LT2748179T - Baltymų gryninimas anijonų mainų chromatografija - Google Patents
Baltymų gryninimas anijonų mainų chromatografijaInfo
- Publication number
- LT2748179T LT2748179T LTEPPCT/EP2012/070257T LT12070257T LT2748179T LT 2748179 T LT2748179 T LT 2748179T LT 12070257 T LT12070257 T LT 12070257T LT 2748179 T LT2748179 T LT 2748179T
- Authority
- LT
- Lithuania
- Prior art keywords
- anion exchange
- exchange chromatography
- protein purification
- purification
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161547579P | 2011-10-14 | 2011-10-14 | |
PCT/EP2012/070257 WO2013053887A1 (en) | 2011-10-14 | 2012-10-12 | Protein purification by anion exchange chromatography |
Publications (1)
Publication Number | Publication Date |
---|---|
LT2748179T true LT2748179T (lt) | 2022-04-11 |
Family
ID=47010608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEPPCT/EP2012/070257T LT2748179T (lt) | 2011-10-14 | 2012-10-12 | Baltymų gryninimas anijonų mainų chromatografija |
Country Status (9)
Country | Link |
---|---|
US (1) | US10378004B2 (lt) |
EP (1) | EP2748179B1 (lt) |
JP (2) | JP6236008B2 (lt) |
AU (1) | AU2012322948B2 (lt) |
ES (1) | ES2908920T3 (lt) |
HK (1) | HK1198588A1 (lt) |
LT (1) | LT2748179T (lt) |
PL (1) | PL2748179T3 (lt) |
WO (1) | WO2013053887A1 (lt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103025757A (zh) | 2010-04-29 | 2013-04-03 | 巴克斯特国际有限公司 | 二价阳离子结合蛋白在阴离子交换树脂上的纯化方法 |
WO2013053888A1 (en) * | 2011-10-14 | 2013-04-18 | Baxter International Inc. | Protein purification by anion exchange chromatography |
JP6236008B2 (ja) | 2011-10-14 | 2017-11-22 | バクスアルタ ゲーエムベーハー | アニオン交換クロマトグラフィーによるタンパク質の精製 |
SI2970376T1 (sl) * | 2013-03-15 | 2018-09-28 | Baxalta Incorporated | Metoda čiščenja za vitamin k odvisne proteine z anionsko izmenjevalno kromatografijo |
TWI684599B (zh) * | 2014-08-12 | 2020-02-11 | 美商巴克斯歐塔公司 | 因子x活化 |
ES2906118T3 (es) * | 2016-12-22 | 2022-04-13 | Km Biologics Co Ltd | Método cromatográfico para recolectar factor VII de coagulación sanguínea con alto rendimiento |
WO2022172284A1 (en) * | 2021-02-11 | 2022-08-18 | Gennova Biopharmaceuticals Ltd. | Purification of a therapeutic protein |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2045167T5 (es) | 1987-10-23 | 1996-07-01 | Centre Regional De Transfusion | Preparacion de concentrado de factor ix humano de elevada pureza y de otras proteinas plasmaticas. |
US4981952A (en) * | 1988-10-04 | 1991-01-01 | Eli Lilly And Company | Method for the purification of vitamin K-dependent proteins |
WO1994005692A1 (en) * | 1992-08-27 | 1994-03-17 | Stichting Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis | Antibodies specific for a haemostatic protein, their use for isolating intact protein, haemostatic compositions devoid of proteolytic cleavage products of the protein |
DE4406515C1 (de) * | 1994-02-28 | 1995-10-19 | Immuno Ag | Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine |
US5714583A (en) * | 1995-06-07 | 1998-02-03 | Genetics Institute, Inc. | Factor IX purification methods |
ES2340008T3 (es) | 1997-02-14 | 2010-05-27 | American Red Cross | Expresion de factor ix humano activo en tejido mamario de animales transgenicos. |
ATE426611T1 (de) | 2000-07-21 | 2009-04-15 | Chemo Sero Therapeut Res Inst | Verfahren zur reinigung eines kalziumionen- bindenden proteins |
US20040106779A1 (en) | 2002-12-03 | 2004-06-03 | Bigler Douglas E. | Modified factor IX preparation |
EP1797122A2 (en) * | 2004-09-29 | 2007-06-20 | Novo Nordisk Health Care AG | Purification of a drug substance of a factor vii polypeptide by removal of desgla-factor vii polypeptide structures |
KR101364001B1 (ko) * | 2004-12-23 | 2014-02-17 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 관심있는 비타민 k-의존성 단백질을 포함한 조성물 중의단백질 오염물질의 양의 감소 |
WO2007026020A1 (en) | 2005-09-01 | 2007-03-08 | Novo Nordisk Health Care Ag | Purification of coagulation factor vii polypeptides |
EP1991257B1 (en) | 2006-03-07 | 2015-05-06 | Baxter International Inc. | Highly phosphorylated and sulfated recombinant factor ix |
FR2901796A1 (fr) | 2006-05-31 | 2007-12-07 | Lab Francais Du Fractionnement | Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait |
FR2901707B1 (fr) | 2006-05-31 | 2017-09-29 | Lab Francais Du Fractionnement | Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis |
WO2008104372A1 (en) * | 2007-02-28 | 2008-09-04 | Baxter International Inc. | Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules |
JP5984676B2 (ja) | 2009-12-18 | 2016-09-06 | シーエスエル、リミテッド | ポリペプチドを精製する方法 |
CN103025757A (zh) * | 2010-04-29 | 2013-04-03 | 巴克斯特国际有限公司 | 二价阳离子结合蛋白在阴离子交换树脂上的纯化方法 |
JP6236008B2 (ja) | 2011-10-14 | 2017-11-22 | バクスアルタ ゲーエムベーハー | アニオン交換クロマトグラフィーによるタンパク質の精製 |
WO2013053888A1 (en) | 2011-10-14 | 2013-04-18 | Baxter International Inc. | Protein purification by anion exchange chromatography |
-
2012
- 2012-10-12 JP JP2014535102A patent/JP6236008B2/ja active Active
- 2012-10-12 WO PCT/EP2012/070257 patent/WO2013053887A1/en active Application Filing
- 2012-10-12 EP EP12770496.3A patent/EP2748179B1/en active Active
- 2012-10-12 AU AU2012322948A patent/AU2012322948B2/en active Active
- 2012-10-12 US US14/351,541 patent/US10378004B2/en active Active
- 2012-10-12 LT LTEPPCT/EP2012/070257T patent/LT2748179T/lt unknown
- 2012-10-12 PL PL12770496T patent/PL2748179T3/pl unknown
- 2012-10-12 ES ES12770496T patent/ES2908920T3/es active Active
-
2014
- 2014-12-01 HK HK14112075A patent/HK1198588A1/xx unknown
-
2017
- 2017-05-11 JP JP2017094650A patent/JP6820232B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
JP6236008B2 (ja) | 2017-11-22 |
EP2748179A1 (en) | 2014-07-02 |
US10378004B2 (en) | 2019-08-13 |
US20140302591A1 (en) | 2014-10-09 |
JP2017160248A (ja) | 2017-09-14 |
PL2748179T3 (pl) | 2022-04-11 |
AU2012322948A1 (en) | 2013-05-16 |
JP6820232B2 (ja) | 2021-01-27 |
ES2908920T3 (es) | 2022-05-04 |
HK1198588A1 (en) | 2015-04-30 |
EP2748179B1 (en) | 2021-12-29 |
JP2014530230A (ja) | 2014-11-17 |
WO2013053887A1 (en) | 2013-04-18 |
AU2012322948B2 (en) | 2014-11-06 |
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