LT3981B - Therapeutically active substituted benzimidazole and process for its preparation - Google Patents

Therapeutically active substituted benzimidazole and process for its preparation Download PDF

Info

Publication number
LT3981B
LT3981B LTIP1722A LTIP1722A LT3981B LT 3981 B LT3981 B LT 3981B LT IP1722 A LTIP1722 A LT IP1722A LT IP1722 A LTIP1722 A LT IP1722A LT 3981 B LT3981 B LT 3981B
Authority
LT
Lithuania
Prior art keywords
compound
compound according
benzimidazole
dimethoxy
methyl
Prior art date
Application number
LTIP1722A
Other languages
English (en)
Lithuanian (lt)
Inventor
Arne Elof Braendstroem
Per Lennart Lindberg
Carl Ingemar Starke
Gunnel Elisabeth Sunden
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haessle Ab filed Critical Haessle Ab
Publication of LTIP1722A publication Critical patent/LTIP1722A/xx
Publication of LT3981B publication Critical patent/LT3981B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
LTIP1722A 1988-12-22 1993-12-30 Therapeutically active substituted benzimidazole and process for its preparation LT3981B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE19888804628A SE8804628D0 (sv) 1988-12-22 1988-12-22 New compounds

Publications (2)

Publication Number Publication Date
LTIP1722A LTIP1722A (en) 1995-07-25
LT3981B true LT3981B (en) 1996-06-25

Family

ID=20374309

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1722A LT3981B (en) 1988-12-22 1993-12-30 Therapeutically active substituted benzimidazole and process for its preparation

Country Status (26)

Country Link
US (1) US5019584A (ja)
EP (1) EP0451188B1 (ja)
JP (1) JP2793907B2 (ja)
CN (1) CN1028232C (ja)
AT (1) ATE110379T1 (ja)
AU (1) AU636866B2 (ja)
CA (1) CA2005987C (ja)
DD (1) DD296077A5 (ja)
DE (1) DE68917738T2 (ja)
DK (1) DK170801B1 (ja)
FI (1) FI913036A0 (ja)
GR (1) GR1000318B (ja)
HU (1) HUT57203A (ja)
IE (1) IE64850B1 (ja)
IL (1) IL92797A (ja)
LT (1) LT3981B (ja)
LV (1) LV10268B (ja)
NO (1) NO178338C (ja)
PH (1) PH27257A (ja)
PT (1) PT92647B (ja)
RO (1) RO110496B1 (ja)
RU (1) RU2070199C1 (ja)
SE (1) SE8804628D0 (ja)
WO (1) WO1990006926A1 (ja)
YU (1) YU242589A (ja)
ZA (1) ZA899796B (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2083606C (en) * 1990-06-20 2001-08-21 Arne Elof Brandstrom Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use
NZ244301A (en) * 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
US6016044A (en) * 1995-09-11 2000-01-18 Alaris Medical Systems, Inc. Open-loop step motor control system
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
JP2005521662A (ja) * 2002-01-25 2005-07-21 サンタラス インコーポレイティッド プロトンポンプ阻害剤の経粘膜送達
AU2003224781A1 (en) * 2002-03-26 2003-10-13 Dr. Reddy's Laboratories Limited Crystalline forms of rabeprazole sodium
JP2006518751A (ja) * 2003-02-20 2006-08-17 サンタラス インコーポレイティッド 胃酸の急速かつ持続的な抑制のための新規製剤、オメプラゾール制酸剤複合体−即時放出物
US20050031700A1 (en) * 2003-07-18 2005-02-10 Sanatarus, Inc. Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CA2531564C (en) * 2003-07-18 2016-01-19 Santarus, Inc. Pharmaceutical composition for inhibiting acid secretion
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500043A (en) 1974-02-18 1978-02-08 Haessle Ab Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion
GB1525958A (en) 1974-05-16 1978-09-27 Haessle Ab 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
US4182766A (en) 1977-09-19 1980-01-08 Hoffmann-La Roche Inc. Naphth[2,3-d]imidazoles
US4255431A (en) 1978-04-14 1981-03-10 Aktiebolaget Hassle Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
US4555518A (en) 1983-05-03 1985-11-26 Byk Gulden Lomberg Chemische Fabrik Gmbh Fluoroalkoxy substituted benzimidazoles useful as gastric acid secretion inhibitors
US4599347A (en) 1980-08-21 1986-07-08 Hoffmann-La Roche Inc. Tetrahydro-naphth (2.3-d) imidazole derivatives
US4628098A (en) 1984-08-16 1986-12-09 Takeda Chemical Industries, Ltd. 2-[2-pyridylmethylthio-(sulfinyl)]benzimidazoles
EP0208452A2 (en) 1985-07-02 1987-01-14 Takeda Chemical Industries, Ltd. Pyridine derivatives, their production and use
US4727150A (en) 1984-08-16 1988-02-23 Takeda Chemical Industries, Ltd. Pyridyl methylsulfinyl benzimidazole derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331671A (en) * 1981-01-09 1982-05-25 Sterling Drug Inc. 5-(Pyridinyl)-1H-benzimidazoles and 1-hydroxy-6-(pyridinyl)-1H-benzimidazoles and their cardiotonic use
SE8500996D0 (sv) * 1985-03-01 1985-03-01 Haessle Ab Method of treatment
GB8610607D0 (en) * 1986-04-30 1986-06-04 Smith Kline French Lab Chemical compounds
FR2593178B1 (fr) * 1986-01-20 1988-04-29 Esteve Labor Dr Derives de 2-benzimidazolylalkylthio (ou sulfinyle ou sulfonyle) leur preparation et leur application en tant que medicaments.
WO1989003830A1 (en) * 1987-10-30 1989-05-05 Aktiebolaget Hässle 2-pyridinylmethyl (sulfinyl or thio)benzimidazoles for treatment of diseases related to bone loss

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500043A (en) 1974-02-18 1978-02-08 Haessle Ab Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion
GB1525958A (en) 1974-05-16 1978-09-27 Haessle Ab 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
US4182766A (en) 1977-09-19 1980-01-08 Hoffmann-La Roche Inc. Naphth[2,3-d]imidazoles
US4255431A (en) 1978-04-14 1981-03-10 Aktiebolaget Hassle Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
US4599347A (en) 1980-08-21 1986-07-08 Hoffmann-La Roche Inc. Tetrahydro-naphth (2.3-d) imidazole derivatives
US4555518A (en) 1983-05-03 1985-11-26 Byk Gulden Lomberg Chemische Fabrik Gmbh Fluoroalkoxy substituted benzimidazoles useful as gastric acid secretion inhibitors
US4628098A (en) 1984-08-16 1986-12-09 Takeda Chemical Industries, Ltd. 2-[2-pyridylmethylthio-(sulfinyl)]benzimidazoles
US4727150A (en) 1984-08-16 1988-02-23 Takeda Chemical Industries, Ltd. Pyridyl methylsulfinyl benzimidazole derivatives
EP0208452A2 (en) 1985-07-02 1987-01-14 Takeda Chemical Industries, Ltd. Pyridine derivatives, their production and use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A. GOTH: "Medical Pharmacology, 7th ed.", pages: 19
M. ROWLAND, T. N. TORER: "Clinical Pharmacokinetics, 2nd ed.", pages: 42

Also Published As

Publication number Publication date
DE68917738D1 (de) 1994-09-29
CN1043714A (zh) 1990-07-11
PH27257A (en) 1993-05-04
NO178338B (no) 1995-11-27
AU636866B2 (en) 1993-05-13
WO1990006926A1 (en) 1990-06-28
DE68917738T2 (de) 1994-12-22
CN1028232C (zh) 1995-04-19
JPH04502462A (ja) 1992-05-07
HU901085D0 (en) 1991-09-30
AU4817690A (en) 1990-07-10
ATE110379T1 (de) 1994-09-15
YU242589A (en) 1991-04-30
FI913036A0 (fi) 1991-06-20
IL92797A (en) 1994-12-29
DK122391A (da) 1991-06-24
SE8804628D0 (sv) 1988-12-22
GR1000318B (el) 1992-06-25
LTIP1722A (en) 1995-07-25
JP2793907B2 (ja) 1998-09-03
IE894049L (en) 1990-06-22
CA2005987A1 (en) 1990-06-22
DD296077A5 (de) 1991-11-21
PT92647A (pt) 1990-06-29
RU2070199C1 (ru) 1996-12-10
IL92797A0 (en) 1990-09-17
ZA899796B (en) 1990-08-29
EP0451188B1 (en) 1994-08-24
CA2005987C (en) 1999-04-13
DK170801B1 (da) 1996-01-22
LV10268B (en) 1995-02-20
LV10268A (lv) 1994-10-20
NO912416D0 (no) 1991-06-20
IE64850B1 (en) 1995-09-06
PT92647B (pt) 1995-09-12
GR890100834A (en) 1991-03-15
DK122391D0 (da) 1991-06-21
RO110496B1 (ro) 1996-01-30
NO178338C (no) 1996-03-06
HUT57203A (en) 1991-11-28
SE8804628A (ja) 1988-12-22
NO912416L (no) 1991-07-31
US5019584A (en) 1991-05-28
EP0451188A1 (en) 1991-10-16

Similar Documents

Publication Publication Date Title
LT3980B (en) New therapeutically active compound and a process for its preparation
US4965269A (en) Therapeutically active chloro substituted benzimidazoles
EP0593463B1 (en) Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use
LT3981B (en) Therapeutically active substituted benzimidazole and process for its preparation
RO110493B1 (ro) Derivati de benzimidazol si procedee pentru prepararea acestora
US5025024A (en) Therapeutically active fluoro-substituted compound
LT3809B (en) Therapeutically active fluoro substituted benzimidazoles, process for their preparation as well as their use

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 19961230