LT2748179T - Baltymų gryninimas anijonų mainų chromatografija - Google Patents

Baltymų gryninimas anijonų mainų chromatografija

Info

Publication number
LT2748179T
LT2748179T LTEPPCT/EP2012/070257T LT12070257T LT2748179T LT 2748179 T LT2748179 T LT 2748179T LT 12070257 T LT12070257 T LT 12070257T LT 2748179 T LT2748179 T LT 2748179T
Authority
LT
Lithuania
Prior art keywords
anion exchange
exchange chromatography
protein purification
purification
protein
Prior art date
Application number
LTEPPCT/EP2012/070257T
Other languages
English (en)
Inventor
Artur Mitterer
Meinhard Hasslacher
Christian Fiedler
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Publication of LT2748179T publication Critical patent/LT2748179T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LTEPPCT/EP2012/070257T 2011-10-14 2012-10-12 Baltymų gryninimas anijonų mainų chromatografija LT2748179T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161547579P 2011-10-14 2011-10-14
PCT/EP2012/070257 WO2013053887A1 (en) 2011-10-14 2012-10-12 Protein purification by anion exchange chromatography

Publications (1)

Publication Number Publication Date
LT2748179T true LT2748179T (lt) 2022-04-11

Family

ID=47010608

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/EP2012/070257T LT2748179T (lt) 2011-10-14 2012-10-12 Baltymų gryninimas anijonų mainų chromatografija

Country Status (9)

Country Link
US (1) US10378004B2 (lt)
EP (1) EP2748179B1 (lt)
JP (2) JP6236008B2 (lt)
AU (1) AU2012322948B2 (lt)
ES (1) ES2908920T3 (lt)
HK (1) HK1198588A1 (lt)
LT (1) LT2748179T (lt)
PL (1) PL2748179T3 (lt)
WO (1) WO2013053887A1 (lt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5883849B2 (ja) 2010-04-29 2016-03-15 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 陰イオン交換樹脂を用いる二価カチオン結合タンパク質の精製方法
ES2700933T3 (es) * 2011-10-14 2019-02-20 Baxalta GmbH Purificación de proteínas mediante cromatografía de intercambio aniónico
AU2012322948B2 (en) 2011-10-14 2014-11-06 Takeda Pharmaceutical Company Limited Protein purification by anion exchange chromatography
US10202417B2 (en) 2013-03-15 2019-02-12 Baxalta Incorporated Purification method for vitamin K dependent proteins by anion exchange chromatography
AR102331A1 (es) * 2014-08-12 2017-02-22 Baxalta Inc Activación del factor x
WO2018117143A1 (ja) 2016-12-22 2018-06-28 一般財団法人化学及血清療法研究所 血液凝固第ｖｉｉ因子の高収率回収のためのクロマトグラフィー法
WO2022172284A1 (en) * 2021-02-11 2022-08-18 Gennova Biopharmaceuticals Ltd. Purification of a therapeutic protein

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2045167T5 (es) 1987-10-23 1996-07-01 Centre Regional De Transfusion Preparacion de concentrado de factor ix humano de elevada pureza y de otras proteinas plasmaticas.
US4981952A (en) 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins
JP3735112B2 (ja) * 1992-08-27 2006-01-18 ステイヒテイング・セントラール・ラボラトリウム・バン・デ・ブレドトランスフシーデイーンスト・バン・ヘト・ネーデルランドセ・ロデ・クルイス 凝血性蛋白質に特異的な抗体、未変性蛋白質を単離するためのそれらの利用、その蛋白質の蛋白質分解性開裂産物を含まない凝血性組成物
DE4406515C1 (de) * 1994-02-28 1995-10-19 Immuno Ag Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine
US5714583A (en) 1995-06-07 1998-02-03 Genetics Institute, Inc. Factor IX purification methods
DE69841459D1 (en) * 1997-02-14 2010-03-11 American Nat Red Cross Expression des active human factor ix im brustdrüsengewebe transgener tiere
CA2385371A1 (en) 2000-07-21 2002-01-31 Hiroshi Mizokami Method of purifying calcium ion-binding protein
US20040106779A1 (en) 2002-12-03 2004-06-03 Bigler Douglas E. Modified factor IX preparation
WO2006035058A2 (en) 2004-09-29 2006-04-06 Novo Nordisk Health Care Ag Purification of a drug substance of a factor vii polypeptide by removal of desgla-factor vii polypeptide structures
CN101098883B (zh) 2004-12-23 2013-01-23 诺和诺德医疗保健公司 减少含有目的维生素k依赖性蛋白质的组合物中的蛋白质污染物的含量
WO2007026020A1 (en) 2005-09-01 2007-03-08 Novo Nordisk Health Care Ag Purification of coagulation factor vii polypeptides
WO2007101681A1 (en) 2006-03-07 2007-09-13 Baxter International Inc Highly phosphorylated and sulfated recombinant factor ix
FR2901707B1 (fr) 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
FR2901796A1 (fr) 2006-05-31 2007-12-07 Lab Francais Du Fractionnement Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
DK2125866T3 (da) * 2007-02-28 2013-07-29 Baxter Int Fremgangsmåde til rensning af rekombinant blodkoagulationsfaktor IX, som er beriget med sulfaterede og/eller phosphorylerede molekyler
SG181496A1 (en) 2009-12-18 2012-07-30 Csl Ltd Method of purifying polypeptides
JP5883849B2 (ja) * 2010-04-29 2016-03-15 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 陰イオン交換樹脂を用いる二価カチオン結合タンパク質の精製方法
ES2700933T3 (es) * 2011-10-14 2019-02-20 Baxalta GmbH Purificación de proteínas mediante cromatografía de intercambio aniónico
AU2012322948B2 (en) 2011-10-14 2014-11-06 Takeda Pharmaceutical Company Limited Protein purification by anion exchange chromatography

Also Published As

Publication number Publication date
WO2013053887A1 (en) 2013-04-18
AU2012322948B2 (en) 2014-11-06
JP6236008B2 (ja) 2017-11-22
PL2748179T3 (pl) 2022-04-11
EP2748179A1 (en) 2014-07-02
EP2748179B1 (en) 2021-12-29
HK1198588A1 (en) 2015-04-30
US20140302591A1 (en) 2014-10-09
AU2012322948A1 (en) 2013-05-16
JP6820232B2 (ja) 2021-01-27
US10378004B2 (en) 2019-08-13
JP2014530230A (ja) 2014-11-17
ES2908920T3 (es) 2022-05-04
JP2017160248A (ja) 2017-09-14

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