-01 Dana Farber Cancer Inst Inc Chimeric antigen receptors and methods of using them
US10736956B2 (en) 2015-01-23 2020-08-11 Icahn School Of Medicine At Mount Sinai Influenza virus vaccination regimens
US11535665B2 (en) 2015-05-13 2022-12-27 The Trustees Of The University Of Pennsylvania AAV-mediated expression of anti-influenza antibodies and methods of use thereof
WO2017083627A1 (fr) 2015-11-13 2017-05-18 Visterra, Inc. Compositions et méthodes pour traiter et prévenir la grippe
WO2017124001A2 (fr) * 2016-01-14 2017-07-20 Memorial Sloan-Kettering Cancer Center Anticorps de type récepteurs des lymphocytes t spécifiques pour des peptides dérivés de foxp3
EP3419663A1 (fr) 2016-02-24 2019-01-02 Visterra, Inc. Formulations de molécules d'anticorps contre le virus de la grippe
WO2017189588A1 (fr) * 2016-04-25 2017-11-02 Sorrento Therapeutics, Inc. Anticorps thérapeutiques qui se lient à stat3
WO2017218624A1 (fr) 2016-06-15 2017-12-21 Icahn School Of Medicine At Mount Sinai Hémagglutinines du virus de la grippe et utilisations de celles-ci
CN106146657B (zh) * 2016-07-12 2020-07-17 晋明(天津)生物医药技术开发有限公司 广谱结合流感病毒a的重组抗体片段及其制备方法与应用
AU2017341936B2 (en) 2016-10-14 2024-10-31 Dana-Farber Cancer Institute, Inc. Modular tetravalent bispecific antibody platform
US11250328B2 (en) 2016-10-26 2022-02-15 Cognizant Technology Solutions U.S. Corporation Cooperative evolution of deep neural network structures
JOP20190200A1 (ar) 2017-02-28 2019-08-27 Univ Pennsylvania تركيبات نافعة في معالجة ضمور العضل النخاعي
US10786568B2 (en) 2017-02-28 2020-09-29 The Trustees Of The University Of Pennsylvania AAV mediated influenza vaccines
SI3589730T1 (sl) 2017-02-28 2024-04-30 The Trustees Of The University Of Pennsylvania Adeno-povezan virus (AAV) clade F vektor in njihova uporaba
US11507844B2 (en) 2017-03-07 2022-11-22 Cognizant Technology Solutions U.S. Corporation Asynchronous evaluation strategy for evolution of deep neural networks
WO2018187706A2 (fr) 2017-04-07 2018-10-11 Icahn School Of Medicine At Mount Sinai Anticorps anti-neuraminidase du virus influenza de type b et leurs utilisations
JPWO2019069561A1 (ja) * 2017-10-03 2020-10-22 公益財団法人東京都医学総合研究所 インフルエンザに対する医薬
US11250314B2 (en) 2017-10-27 2022-02-15 Cognizant Technology Solutions U.S. Corporation Beyond shared hierarchies: deep multitask learning through soft layer ordering
US11182677B2 (en) 2017-12-13 2021-11-23 Cognizant Technology Solutions U.S. Corporation Evolving recurrent networks using genetic programming
CA3085897C (fr) 2017-12-13 2023-03-14 Cognizant Technology Solutions U.S. Corporation Architectures evolutives pour l'evolution de reseaux neuronaux profonds
SG11202006379UA (en) 2018-01-26 2020-07-29 Regeneron Pharma Human antibodies to influenza hemagglutinin
US11527308B2 (en) 2018-02-06 2022-12-13 Cognizant Technology Solutions U.S. Corporation Enhanced optimization with composite objectives and novelty-diversity selection
US12033079B2 (en) 2018-02-08 2024-07-09 Cognizant Technology Solutions U.S. Corporation System and method for pseudo-task augmentation in deep multitask learning
US12258378B2 (en) 2018-03-14 2025-03-25 Dana-Farber Cancer Institute, Inc. Engineered cells, T cell immune modulating antibodies and methods for using the same
CN108409841B (zh) * 2018-04-10 2021-06-04 北京康亿鸿科技发展有限公司 用于检测特异性过敏原IgE的单域结合蛋白及应用
EP3810634A4 (fr) 2018-06-21 2022-07-27 Icahn School of Medicine at Mount Sinai Polypeptides d'hémagglutinines du virus de la grippe en mosaïque et leurs utilisations
KR102143274B1 (ko) 2018-07-19 2020-08-10 전주대학교 산학협력단 이온화 및 나노화 미네랄을 함유하는 고병원성 조류독감 바이러스 소독제 조성물의 제조방법
US12282845B2 (en) 2018-11-01 2025-04-22 Cognizant Technology Solutions US Corp. Multiobjective coevolution of deep neural network architectures
CN109448781B (zh) * 2018-11-06 2021-09-14 云南大学 一种流感病毒抗原变化的预测方法
CN109608552A (zh) * 2018-12-26 2019-04-12 杭州亿米诺生物科技有限公司 一种小反刍兽疫重组融合蛋白及其制备方法和应用
CN111423507B (zh) * 2019-01-10 2022-04-15 中国科学院分子细胞科学卓越创新中心 广谱性中和流感病毒的全人抗体
US11481639B2 (en) 2019-02-26 2022-10-25 Cognizant Technology Solutions U.S. Corporation Enhanced optimization with composite objectives and novelty pulsation
EP3938898A4 (fr) 2019-03-13 2023-03-29 Cognizant Technology Solutions U.S. Corporation Système et procédé permettant de mettre en oeuvre un reparamétrage universel modulaire pour un apprentissage multitâche profond à travers divers domaines
CN113924147A (zh) 2019-03-25 2022-01-11 威特拉公司 用于治疗和预防流感的组合物和方法
CA3131688A1 (fr) 2019-03-27 2020-10-01 Olivier Francon Processus et systeme contenant un moteur d'optimisation a prescriptions assistees par substitut evolutives
EP3959216A4 (fr) 2019-04-24 2023-01-11 Icahn School of Medicine at Mount Sinai Anticorps anti-neuraminidase du virus influenza de type b et leurs utilisations
US12026624B2 (en) 2019-05-23 2024-07-02 Cognizant Technology Solutions U.S. Corporation System and method for loss function metalearning for faster, more accurate training, and smaller datasets
JP2022540638A (ja) * 2019-07-12 2022-09-16 コントラフェクト コーポレイション 抗体を含む治療用タンパク質製剤及びその使用
US12292944B2 (en) 2019-09-19 2025-05-06 Cognizant Technology Solutions U.S. Corp. Loss function optimization using Taylor series expansion
WO2021119467A1 (fr) * 2019-12-11 2021-06-17 Visterra, Inc. Compositions et méthodes de traitement et de prévention de la grippe
WO2021201677A1 (fr) 2020-04-01 2021-10-07 Kiadis Pharma Intellectual Property B.V. Compositions et procédés ciblant la grippe
US12099934B2 (en) * 2020-04-07 2024-09-24 Cognizant Technology Solutions U.S. Corporation Framework for interactive exploration, evaluation, and improvement of AI-generated solutions
US11775841B2 (en) 2020-06-15 2023-10-03 Cognizant Technology Solutions U.S. Corporation Process and system including explainable prescriptions through surrogate-assisted evolution
US12424335B2 (en) 2020-07-08 2025-09-23 Cognizant Technology Solutions U.S. Corporation AI based optimized decision making for epidemiological modeling
CN114181303B (zh) * 2020-09-14 2022-12-23 东莞市朋志生物科技有限公司 抗甲型流感病毒的抗体和试剂盒
EP4352659A4 (fr) 2021-06-08 2025-04-09 Cognizant Technology Solutions U.S. Corporation Système et procédé de génération de prescripteurs améliorés
CA3256034A1 (fr) 2022-04-14 2023-10-19 Invisishield Technologies Ltd. Compositions pour prévenir ou traiter des infections par la grippe
CN114957479B (zh) * 2022-05-28 2024-06-18 浙江大学医学院附属第一医院 抗H1N1流感病毒双特异性中和抗体Bis-Hu11-1及其应用
WO2025019631A1 (fr) 2023-07-19 2025-01-23 Icahn School Of Medicine At Mount Sinai Compositions immunogènes contenant un virus de la grippe a inactivé et un adjuvant oligonucléotidique cpg et leurs utilisations

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5030719A (en) 1986-08-28 1991-07-09 Teijin Limited Cytotoxic antibody conjugates and a process for preparation thereof
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
ES2096590T3 (es) 1989-06-29 1997-03-16 Medarex Inc Reactivos biespecificos para la terapia del sida.
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
ES2087997T3 (es) 1990-01-12 1996-08-01 Cell Genesys Inc Generacion de anticuerpos xenogenicos.
AU8295491A (en) 1990-06-29 1992-01-23 Biosource Technologies Incorporated Melanin production by transformed microorganisms
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
JPH06507398A (ja) 1991-05-14 1994-08-25 リプリジェン　コーポレーション Ｈｉｖ感染治療のための異種複合抗体
KR100252547B1 (ko) 1991-09-05 2000-09-01 프레드 마리얀스키 폴리-또는 올리고누클레오티드의 세포로의 표적화된 전달
CA2125396A1 (fr) 1991-12-10 1993-06-24 Wayne A. Marasco Reactif neutralisant l'anticorps recombinant anti-gp 120 humain, adn codant cet anticorps et son utilisation
US5233409A (en) 1992-02-25 1993-08-03 Schwab Karl W Color analysis of organic constituents in sedimentary rocks for thermal maturity
ATE348175T1 (de) 1992-07-17 2007-01-15 Dana Farber Cancer Inst Inc Method eder intrazellularen bindung von zielgerichteten molekülen
JPH07509137A (ja) 1992-07-24 1995-10-12 セル　ジェネシス，インク． 異種抗体の生産
JP3061960B2 (ja) * 1992-09-17 2000-07-10 寳酒造株式会社 抗ヒトインフルエンザウイルス抗体
US5589174A (en) * 1992-09-17 1996-12-31 Takara Shuzo Co., Ltd. Anti-human influenza virus antibody
GB9221654D0 (en) * 1992-10-15 1992-11-25 Scotgen Ltd Recombinant human anti-cytomegalovirus antibodies
EP1005870B1 (fr) 1992-11-13 2009-01-21 Biogen Idec Inc. Application thérapeutique d'anticorps chimériques et radio-marqués contre l'antigène à différentiation restreinte des lymphocytes B humains pour le traitement du lymphome des cellules B
EP0745134A1 (fr) 1994-02-22 1996-12-04 Danafarber Cancer Institute Systeme de liberation d'acide nucleique, son procede de synthese et ses utilisations
EP0822830B1 (fr) 1995-04-27 2008-04-02 Amgen Fremont Inc. Anticorps anti-IL-8 dérivés de xenosouris immunisées
CA2219486A1 (fr) 1995-04-28 1996-10-31 Abgenix, Inc. Anticorps humains derives de xeno-souris immunisees
EP0857217B1 (fr) 1995-10-16 2005-04-13 Dana-Farber Cancer Institute Nouveaux vecteurs d'expression et procedes d'utilisation correspondants
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
EP1015616A2 (fr) 1997-09-19 2000-07-05 Dana Farber Cancer Institute, Inc. Regulation a mediation intracorps de reactions immunitaires.
WO1999045959A1 (fr) 1998-03-13 1999-09-16 Dana-Farber Cancer Institute, Inc. Anticorps humanises et utilisations correspondantes
US20020029391A1 (en) 1998-04-15 2002-03-07 Claude Geoffrey Davis Epitope-driven human antibody production and gene expression profiling
AU3893000A (en) 1999-03-16 2000-10-04 Dana-Farber Cancer Institute, Inc. Lentiviral vector system for high quantity screening
GB0027328D0 (en) 2000-06-23 2000-12-27 Aventis Pharma Inc Bioengineered vehicles for targeted nucleic acid delivery
FR2817869B1 (fr) 2000-12-07 2005-01-14 Technopharm Anticorps monoclonal humain dirige contre le virus influenza ou un fragment de celui-ci
EP1470159B1 (fr) 2001-12-04 2013-08-07 Dana-Farber Cancer Institute, Inc. Anticorps dirige contre des proteines membranaires latentes (lmp) et utilisations de ceux-ci
US20030206898A1 (en) 2002-04-26 2003-11-06 Steven Fischkoff Use of anti-TNFalpha antibodies and another drug
WO2005005615A2 (fr) 2003-07-08 2005-01-20 Fox Chase Cancer Center Immunoconjugues du recepteur de type ii de l'hormone anti-mullerienne utiles pour detecter et traiter le cancer
US7750123B2 (en) * 2003-11-25 2010-07-06 Dana Farber Cancer Institute, Inc. Antibodies against SARS-CoV and methods of use thereof
WO2005123774A2 (fr) 2004-06-15 2005-12-29 Erol Fikrig Anticorps de polypeptides du virus du nil occidental
JP4956427B2 (ja) 2004-07-21 2012-06-20 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド レンチウイルスベクターおよびその使用
JP4031478B2 (ja) 2004-12-13 2008-01-09 プロテイン サイエンシーズ インフルエンザ血球凝集素多価ワクチンの製造方法
JP2008528668A (ja) * 2005-02-03 2008-07-31 アンチトープ リミテッド ヒト抗体及びタンパク質
KR20060089390A (ko) * 2005-02-04 2006-08-09 주식회사 중앙백신연구소 돼지 인플루엔자 바이러스ａ／ｓｗｉｎｅ／ｋｏｒｅａ／ｓ10/2004(ｈ1ｎ1) 및 이의백신
US8329178B2 (en) 2005-02-18 2012-12-11 Dana-Farber Cancer Institute, Inc. Antibodies against CXCR4 and methods of use thereof
EP1874824A4 (fr) * 2005-04-06 2009-12-30 Ibc Pharmaceuticals Inc Méthodes de génération de complexes liés stablement composés d'homodimères, d'homotetramères ou de dimères de dimères et utilisations associees
JP2007000141A (ja) * 2005-05-25 2007-01-11 Tokyo Univ Of Science 完全ヒト抗体産生ハイブリドーマの作製方法、及び融合ミエローマ細胞
WO2007044695A2 (fr) 2005-10-07 2007-04-19 Dana-Farber Cancer Institute Anticorps diriges contre le sras-cov et procedes d'utilisation de ceux-ci
US8466263B2 (en) 2005-12-02 2013-06-18 Dana-Farber Cancer Institute, Inc. Carbonic anhydrase IX (G250) anitbodies
CA2637837A1 (fr) * 2006-01-26 2007-08-09 Hx Diagnostics, Inc. Anticorps monoclonaux qui se lient a l'hemagglutinine de la sous-classe h5 du virus de la grippe aviaire et leurs utilisations
WO2007134327A2 (fr) 2006-05-15 2007-11-22 Sea Lane Biotechnologies, Llc. Anticorps neutralisants dirigés contre les virus de la grippe
EP2032691A2 (fr) 2006-06-15 2009-03-11 Neostem, Inc Procédure de traitement de cellules souches du sang périphérique
CA2663388C (fr) 2006-09-07 2017-01-17 Crucell Holland B.V. Molecules de liaison humaines capables de neutraliser le virus de la grippe h5n1 et leurs utilisations
US20090155225A1 (en) 2006-11-02 2009-06-18 Mariusz Ratajczak Uses and isolation of very small of embryonic-like (vsel) stem cells
FR2921928B1 (fr) * 2007-10-08 2011-03-04 Sanofi Pasteur Anticorps monoclonaux specifiques de l'hemagglutinine du virus grippal
MX2010006148A (es) 2007-12-06 2011-02-23 Dana Farber Cancer Inst Inc Anti-cuerpos contra el virus de la influenza y metodos de uso de los mismos.
US8962806B2 (en) 2007-12-28 2015-02-24 Dana-Farber Cancer Institute, Inc. Humanized monoclonal antibodies and methods of use
ITTO20080204A1 (it) 2008-03-17 2009-09-18 Pomona Biotechnologies Llc Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a
ES2662519T3 (es) 2008-07-25 2018-04-06 Institute For Research In Biomedicine Anticuerpos neutralizantes contra el virus de la gripe A y usos de estos
CA2736799A1 (fr) 2008-08-25 2010-03-11 Burnham Institute For Medical Research Epitope conserve d'hemagglutinine, anticorps contre l'epitope et procedes d'utilisation
WO2010130636A1 (fr) 2009-05-11 2010-11-18 Crucell Holland B.V. Molécules de liaison humaines pouvant neutraliser le virus de la grippe h3n2 et leurs utilisations
US9111624B2 (en) 2013-03-22 2015-08-18 Katsuyuki Fujita Semiconductor memory device

Also Published As

Publication number Publication date
WO2009079259A2 (fr) 2009-06-25
NZ586611A (en) 2012-09-28
CA2708221C (fr) 2017-07-25
WO2009079259A9 (fr) 2009-10-01
AU2008338691A1 (en) 2009-06-25
CR11553A (es) 2010-11-12
ZA201004478B (en) 2011-12-28
IL206156A0 (en) 2010-12-30
JP2017122087A (ja) 2017-07-13
ECSP10010322A (es) 2010-09-30
JP2011506344A (ja) 2011-03-03
AU2008338691B2 (en) 2015-01-22
RU2010127156A (ru) 2012-01-20
US9951122B2 (en) 2018-04-24
AU2008338691A2 (en) 2011-03-10
JP2019104736A (ja) 2019-06-27
EP2222701B1 (fr) 2017-11-01
US20180312575A1 (en) 2018-11-01
EP3333187A1 (fr) 2018-06-13
JP2015180619A (ja) 2015-10-15
JP2021176841A (ja) 2021-11-11
JP6149213B2 (ja) 2017-06-21
US20140011982A1 (en) 2014-01-09
WO2009079259A3 (fr) 2010-02-18
EP3524619A1 (fr) 2019-08-14
CN101970483A (zh) 2011-02-09
MX2010006148A (es) 2011-02-23
CO6331300A2 (es) 2011-10-20
KR20100115346A (ko) 2010-10-27
EP2222701A2 (fr) 2010-09-01
EP3333187B1 (fr) 2022-06-22
US20110038935A1 (en) 2011-02-17
CA2708221A1 (fr) 2009-06-25
BRPI0819971A2 (pt) 2017-06-27

Similar Documents

Publication Publication Date Title
MA31991B1 (fr) Anticorps contre le virus de la grippe et procedes pour leur utilisation
MA31225B1 (fr) Anticorps neutralisants des cytomegalovirus humains et leur utilisation
EA201690111A1 (ru) Имидазопиразиновые ингибиторы тирозинкиназы syk
BR112012003064B8 (pt) anticorpo ou fragmento de ligação de antígeno do mesmo, combinação que os compreende, método de detecção de infecção por rsv, moléculas de ácido nucléico, e método de produção de um anticorpo ou fragmento de ligação de antígeno do mesmo
EA201590833A1 (ru) Антитела для лечения и профилактики болезни альцгеймера и их применение
MA31899B1 (fr) Anticorps monoclonaux qui se lient au hgm-csf et compositions medicales les comprenant
EP2987807A3 (fr) Anticorps dirigés contre tau phosphorylée
MA46665B1 (fr) Composés de tyrosine tyrosine de peptide cyclique couplés à un anticorps en tant que modulateurs des récepteurs du neuropeptide y
EP2103628A4 (fr) Anticorps monoclonal anti-claudine 3, et traitement et diagnostic du cancer au moyen d'un tel anticorps
UA101167C2 (ru) Фармацевтическая композиция, предназначенная для лечения глазной болезни
TNSN07031A1 (fr) Anticorps diriges contre le peptide amyloide-beta et methodes pour leur utilisation
MA32725B1 (fr) Anticorps contre l'il 17 humaine et utilisations associees
MA37761A1 (fr) Protéines de liaison à un antigène antagoniste d'un double récepteur et leurs utilisations
WO2006009702A3 (fr) Methodes et systemes se rapportant aux maladies hepatiques
BRPI0619357A8 (pt) Anticorpos monoclonais, composição farmacêutica, vacina, uso dos mesmos para tratamento ou prevenção de doença de alzheimer, métodos in vitro para diagnosticar e para identificar compostos apropriados para imunização de doença de alzheimer e kits
MA30353B1 (fr) Anticorps se liant à la protéine tyrosine phosphatase bêta humaine (hptpbêta) et utilisations correspondantes.
WO2006127861A3 (fr) Diagnostic de maladies et d'etats pathologiques par l'analyse d'echantillons biologiques traites par voie histopathologique a l'aide de preparations tissulaires liquides
MA34053B1 (fr) Polypeptides agonistes de liaison à dr5
WO2008134569A3 (fr) Diagnostic et traitement de la rectocolite hémorragique chez la population portoricaine
EA201070400A1 (ru) Фактор, вовлеченный в латентную инфекцию герпес-вирусом, и его применение
WO2007044695A3 (fr) Anticorps diriges contre le sras-cov et procedes d'utilisation de ceux-ci
MA37670B1 (fr) Anticorps anti-transglutaminase 2
EP1742654A4 (fr) Anticorps anti-lfl2 pour le diagnostic, le pronostic et le traitement d'un cancer
EP2005194A4 (fr) Procédés utilisant de l'hémoglobine pour la prophylaxie, le diagnostic et/ou le traitement de troubles de la rétine
BRPI0414688A (pt) tratamento de doença respiratória com anti-receptor de il-2