LT5504B - Benzimidazo[1,2-c][1,2,3]tiadiazolo sulfonamidai - karboanhidrazių slopikliai ir tarpiniai junginiai jiems gauti - Google Patents

Benzimidazo[1,2-c][1,2,3]tiadiazolo sulfonamidai - karboanhidrazių slopikliai ir tarpiniai junginiai jiems gauti Download PDF

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Publication number
LT5504B
LT5504B LT2006066A LT2006066A LT5504B LT 5504 B LT5504 B LT 5504B LT 2006066 A LT2006066 A LT 2006066A LT 2006066 A LT2006066 A LT 2006066A LT 5504 B LT5504 B LT 5504B
Authority
LT
Lithuania
Prior art keywords
thiadiazole
sulfonamide
sulfonamides
compound
preparation
Prior art date
Application number
LT2006066A
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English (en)
Lithuanian (lt)
Other versions
LT2006066A (en
Inventor
Daumantas Matulis
Virginija DUDUTIEN�
Jurgita MATULIEN�
Lina MI�TINAIT�
Original Assignee
Biotechnologijos Institutas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotechnologijos Institutas filed Critical Biotechnologijos Institutas
Priority to LT2006066A priority Critical patent/LT5504B/lt
Priority to PCT/LT2007/000005 priority patent/WO2008016288A1/en
Priority to AT07793796T priority patent/ATE513836T1/de
Priority to EP07793796A priority patent/EP2054420B1/de
Publication of LT2006066A publication Critical patent/LT2006066A/xx
Publication of LT5504B publication Critical patent/LT5504B/lt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
LT2006066A 2006-08-02 2006-08-02 Benzimidazo[1,2-c][1,2,3]tiadiazolo sulfonamidai - karboanhidrazių slopikliai ir tarpiniai junginiai jiems gauti LT5504B (lt)

Priority Applications (4)

Application Number Priority Date Filing Date Title
LT2006066A LT5504B (lt) 2006-08-02 2006-08-02 Benzimidazo[1,2-c][1,2,3]tiadiazolo sulfonamidai - karboanhidrazių slopikliai ir tarpiniai junginiai jiems gauti
PCT/LT2007/000005 WO2008016288A1 (en) 2006-08-02 2007-08-01 Benzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamides as inhibitors of carbonic anhydrase and the intermediates for production thereof
AT07793796T ATE513836T1 (de) 2006-08-02 2007-08-01 Benzimidazoä1,2-cüä1,2,3üthiadiazol-7- sulfonsäureamide als carboanhydraseinhibitoren und zwischenprodukte zu deren herstellung
EP07793796A EP2054420B1 (de) 2006-08-02 2007-08-01 Benzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonsäureamide als carboanhydraseinhibitoren und zwischenprodukte zu deren herstellung

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LT2006066A LT5504B (lt) 2006-08-02 2006-08-02 Benzimidazo[1,2-c][1,2,3]tiadiazolo sulfonamidai - karboanhidrazių slopikliai ir tarpiniai junginiai jiems gauti

Publications (2)

Publication Number Publication Date
LT2006066A LT2006066A (en) 2008-02-25
LT5504B true LT5504B (lt) 2008-06-25

Family

ID=38616554

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2006066A LT5504B (lt) 2006-08-02 2006-08-02 Benzimidazo[1,2-c][1,2,3]tiadiazolo sulfonamidai - karboanhidrazių slopikliai ir tarpiniai junginiai jiems gauti

Country Status (4)

Country Link
EP (1) EP2054420B1 (de)
AT (1) ATE513836T1 (de)
LT (1) LT5504B (de)
WO (1) WO2008016288A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201106548D0 (en) * 2011-04-18 2011-06-01 Evitraproteoma Ab A method for determining ligand binding to a target protein using a thermal shift assahy
CN105362890A (zh) * 2015-12-18 2016-03-02 杜小卫 一种治疗女性肾虚症的中药药酒

Citations (28)

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US4668697A (en) 1983-10-31 1987-05-26 Merck & Co., Inc. Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
US4731368A (en) 1986-12-08 1988-03-15 Merck & Co., Inc. Thienopyridine sulfonamides and their ophthalmological formulation
US4751231A (en) 1987-09-16 1988-06-14 Merck & Co., Inc. Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents
US4788192A (en) 1983-06-20 1988-11-29 Merck & Co., Inc. 2-Sulfamoylbenzo(b)thiophene derivatives pharmaceutical compositions and use
US4798831A (en) 1987-09-16 1989-01-17 Merck & Co., Inc. Substituted thieno[2,3-B]furan-2-sulfonamides as antiglaucoma agents
US4847289A (en) 1987-06-08 1989-07-11 Merck & Co., Inc. Thiophene sulfonamide antiglaucoma agents
US4894390A (en) 1987-08-03 1990-01-16 Merck & Co., Inc. Substituted thieno[2,3-b]thiophene-2-sulfonamides as antiglaucoma agents
US4929549A (en) 1989-02-08 1990-05-29 Merck & Co., Inc. 5-carbamoylthieno[2,3-b]thiophene-2-sulfon-amides as topically active carbonic anhydrase inhibitors
US4929637A (en) 1985-12-24 1990-05-29 Merck & Co., Inc. Substituted thiophene-2-sulfonamide antiglaucoma agents
US4975447A (en) 1983-02-04 1990-12-04 University Of Iowa Research Foundation 6-hydroxyethoxy-2-benzothiazolesulfonamide and topical treatment compositions and method for glaucoma
US5059613A (en) 1990-03-19 1991-10-22 Research Corporation Technologies, Inc. Topically active ocular benzothiazole sulfonamide carbonic anhydrase inhibitors
US5091409A (en) 1990-05-17 1992-02-25 Merck & Co., Inc. 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides
US5093332A (en) 1990-10-01 1992-03-03 Merck & Co., Inc. Substituted thieno(2,3-b)(1,4)thiazine-6-sulfonamides as antiglaucoma agents
US5120757A (en) 1989-07-31 1992-06-09 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents
US5157129A (en) 1990-04-18 1992-10-20 Merck & Co., Inc. Enantiospecific synthesis of s-(+)-5,6-dihydro-4-(r-amino)-4h-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide
US5240923A (en) 1990-04-09 1993-08-31 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
US5378703A (en) 1990-04-09 1995-01-03 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
US5424448A (en) 1993-02-18 1995-06-13 Alcon Laboratories, Inc. Preparation of carbonic anhydrase inhibitors
LT3368B (en) 1991-04-17 1995-08-25 Merck & Co Inc Ophtalmic combinations of carbonic anhydrase inhibitors and b-blockers
US5464831A (en) 1994-09-09 1995-11-07 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US5510347A (en) 1994-09-09 1996-04-23 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US5519040A (en) 1994-04-29 1996-05-21 Allergan Substituted thiazole sulfonamides as antiglaucoma agents
US5538966A (en) 1994-01-21 1996-07-23 Alcon Laboratories, Inc. Carbonic anhydrase inhibitors
US5646142A (en) 1994-07-08 1997-07-08 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US6316443B1 (en) 1994-08-04 2001-11-13 Merck & Co., Inc. Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist
WO2004048544A2 (en) 2002-11-26 2004-06-10 Bayer Healthcare Ca ix-specific inhibitors
WO2005107470A2 (en) 2004-04-29 2005-11-17 University Of Florida Research Foundation, Inc. Use of carbonic anhydrase inhibitors for insect control and malaria treatment
US7030250B2 (en) 2000-09-04 2006-04-18 Ragatives, S.L. Process for obtaining 4-(N-alkylamino)-5,6-dihydro-4H-thien-(2,3-b)-thiopyran-2-sulfonamide-7,7-dioxides and intermediates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235059A (en) * 1991-10-15 1993-08-10 Merck & Co., Inc. Tricyclic thienothiopyran carbonic anhydrase inhibitors
US5681834A (en) * 1995-12-04 1997-10-28 Alcon Laboratories, Inc. Heterocyclic sulfonamides
BR0211836A (pt) * 2001-08-10 2004-12-14 Pharmacia Corp Inibidor de anidrase carbÈnica

Patent Citations (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4975447A (en) 1983-02-04 1990-12-04 University Of Iowa Research Foundation 6-hydroxyethoxy-2-benzothiazolesulfonamide and topical treatment compositions and method for glaucoma
US4788192A (en) 1983-06-20 1988-11-29 Merck & Co., Inc. 2-Sulfamoylbenzo(b)thiophene derivatives pharmaceutical compositions and use
US4668697A (en) 1983-10-31 1987-05-26 Merck & Co., Inc. Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
US4929637A (en) 1985-12-24 1990-05-29 Merck & Co., Inc. Substituted thiophene-2-sulfonamide antiglaucoma agents
US4731368A (en) 1986-12-08 1988-03-15 Merck & Co., Inc. Thienopyridine sulfonamides and their ophthalmological formulation
US4847289A (en) 1987-06-08 1989-07-11 Merck & Co., Inc. Thiophene sulfonamide antiglaucoma agents
US4894390A (en) 1987-08-03 1990-01-16 Merck & Co., Inc. Substituted thieno[2,3-b]thiophene-2-sulfonamides as antiglaucoma agents
US4751231A (en) 1987-09-16 1988-06-14 Merck & Co., Inc. Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents
US4798831A (en) 1987-09-16 1989-01-17 Merck & Co., Inc. Substituted thieno[2,3-B]furan-2-sulfonamides as antiglaucoma agents
US4929549A (en) 1989-02-08 1990-05-29 Merck & Co., Inc. 5-carbamoylthieno[2,3-b]thiophene-2-sulfon-amides as topically active carbonic anhydrase inhibitors
US5120757A (en) 1989-07-31 1992-06-09 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents
US5059613A (en) 1990-03-19 1991-10-22 Research Corporation Technologies, Inc. Topically active ocular benzothiazole sulfonamide carbonic anhydrase inhibitors
US5378703A (en) 1990-04-09 1995-01-03 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
US5240923A (en) 1990-04-09 1993-08-31 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
US5157129A (en) 1990-04-18 1992-10-20 Merck & Co., Inc. Enantiospecific synthesis of s-(+)-5,6-dihydro-4-(r-amino)-4h-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide
US5091409A (en) 1990-05-17 1992-02-25 Merck & Co., Inc. 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides
US5093332A (en) 1990-10-01 1992-03-03 Merck & Co., Inc. Substituted thieno(2,3-b)(1,4)thiazine-6-sulfonamides as antiglaucoma agents
US6248735B1 (en) 1991-04-17 2001-06-19 Merck & Co., Inc. Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist
LT3368B (en) 1991-04-17 1995-08-25 Merck & Co Inc Ophtalmic combinations of carbonic anhydrase inhibitors and b-blockers
US5424448A (en) 1993-02-18 1995-06-13 Alcon Laboratories, Inc. Preparation of carbonic anhydrase inhibitors
US5538966A (en) 1994-01-21 1996-07-23 Alcon Laboratories, Inc. Carbonic anhydrase inhibitors
US5519040A (en) 1994-04-29 1996-05-21 Allergan Substituted thiazole sulfonamides as antiglaucoma agents
US5646142A (en) 1994-07-08 1997-07-08 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US6316443B1 (en) 1994-08-04 2001-11-13 Merck & Co., Inc. Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist
US5464831A (en) 1994-09-09 1995-11-07 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US5510347A (en) 1994-09-09 1996-04-23 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US7030250B2 (en) 2000-09-04 2006-04-18 Ragatives, S.L. Process for obtaining 4-(N-alkylamino)-5,6-dihydro-4H-thien-(2,3-b)-thiopyran-2-sulfonamide-7,7-dioxides and intermediates
WO2004048544A2 (en) 2002-11-26 2004-06-10 Bayer Healthcare Ca ix-specific inhibitors
US20040146955A1 (en) 2002-11-26 2004-07-29 Claudiu Supuran CA IX-specific inhibitors
WO2005107470A2 (en) 2004-04-29 2005-11-17 University Of Florida Research Foundation, Inc. Use of carbonic anhydrase inhibitors for insect control and malaria treatment

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SUPURAN CT, SCOZZAFAVA A.: "Carbonic anhydrase inhibitors--Part 94. 1,3,4-thiadiazole-2-sulfonamidederivatives as antitumor agents?", EUR J MED CHEM., 2000, pages 867 - 874

Also Published As

Publication number Publication date
EP2054420B1 (de) 2011-06-22
EP2054420A1 (de) 2009-05-06
ATE513836T1 (de) 2011-07-15
WO2008016288A1 (en) 2008-02-07
LT2006066A (en) 2008-02-25

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