MA26431A1 - Procede pour la preparation des arylpyrimidines, leur utilisation pour preparer des medicaments et pour traiter un mamifere dont l'etat pathologique peut etre attenue par traitement avec antagoniste du 5ht2b - Google Patents

Procede pour la preparation des arylpyrimidines, leur utilisation pour preparer des medicaments et pour traiter un mamifere dont l'etat pathologique peut etre attenue par traitement avec antagoniste du 5ht2b

Info

Publication number
MA26431A1
MA26431A1 MA24630A MA24630A MA26431A1 MA 26431 A1 MA26431 A1 MA 26431A1 MA 24630 A MA24630 A MA 24630A MA 24630 A MA24630 A MA 24630A MA 26431 A1 MA26431 A1 MA 26431A1
Authority
MA
Morocco
Prior art keywords
preparation
treatment
mamifer
arylpyrimidines
medicaments
Prior art date
Application number
MA24630A
Other languages
English (en)
Inventor
Berger Jacob
Jaime-Figueroa Saul
George Putman David
Zhao Shu-Hai
Allen Flippin Lee
Greenhouse Robert
Liu Yanzhou
Kern Miller Aubry
Kurt Weinhardt Klaus
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA26431A1 publication Critical patent/MA26431A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
MA24630A 1996-05-23 1997-05-21 Procede pour la preparation des arylpyrimidines, leur utilisation pour preparer des medicaments et pour traiter un mamifere dont l'etat pathologique peut etre attenue par traitement avec antagoniste du 5ht2b MA26431A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1821896P 1996-05-23 1996-05-23
US4037797P 1997-03-10 1997-03-10

Publications (1)

Publication Number Publication Date
MA26431A1 true MA26431A1 (fr) 2004-12-20

Family

ID=26690869

Family Applications (1)

Application Number Title Priority Date Filing Date
MA24630A MA26431A1 (fr) 1996-05-23 1997-05-21 Procede pour la preparation des arylpyrimidines, leur utilisation pour preparer des medicaments et pour traiter un mamifere dont l'etat pathologique peut etre attenue par traitement avec antagoniste du 5ht2b

Country Status (32)

Country Link
US (1) US5863924A (fr)
EP (1) EP0901474B1 (fr)
JP (1) JP2001525794A (fr)
KR (1) KR100518101B1 (fr)
CN (1) CN1109675C (fr)
AR (1) AR007253A1 (fr)
AT (1) ATE323682T1 (fr)
AU (1) AU725891B2 (fr)
BR (1) BR9709599A (fr)
CA (1) CA2255705A1 (fr)
CO (1) CO4950514A1 (fr)
CZ (1) CZ291849B6 (fr)
DE (1) DE69735712T2 (fr)
DK (1) DK0901474T3 (fr)
ES (1) ES2262178T3 (fr)
HK (1) HK1020345A1 (fr)
HR (1) HRP970275B1 (fr)
HU (1) HUP9901535A3 (fr)
ID (1) ID16969A (fr)
IL (1) IL127056A (fr)
MA (1) MA26431A1 (fr)
MY (1) MY119181A (fr)
NO (1) NO311800B1 (fr)
NZ (1) NZ332802A (fr)
PT (1) PT901474E (fr)
RU (1) RU2189976C2 (fr)
SA (2) SA05260356B1 (fr)
TR (1) TR199802391T2 (fr)
TW (1) TW440563B (fr)
UY (1) UY24560A1 (fr)
WO (1) WO1997044326A1 (fr)
YU (1) YU53298A (fr)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1012151B1 (fr) * 1997-09-02 2002-08-07 Bristol-Myers Squibb Pharma Company Pyridines a cycle fusionne et a substitution heterocyclyle, antagonistes du facteur de liberation de la cortitropine (crf), utiles dans le traitement des troubles lies au snc et au stress
US6040315A (en) * 1997-10-30 2000-03-21 Day; Charles E. Antacid co-polymer of guanidine and polyethylenimine
DE19844291A1 (de) * 1998-09-18 2000-03-23 Schering Ag Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
US6495558B1 (en) 1999-01-22 2002-12-17 Amgen Inc. Kinase inhibitors
EP1144390A2 (fr) * 1999-01-22 2001-10-17 Amgen Inc., Inhibiteurs de kinase
EP1057831B1 (fr) * 1999-05-26 2004-09-22 F. Hoffmann-La Roche Ag Procédé de fabrication de dérivés de type vinylpyrimidine
ATE250417T1 (de) * 1999-07-30 2003-10-15 Pharmagene Lab Ltd Verwendung von 2-amino-4-(4-fluoronaphth-1-yl)-6- isopropylpyrimidine zur behandlung von erkrankungen des magen-darm-traktes
GB9919778D0 (en) 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
PL355639A1 (en) 1999-09-10 2004-05-04 Merck & Co, Inc. Tyrosine kinase inhibitors
US7101869B2 (en) 1999-11-30 2006-09-05 Pfizer Inc. 2,4-diaminopyrimidine compounds useful as immunosuppressants
BR0108611A (pt) * 2000-02-25 2003-05-06 Hoffmann La Roche Moduladores de receptor de adenosina
GB0004886D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004888D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004887D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0007371D0 (en) 2000-03-28 2000-05-17 Astrazeneca Uk Ltd Chemical compounds
GB0016877D0 (en) 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
GB0021726D0 (en) 2000-09-05 2000-10-18 Astrazeneca Ab Chemical compounds
US6444477B1 (en) 2000-11-28 2002-09-03 Pharmagene Laboratories Limited Assay method for detecting 5-HT2B antagonists
GB0103926D0 (en) 2001-02-17 2001-04-04 Astrazeneca Ab Chemical compounds
YU90503A (sh) * 2001-05-14 2006-03-03 Bristol-Myers Squibb Pharma Company Supstituisani pirazinoni, piridini i pirimidini kao faktor oslobađanja kortikotropina
GB0113041D0 (en) 2001-05-30 2001-07-18 Astrazeneca Ab Chemical compounds
JP2005500294A (ja) * 2001-06-19 2005-01-06 ブリストル−マイヤーズ　スクイブ　カンパニー ホスホジエステラーゼ７に対するピリミジン阻害剤
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
CA2450562A1 (fr) 2001-06-22 2003-01-03 Merck & Co., Inc. Inhibiteurs de tyrosine kinase
TWI329105B (en) * 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
GB0203412D0 (en) 2002-02-13 2002-04-03 Pharmagene Lab Ltd 5-HT 2B receptor antagonists
CN1633293A (zh) * 2002-02-13 2005-06-29 药物基因实验室有限公司 5－ht2b受体拮抗剂
GB0205693D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0205690D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0205688D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
WO2003076434A1 (fr) 2002-03-09 2003-09-18 Astrazeneca Ab Derives de la pyrimidine substituee par 4-imidazolyle presentant une activite d'inhibition de cdk
US20040023978A1 (en) * 2002-07-24 2004-02-05 Yu Ren Active salt forms with tyrosine kinase activity
US20040023981A1 (en) * 2002-07-24 2004-02-05 Yu Ren Salt forms with tyrosine kinase activity
US6872724B2 (en) 2002-07-24 2005-03-29 Merck & Co., Inc. Polymorphs with tyrosine kinase activity
IL166241A0 (en) * 2002-07-29 2006-01-15 Rigel Pharmaceuticals Inc Method of treating or preventing autoimmune diseases with 2,4-pyrimidinedinediamine compounds
AP2385A (en) * 2002-12-20 2012-03-23 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth.
US7109337B2 (en) * 2002-12-20 2006-09-19 Pfizer Inc Pyrimidine derivatives for the treatment of abnormal cell growth
UA80767C2 (en) * 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
GB0311276D0 (en) 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
GB0311274D0 (en) 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
JP2006528617A (ja) * 2003-07-24 2006-12-21 ファーマジーン ラボラトリーズ リミテッド ５−ｈｔ２ｂ受容体アンタゴニスト
CN100441228C (zh) * 2003-07-25 2008-12-10 西巴特殊化学制品控股公司 取代的2,4-双(烷基氨基)嘧啶或-喹唑啉作为抗菌剂的用途
DK1656372T3 (da) 2003-07-30 2013-07-01 Rigel Pharmaceuticals Inc 2,4-pyrimidindiaminforbindelser til anvendelse til behandling eller forebyggelse af autoimmunsygdomme
US20070099938A1 (en) * 2003-10-24 2007-05-03 Ono Pharmaceutical Co., Ltd. Antistress drug and medical use thereof
US20080275062A1 (en) * 2004-01-30 2008-11-06 David Harold Drewry Chemical Compounds
TW200528101A (en) 2004-02-03 2005-09-01 Astrazeneca Ab Chemical compounds
WO2005079845A1 (fr) 2004-02-20 2005-09-01 Astellas Pharma Inc. Agents de prévention pour la migraine
ATE485824T1 (de) * 2004-04-13 2010-11-15 Icagen Inc Polycyclische pyrimidine als kaliumionenkanal- modulatoren
MXPA06013165A (es) * 2004-05-14 2007-02-13 Pfizer Prod Inc Derivados de pirimidina para el tratamiento de crecimiento de celulas anormal.
EP1751142A1 (fr) * 2004-05-14 2007-02-14 Pfizer Products Incorporated Derives pyrimidiques pour le traitement de la croissance de cellules anormales
CA2566477A1 (fr) * 2004-05-14 2005-11-24 Pfizer Products Inc. Derives de pyrimidine destines au traitement de croissance cellulaire anormale
US20060205945A1 (en) * 2004-05-14 2006-09-14 Pfizer Inc Pyrimidine derivatives for the treatment of abnormal cell growth
EP1796673A2 (fr) * 2004-09-23 2007-06-20 Reddy US Therapeutics, Inc. Nouveaux composes de pyrimidine, leur procede de preparation, et compositions les contenant
ES2380550T3 (es) 2004-11-24 2012-05-16 Rigel Pharmaceuticals, Inc. Compuestos de espiro-2,4-pirimidindiamina y sus usos
GB0500492D0 (en) * 2005-01-11 2005-02-16 Cyclacel Ltd Compound
US7449458B2 (en) 2005-01-19 2008-11-11 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
CN101151249B (zh) * 2005-03-31 2011-04-06 辉瑞产品公司 环戊吡啶及四氢喹啉衍生物
US20060270694A1 (en) * 2005-05-03 2006-11-30 Rigel Pharmaceuticals, Inc. JAK kinase inhibitors and their uses
US8193206B2 (en) 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
EP1890703B1 (fr) * 2005-06-14 2016-05-11 Taigen Biotechnology Composes pyrimidine en tant qu'inhibiteurs des recepteurs chemokine
US7745428B2 (en) 2005-09-30 2010-06-29 Astrazeneca Ab Imidazo[1,2-A]pyridine having anti-cell-proliferation activity
US20080293942A1 (en) * 2005-11-28 2008-11-27 Cousins Russell D Methods of Preparing 2-Imidazol-1-Yl-4-Methyl-6-Pyrrolidin-2-Yl-Pyrimidine and 4-(1-Alkylpyrrolidin-2-Yl)-2-(1H-Imidazol-1-Yl)-6-Methylpyrimidine Derivatives
US8222274B2 (en) 2006-02-20 2012-07-17 Astellas Pharma Inc. Pyrrole derivative or salt thereof
AR061185A1 (es) 2006-05-26 2008-08-13 Chugai Pharmaceutical Co Ltd Compuestos heterociclicos como inhibidores de hsp90. composiciones farmaceuticas.
WO2008079918A1 (fr) * 2006-12-22 2008-07-03 Novartis Ag Dérivés d'indol-4-yl-pyrimidinyl-2-yl-amine et leur utilisation comme inhibiteurs de la kinase dépendante des cyclines
AU2008220009A1 (en) 2007-03-01 2008-09-04 Chugai Seiyaku Kabushiki Kaisha Macrocyclic compound
DK2146779T3 (en) 2007-04-18 2016-11-28 Pfizer Prod Inc Sulfonylamid derivatives to treat abnormal cell growth.
KR101294731B1 (ko) * 2007-06-04 2013-08-16 삼성디스플레이 주식회사 어레이 기판, 이를 갖는 표시패널 및 이의 제조방법
WO2009026276A1 (fr) * 2007-08-22 2009-02-26 Irm Llc Composés et compositions de 5- (4- (haloalkoxy) phényl) pyrimidine-2-amine utilisés comme inhibiteurs de kinases
RU2378278C2 (ru) * 2008-01-24 2010-01-10 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 3-СУЛЬФОНИЛ-[1,2,3]ТРИАЗОЛО[1,5-a]ПИРИМИДИНЫ-АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ
CA2715192A1 (fr) 2008-02-19 2009-08-27 Adolor Corporation Beloxepine, ses enantiomeres et certains de leurs analogues convenant au traitement de la douleur
DK2268635T3 (en) 2008-04-21 2015-09-14 Taigen Biotechnology Co Ltd Heterocyclic Compounds
NZ596123A (en) * 2009-05-19 2014-08-29 Dow Agrosciences Llc Compounds and methods for controlling fungi
KR20130005263A (ko) 2009-12-30 2013-01-15 아르퀼 인코포레이티드 치환된 나프탈레닐-피리미딘 화합물
CN102786512A (zh) * 2012-05-31 2012-11-21 中国人民解放军军事医学科学院毒物药物研究所 N-芳基不饱和稠环叔胺类化合物及其制备方法和抗肿瘤应用
CA2952230C (fr) 2014-06-13 2023-03-21 Yuma Therapeutics, Inc. Composes pyrimidiques et procedes les utilisant
CN104725322B (zh) * 2015-02-16 2017-05-24 同济大学 一种2‑胺基嘧啶类化合物及其制备方法
WO2016173438A1 (fr) * 2015-04-29 2016-11-03 南京明德新药研发股份有限公司 Composé aryl-pyrimidine tricyclique ou à cycle fusionné utilisé comme inhibiteur de kinase
RU2605265C1 (ru) * 2015-10-06 2016-12-20 федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургская государственная химико-фармацевтическая академия" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФА Минздрава России) Анальгезирующее и противовоспалительное средство на основе 5-бутил-6-гидрокси-2-метилпиримидин-4(3h)-она
US10513509B2 (en) 2016-05-26 2019-12-24 Recurium Ip Holdings, Llc EGFR inhibitor compounds
AU2018352695A1 (en) 2017-10-19 2020-05-28 Effector Therapeutics, Inc. Benzimidazole-indole inhibitors of Mnk1 and Mnk2
CN108904503B (zh) * 2018-07-02 2021-09-28 陕西科技大学 6-氯-5-硝基-2,4-二氨基嘧啶在治疗慢性粒细胞白血病药物中的应用
AR122450A1 (es) 2020-05-08 2022-09-14 Lilly Co Eli Compuestos de (trifluorometil)pirimidin-2-amina

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3535330A (en) * 1968-04-29 1970-10-20 Sandoz Ag 2,6-diphenyl - 4 - (p-(dilower-alkyl amino lower - alkoxy)phenyl)pyridines and derivatives thereof
US3965101A (en) * 1973-07-26 1976-06-22 E. R. Squibb & Sons, Inc. 1-(O-Bromo-phenoxyalkyl)-1,2-dihydro-2-iminopyrimidines
DE2750288A1 (de) * 1977-11-10 1979-05-17 Thomae Gmbh Dr K Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4543248A (en) * 1979-03-19 1985-09-24 The Upjohn Company Method for immunoregulation with 6-aryl pyrimidine compounds
US5002951A (en) * 1979-03-19 1991-03-26 The Upjohn Company Method for treating bacterial and protozoal infections
US4665077A (en) * 1979-03-19 1987-05-12 The Upjohn Company Method for treating rejection of organ or skin grafts with 6-aryl pyrimidine compounds
AU531507B2 (en) * 1979-08-08 1983-08-25 G.D. Searle & Co. 8-substituted 7-phenyl-1,2,4-triazolo(4,3-c) pyrimidines -5-amines and amides
US4619933A (en) * 1979-09-28 1986-10-28 The Upjohn Company 6-aryl pyrimidines for treating aplastic anemia
FR2539741A1 (fr) * 1983-01-21 1984-07-27 Sanofi Sa Composes a noyau heterocyclique diazote, leur procede de preparation et les medicaments, actifs sur le systeme nerveux central, qui en contiennent
US4512993A (en) * 1983-07-25 1985-04-23 Sterling Drug Inc. 4(Or 5)-(pyridinyl)-2-pyrimidinamines and cardiotonic use thereof
US4504482A (en) * 1983-07-28 1985-03-12 Sterling Drug Inc. [5(or 4)-(Pyridinyl)-2-pyrimidinyl]ureas and cardiotonic use thereof
EP0210228A1 (fr) * 1985-02-05 1987-02-04 The Upjohn Company Composes de 4-substitue-6-aryl-pyrimidine
US4711888A (en) * 1985-07-24 1987-12-08 Pfizer Inc. Hydroxy and alkoxy pyrimidines
US4929726A (en) * 1988-02-09 1990-05-29 Georgia State University Foundation, Inc. Novel diazines and their method of preparation
WO1989011279A1 (fr) * 1988-05-16 1989-11-30 Georgia State University Foundation, Inc. Compose heteropolycyclique non fusionne ayant une interaction avec des acides nucleiques
HU206337B (en) * 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions
IE63502B1 (en) * 1989-04-21 1995-05-03 Zeneca Ltd Aminopyrimidine derivatives useful for treating cardiovascular disorders
GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
DE4237768A1 (en) * 1991-11-12 1993-05-13 Ciba Geigy Ag New polyarylene ether derivs. with reduced viscosity - used to prepare moulded bodies, foils, fibres and membranes, as matrix resins, adhesives or coating agents or as polymer additives
US5698444A (en) * 1993-12-23 1997-12-16 Eli Lilly And Company Serotonin receptor protein and related nucleic acid compounds
US5688807A (en) * 1994-03-11 1997-11-18 Eli Lilly And Company Method for treating 5HT2B receptor related conditions
JP3145410B2 (ja) * 1995-04-13 2001-03-12 大鵬薬品工業株式会社 新規な４，６−ジアリールピリミジン誘導体及びその塩
US5795905A (en) * 1995-06-06 1998-08-18 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto

Also Published As

Publication number Publication date
AR007253A1 (es) 1999-10-27
ATE323682T1 (de) 2006-05-15
HRP970275A2 (en) 1998-04-30
CN1223641A (zh) 1999-07-21
RU2189976C2 (ru) 2002-09-27
UY24560A1 (es) 2000-12-29
US5863924A (en) 1999-01-26
SA97180191B1 (ar) 2006-03-15
DE69735712D1 (de) 2006-05-24
KR20000015900A (ko) 2000-03-15
HUP9901535A2 (hu) 1999-09-28
IL127056A0 (en) 1999-09-22
AU2897897A (en) 1997-12-09
DE69735712T2 (de) 2006-11-30
HK1020345A1 (en) 2000-04-14
YU53298A (en) 1999-11-22
ES2262178T3 (es) 2006-11-16
WO1997044326A1 (fr) 1997-11-27
DK0901474T3 (da) 2006-07-31
IL127056A (en) 2003-11-23
PT901474E (pt) 2006-07-31
ID16969A (id) 1997-11-27
NO985392D0 (no) 1998-11-19
HUP9901535A3 (en) 2002-07-29
JP2001525794A (ja) 2001-12-11
NZ332802A (en) 2000-07-28
NO985392L (no) 1999-01-25
NO311800B1 (no) 2002-01-28
EP0901474A1 (fr) 1999-03-17
CA2255705A1 (fr) 1997-11-27
TR199802391T2 (xx) 1999-02-22
CZ291849B6 (cs) 2003-06-18
BR9709599A (pt) 1999-08-10
TW440563B (en) 2001-06-16
CZ380398A3 (cs) 1999-04-14
SA05260356B1 (ar) 2006-04-25
AU725891B2 (en) 2000-10-26
MY119181A (en) 2005-04-30
HRP970275B1 (en) 2002-12-31
CO4950514A1 (es) 2000-09-01
EP0901474B1 (fr) 2006-04-19
KR100518101B1 (ko) 2005-12-26
CN1109675C (zh) 2003-05-28

Similar Documents

Publication Publication Date Title
MA26431A1 (fr) Procede pour la preparation des arylpyrimidines, leur utilisation pour preparer des medicaments et pour traiter un mamifere dont l'etat pathologique peut etre attenue par traitement avec antagoniste du 5ht2b
HUP9903654A3 (en) Biconvex rapidly disintegrating dosage forms
TR199501517A2 (tr) Yeni antitrombotik formül, bunun imal edilmesi icin proses, ve bunun kullanilmasi.
EP0749302A4 (fr) Derives de l'acide hydroxamique et de l'acide carboxylique, leur mode de preparation et d'utilisation
HK1000781A1 (en) Apparatus and process to ascertain an action, and use of the apparatus and the process
FR2732680B1 (fr) Composes de type ceramides, leur procede de preparation et leur utilisation
FR2660556B1 (fr) Microspheres, leur procede de preparation et leur utilisation.
FR2772617B1 (fr) Comprime de progesterone et son procede de preparation
IT7928062A0 (it) 4(3h)-chinazolinoni sostituiti nella meta' 3-aromatica, procedimento per la loro produzione e loro impiego.
MA23309A1 (fr) Procede de preparation de nouveaux composes.
FR2668389B1 (fr) Procede de traitement antipollution d'un catalyseur de raffinage a l'etat use et recuperation des metaux.
DE69203755T2 (de) Kernbrennstofftabletten und Verfahren zur Herstellung derselben.
FR2668031B1 (fr) Bouillies bordelaises et leur procede de preparation.
FR2682371B1 (fr) Phyllosilicates 2:1 trioctaedriques et leur procede de preparation.
DK558083A (da) Somatostatinforbindelse, fremgangsmaade til fremstilling deraf samt mellemprodukt til brug ved udoevelse af fremgangsmaaden
DZ2077A1 (fr) Procédé nouveau pour formuler des formes posologiques solides, et formes posologiques ainsi produites.
FR2725450B1 (fr) Aminoplastes, procede pour leur preparation et leur utilisation
FR2679229B1 (fr) Procede de preparation du cis-inositol, du meso-inositol, de l'epi-inositol et/ou du cis-quercitol eventuellement deuteres.
MA21770A1 (fr) Peptides sdk ainsi que leur procede de preparation .
DE3262930D1 (en) Compounds of 3-phenoxybenzyl, process for the preparation thereof and their use in the synthesis of biocidal compounds
ZA9710972B (en) Steroid esters, process for their production and their pharmaceutical use.
FR2696171B1 (fr) Procede de preparation du divinylbenzene.
FR2683552B1 (fr) Phyllosilicates 2:1 trioctaedriques non gonflants et leur procede de preparation.
DE69105566D1 (de) Bilderzeugungsverfahren und magnetisches Entwicklungssystem zur Durchführung des Verfahrens.
FR2702769B1 (fr) Nouveau procede de preparation d'alkylpolyosides faiblement colores.