LT3241B - Process for the manufacture of a preparation having immunomodulating activity and stimulating cytokine formation by extracting plants and plant residues - Google Patents
Process for the manufacture of a preparation having immunomodulating activity and stimulating cytokine formation by extracting plants and plant residues Download PDFInfo
- Publication number
- LT3241B LT3241B LTIP1509A LTIP1509A LT3241B LT 3241 B LT3241 B LT 3241B LT IP1509 A LTIP1509 A LT IP1509A LT IP1509 A LTIP1509 A LT IP1509A LT 3241 B LT3241 B LT 3241B
- Authority
- LT
- Lithuania
- Prior art keywords
- extract
- reaction
- solution
- peat
- concentrated
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 230000015572 biosynthetic process Effects 0.000 title claims abstract description 10
- 102000004127 Cytokines Human genes 0.000 title claims abstract description 6
- 108090000695 Cytokines Proteins 0.000 title claims abstract description 6
- 230000002519 immonomodulatory effect Effects 0.000 title claims abstract description 5
- 238000000034 method Methods 0.000 title claims description 24
- 230000008569 process Effects 0.000 title claims description 19
- 230000004936 stimulating effect Effects 0.000 title abstract description 3
- 238000004519 manufacturing process Methods 0.000 title description 6
- 239000000284 extract Substances 0.000 claims abstract description 37
- 239000003415 peat Substances 0.000 claims abstract description 32
- 238000006243 chemical reaction Methods 0.000 claims abstract description 22
- 239000000126 substance Substances 0.000 claims abstract description 18
- 239000000203 mixture Substances 0.000 claims abstract description 13
- 238000001728 nano-filtration Methods 0.000 claims abstract description 11
- 150000004676 glycans Chemical class 0.000 claims abstract description 8
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 8
- 239000005017 polysaccharide Substances 0.000 claims abstract description 8
- 230000000686 immunotropic effect Effects 0.000 claims abstract description 7
- 150000003839 salts Chemical class 0.000 claims abstract description 7
- 150000001413 amino acids Chemical class 0.000 claims abstract description 6
- 229920005989 resin Polymers 0.000 claims abstract description 6
- 239000011347 resin Substances 0.000 claims abstract description 6
- 238000001816 cooling Methods 0.000 claims abstract description 5
- 150000002482 oligosaccharides Polymers 0.000 claims abstract description 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 5
- 241001465754 Metazoa Species 0.000 claims abstract description 4
- 238000001704 evaporation Methods 0.000 claims abstract description 4
- 230000008020 evaporation Effects 0.000 claims abstract description 4
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 4
- 238000001179 sorption measurement Methods 0.000 claims abstract description 4
- 235000021309 simple sugar Nutrition 0.000 claims abstract description 3
- 239000006188 syrup Substances 0.000 claims abstract description 3
- 235000020357 syrup Nutrition 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 40
- 239000000047 product Substances 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 239000012153 distilled water Substances 0.000 claims description 10
- 230000007935 neutral effect Effects 0.000 claims description 7
- 239000011541 reaction mixture Substances 0.000 claims description 7
- 230000002378 acidificating effect Effects 0.000 claims description 6
- 239000006286 aqueous extract Substances 0.000 claims description 5
- 239000002244 precipitate Substances 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 5
- 239000003513 alkali Substances 0.000 claims description 4
- 239000012467 final product Substances 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 229920001429 chelating resin Polymers 0.000 claims description 3
- 230000008707 rearrangement Effects 0.000 claims description 3
- 208000007976 Ketosis Diseases 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 238000006664 bond formation reaction Methods 0.000 claims description 2
- 238000011085 pressure filtration Methods 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 230000002745 absorbent Effects 0.000 claims 1
- 239000002250 absorbent Substances 0.000 claims 1
- 238000003916 acid precipitation Methods 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract description 8
- 239000007787 solid Substances 0.000 abstract description 7
- 238000003691 Amadori rearrangement reaction Methods 0.000 abstract description 5
- 230000001225 therapeutic effect Effects 0.000 abstract description 5
- 102000014150 Interferons Human genes 0.000 abstract description 4
- 108010050904 Interferons Proteins 0.000 abstract description 4
- 231100000252 nontoxic Toxicity 0.000 abstract description 4
- 230000003000 nontoxic effect Effects 0.000 abstract description 4
- 230000020477 pH reduction Effects 0.000 abstract description 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract description 3
- 229940047124 interferons Drugs 0.000 abstract description 3
- 238000000926 separation method Methods 0.000 abstract description 3
- 102000003390 tumor necrosis factor Human genes 0.000 abstract description 3
- 238000001694 spray drying Methods 0.000 abstract description 2
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- 238000000605 extraction Methods 0.000 description 15
- 238000012360 testing method Methods 0.000 description 15
- 239000012528 membrane Substances 0.000 description 10
- 239000007788 liquid Substances 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 235000011121 sodium hydroxide Nutrition 0.000 description 6
- 235000000346 sugar Nutrition 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- 239000013543 active substance Substances 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 150000008163 sugars Chemical class 0.000 description 5
- AWDBHOZBRXWRKS-UHFFFAOYSA-N tetrapotassium;iron(6+);hexacyanide Chemical compound [K+].[K+].[K+].[K+].[Fe+6].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] AWDBHOZBRXWRKS-UHFFFAOYSA-N 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000003463 adsorbent Substances 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 239000012670 alkaline solution Substances 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000004021 humic acid Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000035931 haemagglutination Effects 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- DCYOBGZUOMKFPA-UHFFFAOYSA-N iron(2+);iron(3+);octadecacyanide Chemical compound [Fe+2].[Fe+2].[Fe+2].[Fe+3].[Fe+3].[Fe+3].[Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] DCYOBGZUOMKFPA-UHFFFAOYSA-N 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000005416 organic matter Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000006462 rearrangement reaction Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 210000004988 splenocyte Anatomy 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- QJZYHAIUNVAGQP-UHFFFAOYSA-N 3-nitrobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid Chemical compound C1C2C=CC1C(C(=O)O)C2(C(O)=O)[N+]([O-])=O QJZYHAIUNVAGQP-UHFFFAOYSA-N 0.000 description 1
- IJJWOSAXNHWBPR-HUBLWGQQSA-N 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-n-(6-hydrazinyl-6-oxohexyl)pentanamide Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)NCCCCCC(=O)NN)SC[C@@H]21 IJJWOSAXNHWBPR-HUBLWGQQSA-N 0.000 description 1
- XXXSILNSXNPGKG-ZHACJKMWSA-N Crotoxyphos Chemical compound COP(=O)(OC)O\C(C)=C\C(=O)OC(C)C1=CC=CC=C1 XXXSILNSXNPGKG-ZHACJKMWSA-N 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001323 aldoses Chemical class 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 238000011026 diafiltration Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000011143 downstream manufacturing Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000002509 fulvic acid Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000000899 immune system response Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- RUTXIHLAWFEWGM-UHFFFAOYSA-H iron(3+) sulfate Chemical group [Fe+3].[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O RUTXIHLAWFEWGM-UHFFFAOYSA-H 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011155 quantitative monitoring Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000005364 simax Substances 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
- A61K35/10—Peat; Amber; Turf; Humus
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL92296811A PL170294B1 (pl) | 1992-12-02 | 1992-12-02 | Sposób otrzymywania z torfu aktywnego, nietoksycznego preparatuo dzialaniu immunomodulacyjnym i stymulujacym wytwarzanie w organizmie cytokin PL |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTIP1509A LTIP1509A (en) | 1994-12-27 |
| LT3241B true LT3241B (en) | 1995-04-25 |
Family
ID=20059002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTIP1509A LT3241B (en) | 1992-12-02 | 1993-12-01 | Process for the manufacture of a preparation having immunomodulating activity and stimulating cytokine formation by extracting plants and plant residues |
Country Status (9)
| Country | Link |
|---|---|
| AU (1) | AU5629594A (en, 2012) |
| CO (1) | CO4180517A1 (en, 2012) |
| EE (1) | EE03136B1 (en, 2012) |
| LT (1) | LT3241B (en, 2012) |
| PE (1) | PE55894A1 (en, 2012) |
| PL (1) | PL170294B1 (en, 2012) |
| TW (1) | TW272129B (en, 2012) |
| WO (1) | WO1994012197A1 (en, 2012) |
| ZA (1) | ZA938950B (en, 2012) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2818967A1 (fr) * | 2001-01-04 | 2002-07-05 | Evatex | Dispositif de recyclage des eaux chargees en saumure et en polluants organiques |
| RU2219935C1 (ru) * | 2002-07-09 | 2003-12-27 | НИИ онкологии им. проф. Н.Н. Петрова | Средство для профилактики рака |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL124110B1 (en) | 1977-10-25 | 1982-12-31 | Akad Rolnicza | Method of obtaining an antineoplastic preparation from the acidified alkaline hydrolyzate from peat |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE131859T1 (de) * | 1991-03-16 | 1996-01-15 | Torf Ets | Verfahren zur kontinuierlichen extraction von torf und apparat zur durchführung dieses verfahrens |
| DE69224024T2 (de) * | 1991-03-16 | 1998-08-27 | Torf Ets | Torf-derivierte bioaktive produkte und diese enthaltende pharmazeutische und kosmetische zusammensetzungen |
-
1992
- 1992-12-02 PL PL92296811A patent/PL170294B1/pl unknown
-
1993
- 1993-11-30 ZA ZA938950A patent/ZA938950B/xx unknown
- 1993-11-30 PE PE1993232205A patent/PE55894A1/es not_active Application Discontinuation
- 1993-12-01 CO CO93420757A patent/CO4180517A1/es unknown
- 1993-12-01 LT LTIP1509A patent/LT3241B/lt not_active IP Right Cessation
- 1993-12-01 WO PCT/EP1993/003362 patent/WO1994012197A1/en active Application Filing
- 1993-12-01 AU AU56295/94A patent/AU5629594A/en not_active Abandoned
- 1993-12-28 TW TW082111047A patent/TW272129B/zh active
-
1994
- 1994-07-12 EE EE9400034A patent/EE03136B1/xx unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL124110B1 (en) | 1977-10-25 | 1982-12-31 | Akad Rolnicza | Method of obtaining an antineoplastic preparation from the acidified alkaline hydrolyzate from peat |
Also Published As
| Publication number | Publication date |
|---|---|
| EE03136B1 (et) | 1998-12-15 |
| TW272129B (en, 2012) | 1996-03-11 |
| CO4180517A1 (es) | 1995-06-07 |
| PL170294B1 (pl) | 1996-11-29 |
| PE55894A1 (es) | 1995-02-17 |
| WO1994012197A1 (en) | 1994-06-09 |
| LTIP1509A (en) | 1994-12-27 |
| ZA938950B (en) | 1994-08-02 |
| AU5629594A (en) | 1994-06-22 |
| PL296811A1 (en) | 1994-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9A | Lapsed patents |
Effective date: 20001201 |