LU84902A1 - Composition pharmaceutique antihypertensive synergetique - Google Patents
Composition pharmaceutique antihypertensive synergetique Download PDFInfo
- Publication number
- LU84902A1 LU84902A1 LU84902A LU84902A LU84902A1 LU 84902 A1 LU84902 A1 LU 84902A1 LU 84902 A LU84902 A LU 84902A LU 84902 A LU84902 A LU 84902A LU 84902 A1 LU84902 A1 LU 84902A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- indapamide
- pharmaceutical composition
- tert
- butylamino
- synergetic
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 7
- 230000003276 anti-hypertensive effect Effects 0.000 title description 2
- 230000002195 synergetic effect Effects 0.000 title 1
- 229960004569 indapamide Drugs 0.000 claims description 15
- NDDAHWYSQHTHNT-UHFFFAOYSA-N indapamide Chemical compound CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1 NDDAHWYSQHTHNT-UHFFFAOYSA-N 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 5
- HTWFXPCUFWKXOP-UHFFFAOYSA-N Tertatalol Chemical compound C1CCSC2=C1C=CC=C2OCC(O)CNC(C)(C)C HTWFXPCUFWKXOP-UHFFFAOYSA-N 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 230000003287 optical effect Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 description 11
- 102000030621 adenylate cyclase Human genes 0.000 description 8
- 108060000200 adenylate cyclase Proteins 0.000 description 8
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 6
- IVOMOUWHDPKRLL-UHFFFAOYSA-N UNPD107823 Natural products O1C2COP(O)(=O)OC2C(O)C1N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-UHFFFAOYSA-N 0.000 description 6
- 229940095074 cyclic amp Drugs 0.000 description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 241000272201 Columbiformes Species 0.000 description 3
- 206010020772 Hypertension Diseases 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 2
- 206010020850 Hyperthyroidism Diseases 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- 239000002876 beta blocker Substances 0.000 description 2
- 229940097320 beta blocking agent Drugs 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000002934 diuretic Substances 0.000 description 2
- 230000001882 diuretic effect Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 208000013403 hyperactivity Diseases 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 229940039009 isoproterenol Drugs 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- LPBCJDNVLKNRAZ-UHFFFAOYSA-N 1-(tert-butylamino)-3-(3,4-dihydro-2h-thiochromen-8-yloxy)propan-2-ol;hydron;chloride Chemical compound Cl.C1CCSC2=C1C=CC=C2OCC(O)CNC(C)(C)C LPBCJDNVLKNRAZ-UHFFFAOYSA-N 0.000 description 1
- QRWRJDVVXAXGBT-UHFFFAOYSA-N 2-Methylindoline Chemical compound C1=CC=C2NC(C)CC2=C1 QRWRJDVVXAXGBT-UHFFFAOYSA-N 0.000 description 1
- AJVBPNRMKNARPG-UHFFFAOYSA-N 3-sulfamoylbenzamide Chemical compound NC(=O)C1=CC=CC(S(N)(=O)=O)=C1 AJVBPNRMKNARPG-UHFFFAOYSA-N 0.000 description 1
- 102000004420 Creatine Kinase Human genes 0.000 description 1
- 108010042126 Creatine kinase Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- AQLLBJAXUCIJSR-UHFFFAOYSA-N OC(=O)C[Na] Chemical compound OC(=O)C[Na] AQLLBJAXUCIJSR-UHFFFAOYSA-N 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000037849 arterial hypertension Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 description 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000008119 colloidal silica Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 210000003617 erythrocyte membrane Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000009454 functional inhibition Effects 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- LWJROJCJINYWOX-UHFFFAOYSA-L mercury dichloride Chemical compound Cl[Hg]Cl LWJROJCJINYWOX-UHFFFAOYSA-L 0.000 description 1
- 210000003975 mesenteric artery Anatomy 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 230000022082 negative regulation of vasoconstriction Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229940080313 sodium starch Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8212058A FR2529785A1 (fr) | 1982-07-09 | 1982-07-09 | Composition pharmaceutique a base d'indapamide et de 8-(3-tertbutylamino 2-hydroxypropoxy)-thiachromanne |
| FR8212058 | 1982-07-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU84902A1 true LU84902A1 (fr) | 1984-03-22 |
Family
ID=9275835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU84902A LU84902A1 (fr) | 1982-07-09 | 1983-07-06 | Composition pharmaceutique antihypertensive synergetique |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5927813A (OSRAM) |
| AU (1) | AU557601B2 (OSRAM) |
| BE (1) | BE897251A (OSRAM) |
| CA (1) | CA1197191A (OSRAM) |
| CH (1) | CH655007A5 (OSRAM) |
| DE (1) | DE3324785C2 (OSRAM) |
| FR (1) | FR2529785A1 (OSRAM) |
| GB (1) | GB2123293B (OSRAM) |
| IE (1) | IE55364B1 (OSRAM) |
| IT (1) | IT1173729B (OSRAM) |
| LU (1) | LU84902A1 (OSRAM) |
| NL (1) | NL8302435A (OSRAM) |
| NZ (1) | NZ204849A (OSRAM) |
| OA (1) | OA07489A (OSRAM) |
| SE (1) | SE8303886L (OSRAM) |
| ZA (1) | ZA834978B (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8600137A (nl) * | 1985-02-05 | 1986-09-01 | Sandoz Ag | Farmaceutische preparaten die desgewenst met een diureticum gecombineerde 3-aminopropoxyindolen bevatten, alsmede werkwijzen voor het toepassen van deze preparaten. |
| PL193976B1 (pl) * | 2002-07-01 | 2007-04-30 | Pliva Krakow | Tabletka o przedłużonym działaniu zawierająca indapamid i sposób wytwarzania tabletki o przedłużonym działaniu zawierającej indapamid |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1203691A (en) * | 1968-03-06 | 1970-09-03 | Science Union & Cie | New disubstituted n-amino indoline derivatives and process for preparing them |
| GB1308191A (en) * | 1970-04-06 | 1973-02-21 | Science Union & Cie | Thiochroman derivatives and a process for preparing them |
| DE2227423A1 (de) * | 1971-06-15 | 1972-12-21 | Ciba-Geigy Ag, Basel (Schweiz) | Neue pharmazeutische Präparate |
-
1982
- 1982-07-09 FR FR8212058A patent/FR2529785A1/fr active Granted
-
1983
- 1983-07-06 LU LU84902A patent/LU84902A1/fr unknown
- 1983-07-07 SE SE8303886A patent/SE8303886L/xx not_active Application Discontinuation
- 1983-07-07 IT IT48641/83A patent/IT1173729B/it active
- 1983-07-07 ZA ZA834978A patent/ZA834978B/xx unknown
- 1983-07-08 GB GB08318512A patent/GB2123293B/en not_active Expired
- 1983-07-08 JP JP58124582A patent/JPS5927813A/ja active Granted
- 1983-07-08 DE DE3324785A patent/DE3324785C2/de not_active Expired
- 1983-07-08 CH CH3786/83A patent/CH655007A5/fr not_active IP Right Cessation
- 1983-07-08 NL NL8302435A patent/NL8302435A/nl not_active Application Discontinuation
- 1983-07-08 CA CA000432068A patent/CA1197191A/fr not_active Expired
- 1983-07-08 NZ NZ204849A patent/NZ204849A/en unknown
- 1983-07-08 AU AU16702/83A patent/AU557601B2/en not_active Ceased
- 1983-07-08 OA OA58056A patent/OA07489A/xx unknown
- 1983-07-08 BE BE0/211143A patent/BE897251A/fr not_active IP Right Cessation
- 1983-07-08 IE IE1597/83A patent/IE55364B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE897251A (fr) | 1984-01-09 |
| IE831597L (en) | 1984-01-09 |
| FR2529785A1 (fr) | 1984-01-13 |
| AU557601B2 (en) | 1986-12-24 |
| SE8303886D0 (sv) | 1983-07-07 |
| JPS5927813A (ja) | 1984-02-14 |
| DE3324785C2 (de) | 1986-10-09 |
| ZA834978B (en) | 1984-03-28 |
| CH655007A5 (fr) | 1986-03-27 |
| FR2529785B1 (OSRAM) | 1984-12-07 |
| IE55364B1 (en) | 1990-08-29 |
| CA1197191A (fr) | 1985-11-26 |
| NZ204849A (en) | 1986-04-11 |
| DE3324785A1 (de) | 1984-01-12 |
| SE8303886L (sv) | 1984-01-10 |
| JPH0250084B2 (OSRAM) | 1990-11-01 |
| OA07489A (fr) | 1985-03-31 |
| NL8302435A (nl) | 1984-02-01 |
| GB2123293A (en) | 1984-02-01 |
| AU1670283A (en) | 1984-01-12 |
| GB2123293B (en) | 1985-10-09 |
| IT8348641A0 (it) | 1983-07-07 |
| IT1173729B (it) | 1987-06-24 |
| GB8318512D0 (en) | 1983-08-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Mladěnka et al. | Comprehensive review of cardiovascular toxicity of drugs and related agents | |
| HU229383B1 (en) | Antihypersensitive combination of valsartan and calcium channel blocker | |
| CA2696961C (fr) | Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains | |
| Mbalaviele et al. | A novel, highly selective, tight binding IκB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-κB pathway in arthritis-relevant cells and animal models | |
| EP1195166B1 (en) | Use of a vasopressin antagonist such as conivaptan in the manufacture of a medicament for treating pulmonary hypertension | |
| RU2125448C1 (ru) | Фармацевтическая композиция и способ ее получения, способ лечения нарушений, развивающихся вследствие нейродегенеративных процессов | |
| WO2001043747A1 (fr) | Comprime matriciel permettant la liberation prolongee de trimetazidine apres administration par voie orale | |
| LU84902A1 (fr) | Composition pharmaceutique antihypertensive synergetique | |
| EP0966282B1 (en) | Use of the angiotensin ii antagonists losartan and exp-3174 to treat symptomatic heart failure | |
| HU187804B (en) | Process for preparing synergetic pharmaceutical compositions with blood tension decreasing activity | |
| FR2548900A1 (fr) | Compositions pharmaceutiques synergiques | |
| US20160346249A1 (en) | Use of amitifadine, (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane in methods and compositions with enhanced efficacy and reduced metabolic side effects and toxicity for treatment of depression and other central nervous system disorders and conditions affected by monoamine neurotransmitters | |
| FR2775598A1 (fr) | Compositions pharmaceutiques contenant en association un antagoniste selectif des recepteurs v1a de l'arginine-vasopressine et un antagoniste selectif des recepteur v2 de l'arginine-vasopressine | |
| US20030229137A1 (en) | Methods of inhibiting osteoclast activity | |
| EP1115399B1 (fr) | Utilisation d'une composition pharmaceutique contenant, en association, un antagoniste des recepteurs at1 de l'angiotensine ii et l'indomethacine pour la fabrication d'un medicament pour traiter les glomerulonephrites chroniques | |
| FR3027803A1 (fr) | Composition pharmaceutique comprenant un betabloquant et un inhibiteur de l'enzyme de conversion | |
| Rahmani | Vascular smooth muscle, endothelial regulation and effects of aspirin in hypertension | |
| Lomnicka et al. | Effects of nonsteroidal anti-inflammatory drugs on prostacyclin and thromboxane in the kidney | |
| FR2641971A1 (fr) | Composition pharmaceutique antihypertensive associant le benazepril et un diuretique thiazidique | |
| LU87777A1 (fr) | Nouvelle forme galenique orale ameliorant la biodisponibilite | |
| KR102267965B1 (ko) | 베타 차단제, 전환 효소 억제제 및 항고혈압제 또는 nsaid를 포함하는 약학적 조성물 | |
| Pendleton | The discovery of potent inhibitors of phenylethanolamine N-methyltransferase (PNMT) | |
| Mbalaviele et al. | JPET# 143800 | |
| Jackson | Current Therapeutics for Cardiac Disease | |
| EP0927027A1 (fr) | Utilisation d'antagonistes 5-ht 4? dans la regulation de la secretion de corticosteroides |