LT3594199T - Kristalinis 2-fluor-3-nitroluenas ir jo paruošimo būdas - Google Patents
Kristalinis 2-fluor-3-nitroluenas ir jo paruošimo būdasInfo
- Publication number
- LT3594199T LT3594199T LTEP18182368.3T LT18182368T LT3594199T LT 3594199 T LT3594199 T LT 3594199T LT 18182368 T LT18182368 T LT 18182368T LT 3594199 T LT3594199 T LT 3594199T
- Authority
- LT
- Lithuania
- Prior art keywords
- nitrotoluene
- fluoro
- crystalline
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
- C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/16—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18182368.3A EP3594199B1 (en) | 2018-07-09 | 2018-07-09 | Crystalline 2-fluoro-3-nitrotoluene and process for the preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3594199T true LT3594199T (lt) | 2020-11-10 |
Family
ID=62904314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP18182368.3T LT3594199T (lt) | 2018-07-09 | 2018-07-09 | Kristalinis 2-fluor-3-nitroluenas ir jo paruošimo būdas |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20210292271A1 (pt) |
| EP (1) | EP3594199B1 (pt) |
| JP (1) | JP7407166B2 (pt) |
| CN (1) | CN112654602A (pt) |
| AU (1) | AU2019303323A1 (pt) |
| CA (1) | CA3105559A1 (pt) |
| CY (1) | CY1123514T1 (pt) |
| DK (1) | DK3594199T3 (pt) |
| ES (1) | ES2815899T3 (pt) |
| HR (1) | HRP20201198T1 (pt) |
| HU (1) | HUE052049T2 (pt) |
| LT (1) | LT3594199T (pt) |
| MX (1) | MX2021000348A (pt) |
| PL (1) | PL3594199T3 (pt) |
| PT (1) | PT3594199T (pt) |
| SI (1) | SI3594199T1 (pt) |
| WO (1) | WO2020011626A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2970123T3 (pl) | 2013-03-14 | 2020-03-31 | Amgen Inc. | Sól omekamtywu mekarbilu i sposób otrzymywania soli |
| WO2019006235A1 (en) | 2017-06-30 | 2019-01-03 | Amgen Inc. | METHODS OF TREATING CARDIAC INSUFFICIENCY WITH CARDIAC SARCOMER ACTIVATORS |
| IL270663B (en) | 2017-06-30 | 2022-08-01 | Amgen Inc | Synthesis of omecamtib from carbyl |
| AU2018332887B2 (en) | 2017-09-13 | 2022-12-08 | Amgen Inc. | Bisamide sarcomere activating compounds and uses thereof |
| AU2019321573A1 (en) | 2018-08-17 | 2021-03-04 | Amgen Inc. | Salts and crystal forms of omecamtiv mecarbil |
| BR112023018095A2 (pt) | 2021-03-10 | 2023-12-12 | Amgen Inc | Processos para sintetizar 2-fluoro-3-nitrotolueno, 1-(bromometil)-2-fluoro-3-nitrobenzeno e para preparar omecamtiv mecarbil ou um sal do mesmo, um hidrato do mesmo ou um hidrato de sal do mesmo |
| WO2024081611A1 (en) | 2022-10-11 | 2024-04-18 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
| US11986474B1 (en) | 2023-06-27 | 2024-05-21 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR059339A1 (es) | 2006-02-09 | 2008-03-26 | Chugai Pharmaceutical Co Ltd | Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene |
| CN101177400A (zh) | 2006-11-06 | 2008-05-14 | 吕铁环 | 一种生产2-氟-3-硝基甲苯的方法 |
| EP2172198B1 (en) | 2007-07-20 | 2014-04-16 | Chugai Seiyaku Kabushiki Kaisha | p27 PROTEIN INDUCER |
| PL2970123T3 (pl) | 2013-03-14 | 2020-03-31 | Amgen Inc. | Sól omekamtywu mekarbilu i sposób otrzymywania soli |
-
2018
- 2018-07-09 HU HUE18182368A patent/HUE052049T2/hu unknown
- 2018-07-09 LT LTEP18182368.3T patent/LT3594199T/lt unknown
- 2018-07-09 PT PT181823683T patent/PT3594199T/pt unknown
- 2018-07-09 EP EP18182368.3A patent/EP3594199B1/en active Active
- 2018-07-09 DK DK18182368.3T patent/DK3594199T3/da active
- 2018-07-09 SI SI201830120T patent/SI3594199T1/sl unknown
- 2018-07-09 ES ES18182368T patent/ES2815899T3/es active Active
- 2018-07-09 PL PL18182368T patent/PL3594199T3/pl unknown
-
2019
- 2019-07-03 MX MX2021000348A patent/MX2021000348A/es unknown
- 2019-07-03 CN CN201980058205.6A patent/CN112654602A/zh active Pending
- 2019-07-03 US US17/258,385 patent/US20210292271A1/en active Pending
- 2019-07-03 AU AU2019303323A patent/AU2019303323A1/en active Pending
- 2019-07-03 CA CA3105559A patent/CA3105559A1/en active Pending
- 2019-07-03 WO PCT/EP2019/067894 patent/WO2020011626A1/en active Application Filing
- 2019-07-03 JP JP2021500471A patent/JP7407166B2/ja active Active
-
2020
- 2020-07-30 HR HRP20201198TT patent/HRP20201198T1/hr unknown
- 2020-09-15 CY CY20201100873T patent/CY1123514T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUE052049T2 (hu) | 2021-04-28 |
| MX2021000348A (es) | 2021-06-08 |
| PL3594199T3 (pl) | 2020-11-16 |
| WO2020011626A1 (en) | 2020-01-16 |
| SI3594199T1 (sl) | 2020-10-30 |
| US20210292271A1 (en) | 2021-09-23 |
| HRP20201198T1 (hr) | 2020-11-13 |
| JP7407166B2 (ja) | 2023-12-28 |
| CA3105559A1 (en) | 2020-01-16 |
| AU2019303323A1 (en) | 2021-01-28 |
| EP3594199A1 (en) | 2020-01-15 |
| ES2815899T3 (es) | 2021-03-31 |
| PT3594199T (pt) | 2020-09-04 |
| CY1123514T1 (el) | 2022-03-24 |
| DK3594199T3 (da) | 2020-09-14 |
| JP2021532076A (ja) | 2021-11-25 |
| CN112654602A (zh) | 2021-04-13 |
| EP3594199B1 (en) | 2020-07-01 |
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