LT3672965T - Pirimidino junginys, kaip jak kinazės inhibitorius - Google Patents

Pirimidino junginys, kaip jak kinazės inhibitorius

Info

Publication number
LT3672965T
LT3672965T LTEPPCT/US2018/057682T LTUS2018057682T LT3672965T LT 3672965 T LT3672965 T LT 3672965T LT US2018057682 T LTUS2018057682 T LT US2018057682T LT 3672965 T LT3672965 T LT 3672965T
Authority
LT
Lithuania
Prior art keywords
kinase inhibitor
pyrimidine compound
jak kinase
jak
pyrimidine
Prior art date
Application number
LTEPPCT/US2018/057682T
Other languages
English (en)
Lithuanian (lt)
Inventor
Jennifer KOZAK
Ryan Hudson
Gary E.L. BRANDT
Robert Murray Mckinnell
Marta Dabros
Jerry NZEREM
Original Assignee
Theravance Biopharma R&D Ip, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Biopharma R&D Ip, Llc filed Critical Theravance Biopharma R&D Ip, Llc
Publication of LT3672965T publication Critical patent/LT3672965T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Dental Preparations (AREA)
LTEPPCT/US2018/057682T 2017-10-27 2018-10-26 Pirimidino junginys, kaip jak kinazės inhibitorius LT3672965T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762577852P 2017-10-27 2017-10-27
PCT/US2018/057682 WO2019084383A1 (en) 2017-10-27 2018-10-26 PYRIMIDINE COMPOUNDS AS JAK KINASE INHIBITORS

Publications (1)

Publication Number Publication Date
LT3672965T true LT3672965T (lt) 2022-10-10

Family

ID=64277858

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2018/057682T LT3672965T (lt) 2017-10-27 2018-10-26 Pirimidino junginys, kaip jak kinazės inhibitorius

Country Status (38)

Country Link
US (7) US10308646B2 (OSRAM)
EP (1) EP3672965B1 (OSRAM)
JP (1) JP7218364B2 (OSRAM)
KR (1) KR102613503B1 (OSRAM)
CN (1) CN111247142B (OSRAM)
AR (1) AR113803A1 (OSRAM)
AU (1) AU2018354370B2 (OSRAM)
BR (1) BR112020008015A2 (OSRAM)
CA (1) CA3074034A1 (OSRAM)
CL (1) CL2020001090A1 (OSRAM)
CR (1) CR20200180A (OSRAM)
CU (1) CU24671B1 (OSRAM)
DK (1) DK3672965T3 (OSRAM)
DO (1) DOP2020000083A (OSRAM)
EA (1) EA202091016A1 (OSRAM)
EC (1) ECSP20023795A (OSRAM)
ES (1) ES2932526T3 (OSRAM)
GE (1) GEP20227344B (OSRAM)
HR (1) HRP20221221T1 (OSRAM)
HU (1) HUE060401T2 (OSRAM)
IL (1) IL274037B2 (OSRAM)
LT (1) LT3672965T (OSRAM)
MA (1) MA49956B1 (OSRAM)
MD (1) MD3672965T2 (OSRAM)
MX (1) MX2020004255A (OSRAM)
NI (1) NI202000032A (OSRAM)
PE (1) PE20201495A1 (OSRAM)
PH (1) PH12020500528A1 (OSRAM)
PL (1) PL3672965T3 (OSRAM)
PT (1) PT3672965T (OSRAM)
RS (1) RS63608B1 (OSRAM)
SG (1) SG11202001706RA (OSRAM)
SI (1) SI3672965T1 (OSRAM)
SM (1) SMT202200409T1 (OSRAM)
TW (1) TWI789446B (OSRAM)
UA (1) UA125130C2 (OSRAM)
WO (1) WO2019084383A1 (OSRAM)
ZA (1) ZA202001641B (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018354370B2 (en) 2017-10-27 2023-04-27 Theravance Biopharma R&D Ip, Llc Pyrimidine compound as JAK kinase inhibitor
MX2021006283A (es) * 2018-11-30 2021-10-22 Jiangsu Hansoh Pharmaceutical Group Co Ltd Derivados heteroaromáticos para uso como regulador, método de preparación de los mismos y uso de los mismos.
AR118768A1 (es) 2019-04-24 2021-10-27 Theravance Biopharma R&D Ip Llc Derivados de pirimidina como inhibidores de las cinasas jak
HRP20241053T1 (hr) * 2019-04-24 2024-11-08 Theravance Biopharma R&D Ip, Llc Pirimidinski inhibitori jak, namijenjeni liječenju kožnih bolesti
KR102891680B1 (ko) * 2020-07-28 2025-11-27 아큐티스 바이오테라퓨틱스, 인크. Jak 저해제 및 라우레스-4를 함유하는 국소 제형
BR112023003517A2 (pt) * 2020-08-26 2023-05-09 Nalo Therapeutics Moduladores da proteína proto-oncogênica da família myc
WO2022076771A1 (en) * 2020-10-08 2022-04-14 Icahn School Of Medicine At Mount Sinai Compositions for treatment alopecia areata, biomarkers for treatment success, and methods of use thereof
TW202311256A (zh) * 2021-06-18 2023-03-16 美商基利科學股份有限公司 用於治療ｆｘｒ誘發之搔癢之ｉｌ－３１調節劑
US20250051338A1 (en) 2021-10-25 2025-02-13 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
MX2024007437A (es) 2021-12-15 2024-09-04 Arcutis Biotherapeutics Inc Formulaciones estables de shr0302.
CN114246938A (zh) * 2022-01-25 2022-03-29 中山大学中山眼科中心 Il-4在制备用于治疗视网膜变性疾病药物中的应用
CN115487301B (zh) * 2022-11-08 2023-07-07 四川大学华西医院 Il-13抑制剂在制备延缓或治疗视网膜色素变性的药物中的用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4919934A (en) 1989-03-02 1990-04-24 Richardson-Vicks Inc. Cosmetic sticks
US6660731B2 (en) 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
ATE346064T1 (de) 2000-09-15 2006-12-15 Vertex Pharma Pyrazolverbindungen als protein-kinasehemmer
ATE354573T1 (de) 2000-12-21 2007-03-15 Vertex Pharma ßPYRAZOLVERBINDUNGEN, DIE SICH ALS PROTEINKINASEINHIBITOREN EIGNENß
CA2588220A1 (en) 2004-12-23 2006-06-29 Pfizer Products Inc. Heteroaromatic derivatives useful as anticancer agents
CA2629781A1 (en) 2005-11-16 2007-05-24 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
UY30444A1 (es) 2006-06-30 2008-01-31 Astrazeneca Ab Derivados de pirimidina, procesos para su preparacinn, composiciones farmaccuticos y usos de los mismos.
CA2656290A1 (en) 2006-07-05 2008-01-10 Exelixis, Inc. Methods of using igf1r and abl kinase modulators
WO2013092940A1 (en) 2011-12-22 2013-06-27 F. Hoffmann-La Roche Ag 2, 4-diamine-pyrimidine derivative as serine/threonine kinase inhibitors
WO2015094803A1 (en) * 2013-12-16 2015-06-25 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
NO2721710T3 (OSRAM) 2014-08-21 2018-03-31
CN106687467A (zh) * 2014-09-30 2017-05-17 韩美精密化学株式会社 高纯度（r）‑9‑[2‑（磷酰甲氧基）丙基]腺嘌呤的制备方法
DK3303348T3 (da) 2015-05-28 2019-11-11 Theravance Biopharma R&D Ip Llc Naphthyridinforbindelser som JAK-kinaseinhibitorer
US9938257B2 (en) 2015-09-11 2018-04-10 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
AU2017258186B2 (en) 2016-04-28 2020-09-17 Theravance Biopharma R&D Ip, Llc Pyrimidine compounds as JAK kinase inhibitors
AU2018354370B2 (en) * 2017-10-27 2023-04-27 Theravance Biopharma R&D Ip, Llc Pyrimidine compound as JAK kinase inhibitor
AR118768A1 (es) 2019-04-24 2021-10-27 Theravance Biopharma R&D Ip Llc Derivados de pirimidina como inhibidores de las cinasas jak
HRP20241053T1 (hr) 2019-04-24 2024-11-08 Theravance Biopharma R&D Ip, Llc Pirimidinski inhibitori jak, namijenjeni liječenju kožnih bolesti

Also Published As

Publication number Publication date
BR112020008015A2 (pt) 2020-10-27
US20190127364A1 (en) 2019-05-02
CA3074034A1 (en) 2019-05-02
UA125130C2 (uk) 2022-01-12
HRP20221221T1 (hr) 2022-12-09
AU2018354370B2 (en) 2023-04-27
JP7218364B2 (ja) 2023-02-06
WO2019084383A1 (en) 2019-05-02
US20190241555A1 (en) 2019-08-08
CN111247142A (zh) 2020-06-05
US11814377B2 (en) 2023-11-14
US20200140430A1 (en) 2020-05-07
ES2932526T3 (es) 2023-01-20
CU20200053A7 (es) 2021-03-11
GEP20227344B (en) 2022-01-25
IL274037B2 (en) 2023-11-01
SMT202200409T1 (it) 2022-11-18
US10308646B2 (en) 2019-06-04
US10562894B2 (en) 2020-02-18
NI202000032A (es) 2020-10-09
US20240158389A1 (en) 2024-05-16
EP3672965A1 (en) 2020-07-01
PT3672965T (pt) 2022-09-29
JP2021501151A (ja) 2021-01-14
MA49956B1 (fr) 2022-11-30
US20210214349A1 (en) 2021-07-15
DK3672965T3 (da) 2022-10-03
KR20200078517A (ko) 2020-07-01
SG11202001706RA (en) 2020-03-30
TW201930304A (zh) 2019-08-01
EP3672965B1 (en) 2022-09-07
US10774080B2 (en) 2020-09-15
US10988470B2 (en) 2021-04-27
RS63608B1 (sr) 2022-10-31
TWI789446B (zh) 2023-01-11
MX2020004255A (es) 2020-07-29
US20220396573A1 (en) 2022-12-15
CU24671B1 (es) 2023-07-12
MD3672965T2 (ro) 2022-12-31
PE20201495A1 (es) 2020-12-29
ECSP20023795A (es) 2020-06-30
US11420965B2 (en) 2022-08-23
CR20200180A (es) 2020-08-12
AR113803A1 (es) 2020-06-10
KR102613503B1 (ko) 2023-12-13
PL3672965T3 (pl) 2023-01-16
IL274037A (en) 2020-06-30
EA202091016A1 (ru) 2020-07-17
US20200369660A1 (en) 2020-11-26
PH12020500528A1 (en) 2021-06-07
IL274037B1 (en) 2023-07-01
CN111247142B (zh) 2022-12-02
DOP2020000083A (es) 2020-08-15
CL2020001090A1 (es) 2020-08-21
US12172994B2 (en) 2024-12-24
ZA202001641B (en) 2021-04-28
AU2018354370A1 (en) 2020-04-09
HUE060401T2 (hu) 2023-02-28
SI3672965T1 (sl) 2022-11-30
MA49956A (fr) 2020-07-01

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