LU92099I2 - Golimumab et ses dérivés pharmaceutiquement acceptables (SIMPONI®) - Google Patents
Golimumab et ses dérivés pharmaceutiquement acceptables (SIMPONI®)Info
- Publication number
- LU92099I2 LU92099I2 LU92099C LU92099C LU92099I2 LU 92099 I2 LU92099 I2 LU 92099I2 LU 92099 C LU92099 C LU 92099C LU 92099 C LU92099 C LU 92099C LU 92099 I2 LU92099 I2 LU 92099I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- simponi
- golimumab
- pharmaceutically acceptable
- acceptable derivatives
- tnf
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/690,775 US6270766B1 (en) | 1992-10-08 | 1996-08-01 | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
Publications (1)
Publication Number | Publication Date |
---|---|
LU92099I2 true LU92099I2 (fr) | 2013-01-16 |
Family
ID=24773909
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU92004C LU92004I2 (fr) | 1996-08-01 | 2012-05-23 | adalimumab et ses dérivés pharmaceutiquement acceptables (HUMIRA®) |
LU92005C LU92005I2 (fr) | 1996-08-01 | 2012-05-23 | golimumab et ses dérivés pharmaceutiquement acceptables (SIMPONI®) |
LU92098C LU92098I2 (fr) | 1996-08-01 | 2012-11-16 | Adalimumab et ses dérivés pharmaceutiquement acceptables (HUMIRA®) |
LU92099C LU92099I2 (fr) | 1996-08-01 | 2012-11-16 | Golimumab et ses dérivés pharmaceutiquement acceptables (SIMPONI®) |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU92004C LU92004I2 (fr) | 1996-08-01 | 2012-05-23 | adalimumab et ses dérivés pharmaceutiquement acceptables (HUMIRA®) |
LU92005C LU92005I2 (fr) | 1996-08-01 | 2012-05-23 | golimumab et ses dérivés pharmaceutiquement acceptables (SIMPONI®) |
LU92098C LU92098I2 (fr) | 1996-08-01 | 2012-11-16 | Adalimumab et ses dérivés pharmaceutiquement acceptables (HUMIRA®) |
Country Status (12)
Country | Link |
---|---|
US (10) | US6270766B1 (fr) |
EP (3) | EP1941904B1 (fr) |
AT (2) | ATE305798T1 (fr) |
AU (1) | AU719015B2 (fr) |
CA (2) | CA2791778A1 (fr) |
DE (1) | DE69734317T2 (fr) |
DK (3) | DK0914157T3 (fr) |
ES (3) | ES2247635T3 (fr) |
HK (1) | HK1020011A1 (fr) |
LU (4) | LU92004I2 (fr) |
PT (2) | PT1941904E (fr) |
WO (1) | WO1998005357A1 (fr) |
Families Citing this family (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5959087A (en) * | 1989-08-07 | 1999-09-28 | Peptide Technology, Ltd. | Tumour necrosis factor binding ligands |
EP0486526B2 (fr) * | 1989-08-07 | 2001-03-07 | Peptech Limited | Ligands de liaison du facteur de necrose de tumeurs |
US20030225254A1 (en) * | 1989-08-07 | 2003-12-04 | Rathjen Deborah Ann | Tumour necrosis factor binding ligands |
US6277969B1 (en) * | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
US6764681B2 (en) * | 1991-10-07 | 2004-07-20 | Biogen, Inc. | Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction |
US6270766B1 (en) * | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
US6770279B1 (en) * | 1992-10-08 | 2004-08-03 | The Kennedy Institute Of Rheumatology | TNFα antagonists and cyclosporin in therapy of rheumatoid arthritis |
US7070783B1 (en) | 1995-05-09 | 2006-07-04 | The Mathilda And Terence Kennedy Institute Of Rheumatology | Small molecular weight TNF receptor multimeric molecule |
US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
CN103275221B (zh) * | 1996-02-09 | 2016-08-17 | 艾伯维生物技术有限公司 | 结合人TNFα的人抗体 |
TW555765B (en) | 1996-07-09 | 2003-10-01 | Amgen Inc | Low molecular weight soluble tumor necrosis factor type-I and type-II proteins |
US7129061B1 (en) * | 1996-08-07 | 2006-10-31 | Biogen Idec Ma Inc. | Tumor necrosis factor related ligand |
SI0942740T1 (en) * | 1996-12-06 | 2003-12-31 | Amgen Inc. | Combination therapy using a tnf binding protein for treating tnf-mediated diseases |
JP2001513754A (ja) | 1996-12-06 | 2001-09-04 | アムジェン インコーポレイテッド | Tnf媒介疾患を処置するためのtnf結合タンパク質を使用する組み合わせ治療 |
WO1998051344A1 (fr) * | 1997-05-12 | 1998-11-19 | The Kennedy Institute Of Rheumatology | Suppression therapeutique du facteur de necrose tumorale alpha et du facteur de croissance des cellules endotheliales vasculaires |
EP1109570B1 (fr) * | 1998-08-31 | 2005-10-19 | Biogen, Inc. | Modulation de cellules t effectrices de memoire par des ligands de cd2 |
US6015557A (en) * | 1999-02-24 | 2000-01-18 | Tobinick; Edward L. | Tumor necrosis factor antagonists for the treatment of neurological disorders |
MXPA01011279A (es) | 1999-05-07 | 2002-07-02 | Genentech Inc | Tratamiento de enfermedades autoinmunes con antagonistas que se unene a los marcadores de superficie, de celulas b. |
AU6376700A (en) * | 1999-07-28 | 2001-02-19 | Schering Corporation | Combined use of interleukin 10 and methotrexate for immuno-modulatory therapy |
US6544504B1 (en) | 1999-07-28 | 2003-04-08 | Schering Corporation | Combined use of interleukin 10 and methotrexate for immuno-modulatory therapy |
US8147824B2 (en) * | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
CA2781858C (fr) * | 2000-05-12 | 2015-03-31 | Genzyme Corporation | Modulateurs de marquage du tnf-.alpha. |
US20110195063A1 (en) * | 2000-08-07 | 2011-08-11 | Centocor, Inc. | Methods of Treating Ankylosing Spondylitis Using Anti-TNF Antibodies and Peptides of Human Tumor Necrosis Factor |
US6709655B2 (en) | 2001-02-28 | 2004-03-23 | Instituto Bioclon, S.A. De C.V. | Pharmaceutical composition of F(ab1)2 antibody fragments and a process for the preparation thereof |
JP2004536786A (ja) * | 2001-03-02 | 2004-12-09 | メディミューン,インコーポレイテッド | インテグリンαvβ3拮抗薬を他の予防薬もしくは治療薬と組み合わせて投与することによる炎症性疾患または自己免疫疾患の予防または治療方法 |
WO2002072788A2 (fr) * | 2001-03-14 | 2002-09-19 | Centocor, Inc. | Proteines provenant de l'immunoglobuline associees a la bronchopneumopathie chronique obstructive, compositions, procedes et utilisations |
CN101979095A (zh) * | 2001-05-02 | 2011-02-23 | 普渡研究基金会 | 巨噬细胞介导的疾病的治疗和诊断 |
CA2868614A1 (fr) * | 2001-06-08 | 2002-12-08 | Abbott Laboratories (Bermuda) Ltd. | Methodes pour administrer des anticorps anti-tnf.alpha. |
CA2454618C (fr) * | 2001-07-24 | 2012-04-03 | Biogen Idec Ma, Inc. | Methodes de traitement ou de prevention de troubles sclereux par l'usage d'agents se liant a cd2 |
US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
US8043603B2 (en) * | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
US20030206898A1 (en) * | 2002-04-26 | 2003-11-06 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
US20040009172A1 (en) * | 2002-04-26 | 2004-01-15 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
US20040136990A1 (en) * | 2002-07-19 | 2004-07-15 | Abbott Biotechnology Ltd. | Treatment of pain using TNFalpha inhibitors |
MY150740A (en) | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
DK1562571T3 (da) * | 2002-11-21 | 2011-12-05 | Genzyme Corp | Kombination af et diamidderivat og immunsuppressive midler til hæmning af transplantatafstødning |
WO2004047825A1 (fr) * | 2002-11-21 | 2004-06-10 | Genzyme Corporation | Utilisation de derives de diamide pour inhiber le rejet de transplantation tissulaire chronique |
WO2004050683A2 (fr) | 2002-12-02 | 2004-06-17 | Abgenix, Inc. | Anticorps agissant sur le facteur de necrose des tumeurs (tnf) et leurs utilisation |
US20050042219A1 (en) * | 2002-12-05 | 2005-02-24 | Woulfe Susan L. | Engineered Fab' fragment anti-tumor necrosis factor alpha in combination with disease modifying anti-rheumatic drugs |
US7101978B2 (en) * | 2003-01-08 | 2006-09-05 | Applied Molecular Evolution | TNF-α binding molecules |
EP1460088A1 (fr) * | 2003-03-21 | 2004-09-22 | Biotest AG | Anticorps humanisé contre CD4 avec des caractéristiques immunosuppressives |
GB2401040A (en) * | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
JP4680185B2 (ja) | 2003-05-30 | 2011-05-11 | パーデュー・リサーチ・ファウンデーション | アテローム性動脈硬化症の診断法 |
AU2004251750A1 (en) * | 2003-06-25 | 2005-01-06 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating rheumatoid arthritis |
WO2005009464A1 (fr) * | 2003-07-25 | 2005-02-03 | Lopez De Silanes Juan | Administration de fragments d'anticorps f(ab')2 anti-cytokiniques |
US7435799B2 (en) * | 2004-01-08 | 2008-10-14 | Applied Molecular Evolution | TNF-α binding molecules |
US20070172478A1 (en) * | 2004-02-06 | 2007-07-26 | Astellas Us Llc | Methods of treating skin disorders |
TWI439284B (zh) | 2004-04-09 | 2014-06-01 | Abbvie Biotechnology Ltd | 用於治療TNFα相關失調症之多重可變劑量療法 |
BRPI0510691A (pt) * | 2004-05-04 | 2007-12-26 | Genaissance Pharmaceuticals | marcadores de haplótipos e métodos de uso dos mesmos para determinar resposta ao tratamento |
CA2565259A1 (fr) * | 2004-05-07 | 2005-12-08 | Astellas Us Llc | Polypeptide lfa-3 soluble destine a traiter de troubles viraux |
US20060083741A1 (en) * | 2004-10-08 | 2006-04-20 | Hoffman Rebecca S | Treatment of respiratory syncytial virus (RSV) infection |
EP1827469A2 (fr) * | 2004-11-22 | 2007-09-05 | Henry J. Smith | Recepteurs cellulaires utilises comme excipients pour composes pharmaceutiques servant dans le traitement de l'arthrite, et des troubles inflammatoires et immunitaires |
EP2452695A3 (fr) * | 2004-12-23 | 2013-01-23 | Purdue Research Foundation | Procédé d'imagerie par tomographie à émission de positrons |
EP1859277A4 (fr) | 2005-02-17 | 2010-03-17 | Biogen Idec Inc | Traitement de troubles neurologiques |
JP5339901B2 (ja) | 2005-05-10 | 2013-11-13 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 炎症傷害の処置および評価 |
CN101500607B (zh) * | 2005-05-16 | 2013-11-27 | 阿布维生物技术有限公司 | TNFα抑制剂治疗腐蚀性多关节炎的用途 |
EP1904183B1 (fr) | 2005-07-05 | 2014-10-15 | Purdue Research Foundation | Composition pharmaceutique pour le traitement de l'arthrose |
US20070041905A1 (en) * | 2005-08-19 | 2007-02-22 | Hoffman Rebecca S | Method of treating depression using a TNF-alpha antibody |
WO2007038346A2 (fr) | 2005-09-23 | 2007-04-05 | Purdue Research Foundation | Procede et dispositif de cytometrie en flux in vivo multiphoton |
AU2016203976B2 (en) * | 2005-11-09 | 2018-02-01 | Abt Holding Company | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
US10117900B2 (en) | 2005-11-09 | 2018-11-06 | Athersys, Inc. | MAPC treatment of brain injuries and diseases |
US11000546B2 (en) | 2005-11-09 | 2021-05-11 | Athersys, Inc. | Immunomodulatory properties of MAPCs and uses thereof |
NZ727755A (en) | 2006-01-23 | 2023-01-27 | Abt Holding Co | Mapc therapeutics without adjunctive immunosuppressive treatment |
US20080118496A1 (en) * | 2006-04-10 | 2008-05-22 | Medich John R | Uses and compositions for treatment of juvenile rheumatoid arthritis |
US20090317399A1 (en) * | 2006-04-10 | 2009-12-24 | Pollack Paul F | Uses and compositions for treatment of CROHN'S disease |
US9605064B2 (en) | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
US9624295B2 (en) | 2006-04-10 | 2017-04-18 | Abbvie Biotechnology Ltd. | Uses and compositions for treatment of psoriatic arthritis |
US9399061B2 (en) | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
US20080131374A1 (en) * | 2006-04-19 | 2008-06-05 | Medich John R | Uses and compositions for treatment of rheumatoid arthritis |
CN103316402A (zh) | 2006-06-30 | 2013-09-25 | 艾伯维生物技术有限公司 | 自动注射装置 |
US20080064626A1 (en) * | 2006-09-08 | 2008-03-13 | Zanella John M | Methods of treating tendonitis in a subject by using an anti-cytokine agent |
RU2486201C2 (ru) | 2006-10-12 | 2013-06-27 | Дженентек, Инк. | Антитела к лимфотоксину-альфа |
US8685752B2 (en) | 2006-11-03 | 2014-04-01 | Purdue Research Foundation | Ex vivo flow cytometry method and device |
US8586595B2 (en) * | 2007-02-07 | 2013-11-19 | Purdue Research Foundation | Positron emission tomography imaging method |
US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
AR066016A1 (es) * | 2007-04-11 | 2009-07-15 | Alcon Res Ltd | Uso de un inhibidor del tnf alfa junto con una antihistamina para tratar la rinitis alergica y la conjuntivitis alergica |
CA2688308A1 (fr) * | 2007-05-25 | 2008-12-04 | Purdue Research Foundation | Methode d'imagerie d'infections localisees |
NZ581742A (en) | 2007-06-08 | 2012-09-28 | Biogen Idec Inc | Biomarkers for predicting anti-tnf responsiveness or non-responsiveness |
EP2171451A4 (fr) | 2007-06-11 | 2011-12-07 | Abbott Biotech Ltd | Procédés de traitement de l'arthrite idiopathique juvénile |
CN101969929B (zh) | 2008-01-15 | 2014-07-30 | Abbvie德国有限责任两合公司 | 粉末状蛋白质组合物及其制备方法 |
BRPI0909179A2 (pt) * | 2008-03-13 | 2015-08-25 | Biotest Ag | Composição farmacêutica, e, método de tratamento de uma doença autoimune. |
KR20100135257A (ko) * | 2008-03-13 | 2010-12-24 | 바이오테스트 아게 | 질병 치료제 |
CA2718191C (fr) * | 2008-03-13 | 2018-05-15 | Biotest Ag | Agent pour traiter une maladie |
CA2738598C (fr) * | 2008-09-29 | 2017-11-21 | Biotest Ag | Composition destinee au traitement de maladies |
WO2010091381A2 (fr) * | 2009-02-09 | 2010-08-12 | Callisto Pharmaceuticals, Inc. | Stratégie d'administration intermittente pour le traitement de la polyarthrite rhumatoïde |
CA2773483A1 (fr) * | 2009-10-01 | 2011-04-07 | Alcon Research, Ltd. | Compositions d'olopatadine et leurs utilisations |
GB0920944D0 (en) | 2009-11-30 | 2010-01-13 | Biotest Ag | Agents for treating disease |
JP2013512674A (ja) * | 2009-12-02 | 2013-04-18 | アクセルロン ファーマ, インコーポレイテッド | Fc融合タンパク質の血清半減期を増加させるための組成物および方法 |
WO2012149197A2 (fr) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Procédé de contrôle du profil de galactosylation de protéines exprimées de manière recombinante |
EP2718328A4 (fr) | 2011-06-08 | 2014-12-24 | Acceleron Pharma Inc | Compositions et procédés pour augmenter la demi-vie sérique |
US20140309192A1 (en) | 2011-11-08 | 2014-10-16 | Arena Pharmaceuticals, Inc. | Modulators of the g protein-coupled mas receptor and the treatment of disorders related thereto |
WO2013158279A1 (fr) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Procédés de purification de protéines pour réduire des espèces acides |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
US9789062B2 (en) * | 2012-07-05 | 2017-10-17 | Tlc Biopharmaceuticals, Inc. | Methods of treating arthritis |
US8958362B2 (en) * | 2012-08-24 | 2015-02-17 | William Marsh Rice University | Method and system for wirelessly transmitting data |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
WO2014035475A1 (fr) | 2012-09-02 | 2014-03-06 | Abbvie Inc. | Procédés de contrôle de l'hétérogénéité des protéines |
DE102012020496A1 (de) | 2012-10-18 | 2014-04-24 | Charité - Universitätsmedizin Berlin | Biomarker zur Diagnostik und Behandlung von Neurofibromatose Typ 1 |
CA2898354C (fr) | 2013-01-25 | 2017-11-21 | Thymon, Llc | Compositions pour la reduction selective de tnf soluble bioactif en circulation et methodes de traitement d'une maladie a mediation par tnf |
EP2830651A4 (fr) | 2013-03-12 | 2015-09-02 | Abbvie Inc | Anticorps humains qui se lient au tnf-alpha et leurs procédés de préparation |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
WO2014182673A1 (fr) | 2013-05-07 | 2014-11-13 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur mas couplé à la protéine g et traitement de troubles apparentés |
TWI516272B (zh) | 2013-06-05 | 2016-01-11 | 財團法人工業技術研究院 | 應用於生髮之方法及醫藥組成物 |
US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
WO2015073884A2 (fr) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Compositions de protéines de liaison génétiquement glycomodifiées |
US10298750B2 (en) * | 2013-11-21 | 2019-05-21 | Vodafone Ip Licensing Limited | Telecommunication networks for content delivery and lawful interception, content filtering and further content services using a SAVI platform |
US9402876B2 (en) | 2013-11-27 | 2016-08-02 | Industrial Technology Research Institute | Method and pharmaceutical composition for hair growth |
KR102372512B1 (ko) * | 2017-11-20 | 2022-03-10 | 가톨릭대학교 산학협력단 | 폴리감마글루탐산 및 메토트렉세이트를 유효성분으로 포함하는 관절염 예방 또는 치료용 조성물 |
CN116688094A (zh) * | 2021-12-15 | 2023-09-05 | 苏州澳宗生物科技有限公司 | p75细胞外结构域在类风湿性关节炎治疗和/或预防中的应用 |
Family Cites Families (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (fr) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Récepteurs chimériques par liaison et expression de l'ADN |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
US4695459A (en) * | 1984-12-26 | 1987-09-22 | The Board Of Trustees Of Leland Stanford Junior University | Method of treating autoimmune diseases that are mediated by Leu3/CD4 phenotype T cells |
US4870163A (en) | 1985-08-29 | 1989-09-26 | New York Blood Center, Inc. | Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor |
AU606320B2 (en) | 1985-11-01 | 1991-02-07 | International Genetic Engineering, Inc. | Modular assembly of antibody genes, antibodies prepared thereby and use |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
GB8608068D0 (en) | 1986-04-02 | 1986-05-08 | Cobbold S P | Monoclonal antibodies |
US5096906A (en) * | 1986-12-31 | 1992-03-17 | University Of Virginia Alumni Patents Foundation | Method of inhibiting the activity of leukocyte derived cytokines |
US5075236A (en) | 1987-04-24 | 1991-12-24 | Teijin Limited | Method of detecting kawasaki disease using anti-tumor necrosis antibody |
GB8805792D0 (en) | 1988-03-11 | 1988-04-13 | Celltech Ltd | Medicaments |
US5468481A (en) * | 1988-06-23 | 1995-11-21 | Amergen, Inc. | MHC class II-peptide conjugates useful in ameliorating autoimmunity |
US5260422A (en) * | 1988-06-23 | 1993-11-09 | Anergen, Inc. | MHC conjugates useful in ameliorating autoimmunity |
US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
GB8912497D0 (en) | 1989-05-31 | 1989-07-19 | Cobbold Stephen P | Monoclonal antibodies |
AU6355190A (en) | 1989-06-13 | 1991-01-17 | Smithkline Beecham Corporation | Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages |
IL95031A (en) | 1989-07-18 | 2007-03-08 | Amgen Inc | A method of producing a recombinant human necrotic factor absorber |
EP0486526B2 (fr) | 1989-08-07 | 2001-03-07 | Peptech Limited | Ligands de liaison du facteur de necrose de tumeurs |
US5298396A (en) * | 1989-11-15 | 1994-03-29 | National Jewish Center For Immunology And Respiratory Medicine | Method for identifying T cells disease involved in autoimmune disease |
EP0511308B2 (fr) | 1989-12-27 | 2003-07-09 | Centocor, Inc. | Immunoglobuline chimerique pour recepteurs de cd4 |
DE4006269A1 (de) | 1990-02-28 | 1991-08-29 | Max Planck Gesellschaft | Antikoerper gegen den tumor-nekrosefaktor-rezeptor |
US5204329A (en) * | 1990-06-11 | 1993-04-20 | Du Pont Merck Pharmaceutical Company | Treatment of organ transplantation rejection |
GB2246569A (en) | 1990-06-15 | 1992-02-05 | Charing Cross Sunley Research | Tumour necrosis factor - alpha binding protein |
GB9022648D0 (en) | 1990-10-18 | 1990-11-28 | Charing Cross Sunley Research | Polypeptide and its use |
US5958413A (en) * | 1990-11-01 | 1999-09-28 | Celltech Limited | Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor |
GB9023783D0 (en) | 1990-11-01 | 1990-12-12 | Celltech Ltd | Pharmaceutical product |
AU8910891A (en) | 1990-11-20 | 1992-06-11 | National Heart & Lung Institute, The | Treatment of lung diseases |
US5994510A (en) * | 1990-12-21 | 1999-11-30 | Celltech Therapeutics Limited | Recombinant antibodies specific for TNFα |
GB9109645D0 (en) | 1991-05-03 | 1991-06-26 | Celltech Ltd | Recombinant antibodies |
DE4108204A1 (de) | 1991-03-14 | 1992-09-17 | Schering Ag | Verfahren zur herstellung von alkoxymagnesiumhalogeniden |
US5656272A (en) * | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
US7192584B2 (en) * | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
ES2156859T5 (es) | 1991-03-18 | 2008-03-16 | New York University | Anticuerpos monoclonales y quimericos especificos para el factor de necrosis tumoral humano. |
US6284471B1 (en) | 1991-03-18 | 2001-09-04 | New York University Medical Center | Anti-TNFa antibodies and assays employing anti-TNFa antibodies |
US5919452A (en) * | 1991-03-18 | 1999-07-06 | New York University | Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies |
US5698195A (en) * | 1991-03-18 | 1997-12-16 | New York University Medical Center | Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies |
DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
MX9204374A (es) * | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
DE69230862T2 (de) | 1991-10-15 | 2000-12-14 | Michael F. Mullarkey | Rezeptoren zur Behandlung von Entzündungen vom verzögerten Typ |
US5201329A (en) * | 1992-01-21 | 1993-04-13 | Claire Quackenbush | Permanent wave rod having hinged end-cap |
US5567704A (en) * | 1992-03-04 | 1996-10-22 | Cell Therapeutics, Inc. | R-enatiomerically pure hydroxylated xanthine compounds to treat baldness |
US5447851B1 (en) | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
WO1994006476A1 (fr) | 1992-09-15 | 1994-03-31 | Immunex Corporation | Procede de traitement de l'inflammation dependante du facteur necrosant des tumeurs malignes (tnf) a l'aide d'antagonistes dudit tnf |
WO1995009652A1 (fr) | 1993-10-06 | 1995-04-13 | The Kennedy Institute For Rheumatology | Traitement des troubles auto-immuns et inflammatoires |
US6270766B1 (en) | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
US5741488A (en) * | 1992-10-08 | 1998-04-21 | The Kennedy Institute For Rheumatology | Treatment of rheumatoid arthritis with anti-CD4 antibodies in conjunction with anti-TNF antibodies |
US6770279B1 (en) * | 1992-10-08 | 2004-08-03 | The Kennedy Institute Of Rheumatology | TNFα antagonists and cyclosporin in therapy of rheumatoid arthritis |
DE4320157A1 (de) * | 1993-06-18 | 1994-12-22 | Bayer Ag | Verwendung von 1,2,4-Dithiazolium-Salzen als Chemotherapeutica |
ES2153384T3 (es) | 1993-07-30 | 2001-03-01 | Kennedy Inst Of Rheumatology | Metodo para tratar la esclerosis multiple. |
WO1995010538A1 (fr) | 1993-10-15 | 1995-04-20 | The University Of North Carolina At Chapel Hill | Adn codant le recepteur humain p2u et cellules nulles exprimant les recepteurs p¿2u? |
US20020068057A1 (en) * | 1994-03-10 | 2002-06-06 | Marc Feldmann | Treatment of autoimmune and inflammatory disorders |
US6190691B1 (en) * | 1994-04-12 | 2001-02-20 | Adolor Corporation | Methods for treating inflammatory conditions |
GB2289218A (en) | 1994-05-06 | 1995-11-15 | Merck & Co Inc | Inhibition of TNFalpha production with agonists of the A2b subtype of the adenosine receptor |
US5525613A (en) * | 1994-06-16 | 1996-06-11 | Entropin, Inc. | Covalently coupled benzoylecgonine ecgonine and ecgonidine |
US5530157A (en) * | 1995-02-16 | 1996-06-25 | Scios Nova Inc. | Anti-inflammatory benzoic acid derivatives |
EP0871641A4 (fr) | 1995-04-20 | 2001-09-26 | Kennedy Inst Of Rheumatology | Administrations multiples d'anticorps diriges contre le facteur necrosant des tumeurs (anticorps anti-tnf) |
US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
CN103275221B (zh) | 1996-02-09 | 2016-08-17 | 艾伯维生物技术有限公司 | 结合人TNFα的人抗体 |
AU2012202134B2 (en) | 1996-08-01 | 2013-02-14 | The Kennedy Trust For Rheumatology Research | Anti-TNF antibodies and methotrexate in the treatment of autoimmune disease |
AU5182500A (en) | 1996-08-01 | 2000-10-26 | Kennedy Institute Of Rheumatology, The | Anti-TNF antibodies and methotrexate in the treatment of autoimmune disease |
DE19650115C1 (de) | 1996-12-03 | 1998-07-02 | Fraunhofer Ges Forschung | Medikamenten-Dosiervorrichtung |
JP2001513754A (ja) | 1996-12-06 | 2001-09-04 | アムジェン インコーポレイテッド | Tnf媒介疾患を処置するためのtnf結合タンパク質を使用する組み合わせ治療 |
US6177077B1 (en) * | 1999-02-24 | 2001-01-23 | Edward L. Tobinick | TNT inhibitors for the treatment of neurological disorders |
US6015557A (en) * | 1999-02-24 | 2000-01-18 | Tobinick; Edward L. | Tumor necrosis factor antagonists for the treatment of neurological disorders |
EP4006269B1 (fr) | 2021-11-15 | 2023-12-27 | E-Parktower GmbH | Dispositif de stockage / stationnement pour véhicules |
-
1996
- 1996-08-01 US US08/690,775 patent/US6270766B1/en not_active Expired - Fee Related
-
1997
- 1997-08-01 AT AT97933799T patent/ATE305798T1/de active
- 1997-08-01 ES ES97933799T patent/ES2247635T3/es not_active Expired - Lifetime
- 1997-08-01 AU AU37035/97A patent/AU719015B2/en not_active Withdrawn - After Issue
- 1997-08-01 AT AT05076131T patent/ATE535255T1/de active
- 1997-08-01 EP EP08005013A patent/EP1941904B1/fr not_active Revoked
- 1997-08-01 CA CA2791778A patent/CA2791778A1/fr not_active Abandoned
- 1997-08-01 PT PT08005013T patent/PT1941904E/pt unknown
- 1997-08-01 DE DE69734317T patent/DE69734317T2/de not_active Expired - Lifetime
- 1997-08-01 DK DK97933799T patent/DK0914157T3/da active
- 1997-08-01 EP EP05076131A patent/EP1593393B1/fr not_active Revoked
- 1997-08-01 EP EP97933799A patent/EP0914157B1/fr not_active Revoked
- 1997-08-01 WO PCT/GB1997/002058 patent/WO1998005357A1/fr active IP Right Grant
- 1997-08-01 CA CA2261630A patent/CA2261630C/fr not_active Expired - Lifetime
- 1997-08-01 ES ES05076131T patent/ES2378446T3/es not_active Expired - Lifetime
- 1997-08-01 PT PT05076131T patent/PT1593393E/pt unknown
- 1997-08-01 DK DK08005013.1T patent/DK1941904T3/da active
- 1997-08-01 DK DK05076131.1T patent/DK1593393T3/da active
- 1997-08-01 ES ES08005013T patent/ES2388244T3/es not_active Expired - Lifetime
-
1999
- 1999-11-12 HK HK99105260A patent/HK1020011A1/xx not_active IP Right Cessation
-
2001
- 2001-01-03 US US09/754,004 patent/US20020010180A1/en not_active Abandoned
- 2001-08-03 US US09/921,937 patent/US20020136723A1/en not_active Abandoned
-
2005
- 2005-09-12 US US11/225,631 patent/US7846442B2/en not_active Expired - Fee Related
-
2008
- 2008-10-07 US US12/287,340 patent/US7838489B2/en not_active Expired - Fee Related
-
2009
- 2009-08-26 US US12/583,855 patent/US20110014188A1/en not_active Abandoned
- 2009-08-26 US US12/583,851 patent/US20110123543A1/en not_active Abandoned
-
2012
- 2012-01-13 US US13/350,262 patent/US8298537B2/en not_active Expired - Fee Related
- 2012-01-13 US US13/350,065 patent/US8383120B2/en not_active Expired - Fee Related
- 2012-05-23 LU LU92004C patent/LU92004I2/fr unknown
- 2012-05-23 LU LU92005C patent/LU92005I2/fr unknown
- 2012-10-04 US US13/645,332 patent/US20130064816A1/en not_active Abandoned
- 2012-11-16 LU LU92098C patent/LU92098I2/fr unknown
- 2012-11-16 LU LU92099C patent/LU92099I2/fr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
LU92099I2 (fr) | Golimumab et ses dérivés pharmaceutiquement acceptables (SIMPONI®) | |
AU2005202257C1 (en) | Azacyclic compounds for use in the treatment of serotonin related diseases | |
PL328430A1 (en) | Intracolonic administration of nicotine for treating intestinal inflammatory diseases | |
GB8817015D0 (en) | Method of treatment | |
NO923859L (no) | Medikament | |
YU49026B (sh) | UPOTREBA 17 Гџ -(N-TERC-BUTILKARBAMOIL)-4-AZA-5-ALFA-ANDROST-1-3-ON ZA PROIZVODNJU LEKA ZA TRETIRANJE ANDROGENE ALOPECIJE | |
EP0957925A4 (fr) | Traitement de l'arthrose par administration de poly-n-acetyl-d-glucosamine | |
HK1034446A1 (en) | Therapeutic agents. | |
SE8500996D0 (sv) | Method of treatment | |
IL121440A0 (en) | The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives | |
EP0338679A3 (fr) | Utilisation du facteur necrosant des tumeurs dans le traitement du cancer de la vessie | |
EA200000448A1 (ru) | Новые полиморфные формы ципамфиллина | |
MXPA02006146A (es) | Uso de metabolitos bioactivos de gepirona para el tratamiento de desordenes psicologicos. | |
EP0378146A3 (fr) | Dérivés de polyamine comme agents antinéoplastiques | |
CA2392902A1 (fr) | Bisindolylmaleimides substitues destines a inhiber la proliferation cellulaire | |
BE1002099A3 (fr) | Nouvelles quinazolinones tetracycliques, leur preparation et leur utilisation comme medicaments. | |
HU913660D0 (en) | The use of imidoazepine derivatives for treating of sleep impairments | |
WO2000033823A3 (fr) | Procedes d'utilisation de temozolomide dans le traitement de cancers | |
WO2002019964A3 (fr) | Procedes et compositions pharmaceutiques utilisant la desmethylselegiline pour traiter des maladies ou des etats neoplasiques | |
UA30654A (uk) | Спосіб лікування посттравматичних дисфункцій висково- нижньощелепового суглоба | |
NZ505530A (en) | Cytokine related treatments of disease using a nucleoside | |
UA23882A (uk) | Спосіб лікування виразкової хвороби дванадцятипало ї кишки | |
RU99122488A (ru) | Способ лечения рака эндометрия |