LT3368571T - Į transformuojantį augimo faktorių beta atsaką sukuriantys polipeptidai ir jų panaudojimo būdai - Google Patents

Į transformuojantį augimo faktorių beta atsaką sukuriantys polipeptidai ir jų panaudojimo būdai

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Publication number
LT3368571T
LT3368571T LTEPPCT/US2016/059444T LT16059444T LT3368571T LT 3368571 T LT3368571 T LT 3368571T LT 16059444 T LT16059444 T LT 16059444T LT 3368571 T LT3368571 T LT 3368571T
Authority
LT
Lithuania
Prior art keywords
methods
growth factor
transforming growth
factor beta
beta response
Prior art date
Application number
LTEPPCT/US2016/059444T
Other languages
English (en)
Lithuanian (lt)
Inventor
Yvonne Yu-Hsuan CHEN
ZeNan Li CHANG
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Publication of LT3368571T publication Critical patent/LT3368571T/lt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
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    • A—HUMAN NECESSITIES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
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    • C07K2319/00—Fusion polypeptide
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LTEPPCT/US2016/059444T 2015-10-30 2016-10-28 Į transformuojantį augimo faktorių beta atsaką sukuriantys polipeptidai ir jų panaudojimo būdai LT3368571T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562248685P 2015-10-30 2015-10-30
PCT/US2016/059444 WO2017075433A1 (en) 2015-10-30 2016-10-28 Transforming growth factor-beta-responsive polypeptides and their methods for use

Publications (1)

Publication Number Publication Date
LT3368571T true LT3368571T (lt) 2023-02-10

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LTEPPCT/US2016/059444T LT3368571T (lt) 2015-10-30 2016-10-28 Į transformuojantį augimo faktorių beta atsaką sukuriantys polipeptidai ir jų panaudojimo būdai

Country Status (17)

Country Link
US (2) US11014980B2 (OSRAM)
EP (2) EP3368571B1 (OSRAM)
JP (3) JP7104624B2 (OSRAM)
KR (1) KR102771979B1 (OSRAM)
CN (2) CN108884155B (OSRAM)
DK (1) DK3368571T5 (OSRAM)
ES (1) ES2935372T3 (OSRAM)
FI (1) FI3368571T3 (OSRAM)
HR (1) HRP20230239T1 (OSRAM)
HU (1) HUE061424T2 (OSRAM)
LT (1) LT3368571T (OSRAM)
PL (1) PL3368571T3 (OSRAM)
PT (1) PT3368571T (OSRAM)
RS (1) RS64053B1 (OSRAM)
SI (1) SI3368571T1 (OSRAM)
SM (1) SMT202300027T1 (OSRAM)
WO (1) WO2017075433A1 (OSRAM)

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EP3368571B1 (en) * 2015-10-30 2022-12-07 The Regents of The University of California Transforming growth factor-beta-responsive polypeptides and their methods for use
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EP4204443A4 (en) * 2020-08-26 2025-02-26 The Regents of The University of California METHODS AND COMPOSITIONS FOR THE TREATMENT OF GLIOBLASTOMA
CN112500491B (zh) * 2020-12-18 2022-04-08 深圳市迈加瑞生物技术有限公司 一种特异性中和辅助性T细胞TGF-β信号的双特异性抗体、其药物组合及其用途
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CN115960264A (zh) 2023-04-14
US20210277099A1 (en) 2021-09-09
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EP4169945A1 (en) 2023-04-26
SMT202300027T1 (it) 2023-05-12
CN108884155A (zh) 2018-11-23
ES2935372T3 (es) 2023-03-06
JP2019500012A (ja) 2019-01-10
US20180312580A1 (en) 2018-11-01
PL3368571T3 (pl) 2023-05-02
RS64053B1 (sr) 2023-04-28
WO2017075433A1 (en) 2017-05-04
EP3368571A4 (en) 2019-11-06
JP7539434B2 (ja) 2024-08-23
DK3368571T5 (da) 2024-09-30
US11014980B2 (en) 2021-05-25
SI3368571T1 (sl) 2023-04-28
JP2022141761A (ja) 2022-09-29
HRP20230239T1 (hr) 2023-04-14
JP7104624B2 (ja) 2022-07-21
PT3368571T (pt) 2023-01-03
KR102771979B1 (ko) 2025-02-21
CN108884155B (zh) 2022-12-06
KR20180092947A (ko) 2018-08-20
EP3368571A1 (en) 2018-09-05
HUE061424T2 (hu) 2023-06-28
FI3368571T3 (fi) 2023-02-28
EP3368571B1 (en) 2022-12-07

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