LU81068A1 - Derives de la glycinamide, leur preparation et utilisation, ainsi que compositions contenant ces derives - Google Patents
Derives de la glycinamide, leur preparation et utilisation, ainsi que compositions contenant ces derives Download PDFInfo
- Publication number
- LU81068A1 LU81068A1 LU81068A LU81068A LU81068A1 LU 81068 A1 LU81068 A1 LU 81068A1 LU 81068 A LU81068 A LU 81068A LU 81068 A LU81068 A LU 81068A LU 81068 A1 LU81068 A1 LU 81068A1
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- Prior art keywords
- group
- formula
- glycinamide
- derivative
- ester
- Prior art date
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- BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical class NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 title claims description 22
- 239000000203 mixture Substances 0.000 title claims description 9
- 238000002360 preparation method Methods 0.000 title claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 66
- 238000000034 method Methods 0.000 claims description 58
- 150000001875 compounds Chemical class 0.000 claims description 36
- 230000008569 process Effects 0.000 claims description 26
- -1 2-n-pentylaminoacetamide 2-n-hexylaminoacetamide 2-n-nonylaminoacetamide 2-n-octadecylaminoacetamide 2-n-octadecen-9-ylaminoacetamide Chemical compound 0.000 claims description 24
- 239000002253 acid Substances 0.000 claims description 20
- 230000015572 biosynthetic process Effects 0.000 claims description 18
- 150000001408 amides Chemical class 0.000 claims description 16
- 150000002148 esters Chemical class 0.000 claims description 16
- 230000007062 hydrolysis Effects 0.000 claims description 15
- 238000006460 hydrolysis reaction Methods 0.000 claims description 15
- 238000003786 synthesis reaction Methods 0.000 claims description 15
- 150000001412 amines Chemical class 0.000 claims description 14
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
- 150000002466 imines Chemical class 0.000 claims description 9
- 150000002825 nitriles Chemical class 0.000 claims description 8
- 230000002829 reductive effect Effects 0.000 claims description 8
- 239000004471 Glycine Substances 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 238000007098 aminolysis reaction Methods 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 5
- LTYRAPJYLUPLCI-UHFFFAOYSA-N glycolonitrile Chemical compound OCC#N LTYRAPJYLUPLCI-UHFFFAOYSA-N 0.000 claims description 5
- 125000005843 halogen group Chemical group 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 150000001299 aldehydes Chemical class 0.000 claims description 4
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 4
- VXIVSQZSERGHQP-UHFFFAOYSA-N chloroacetamide Chemical compound NC(=O)CCl VXIVSQZSERGHQP-UHFFFAOYSA-N 0.000 claims description 4
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- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 claims description 4
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- HFFLGKNGCAIQMO-UHFFFAOYSA-N trichloroacetaldehyde Chemical compound ClC(Cl)(Cl)C=O HFFLGKNGCAIQMO-UHFFFAOYSA-N 0.000 claims description 4
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (24)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU81068A LU81068A1 (fr) | 1979-03-22 | 1979-03-22 | Derives de la glycinamide, leur preparation et utilisation, ainsi que compositions contenant ces derives |
| DE3050800A DE3050800C2 (en, 2012) | 1979-03-22 | 1980-03-20 | |
| DE19803010599 DE3010599A1 (de) | 1979-03-22 | 1980-03-20 | Derivate von glycinamid, deren herstellung und verwendung |
| SE8002204A SE453917B (sv) | 1979-03-22 | 1980-03-21 | Derivat av glycinamid samt framstellning derav och farmaceutisk komposition innehallande denna |
| ZA00801682A ZA801682B (en) | 1979-03-22 | 1980-03-21 | Derivatives of glycinamide, their preparation and their use |
| FI800900A FI82033C (fi) | 1979-03-22 | 1980-03-21 | Foerfarande foer framstaellning av terapeutiskt aktivt glycinamidderivat. |
| PT70992A PT70992A (fr) | 1979-03-22 | 1980-03-21 | Procede pour la preparation de derives de la glycinamide |
| DK123580A DK162714C (da) | 1979-03-22 | 1980-03-21 | Analogifremgangsmaade til fremstilling af glycinamidderivater eller syreadditionssalte deraf |
| IL59679A IL59679A (en) | 1979-03-22 | 1980-03-21 | Derivatives of glycinamide,their preparation and pharmaceutical compositions containing them |
| CH225380A CH645091A5 (fr) | 1979-03-22 | 1980-03-21 | Derives de la glycinamide, leur preparation et compositions pharmaceutiques les contenant. |
| AT0154680A AT381302B (de) | 1979-03-22 | 1980-03-21 | Verfahren zur herstellung von neuen glycinamidderivaten |
| FR8006390A FR2451913A1 (fr) | 1979-03-22 | 1980-03-21 | Derives de la glycinamide, leur preparation et leur utilisation dans le traitement de diverses formes d'epilepsie, des dyskinesies et des troubles de la memoire |
| NO800830A NO157817C (no) | 1979-03-22 | 1980-03-21 | Analogifremgangsmaate ved fremstilling av terapeutisk aktive glycinamidderivater. |
| ES490536A ES490536A0 (es) | 1979-03-22 | 1980-03-21 | Procedimiento para la preparacion de derivados de la glici- namida |
| JP3680680A JPS55143944A (en) | 1979-03-22 | 1980-03-22 | Glycineamide derivative* its manufacture and medical composition as chief component of same |
| GR61512A GR68005B (en, 2012) | 1979-03-22 | 1980-03-22 | |
| GB8009801A GB2048852B (en) | 1979-03-22 | 1980-03-24 | Derivatives of glycinamide |
| IE599/80A IE49751B1 (en) | 1979-03-22 | 1980-03-24 | Derivatives of glycinamide,their preparation and their use |
| NL8001721A NL191508C (nl) | 1979-03-22 | 1980-03-24 | Farmaceutisch preparaat, dat tenminste één glycinamidederivaat bevat, alsmede glycinamide derivaat, dat geschikt is voor gebruik in een zodanig preparaat. |
| CA000348319A CA1184567A (en) | 1979-03-22 | 1980-03-24 | Derivatives of glycinamide, their preparation and their use |
| AU56784/80A AU536499B2 (en) | 1979-03-22 | 1980-03-24 | Glycinamide |
| AT275184A AT392271B (de) | 1979-03-22 | 1984-08-28 | Verfahren zum herstellen von neuen glycinamidderivaten, deren additionssalzen und deren optischen isomeren |
| AT275084A AT391134B (de) | 1979-03-22 | 1984-08-28 | Verfahren zum herstellen von neuen glycinamidderivaten, deren additionssalzen und deren optischen isomeren |
| US06/768,185 US4639468A (en) | 1979-03-22 | 1985-08-23 | Derivatives of glycinamide, their preparation and their use |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU81068 | 1979-03-22 | ||
| LU81068A LU81068A1 (fr) | 1979-03-22 | 1979-03-22 | Derives de la glycinamide, leur preparation et utilisation, ainsi que compositions contenant ces derives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU81068A1 true LU81068A1 (fr) | 1980-10-08 |
Family
ID=19729127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU81068A LU81068A1 (fr) | 1979-03-22 | 1979-03-22 | Derives de la glycinamide, leur preparation et utilisation, ainsi que compositions contenant ces derives |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS55143944A (en, 2012) |
| LU (1) | LU81068A1 (en, 2012) |
| ZA (1) | ZA801682B (en, 2012) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030035784A1 (en) | 2001-03-05 | 2003-02-20 | Kao Corporation | Hair cosmetic, aminocarboxylic acid amide and method for producing the same |
| EP1791932A1 (en) * | 2004-09-13 | 2007-06-06 | Ciba Specialty Chemicals Holding Inc. | Alkylaminoacetamide lubricant additives |
-
1979
- 1979-03-22 LU LU81068A patent/LU81068A1/fr unknown
-
1980
- 1980-03-21 ZA ZA00801682A patent/ZA801682B/xx unknown
- 1980-03-22 JP JP3680680A patent/JPS55143944A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS55143944A (en) | 1980-11-10 |
| ZA801682B (en) | 1981-08-26 |
| JPS639491B2 (en, 2012) | 1988-02-29 |
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| TP | Transfer of rights |
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