LU92976I2 - Asfotase alfa - Google Patents
Asfotase alfa Download PDFInfo
- Publication number
- LU92976I2 LU92976I2 LU92976C LU92976C LU92976I2 LU 92976 I2 LU92976 I2 LU 92976I2 LU 92976 C LU92976 C LU 92976C LU 92976 C LU92976 C LU 92976C LU 92976 I2 LU92976 I2 LU 92976I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- amino acid
- absent
- acid sequence
- asfotase alfa
- salp
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03001—Alkaline phosphatase (3.1.3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cereal-Derived Products (AREA)
- Adornments (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91758907P | 2007-05-11 | 2007-05-11 | |
| PCT/CA2008/000923 WO2008138131A1 (en) | 2007-05-11 | 2008-05-12 | Bone targeted alkaline phosphatase, kits and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU92976I2 true LU92976I2 (en) | 2016-04-11 |
Family
ID=40001639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU92976C LU92976I2 (en) | 2007-05-11 | 2016-02-10 | Asfotase alfa |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20100297119A1 (nl) |
| EP (3) | EP2662448B1 (nl) |
| JP (1) | JP5732603B2 (nl) |
| AT (1) | ATE536413T1 (nl) |
| AU (1) | AU2008250945B2 (nl) |
| BR (2) | BR122019000505B1 (nl) |
| CA (1) | CA2687001C (nl) |
| CY (1) | CY2016005I1 (nl) |
| DE (1) | DE202008018131U1 (nl) |
| DK (3) | DK2158319T3 (nl) |
| ES (3) | ES2380546T3 (nl) |
| HK (3) | HK1141047A1 (nl) |
| HR (1) | HRP20140416T1 (nl) |
| HU (2) | HUE031655T2 (nl) |
| IL (1) | IL202057A0 (nl) |
| LT (1) | LTC2368999I2 (nl) |
| LU (1) | LU92976I2 (nl) |
| ME (1) | ME01828B (nl) |
| NL (1) | NL300798I1 (nl) |
| NO (1) | NO2016002I2 (nl) |
| PL (3) | PL2662448T3 (nl) |
| PT (3) | PT2158319E (nl) |
| RS (1) | RS53302B (nl) |
| SI (2) | SI2662448T1 (nl) |
| WO (1) | WO2008138131A1 (nl) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4874954B2 (ja) * | 2004-04-21 | 2012-02-15 | エノビア ファーマ インコーポレイティド | 骨送達複合体ならびにタンパク質に骨を標的化させるためのその使用方法 |
| US20070081984A1 (en) | 2005-10-11 | 2007-04-12 | Shunji Tomatsu | Compositions and methods for treating hypophosphatasia |
| US8784833B2 (en) * | 2006-06-27 | 2014-07-22 | Saint Louis University | Prenatal enzyme replacement therapy for hypophosphatasia |
| KR101580937B1 (ko) | 2007-06-01 | 2015-12-31 | 유니버시티 오브 매릴랜드, 발티모어 | 면역글로불린 불변영역 Ｆｃ 수용체 결합제 |
| WO2011113027A2 (en) | 2010-03-12 | 2011-09-15 | Synageva Biopharma Corp | Npp1 fusion proteins |
| BR112012027765A2 (pt) * | 2010-04-30 | 2019-09-24 | Enobia Pharma Inc | métodos, composições e kits para tratamento de distúrbios de mineralização da matriz. |
| DK2598533T3 (en) | 2010-07-28 | 2019-04-23 | Gliknik Inc | Fusion proteins of natural human protein fragments to create in an orderly fashion multimerized immunoglobulin FC compositions |
| WO2012088608A1 (en) | 2010-12-27 | 2012-07-05 | Enobia Canada Limited Partnership | Compositions comprising natriuretic peptides and methods of use thereof |
| CA2852874A1 (en) * | 2011-10-19 | 2013-04-25 | Alexion Pharma Holding | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| US10052366B2 (en) | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| KR20150058236A (ko) | 2012-08-20 | 2015-05-28 | 글리크닉 인코포레이티드 | 항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자 |
| SG11201606060WA (en) * | 2014-01-24 | 2016-08-30 | Am Pharma Bv | Chimeric alkaline phosphatase-like proteins |
| WO2016007873A1 (en) | 2014-07-11 | 2016-01-14 | The Regents Of The University Of Michigan | Compositions and methods for treating craniosynostosis |
| US10449236B2 (en) * | 2014-12-05 | 2019-10-22 | Alexion Pharmaceuticals, Inc. | Treating seizure with recombinant alkaline phosphatase |
| JP6868561B2 (ja) | 2015-01-28 | 2021-05-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼ欠損を有する被験者を治療する方法 |
| MX2018002121A (es) * | 2015-08-17 | 2018-06-18 | Alexion Pharma Inc | Elaboracion de fosfatasas alcalinas. |
| WO2017058822A1 (en) * | 2015-09-28 | 2017-04-06 | Alexion Pharmaceuticals, Inc. | Identifying effective dosage regimens for tissue non-specific alkaline phosphatase (tnsalp)-enzyme replacement therapy of hypophosphatasia |
| JP2018533571A (ja) * | 2015-10-30 | 2018-11-15 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 患者の頭蓋縫合早期癒合症を治療するための方法 |
| US11065306B2 (en) | 2016-03-08 | 2021-07-20 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
| US10898549B2 (en) | 2016-04-01 | 2021-01-26 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| EP3436052A4 (en) * | 2016-04-01 | 2019-10-09 | Alexion Pharmaceuticals, Inc. | TREATMENT OF MUSCLE WEAKNESS USING ALKALINE PHOSPHATASES |
| WO2017171871A1 (en) * | 2016-04-01 | 2017-10-05 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| EP3464573A4 (en) | 2016-06-06 | 2020-02-19 | Alexion Pharmaceuticals, Inc. | IMPACT OF METAL ON THE PRODUCTION OF ALKALINE PHOSPHATASES |
| WO2017214321A1 (en) | 2016-06-07 | 2017-12-14 | Gliknik Inc. | Cysteine-optimized stradomers |
| WO2018004517A1 (en) | 2016-06-27 | 2018-01-04 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children and adolescents |
| WO2018035420A1 (en) | 2016-08-18 | 2018-02-22 | Alexion Pharmaceuticals, Inc. | Methods for treating tracheobronchomalacia |
| IL266977B2 (en) * | 2016-11-30 | 2024-01-01 | Purdue Research Foundation | Fracture-targeted bone regeneration using thyroid hormone receptor stimulation |
| CA3043261A1 (en) | 2016-12-09 | 2018-06-14 | Gliknik Inc. | Manufacturing optimization of gl-2045, a multimerizing stradomer |
| EP3592372A4 (en) * | 2017-03-09 | 2021-01-13 | Alexion Pharmaceuticals, Inc. | GLYCOPROTEIN MANUFACTURING PROCESS |
| JP2020512363A (ja) * | 2017-03-31 | 2020-04-23 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 成人及び青年における低ホスファターゼ症（ｈｐｐ）を治療する方法 |
| CA3087569A1 (en) | 2018-01-09 | 2019-07-18 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
| JP7214962B2 (ja) * | 2018-01-17 | 2023-01-31 | 東ソー株式会社 | アルカリホスファターゼ高発現動物細胞 |
| CA3094173A1 (en) | 2018-03-20 | 2019-09-26 | Synthetic Biologics, Inc. | Intestinal alkaline phosphatase formulations |
| EP4275761A3 (en) | 2018-03-20 | 2024-02-28 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
| EP3773684A1 (en) | 2018-03-30 | 2021-02-17 | Alexion Pharmaceuticals, Inc. | Manufacturing of glycoproteins |
| CN110499284A (zh) * | 2018-05-17 | 2019-11-26 | 西安组织工程与再生医学研究所 | Wnt信号通路激活剂在制备治疗基因ALPL敲除小鼠牙硬组织矿化异常产品中的应用 |
| MX2022007114A (es) * | 2019-12-09 | 2022-07-11 | Alexion Pharma Inc | Polipeptidos de fosfatasa alcalina y metodos de uso de los mismos. |
| KR20230117327A (ko) * | 2020-09-03 | 2023-08-08 | 어빈 에스.와이. 첸 | 가용성 알칼리성 포스파타제 작제물 및 가용성 알칼리성 포스파타제 작제물을 인코딩하는 폴리뉴클레오티드를 포함하는 발현 벡터 |
| KR102571967B1 (ko) * | 2021-01-21 | 2023-08-30 | 주식회사 마라나노텍코리아 | Alp 측정용 바이오 센서 |
| MX2023009463A (es) * | 2021-02-12 | 2023-09-21 | Alexion Pharma Inc | Polipeptidos de fosfatasa alcalina y metodos para su uso. |
| WO2024050464A2 (en) * | 2022-08-31 | 2024-03-07 | University Of Utah Research Foundation | Gja1-20k compositions and methods for mitigating ischemia-reperfusion injury |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7008A (en) * | 1850-01-08 | Improvement in alloys for points of lightning-rods | ||
| ES2249761T3 (es) | 1993-06-24 | 2006-04-01 | Advec Inc. | Vectores de adenovirus para terapia genica. |
| ATE314482T1 (de) | 1993-10-25 | 2006-01-15 | Canji Inc | Rekombinante adenoviren-vektor und verfahren zur verwendung |
| US7252989B1 (en) | 1994-04-04 | 2007-08-07 | Board Of Regents, The University Of Texas System | Adenovirus supervector system |
| AU1920201A (en) | 1999-11-16 | 2001-05-30 | Genzyme Corporation | Improved regulatory elements for delivery to the liver |
| ATE437221T1 (de) | 2001-05-14 | 2009-08-15 | Gbp Ip Llc | Lentivirale vektoren kodierend für gerinnungsfaktoren für die gentherapie |
| CA2433479A1 (en) | 2002-07-22 | 2004-01-22 | F. Hoffmann-La Roche Ag | Conjugate of a tissue non-specific alkaline phosphatase and dextran, process for its production and use thereof |
| JP4874954B2 (ja) | 2004-04-21 | 2012-02-15 | エノビア ファーマ インコーポレイティド | 骨送達複合体ならびにタンパク質に骨を標的化させるためのその使用方法 |
| US20070081984A1 (en) * | 2005-10-11 | 2007-04-12 | Shunji Tomatsu | Compositions and methods for treating hypophosphatasia |
| JP2008504270A (ja) | 2004-06-23 | 2008-02-14 | ジェンザイム・コーポレイション | 嚢胞性疾患を処置するための方法および組成物 |
| US20090142347A1 (en) * | 2004-09-29 | 2009-06-04 | The Burnham Institute For Medical Research | Tissue-Nonspecific Alkaline Phosphatase (TNAP): a Therapeutic Target for Arterial Calcification |
| MX2007006524A (es) | 2004-12-01 | 2007-06-22 | Genzyme Corp | Metodos para el suministro dirigido de material genetico al higado. |
-
2008
- 2008-05-12 DK DK08757088.3T patent/DK2158319T3/da active
- 2008-05-12 SI SI200831780A patent/SI2662448T1/sl unknown
- 2008-05-12 ME MEP-2014-48A patent/ME01828B/me unknown
- 2008-05-12 PT PT08757088T patent/PT2158319E/pt unknown
- 2008-05-12 DE DE202008018131U patent/DE202008018131U1/de not_active Expired - Lifetime
- 2008-05-12 ES ES08757088T patent/ES2380546T3/es active Active
- 2008-05-12 PL PL13002327T patent/PL2662448T3/pl unknown
- 2008-05-12 ES ES13002327T patent/ES2619332T3/es active Active
- 2008-05-12 RS RS20140237A patent/RS53302B/en unknown
- 2008-05-12 AU AU2008250945A patent/AU2008250945B2/en active Active
- 2008-05-12 ES ES11004496.3T patent/ES2471915T3/es active Active
- 2008-05-12 DK DK13002327.8T patent/DK2662448T3/en active
- 2008-05-12 HU HUE13002327A patent/HUE031655T2/hu unknown
- 2008-05-12 PL PL11004496T patent/PL2368999T3/pl unknown
- 2008-05-12 AT AT08757088T patent/ATE536413T1/de active
- 2008-05-12 EP EP13002327.8A patent/EP2662448B1/en active Active
- 2008-05-12 PL PL08757088T patent/PL2158319T4/pl unknown
- 2008-05-12 WO PCT/CA2008/000923 patent/WO2008138131A1/en active Application Filing
- 2008-05-12 SI SI200831200T patent/SI2368999T1/sl unknown
- 2008-05-12 DK DK11004496.3T patent/DK2368999T3/da active
- 2008-05-12 PT PT130023278T patent/PT2662448T/pt unknown
- 2008-05-12 EP EP11004496.3A patent/EP2368999B1/en active Active
- 2008-05-12 BR BR122019000505-2A patent/BR122019000505B1/pt active Search and Examination
- 2008-05-12 US US12/599,679 patent/US20100297119A1/en not_active Abandoned
- 2008-05-12 EP EP08757088A patent/EP2158319B1/en active Active
- 2008-05-12 JP JP2010507770A patent/JP5732603B2/ja active Active
- 2008-05-12 BR BRPI0811198A patent/BRPI0811198B8/pt active IP Right Grant
- 2008-05-12 CA CA2687001A patent/CA2687001C/en active Active
- 2008-05-12 PT PT110044963T patent/PT2368999E/pt unknown
-
2009
- 2009-11-11 IL IL202057A patent/IL202057A0/en unknown
-
2010
- 2010-08-03 HK HK10107384.7A patent/HK1141047A1/xx unknown
- 2010-08-03 HK HK12102957.3A patent/HK1162589A1/xx unknown
-
2014
- 2014-05-08 HR HRP20140416AT patent/HRP20140416T1/hr unknown
- 2014-05-13 HK HK14104506.3A patent/HK1191372A1/zh unknown
-
2016
- 2016-01-15 HU HUS1600005C patent/HUS1600005I1/hu unknown
- 2016-01-28 LT LTPA2016004C patent/LTC2368999I2/lt unknown
- 2016-02-02 NO NO2016002C patent/NO2016002I2/no not_active IP Right Cessation
- 2016-02-10 LU LU92976C patent/LU92976I2/xx unknown
- 2016-02-23 CY CY2016005C patent/CY2016005I1/el unknown
- 2016-02-26 NL NL300798C patent/NL300798I1/nl unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| LU92976I2 (en) | Asfotase alfa | |
| RS52843B (en) | THE NEW IS THE HYDROGEN SULPHATE | |
| BR112012014082A2 (pt) | composições e métodos que compreendem variantes de protease | |
| DK1817164T3 (da) | Åndbare vind- og vandtætte syede genstande | |
| ATE481987T1 (de) | Verfahren zur radiofluoridierung von biologisch aktiven vektoren | |
| MX347545B (es) | Polipeptidos con actividad xilanasa. | |
| MY151985A (en) | Dental wipe | |
| BRPI0414598A (pt) | indóis substituìdos | |
| DE602006018856D1 (de) | Neue nutrazeutika-zusammensetzungen | |
| TW200630367A (en) | Substituted adenines and the uses thereof | |
| ATE458057T1 (de) | Varianten der faktor-vii- oder -viia-gla-domäne | |
| BR0110999A (pt) | Misturas de adesivos aquosos | |
| DK2084198T3 (da) | Beklædningssammensætning | |
| DE602007010969D1 (de) | Zytokinderivate | |
| MY150639A (en) | T cell adhesion molecule and antibody thereto | |
| FR2902101B1 (fr) | Peptides a activite anti-proliferative | |
| CY1115263T1 (el) | Αλκαλικη φωσφαταση στοχευμενη στα οστα, κιτ και μεθοδοι χρησης αυτων |