LV12859B - PHARMACEUTICAL COMPOSITIONS WITH THE INJECTION OF MORPHIN INTRANASES AND THEIR METHODS - Google Patents
PHARMACEUTICAL COMPOSITIONS WITH THE INJECTION OF MORPHIN INTRANASES AND THEIR METHODS Download PDFInfo
- Publication number
- LV12859B LV12859B LVP-01-169A LV010169A LV12859B LV 12859 B LV12859 B LV 12859B LV 010169 A LV010169 A LV 010169A LV 12859 B LV12859 B LV 12859B
- Authority
- LV
- Latvia
- Prior art keywords
- morphine
- acceptable salt
- pharmaceutically acceptable
- absorption
- pharmaceutical composition
- Prior art date
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title claims abstract description 306
- 229960005181 morphine Drugs 0.000 title claims abstract description 150
- 238000000034 method Methods 0.000 title claims abstract description 35
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 34
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- 238000010521 absorption reaction Methods 0.000 claims abstract description 112
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- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 23
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- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 claims description 18
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 14
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- JYCQQPHGFMYQCF-UHFFFAOYSA-N 4-tert-Octylphenol monoethoxylate Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCO)C=C1 JYCQQPHGFMYQCF-UHFFFAOYSA-N 0.000 claims 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
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| US33453799A | 1999-06-16 | 1999-06-16 |
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|---|---|
| LV12859B true LV12859B (en) | 2002-12-20 |
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| LVP-01-169A LV12859B (en) | 1999-06-16 | 2002-01-18 | PHARMACEUTICAL COMPOSITIONS WITH THE INJECTION OF MORPHIN INTRANASES AND THEIR METHODS |
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| EP (2) | EP1183027A4 (fi) |
| JP (1) | JP2003501467A (fi) |
| KR (1) | KR20020016831A (fi) |
| AU (1) | AU774175B2 (fi) |
| BG (1) | BG106221A (fi) |
| BR (1) | BR0012082A (fi) |
| CA (1) | CA2374877C (fi) |
| CZ (1) | CZ20014399A3 (fi) |
| DE (1) | DE10084709T1 (fi) |
| DK (1) | DK200101859A (fi) |
| EE (1) | EE200100677A (fi) |
| ES (1) | ES2197792B1 (fi) |
| FI (1) | FI20012462A (fi) |
| GB (1) | GB2367005A (fi) |
| HR (1) | HRP20010926A2 (fi) |
| HU (1) | HUP0201856A3 (fi) |
| IS (1) | IS6202A (fi) |
| LT (1) | LT4976B (fi) |
| LU (1) | LU90859B1 (fi) |
| LV (1) | LV12859B (fi) |
| MX (1) | MXPA01012879A (fi) |
| NO (1) | NO20015931L (fi) |
| NZ (1) | NZ515783A (fi) |
| PL (1) | PL352556A1 (fi) |
| SE (1) | SE0104203L (fi) |
| SI (1) | SI20850A (fi) |
| SK (1) | SK18172001A3 (fi) |
| TR (1) | TR200103613T2 (fi) |
| WO (1) | WO2000076506A1 (fi) |
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| GB9924797D0 (en) | 1999-10-20 | 1999-12-22 | West Pharm Serv Drug Res Ltd | Compound |
| US20040115133A1 (en) * | 2000-05-10 | 2004-06-17 | Wermeling Daniel P. | Intranasal opioid compositions |
| US20060083691A1 (en) * | 2000-05-10 | 2006-04-20 | Wermeling Daniel P | Intranasal opioid compositions, delivery devices and methods of using same |
| US6572849B2 (en) * | 2000-09-20 | 2003-06-03 | Lee Shahinian, Jr. | Self-preserved antibacterial nasal, inhalable, and topical ophthalmic preparations and medications |
| WO2003002071A2 (en) * | 2001-06-29 | 2003-01-09 | Lewandowski Leon J | Individualized addiction cessation therapy |
| GB0210264D0 (en) * | 2002-05-03 | 2002-06-12 | Arakis Ltd | The treatment of pain and migraine headache |
| US20040102476A1 (en) * | 2002-11-25 | 2004-05-27 | Chan Tai Wah | High concentration formulations of opioids and opioid derivatives |
| US20050175679A1 (en) * | 2004-02-10 | 2005-08-11 | Michael Moshman | Controlled release formulations |
| US20140162965A1 (en) | 2004-08-25 | 2014-06-12 | Aegis Therapeutics, Inc. | Compositions for oral drug administration |
| US9895444B2 (en) | 2004-08-25 | 2018-02-20 | Aegis Therapeutics, Llc | Compositions for drug administration |
| SI2522365T1 (sl) | 2004-11-24 | 2017-02-28 | Meda Pharmaceuticals Inc. | Sestavki, ki obsegajo azelastin, in postopki njihove uporabe |
| US9415034B2 (en) * | 2005-01-05 | 2016-08-16 | National Defense Medical Center | Inhibitors and enhancers of uridine diphosphate-glucuronosyltransferase 2B (UGT2B) |
| ES2277743B2 (es) | 2005-06-02 | 2008-12-16 | Universidade De Santiago De Compostela | Nanoparticulas que comprenden quitosano y ciclodextrina. |
| WO2007025286A2 (en) * | 2005-08-26 | 2007-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Therapy procedure for drug delivery for trigeminal pain |
| US20070212307A1 (en) * | 2006-02-10 | 2007-09-13 | Daniel Wermeling | Pharmaceutical Compositions Comprising an Opioid Receptor Antagonist and Methods of Using Same |
| US8226949B2 (en) | 2006-06-23 | 2012-07-24 | Aegis Therapeutics Llc | Stabilizing alkylglycoside compositions and methods thereof |
| BRPI0720434A2 (pt) * | 2006-12-22 | 2014-01-07 | Sigma Tau Ind Farmaceuti | Gel útil para liberação de fármacos oftálmicos |
| GB2477545B (en) * | 2010-02-05 | 2011-12-21 | Special Products Ltd | A liquid morphine composition for buccal administration |
| ES2661838T5 (es) | 2011-05-13 | 2021-11-18 | Euro Celtique Sa | Formas de dosificación farmacéuticas intranasales que comprenden naloxona |
| WO2014016653A1 (en) | 2012-07-26 | 2014-01-30 | Wockhardt Limited | Pharmaceutical composition comprising diamorphine for intranasal administration |
| EP3082817A4 (en) * | 2013-12-18 | 2017-06-21 | Aegis Therapeutics, LLC | Compositions for drug administration |
| US11135155B2 (en) | 2014-07-08 | 2021-10-05 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
| US9629894B2 (en) | 2015-01-07 | 2017-04-25 | Trigemina, Inc. | Magnesium-containing oxytocin formulations and methods of use |
| US20180110725A1 (en) * | 2016-10-21 | 2018-04-26 | Somniferum Labs LLC | Compositions, methods and kits for the safe inhaled delivery of targeted opioids for the treatment of pain and addiction |
| WO2019076997A1 (en) * | 2017-10-20 | 2019-04-25 | Chiesi Farmaceutici S.P.A. | PHARMACEUTICAL FORMULATIONS COMPRISING AN OPIOID RECEPTOR AGONIST AS ACTIVE SUBSTANCES, METHODS OF MAKING THEM AND THERAPEUTIC USES THEREOF |
| JP6941224B2 (ja) | 2018-02-06 | 2021-09-29 | イージス セラピューティクス，エルエルシー | 疾患の処置のための鼻腔内エピネフリン製剤及び方法 |
| CN115804754A (zh) * | 2022-12-16 | 2023-03-17 | 广州新济药业科技有限公司 | 吗啡鼻喷剂及其制备方法 |
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| US4464378A (en) * | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
| US4464376A (en) | 1982-07-22 | 1984-08-07 | Richardson-Vicks, Inc. | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
| GB8514665D0 (en) * | 1985-06-11 | 1985-07-10 | Eroceltique Sa | Oral pharmaceutical composition |
| US5202128A (en) | 1989-01-06 | 1993-04-13 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
| GB9202464D0 (en) * | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
| AU6428894A (en) * | 1993-03-26 | 1994-10-24 | Franciscus W.H.M. Merkus | Pharmaceutical compositions for intranasal administration of dihydroergotamine, apomorphine and morphine |
| GB9426102D0 (en) | 1994-12-23 | 1995-02-22 | Merck Sharp & Dohme | Pharmacuetical compositions |
| US5874450A (en) * | 1996-09-27 | 1999-02-23 | Nastech Pharmaceutical Company, Inc. | Intranasal formulations for promoting sleep and method of using the same |
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2000
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- 2000-05-23 DE DE10084709T patent/DE10084709T1/de not_active Ceased
- 2000-05-23 EE EEP200100677A patent/EE200100677A/xx unknown
- 2000-05-23 GB GB0128383A patent/GB2367005A/en not_active Withdrawn
- 2000-05-23 PL PL00352556A patent/PL352556A1/xx not_active Application Discontinuation
- 2000-05-23 BR BR0012082-0A patent/BR0012082A/pt not_active IP Right Cessation
- 2000-05-23 NZ NZ515783A patent/NZ515783A/en unknown
- 2000-05-23 KR KR1020017016009A patent/KR20020016831A/ko not_active Application Discontinuation
- 2000-06-15 US US09/594,916 patent/US6677346B1/en not_active Expired - Fee Related
-
2001
- 2001-12-04 NO NO20015931A patent/NO20015931L/no not_active Application Discontinuation
- 2001-12-12 DK DK200101859A patent/DK200101859A/da not_active Application Discontinuation
- 2001-12-13 FI FI20012462A patent/FI20012462A/fi not_active IP Right Cessation
- 2001-12-13 HR HR20010926A patent/HRP20010926A2/hr not_active Application Discontinuation
- 2001-12-13 LT LT2001119A patent/LT4976B/lt not_active IP Right Cessation
- 2001-12-13 LU LU90859A patent/LU90859B1/en active
- 2001-12-14 BG BG106221A patent/BG106221A/xx unknown
- 2001-12-14 IS IS6202A patent/IS6202A/is unknown
- 2001-12-14 SE SE0104203A patent/SE0104203L/ not_active Application Discontinuation
-
2002
- 2002-01-18 LV LVP-01-169A patent/LV12859B/en unknown
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