MA31798B1 - Composés organiques - Google Patents
Composés organiquesInfo
- Publication number
- MA31798B1 MA31798B1 MA32804A MA32804A MA31798B1 MA 31798 B1 MA31798 B1 MA 31798B1 MA 32804 A MA32804 A MA 32804A MA 32804 A MA32804 A MA 32804A MA 31798 B1 MA31798 B1 MA 31798B1
- Authority
- MA
- Morocco
- Prior art keywords
- organic compounds
- modulator
- parkinson
- progression
- disease
- Prior art date
Links
- 150000002894 organic compounds Chemical class 0.000 title 1
- 101150087728 Grm5 gene Proteins 0.000 abstract 1
- 102100038357 Metabotropic glutamate receptor 5 Human genes 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Abstract
L'INVENTION PORTE SUR L'UTILISATION D'UN MODULATEUR DE MGLUR, PAR EXEMPLE UN MODULATEUR DE MGLUR5, POUR LE TRAITEMENT, LA PRÉVENTION OU RETARDER LA PROGRESSION DE LA MALADIE DE PARKINSON ET DE TROUBLES ASSOCIÉS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97948607P | 2007-10-12 | 2007-10-12 | |
US5033308P | 2008-05-05 | 2008-05-05 | |
PCT/EP2008/063544 WO2009047296A2 (fr) | 2007-10-12 | 2008-10-09 | Composés organiques |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31798B1 true MA31798B1 (fr) | 2010-10-01 |
Family
ID=40348021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32804A MA31798B1 (fr) | 2007-10-12 | 2010-04-30 | Composés organiques |
Country Status (19)
Country | Link |
---|---|
US (2) | US20100249136A1 (fr) |
EP (1) | EP2211859B1 (fr) |
JP (2) | JP5743545B2 (fr) |
KR (1) | KR101572280B1 (fr) |
CN (1) | CN101854935A (fr) |
AU (1) | AU2008309621A1 (fr) |
BR (1) | BRPI0818560A2 (fr) |
CA (1) | CA2701853A1 (fr) |
CL (1) | CL2008003006A1 (fr) |
IL (1) | IL204954A0 (fr) |
MA (1) | MA31798B1 (fr) |
MX (1) | MX2010003913A (fr) |
NZ (1) | NZ584856A (fr) |
RU (1) | RU2508107C2 (fr) |
SG (1) | SG185293A1 (fr) |
TN (1) | TN2010000155A1 (fr) |
TW (1) | TW200924745A (fr) |
WO (1) | WO2009047296A2 (fr) |
ZA (1) | ZA201002423B (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2009265760B2 (en) | 2008-06-30 | 2013-07-18 | Novartis Ag | Combinations comprising mGluR modulators for the treatment of parkinson's disease |
US8084487B2 (en) * | 2008-08-12 | 2011-12-27 | Novartis Ag | Processes for the preparation of 4-oxo-octahydro-indole-1-carbocyclic acid methyl ester and derivatives thereof |
WO2011035209A1 (fr) * | 2009-09-17 | 2011-03-24 | Vanderbilt Universtiy | Analogues de benzamide substitué en tant que modulateurs allostériques négatifs mglur5, et leurs procédés de préparation et d'utilisation |
EP2680849A4 (fr) * | 2011-03-03 | 2015-02-18 | Univ Vanderbilt | Analogues de 6-alkyl-n-(pyridin-2-yl)-4-aryloxypicolinamide en tant que modulateurs allostériques négatifs de mglur5 et procédé pour les préparer et les utiliser |
BR112013023813A2 (pt) | 2011-03-18 | 2016-12-13 | Novartis Ag | combinações de ativadores do receptor acetilcolina nicotínico alfa 7 e antagonistas de mglur5 para uso em dopamina induzida por discinesia na doença de parkinson |
GB201204962D0 (en) | 2012-03-21 | 2012-05-02 | Addex Pharmaceuticals Sa | Pharmaceutical combination products for parkinsons disease |
EP3071568A1 (fr) | 2013-11-19 | 2016-09-28 | Vanderbilt University | Composés imidazopyridine et triazolopyridine substitués utilisés comme modulateurs allostériques négatifs de mglur |
US9533982B2 (en) | 2014-03-20 | 2017-01-03 | Vanderbilt University | Substituted bicyclic heteroaryl carboxamide analogs as mGluR5 negative allosteric modulators |
US9550778B2 (en) | 2014-10-03 | 2017-01-24 | Vanderbilt University | Substituted 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analogs as negative allosteric modulators of mGluR5 |
KR101749675B1 (ko) * | 2015-07-20 | 2017-06-26 | 동국대학교 산학협력단 | 멜라닌 응집 호르몬을 유효성분으로 포함하는 파킨슨병 치료 및 레보도파 부작용 억제용 약학 조성물 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6379666B1 (en) * | 1999-02-24 | 2002-04-30 | Edward L. Tobinick | TNF inhibitors for the treatment of neurological, retinal and muscular disorders |
CH1196397H1 (de) * | 1999-06-02 | 2007-05-31 | Nps Pharma Inc | Metabotrope Glutamatrezeptorantagonisten zur Behandlung von Krankheiten des zentralen Nervensystems. |
GB0128996D0 (en) * | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
US7105548B2 (en) * | 2001-12-18 | 2006-09-12 | Merck & Co., Inc. | Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5 |
EP1539749A4 (fr) * | 2002-09-13 | 2007-06-13 | Merck & Co Inc | Modulateurs du recepteur glutamate metabotropique 5 (mglur5) de phenyle substitues par un fragment heterobicyclo fusionne |
EP1596808A4 (fr) * | 2003-02-07 | 2007-04-04 | Yissum Res Dev Co | Derives d'amide l-dopa et utilisations de ceux-ci |
WO2005030128A2 (fr) * | 2003-09-23 | 2005-04-07 | Merck & Co., Inc. | Modulateurs pyrazole de recepteurs de glutamate metabotropiques |
WO2005079802A1 (fr) * | 2004-02-12 | 2005-09-01 | Merck & Co., Inc. | Amides bipyridyles en tant que modulateurs du récepteur-5 métabotropique du glutamate |
BRPI0607583A2 (pt) * | 2005-03-04 | 2009-09-15 | Hoffmann La Roche | derivados de piridin-2-carboxamida como antagonistas mglur5, método para sua preparação, medicamento contendo os mesmos, bem como uso relacionado aos referidos compostos |
GB0508318D0 (en) * | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
GB0508319D0 (en) * | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
TW200801005A (en) * | 2005-08-15 | 2008-01-01 | Astrazeneca Ab | Acetylenic piperazines as metabotropic glutamate receptor antagonists |
CA2627630A1 (fr) * | 2005-12-20 | 2007-06-28 | Novartis Ag | Derives d'acide nicotinique en tant que modulateurs des recepteurs metabotropiques du glutamate |
WO2008031550A2 (fr) * | 2006-09-11 | 2008-03-20 | Novartis Ag | Nouvelles utilisations de récepteurs de glutamate métabotropiques |
AU2009265760B2 (en) * | 2008-06-30 | 2013-07-18 | Novartis Ag | Combinations comprising mGluR modulators for the treatment of parkinson's disease |
-
2008
- 2008-10-09 SG SG2012075677A patent/SG185293A1/en unknown
- 2008-10-09 CN CN200880110746A patent/CN101854935A/zh active Pending
- 2008-10-09 JP JP2010528396A patent/JP5743545B2/ja not_active Expired - Fee Related
- 2008-10-09 MX MX2010003913A patent/MX2010003913A/es active IP Right Grant
- 2008-10-09 EP EP08805185.9A patent/EP2211859B1/fr not_active Not-in-force
- 2008-10-09 AU AU2008309621A patent/AU2008309621A1/en not_active Abandoned
- 2008-10-09 WO PCT/EP2008/063544 patent/WO2009047296A2/fr active Application Filing
- 2008-10-09 TW TW097139070A patent/TW200924745A/zh unknown
- 2008-10-09 BR BRPI0818560A patent/BRPI0818560A2/pt not_active IP Right Cessation
- 2008-10-09 KR KR1020107010331A patent/KR101572280B1/ko not_active IP Right Cessation
- 2008-10-09 CA CA2701853A patent/CA2701853A1/fr not_active Abandoned
- 2008-10-09 US US12/682,624 patent/US20100249136A1/en not_active Abandoned
- 2008-10-09 RU RU2010118454/15A patent/RU2508107C2/ru not_active IP Right Cessation
- 2008-10-09 NZ NZ584856A patent/NZ584856A/xx not_active IP Right Cessation
- 2008-10-10 CL CL2008003006A patent/CL2008003006A1/es unknown
-
2010
- 2010-04-07 ZA ZA2010/02423A patent/ZA201002423B/en unknown
- 2010-04-08 IL IL204954A patent/IL204954A0/en unknown
- 2010-04-12 TN TN2010000155A patent/TN2010000155A1/fr unknown
- 2010-04-30 MA MA32804A patent/MA31798B1/fr unknown
-
2014
- 2014-08-29 JP JP2014175983A patent/JP2014240425A/ja active Pending
-
2015
- 2015-06-11 US US14/736,901 patent/US20150272929A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2009047296A2 (fr) | 2009-04-16 |
EP2211859B1 (fr) | 2016-01-06 |
NZ584856A (en) | 2012-12-21 |
AU2008309621A1 (en) | 2009-04-16 |
US20150272929A1 (en) | 2015-10-01 |
JP2014240425A (ja) | 2014-12-25 |
JP2011500529A (ja) | 2011-01-06 |
JP5743545B2 (ja) | 2015-07-01 |
ZA201002423B (en) | 2010-12-29 |
KR101572280B1 (ko) | 2015-11-26 |
WO2009047296A3 (fr) | 2009-08-20 |
IL204954A0 (en) | 2010-11-30 |
BRPI0818560A2 (pt) | 2019-09-24 |
US20100249136A1 (en) | 2010-09-30 |
MX2010003913A (es) | 2010-04-27 |
CL2008003006A1 (es) | 2009-05-08 |
RU2508107C2 (ru) | 2014-02-27 |
EP2211859A2 (fr) | 2010-08-04 |
CA2701853A1 (fr) | 2009-04-16 |
SG185293A1 (en) | 2012-11-29 |
TW200924745A (en) | 2009-06-16 |
TN2010000155A1 (en) | 2011-11-11 |
CN101854935A (zh) | 2010-10-06 |
RU2010118454A (ru) | 2011-11-20 |
KR20100088136A (ko) | 2010-08-06 |
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