LT3160956T - Lizinui specifinės demetilazės-1 inhibitoriai - Google Patents
Lizinui specifinės demetilazės-1 inhibitoriaiInfo
- Publication number
- LT3160956T LT3160956T LTEP15811526.1T LT15811526T LT3160956T LT 3160956 T LT3160956 T LT 3160956T LT 15811526 T LT15811526 T LT 15811526T LT 3160956 T LT3160956 T LT 3160956T
- Authority
- LT
- Lithuania
- Prior art keywords
- demetylase
- lysine
- inhibitors
- specific
- specific demetylase
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polyamides (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462018365P | 2014-06-27 | 2014-06-27 | |
| PCT/US2015/038089 WO2015200843A1 (en) | 2014-06-27 | 2015-06-26 | Inhibitors of lysine specific demethylase-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3160956T true LT3160956T (lt) | 2020-09-10 |
Family
ID=54938856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP15811526.1T LT3160956T (lt) | 2014-06-27 | 2015-06-26 | Lizinui specifinės demetilazės-1 inhibitoriai |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US10011583B2 (en:Method) |
| EP (1) | EP3160956B1 (en:Method) |
| JP (2) | JP6587241B2 (en:Method) |
| KR (1) | KR102438302B1 (en:Method) |
| CN (1) | CN106660987B (en:Method) |
| AU (2) | AU2015279591A1 (en:Method) |
| BR (1) | BR112016030697B1 (en:Method) |
| CA (1) | CA2953810C (en:Method) |
| CL (1) | CL2016003350A1 (en:Method) |
| CO (1) | CO2017000362A2 (en:Method) |
| CY (1) | CY1123475T1 (en:Method) |
| DK (1) | DK3160956T3 (en:Method) |
| EA (1) | EA030946B1 (en:Method) |
| EC (1) | ECSP17005635A (en:Method) |
| ES (1) | ES2812626T3 (en:Method) |
| HR (1) | HRP20201337T1 (en:Method) |
| HU (1) | HUE050564T2 (en:Method) |
| IL (1) | IL249733B (en:Method) |
| LT (1) | LT3160956T (en:Method) |
| MX (1) | MX376632B (en:Method) |
| PL (1) | PL3160956T3 (en:Method) |
| PT (1) | PT3160956T (en:Method) |
| RS (1) | RS60658B1 (en:Method) |
| SG (2) | SG11201610866PA (en:Method) |
| SI (1) | SI3160956T1 (en:Method) |
| SM (1) | SMT202000443T1 (en:Method) |
| WO (1) | WO2015200843A1 (en:Method) |
| ZA (1) | ZA201700069B (en:Method) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2734209T3 (es) | 2013-08-06 | 2019-12-04 | Imago Biosciences Inc | Inhibidores de KDM1A para el tratamiento de enfermedades |
| MX376632B (es) | 2014-06-27 | 2025-03-07 | Celgene Quanticel Res Inc | Inhibidores de demetilasa-1 especifica de lisina. |
| EP3511319B1 (en) * | 2014-07-03 | 2023-05-03 | Celgene Quanticel Research, Inc. | Inhibitors of lysine specific demethylase-1 |
| EP4559902A3 (en) | 2015-02-12 | 2025-08-20 | Imago Biosciences Inc. | Kdm1a inhibitors for the treatment of disease |
| CA2987876A1 (en) | 2015-06-12 | 2016-12-15 | Oryzon Genomics, S.A. | Biomarkers associated with lsd1 inhibitors and uses thereof |
| WO2017013061A1 (en) | 2015-07-17 | 2017-01-26 | Oryzon Genomics, S.A. | Biomarkers associated with lsd1 inhibitors and uses thereof |
| EA201892075A1 (ru) | 2016-03-15 | 2019-04-30 | Оризон Дженомикс, С.А. | Комбинации ингибиторов lsd1 для применения для лечения солидных опухолей |
| US11034991B2 (en) | 2016-03-16 | 2021-06-15 | Oryzon Genomics S.A. | Methods to determine KDM1A target engagement and chemoprobes useful therefor |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| WO2018035259A1 (en) | 2016-08-16 | 2018-02-22 | Imago Biosciences, Inc. | Methods and processes for the preparation of kdm1a inhibitors |
| US20190256930A1 (en) | 2016-11-03 | 2019-08-22 | Oryzon Genomics, S.A. | Biomarkers for determining responsiveness to lsd1 inhibitors |
| JP2020121925A (ja) * | 2017-04-10 | 2020-08-13 | 三井化学アグロ株式会社 | ピリドン化合物とキノリン系化合物を含有する有害生物防除組成物および有害生物の防除方法、ならびに新規キノリン系化合物 |
| JP7071962B2 (ja) * | 2017-04-10 | 2022-05-19 | 三井化学アグロ株式会社 | ピリドン化合物と有害生物防除剤を含有する有害生物防除組成物および有害生物の防除方法 |
| WO2018190324A1 (ja) * | 2017-04-10 | 2018-10-18 | 三井化学アグロ株式会社 | ピリドン化合物を有効成分として含有する抗真菌剤およびその使用方法 |
| PL3661510T3 (pl) | 2017-08-03 | 2025-04-14 | Oryzon Genomics, S.A. | Sposoby leczenia zmian zachowania |
| WO2019182960A1 (en) * | 2018-03-21 | 2019-09-26 | Synblia Therapeutics, Inc. | Shp2 inhibitors and uses thereof |
| IL279260B2 (en) | 2018-05-11 | 2024-10-01 | Imago Biosciences Inc | Kdm1a inhibitors for the treatment of disease |
| RS67485B1 (sr) | 2019-03-20 | 2025-12-31 | Oryzon Genomics Sa | Postupci lečenja poremećaja pažnje sa hiperaktivnošću korišćenjem inhibitora kdm1a kao što je jedinjenje vafidemstat |
| KR20210141933A (ko) | 2019-03-20 | 2021-11-23 | 오리존 지노믹스 에스.에이. | 경계성 인격 장애의 치료 방법 |
| EP3994280A1 (en) | 2019-07-05 | 2022-05-11 | Oryzon Genomics, S.A. | Biomarkers and methods for personalized treatment of small cell lung cancer using kdm1a inhibitors |
| MX2023011779A (es) | 2021-04-08 | 2023-11-22 | Oryzon Genomics Sa | Combinaciones de inhibidores de lsd1 para el tratamiento de canceres mieloides. |
| EP4419504A4 (en) * | 2021-10-18 | 2025-09-03 | Imago Biosciences Inc | KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE |
| EP4522136A1 (en) | 2022-05-09 | 2025-03-19 | Oryzon Genomics, S.A. | Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors |
| EP4522137A1 (en) | 2022-05-09 | 2025-03-19 | Oryzon Genomics, S.A. | Methods of treating nf1-mutant tumors using lsd1 inhibitors |
| JP2025538876A (ja) | 2022-11-24 | 2025-12-02 | オリゾン・ゲノミクス・ソシエダッド・アノニマ | がん治療のためのｌｓｄ１阻害薬とメニン阻害薬の組合せ |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2599925A1 (en) * | 2005-03-14 | 2006-09-21 | Merck & Co., Inc. | Cgrp receptor antagonists |
| US20090186907A1 (en) * | 2006-06-21 | 2009-07-23 | E.I. Dupont De Nemours And Company | Pyrazinones As Cellular Proliferation Inhibitors |
| UA98961C2 (uk) * | 2007-06-27 | 2012-07-10 | Астразенека Аб | Похідні піразинону та їх застосування у лікуванні легеневих захворювань |
| CL2008002793A1 (es) * | 2007-09-20 | 2009-09-04 | Cgi Pharmaceuticals Inc | Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras |
| US9006449B2 (en) * | 2010-07-29 | 2015-04-14 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as LSD1 inhibitors |
| RU2632915C2 (ru) | 2012-06-12 | 2017-10-11 | Эббви Инк. | Производные пиридинона и пиридазинона |
| HUE061252T2 (hu) * | 2013-12-11 | 2023-05-28 | Celgene Quanticel Res Inc | Lizinspecifikus demetiláz-1 inhibítorok |
| CN103804312B (zh) * | 2014-02-17 | 2016-04-20 | 四川百利药业有限责任公司 | 一类氮杂环化合物及其制备方法和用途 |
| EP3137169B1 (en) * | 2014-05-01 | 2021-11-10 | Celgene Quanticel Research, Inc. | Inhibitors of lysine specific demethylase-1 |
| MX376632B (es) | 2014-06-27 | 2025-03-07 | Celgene Quanticel Res Inc | Inhibidores de demetilasa-1 especifica de lisina. |
-
2015
- 2015-06-26 MX MX2017000179A patent/MX376632B/es active IP Right Grant
- 2015-06-26 PL PL15811526T patent/PL3160956T3/pl unknown
- 2015-06-26 CN CN201580046216.4A patent/CN106660987B/zh not_active Expired - Fee Related
- 2015-06-26 US US15/322,277 patent/US10011583B2/en active Active
- 2015-06-26 AU AU2015279591A patent/AU2015279591A1/en not_active Abandoned
- 2015-06-26 BR BR112016030697-0A patent/BR112016030697B1/pt not_active IP Right Cessation
- 2015-06-26 WO PCT/US2015/038089 patent/WO2015200843A1/en not_active Ceased
- 2015-06-26 SG SG11201610866PA patent/SG11201610866PA/en unknown
- 2015-06-26 HU HUE15811526A patent/HUE050564T2/hu unknown
- 2015-06-26 EP EP15811526.1A patent/EP3160956B1/en active Active
- 2015-06-26 RS RS20200980A patent/RS60658B1/sr unknown
- 2015-06-26 LT LTEP15811526.1T patent/LT3160956T/lt unknown
- 2015-06-26 PT PT158115261T patent/PT3160956T/pt unknown
- 2015-06-26 ES ES15811526T patent/ES2812626T3/es active Active
- 2015-06-26 HR HRP20201337TT patent/HRP20201337T1/hr unknown
- 2015-06-26 SG SG10201911220TA patent/SG10201911220TA/en unknown
- 2015-06-26 KR KR1020177000953A patent/KR102438302B1/ko active Active
- 2015-06-26 CA CA2953810A patent/CA2953810C/en active Active
- 2015-06-26 SI SI201531328T patent/SI3160956T1/sl unknown
- 2015-06-26 SM SM20200443T patent/SMT202000443T1/it unknown
- 2015-06-26 DK DK15811526.1T patent/DK3160956T3/da active
- 2015-06-26 JP JP2016575362A patent/JP6587241B2/ja not_active Expired - Fee Related
- 2015-06-26 EA EA201692513A patent/EA030946B1/ru unknown
-
2016
- 2016-12-22 IL IL249733A patent/IL249733B/en active IP Right Grant
- 2016-12-27 CL CL2016003350A patent/CL2016003350A1/es unknown
-
2017
- 2017-01-04 ZA ZA2017/00069A patent/ZA201700069B/en unknown
- 2017-01-16 CO CONC2017/0000362A patent/CO2017000362A2/es unknown
- 2017-01-26 EC ECIEPI20175635A patent/ECSP17005635A/es unknown
-
2018
- 2018-05-29 US US15/991,222 patent/US10597376B2/en not_active Expired - Fee Related
-
2019
- 2019-05-03 JP JP2019087186A patent/JP6851418B2/ja not_active Expired - Fee Related
- 2019-11-07 AU AU2019261771A patent/AU2019261771B2/en not_active Ceased
-
2020
- 2020-02-03 US US16/780,704 patent/US11028066B2/en active Active
- 2020-08-14 CY CY20201100759T patent/CY1123475T1/el unknown
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