LU84664A1 - Alkyl-4-indolonaphtyridines et leur application therapeutique - Google Patents
Alkyl-4-indolonaphtyridines et leur application therapeutique Download PDFInfo
- Publication number
- LU84664A1 LU84664A1 LU84664A LU84664A LU84664A1 LU 84664 A1 LU84664 A1 LU 84664A1 LU 84664 A LU84664 A LU 84664A LU 84664 A LU84664 A LU 84664A LU 84664 A1 LU84664 A1 LU 84664A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- naphthyridine
- indolo
- spectrum
- hexahydro
- hydrogen atom
- Prior art date
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- 238000010438 heat treatment Methods 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- OWFXIOWLTKNBAP-UHFFFAOYSA-N isoamyl nitrite Chemical compound CC(C)CCON=O OWFXIOWLTKNBAP-UHFFFAOYSA-N 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- DRYBMFJLYYEOBZ-UHFFFAOYSA-N methyl 1h-indole-5-carboxylate Chemical compound COC(=O)C1=CC=C2NC=CC2=C1 DRYBMFJLYYEOBZ-UHFFFAOYSA-N 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 150000004967 organic peroxy acids Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000002496 oximetry Methods 0.000 description 1
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 230000001706 oxygenating effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 150000004965 peroxy acids Chemical class 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229910003446 platinum oxide Inorganic materials 0.000 description 1
- 125000003367 polycyclic group Chemical group 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- CGRKYEALWSRNJS-UHFFFAOYSA-N sodium;2-methylbutan-2-olate Chemical compound [Na+].CCC(C)(C)[O-] CGRKYEALWSRNJS-UHFFFAOYSA-N 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000012414 tert-butyl nitrite Substances 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical group C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 208000009999 tuberous sclerosis Diseases 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU84664A LU84664A1 (fr) | 1983-02-25 | 1983-02-25 | Alkyl-4-indolonaphtyridines et leur application therapeutique |
| US06/582,314 US4617305A (en) | 1983-02-25 | 1984-02-22 | 4-alkylindolonaphthyridines and their therapeutical application |
| EP84870026A EP0120832B1 (de) | 1983-02-25 | 1984-02-22 | 4-Alkylindolonaphthyridine und diese enthaltende pharmazeutische Zubereitungen |
| DE8484870026T DE3463383D1 (en) | 1983-02-25 | 1984-02-22 | 4-alkylindolonaphthyridines and pharmaceutical compositions containing them |
| JP59034114A JPH0647592B2 (ja) | 1983-02-25 | 1984-02-24 | ４−アルキルインド−ロナフチリジン及びそれを含む医薬組成物 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU84664 | 1983-02-25 | ||
| LU84664A LU84664A1 (fr) | 1983-02-25 | 1983-02-25 | Alkyl-4-indolonaphtyridines et leur application therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU84664A1 true LU84664A1 (fr) | 1984-11-08 |
Family
ID=19730043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU84664A LU84664A1 (fr) | 1983-02-25 | 1983-02-25 | Alkyl-4-indolonaphtyridines et leur application therapeutique |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4617305A (de) |
| EP (1) | EP0120832B1 (de) |
| JP (1) | JPH0647592B2 (de) |
| DE (1) | DE3463383D1 (de) |
| LU (1) | LU84664A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4814452A (en) * | 1986-07-03 | 1989-03-21 | Merck & Co., Inc. | Enantioselective synthesis of 1,3,4,6,7,12b(S)-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin-2-one |
| EP0347980A1 (de) * | 1988-06-20 | 1989-12-27 | Duphar International Research B.V | 8,9-Anellierte B-Carboline und 8,9-anellierte 3,4-dihydro-B-Carboline |
| EP2266607A3 (de) | 1999-10-01 | 2011-04-20 | Immunogen, Inc. | Immunokonjugate für Krebsbehandlung |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE761628A (fr) * | 1971-01-15 | 1971-06-16 | Omnium Chimique Sa | Procede de preparation de la vincamine naturelle a partir de latabersonine et derives indoliques nouveaux. |
| AT325786B (de) * | 1972-05-17 | 1975-11-10 | Richter Gedeon Vegyeszet | Verfahren zur herstellung von eburnamoninen |
| BE816759A (fr) * | 1974-06-24 | 1974-10-16 | Procede de preparation de chano-e-homovincamones et derives indoliques nouveaux | |
| FR2332280A1 (fr) * | 1975-11-20 | 1977-06-17 | Kunesch Nicole | Procede de preparation de vincamine et d'epivincamine a partir de la (-) tabersonine |
| DD129791A5 (de) * | 1976-04-13 | 1978-02-08 | Synthelabo | Verfahren zur herstellung von naphtyridinderivaten |
| HU173511B (hu) * | 1976-07-21 | 1979-05-28 | Richter Gedeon Vegyeszet | Sposob poluchenija vinkamenina, ego solejj i molekuljarnykh soedinenijj |
| JPS5337696A (en) * | 1976-08-26 | 1978-04-06 | Omnium Chimique Sa | Hexahydrocantinonee6 derivative |
| CS190049B1 (en) * | 1976-12-31 | 1979-05-31 | Milos Jansa | Facility for the control of the pressure medium supply to the picking nozzles of the weaving machine |
| US4200638A (en) * | 1977-09-30 | 1980-04-29 | Omnium Chimique Societe Anonyme | Indole derivatives and therapeutically acting drugs |
| FR2404639B1 (fr) * | 1977-09-30 | 1985-06-14 | Omnium Chimique Sa | Composes indoliques nouveaux |
| FR2449449A2 (fr) * | 1978-09-27 | 1980-09-19 | Omnium Chimique Sa | Composes indoliques nouveaux utiles comme medicaments |
| JPS55100383A (en) * | 1979-01-25 | 1980-07-31 | Sumitomo Chem Co Ltd | Preparation of novel nitrogen-containing polycyclic compound |
| HU180929B (en) * | 1979-08-13 | 1983-05-30 | Richter Gedeon Vegyeszet | Process for producing new bromo-vincamone derivatives |
| FR2475394A1 (fr) * | 1980-02-12 | 1981-08-14 | Synthelabo | Compositions pharmaceutiques contenant l'hexahydro-1, 2, 3, 3a, 4, 5, 6h indolo (3, 2, 1 - d. e) (1, 5) naphtyridinone - 6 |
| BE882024A (fr) * | 1980-03-03 | 1980-09-03 | Omnium Chimique Sa | Nouvelles chano-e-homovincamones, leur procede de preparation et leur utilisation en tant que medicaments |
| ES503557A0 (es) * | 1980-07-03 | 1982-04-01 | Omnichem Sa | Procedimiento de preparacion de alquil-3 tetrahidro-1,2,3, 3a-4h-indolo(3,2,1-de)-1,5-naftiridinas. |
| IT1132307B (it) * | 1980-08-04 | 1986-07-02 | Mora Paolo Corvi | Procedimento per la sintesi di vincamina ed alcaloidi indolici correlati |
| US4362739A (en) * | 1981-05-04 | 1982-12-07 | S.A. Omnichem | Pyrrolo(2,3-d)carbazole derivatives, compositions and use |
| FR2527210A1 (fr) * | 1982-05-18 | 1983-11-25 | Synthelabo | Enantiomeres d'hexahydro-2,3,3a,4,5,6 1h-indolo(3,2,1-de) (naphtyridine-1,5), leur procede de separation et leur application en therapeutique |
-
1983
- 1983-02-25 LU LU84664A patent/LU84664A1/fr unknown
-
1984
- 1984-02-22 DE DE8484870026T patent/DE3463383D1/de not_active Expired
- 1984-02-22 US US06/582,314 patent/US4617305A/en not_active Expired - Fee Related
- 1984-02-22 EP EP84870026A patent/EP0120832B1/de not_active Expired
- 1984-02-24 JP JP59034114A patent/JPH0647592B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE3463383D1 (en) | 1987-06-04 |
| JPH0647592B2 (ja) | 1994-06-22 |
| US4617305A (en) | 1986-10-14 |
| EP0120832A1 (de) | 1984-10-03 |
| EP0120832B1 (de) | 1987-04-29 |
| JPS59164789A (ja) | 1984-09-17 |
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