MA23813A1 - Nouveaux derives de l'acide nonatetraenoique - Google Patents

Nouveaux derives de l'acide nonatetraenoique

Info

Publication number
MA23813A1
MA23813A1 MA24170A MA24170A MA23813A1 MA 23813 A1 MA23813 A1 MA 23813A1 MA 24170 A MA24170 A MA 24170A MA 24170 A MA24170 A MA 24170A MA 23813 A1 MA23813 A1 MA 23813A1
Authority
MA
Morocco
Prior art keywords
nonatetraenoic acid
novel derivatives
activity
novel
nonatetraenoic
Prior art date
Application number
MA24170A
Other languages
English (en)
Inventor
Klaus Michael
Moher Peter
Rosen Berger Michael
John Lovey Allen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA23813A1 publication Critical patent/MA23813A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/45—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/548—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings having unsaturation outside the six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Vapour Deposition (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Cosmetics (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
MA24170A 1995-02-24 1996-02-23 Nouveaux derives de l'acide nonatetraenoique MA23813A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39398095A 1995-02-24 1995-02-24
US46828995A 1995-06-06 1995-06-06

Publications (1)

Publication Number Publication Date
MA23813A1 true MA23813A1 (fr) 1996-10-01

Family

ID=27014530

Family Applications (1)

Application Number Title Priority Date Filing Date
MA24170A MA23813A1 (fr) 1995-02-24 1996-02-23 Nouveaux derives de l'acide nonatetraenoique

Country Status (24)

Country Link
US (1) US5986131A (fr)
EP (1) EP0728742B1 (fr)
JP (1) JP2776787B2 (fr)
KR (1) KR100414342B1 (fr)
CN (1) CN1124260C (fr)
AT (1) ATE185799T1 (fr)
AU (1) AU703115B2 (fr)
CA (1) CA2170227A1 (fr)
CZ (1) CZ291352B6 (fr)
DE (1) DE69604713T2 (fr)
DK (1) DK0728742T3 (fr)
ES (1) ES2138765T3 (fr)
FI (1) FI960856A (fr)
GR (1) GR3032407T3 (fr)
HK (1) HK1012330A1 (fr)
HU (1) HU219538B (fr)
IL (1) IL117170A (fr)
MA (1) MA23813A1 (fr)
MY (1) MY113430A (fr)
NO (1) NO309189B1 (fr)
NZ (1) NZ286017A (fr)
RU (1) RU2166499C2 (fr)
SG (1) SG59945A1 (fr)
TW (1) TW343966B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1511519A (zh) 1997-11-12 2004-07-14 - 2型t辅助细胞介导的免疫病的治疗
US6326397B1 (en) 1998-11-10 2001-12-04 Hoffman-La Roche Inc. Retinoid antagonists and use thereof
JP4543513B2 (ja) * 2000-07-17 2010-09-15 ソニー株式会社 双方向通信システム、表示装置、ベース装置および双方向通信方法
EP1935869A1 (fr) 2000-10-02 2008-06-25 F. Hoffmann-La Roche Ag Retinoides destines au traitement de l'emphyseme
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US6495719B2 (en) 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
US7842727B2 (en) 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
WO2003099272A1 (fr) 2002-05-22 2003-12-04 Errant Gene Therapeutics, Llc Inhibiteurs d'histone desacetylase bases sur des composes alpha-ceto-epoxydes
AU2003291097A1 (en) 2002-11-20 2004-06-15 Errant Gene Therapeutics, Llc Treatment of lung cells with histone deacetylase inhibitors
EP1621191A1 (fr) * 2004-07-29 2006-02-01 Werner Bollag Traitement de maladies inflammatoires avec des antagonistes du RXR
WO2006010504A1 (fr) * 2004-07-29 2006-02-02 Werner Bollag Traitement de la sclerose en plaques au moyen d'antagonistes de rxr
EP1940378A1 (fr) * 2005-10-25 2008-07-09 Werner Bollag Agonistes et antagonistes rxr, seuls ou en conjonction avec des ligands ppar, dans le traitement des maladies metaboliques et cardiovasculaires
CN105646311B (zh) * 2016-03-31 2017-09-26 广州巨元生化有限公司 一种制备β‑阿朴‑8’‑胡萝卜醛的方法
EP3301085A1 (fr) * 2016-09-29 2018-04-04 Biogem S.Ca.R.L. Derives de retinoïde a activite antitumorale

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3277147A (en) * 1963-06-05 1966-10-04 Olin Mathieson Lower alkyl esters of beta-cyclocitrylidene fluoroacetic acid and beta-ionylidene fluoroacetic acid
US5514672A (en) * 1981-02-17 1996-05-07 Bazzano; Gail S. Use of retinoids and compositions containing same for hair growth
AU5664294A (en) * 1993-01-11 1995-02-28 Ligand Pharmaceuticals, Inc. Compounds having selective activity for retinoid x receptors, and means for modulation of processes mediated by retinoid x receptors
IL116259A (en) * 1994-12-19 2000-07-16 American Cyanamid Co Analogs of 9-cis retinoic acid and their use

Also Published As

Publication number Publication date
JPH08259527A (ja) 1996-10-08
HU219538B (hu) 2001-05-28
NO960751D0 (no) 1996-02-23
ES2138765T3 (es) 2000-01-16
MY113430A (en) 2002-02-28
CN1124260C (zh) 2003-10-15
NO309189B1 (no) 2000-12-27
RU2166499C2 (ru) 2001-05-10
AU703115B2 (en) 1999-03-18
CN1136557A (zh) 1996-11-27
HUP9600424A2 (en) 1996-12-30
FI960856A0 (fi) 1996-02-23
DK0728742T3 (da) 2000-04-17
DE69604713D1 (de) 1999-11-25
CA2170227A1 (fr) 1996-08-25
CZ291352B6 (cs) 2003-02-12
CZ53796A3 (en) 1996-11-13
ATE185799T1 (de) 1999-11-15
HU9600424D0 (en) 1996-04-29
KR100414342B1 (ko) 2004-05-10
TW343966B (en) 1998-11-01
JP2776787B2 (ja) 1998-07-16
GR3032407T3 (en) 2000-05-31
IL117170A (en) 2000-11-21
EP0728742A2 (fr) 1996-08-28
FI960856A (fi) 1996-08-25
KR960031422A (ko) 1996-09-17
IL117170A0 (en) 1996-06-18
AU4561796A (en) 1996-09-05
HUP9600424A3 (en) 1998-04-28
NO960751L (no) 1996-08-26
HK1012330A1 (en) 1999-07-30
NZ286017A (en) 1997-12-19
US5986131A (en) 1999-11-16
EP0728742A3 (fr) 1996-10-23
DE69604713T2 (de) 2000-06-21
EP0728742B1 (fr) 1999-10-20
SG59945A1 (en) 1999-02-22

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