HK1219285A1 - 通過陰離子交換層析純化維生素 依賴性蛋白的方法 - Google Patents

通過陰離子交換層析純化維生素 依賴性蛋白的方法

Info

Publication number
HK1219285A1
HK1219285A1 HK16107366.3A HK16107366A HK1219285A1 HK 1219285 A1 HK1219285 A1 HK 1219285A1 HK 16107366 A HK16107366 A HK 16107366A HK 1219285 A1 HK1219285 A1 HK 1219285A1
Authority
HK
Hong Kong
Prior art keywords
anion exchange
exchange chromatography
purification method
dependent proteins
vitamin
Prior art date
Application number
HK16107366.3A
Other languages
English (en)
Inventor
Artur Mitterer
Meinhard Hasslacher
Christian Fiedler
Dominik Mittergradnegger
Original Assignee
Baxalta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta Inc filed Critical Baxalta Inc
Publication of HK1219285A1 publication Critical patent/HK1219285A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK16107366.3A 2013-03-15 2016-06-24 通過陰離子交換層析純化維生素 依賴性蛋白的方法 HK1219285A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361792772P 2013-03-15 2013-03-15
PCT/EP2014/055120 WO2014140289A1 (en) 2013-03-15 2014-03-14 Purification method for vitamin k dependent proteins by anion exchange chromatography

Publications (1)

Publication Number Publication Date
HK1219285A1 true HK1219285A1 (zh) 2017-03-31

Family

ID=50277247

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16107366.3A HK1219285A1 (zh) 2013-03-15 2016-06-24 通過陰離子交換層析純化維生素 依賴性蛋白的方法

Country Status (13)

Country Link
US (1) US10202417B2 (zh)
EP (1) EP2970376B1 (zh)
JP (1) JP6571011B2 (zh)
AU (1) AU2014230101B2 (zh)
DK (1) DK2970376T3 (zh)
ES (1) ES2682928T3 (zh)
HK (1) HK1219285A1 (zh)
HU (1) HUE037677T2 (zh)
NZ (1) NZ629845A (zh)
PL (1) PL2970376T3 (zh)
SI (1) SI2970376T1 (zh)
TR (1) TR201808584T4 (zh)
WO (1) WO2014140289A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR102331A1 (es) * 2014-08-12 2017-02-22 Baxalta Inc Activación del factor x

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981952A (en) * 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins
JP3735112B2 (ja) 1992-08-27 2006-01-18 ステイヒテイング・セントラール・ラボラトリウム・バン・デ・ブレドトランスフシーデイーンスト・バン・ヘト・ネーデルランドセ・ロデ・クルイス 凝血性蛋白質に特異的な抗体、未変性蛋白質を単離するためのそれらの利用、その蛋白質の蛋白質分解性開裂産物を含まない凝血性組成物
DE4406515C1 (de) * 1994-02-28 1995-10-19 Immuno Ag Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine
US5714583A (en) 1995-06-07 1998-02-03 Genetics Institute, Inc. Factor IX purification methods
DE69841459D1 (en) 1997-02-14 2010-03-11 American Nat Red Cross Expression des active human factor ix im brustdrüsengewebe transgener tiere
CA2385371A1 (en) 2000-07-21 2002-01-31 Hiroshi Mizokami Method of purifying calcium ion-binding protein
WO2006035058A2 (en) * 2004-09-29 2006-04-06 Novo Nordisk Health Care Ag Purification of a drug substance of a factor vii polypeptide by removal of desgla-factor vii polypeptide structures
CN101098883B (zh) 2004-12-23 2013-01-23 诺和诺德医疗保健公司 减少含有目的维生素k依赖性蛋白质的组合物中的蛋白质污染物的含量
WO2007026020A1 (en) 2005-09-01 2007-03-08 Novo Nordisk Health Care Ag Purification of coagulation factor vii polypeptides
FR2901796A1 (fr) 2006-05-31 2007-12-07 Lab Francais Du Fractionnement Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
FR2901707B1 (fr) 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
DK2125866T3 (da) * 2007-02-28 2013-07-29 Baxter Int Fremgangsmåde til rensning af rekombinant blodkoagulationsfaktor IX, som er beriget med sulfaterede og/eller phosphorylerede molekyler
SG181496A1 (en) 2009-12-18 2012-07-30 Csl Ltd Method of purifying polypeptides
JP5883849B2 (ja) * 2010-04-29 2016-03-15 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 陰イオン交換樹脂を用いる二価カチオン結合タンパク質の精製方法
ES2700933T3 (es) * 2011-10-14 2019-02-20 Baxalta GmbH Purificación de proteínas mediante cromatografía de intercambio aniónico
AU2012322948B2 (en) * 2011-10-14 2014-11-06 Takeda Pharmaceutical Company Limited Protein purification by anion exchange chromatography

Also Published As

Publication number Publication date
PL2970376T3 (pl) 2018-10-31
EP2970376B1 (en) 2018-05-23
JP6571011B2 (ja) 2019-09-04
JP2016512215A (ja) 2016-04-25
HUE037677T2 (hu) 2018-09-28
ES2682928T3 (es) 2018-09-24
AU2014230101B2 (en) 2018-04-19
US10202417B2 (en) 2019-02-12
WO2014140289A1 (en) 2014-09-18
EP2970376A1 (en) 2016-01-20
US20160039869A1 (en) 2016-02-11
DK2970376T3 (en) 2018-07-02
TR201808584T4 (tr) 2018-07-23
SI2970376T1 (sl) 2018-09-28
NZ629845A (en) 2016-10-28
AU2014230101A1 (en) 2015-10-08

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