LT2015064A - Karboanhidrazės selektyvūs inhibitoriai - Google Patents

Karboanhidrazės selektyvūs inhibitoriai

Info

Publication number
LT2015064A
LT2015064A LT2015064A LT2015064A LT2015064A LT 2015064 A LT2015064 A LT 2015064A LT 2015064 A LT2015064 A LT 2015064A LT 2015064 A LT2015064 A LT 2015064A LT 2015064 A LT2015064 A LT 2015064A
Authority
LT
Lithuania
Prior art keywords
carbonic anhydrase
selective inhibitors
compounds
benzenesulfonamides
biomedicine
Prior art date
Application number
LT2015064A
Other languages
English (en)
Other versions
LT6401B (lt
Inventor
Daumantas Matulis
Edita Čapkauskaitė
Audrius Zakšauskas
Vaida Morkūnaitė
Original Assignee
Vilniaus Universitetas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vilniaus Universitetas filed Critical Vilniaus Universitetas
Priority to LT2015064A priority Critical patent/LT6401B/lt
Priority to US15/748,559 priority patent/US11312682B2/en
Priority to PCT/IB2015/056626 priority patent/WO2017017505A1/en
Priority to EP15766651.2A priority patent/EP3328833A1/en
Publication of LT2015064A publication Critical patent/LT2015064A/lt
Publication of LT6401B publication Critical patent/LT6401B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/40—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/08—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Abstract

Išradimas yra susijęs su naujais junginiais - benzensulfonamidais, kurių bendros formulės (I) ir (II). Junginiai gali būti naudojami biomedicinoje, kaip aktyvūs farmakologiniai ingredientai, nes jie slopina fermentus, dalyvaujančius ligos progresavime.
LT2015064A 2015-07-28 2015-07-28 Karboanhidrazės selektyvūs inhibitoriai LT6401B (lt)

Priority Applications (4)

Application Number Priority Date Filing Date Title
LT2015064A LT6401B (lt) 2015-07-28 2015-07-28 Karboanhidrazės selektyvūs inhibitoriai
US15/748,559 US11312682B2 (en) 2015-07-28 2015-09-01 Selective inhibitors of carbonic anhydrase
PCT/IB2015/056626 WO2017017505A1 (en) 2015-07-28 2015-09-01 Selective inhibitors of carbonic anhydrase
EP15766651.2A EP3328833A1 (en) 2015-07-28 2015-09-01 Selective inhibitors of carbonic anhydrase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LT2015064A LT6401B (lt) 2015-07-28 2015-07-28 Karboanhidrazės selektyvūs inhibitoriai

Publications (2)

Publication Number Publication Date
LT2015064A true LT2015064A (lt) 2017-02-27
LT6401B LT6401B (lt) 2017-06-12

Family

ID=54148589

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2015064A LT6401B (lt) 2015-07-28 2015-07-28 Karboanhidrazės selektyvūs inhibitoriai

Country Status (4)

Country Link
US (1) US11312682B2 (lt)
EP (1) EP3328833A1 (lt)
LT (1) LT6401B (lt)
WO (1) WO2017017505A1 (lt)

Family Cites Families (31)

* Cited by examiner, † Cited by third party
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US3291824A (en) 1962-04-06 1966-12-13 Hoffmann La Roche Nu-(2-halo-lower alkanoyl) anthranilic acid derivatives
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US3567746A (en) 1968-07-10 1971-03-02 Pennwalt Corp N-aryl benzamides
DE2031067A1 (de) 1970-02-18 1971-09-02 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt, Budapest Verfahren zur Herstellung von 2 Fur furylamino 4 chlor 5 sulfamoyl benzoe saure
JPS58124767A (ja) * 1982-01-21 1983-07-25 Mitsui Toatsu Chem Inc スルファモイル安息香酸誘導体
FR2540870A1 (fr) 1983-02-15 1984-08-17 Provesan Sa Nouveaux derives de betaines n-iminopyridinium, leur preparation et leur application en tant que medicaments
DE4430212A1 (de) * 1994-08-28 1996-02-29 Merck Patent Gmbh Ortho-substituierte Benzoesäure-Derivate
TR200201260T2 (tr) 1999-11-12 2002-09-23 Biogen, Inc. Adenosin reseptör antagonistleri olarak polisikloalkilpurinler.
CA2691447A1 (en) 2002-11-26 2004-06-10 Institute Of Virology Ca ix-specific inhibitors
JP2006511554A (ja) 2002-12-13 2006-04-06 スミスクライン ビーチャム コーポレーション Ｃｃｒ５アンタゴニストとしてのピペリジン誘導体
JP2007504136A (ja) 2003-08-28 2007-03-01 ニトロメッド インコーポレーティッド ニトロソ化およびニトロシル化利尿化合物、組成物、ならびに使用方法
RS20060473A (en) 2004-02-20 2008-08-07 Sanofi-Aventis Deutschland Gmbh., Furosemide derivatives as modulators of hm74 and their use for the treatment of inflammation
WO2005107470A2 (en) 2004-04-29 2005-11-17 University Of Florida Research Foundation, Inc. Use of carbonic anhydrase inhibitors for insect control and malaria treatment
US20080275093A1 (en) 2004-11-15 2008-11-06 Nitromed, Inc. Diuretic Compounds Comprising Heterocyclic Nitric Oxide Donor Groups, Compositions and Methods of Use
WO2006137092A1 (en) 2005-06-23 2006-12-28 Supuran Claudiu T Fluorescent sulfonamide derivatives having carbonic anhydrase inhibiting activity and their use as theapeutic and diagnostic agents
US7763612B2 (en) 2006-01-03 2010-07-27 Algebra, Inc. Therapeutic amine-arylsulfonamide conjugate compounds
JP2010508300A (ja) 2006-10-26 2010-03-18 フライン、ギャリー・エー． アクアポリン修飾因子並びに浮腫および体液平衡異常の治療のためのそれらの使用方法
WO2008071421A1 (en) 2006-12-15 2008-06-19 Nicox S.A. Nitrate esters of carbonic anhydrase inhibitors
WO2008124703A2 (en) 2007-04-05 2008-10-16 Siemens Medical Solutions Usa, Inc. Development of molecular imaging probes for carbonic anhydrase-ix using click chemistry
RU2498798C2 (ru) 2008-01-09 2013-11-20 Моликьюлар Инсайт Фармасьютикалз, Инк. Ингибиторы карбоангидразы iх
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LT6064B (lt) 2012-10-15 2014-08-25 Vilniaus Universitetas Fluorinti benzensulfonamidai kaip karboanhidrazės inhibitoriai
WO2015025283A2 (en) 2013-08-20 2015-02-26 Stichting Maastricht Radiation Oncology "Maastro-Clinic" Dual action carbonic anhydrase inhibitors

Also Published As

Publication number Publication date
LT6401B (lt) 2017-06-12
US11312682B2 (en) 2022-04-26
WO2017017505A1 (en) 2017-02-02
EP3328833A1 (en) 2018-06-06
US20180222856A1 (en) 2018-08-09

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BB1A Patent application published

Effective date: 20170227

FG9A Patent granted

Effective date: 20170612

MM9A Lapsed patents

Effective date: 20200728