KR970706238A - 양이온성 운반 시약(cationic transport reagents) - Google Patents

양이온성 운반 시약(cationic transport reagents)

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KR970706238A
KR970706238A KR1019970702060A KR19970702060A KR970706238A KR 970706238 A KR970706238 A KR 970706238A KR 1019970702060 A KR1019970702060 A KR 1019970702060A KR 19970702060 A KR19970702060 A KR 19970702060A KR 970706238 A KR970706238 A KR 970706238A
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alkyl
alkenyl
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마이클 에이치. 난쯔
마이클 제이. 베네뜨
로버트 더블유. 말론
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스티븐슨 린다 에스.
더 리전츠 오브 더 유니버시티 오브 캘리포니아
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Priority claimed from US08/316,719 external-priority patent/US5527928A/en
Application filed by 스티븐슨 린다 에스., 더 리전츠 오브 더 유니버시티 오브 캘리포니아 filed Critical 스티븐슨 린다 에스.
Publication of KR970706238A publication Critical patent/KR970706238A/ko

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Abstract

생물학적 활성종을 막 배리어 속으로 통과시켜 운반하는데 사용하기 위하여, 양이온성 대칭 디아민 화합물이 일반적 구조(Ⅰ)를 갖는다.
[식 중, m=1-10이고; R1은 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기, 또는 에테르 함유 알킬 또는 알케닐기이고; R2는 알킬기, 알케닐기, 또는 알킬 또는 알케닐 함유 아실기이고; R3는 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기, 또는 에테르 함유 알킬 또는 알케닐기이고; R4는 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기, 또는 에테르 함유 알킬 또는 알케닐기이고; 및 X-는 음이온이다.]

Description

양이온성 운반 시약 (CATIONIC TRANSPORT REAGENTS)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (21)

  1. 알킬 사슬, 알케닐 사슬, 및 알킬 또는 알케닐 함유 아실 사슬로 구성된 군으로부터 선택한 한쌍 이상의 동일한 리포일 부분 및 히드록시기로 끝나는 알킬 사슬 또는 알케닐 사슬 또는 에테르를 함유하는 알킬 사슬 또는 알케닐 사슬로 구성된 군으로부터 선택한 한쌍 이상의 동일한 히드록시 또는 알콕시 함유 부분을 갖는 양이온성 대칭 디아민을 포함하는 물질의 조성물.
  2. 제1항에 있어서, 디아민이 4차화된 조성물.
  3. 다음 구조를 갖는 물질의 조성물 ;
    [식 중, m=1-10이고; R1은 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기, 또는 에테르 함유 알킬 또는 알케닐기이고; R2는 알킬기, 알케닐기, 또는 알킬 또는 알케닐 함유 아실기이고; R3는 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기, 또는 에테르 함유 알킬 또는 알케닐기이고; R4는 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기, 또는 에테르 함유 알킬 또는 알케닐기이고; 및 X-는 음이온이다.]
  4. 다음 구조를 갖는 물질의 조성물 :
    〔식 중, n=0-10이고; R2는 알킬기, 알케닐기, 또는 일킬 또는 알케닐 함유 아실기이고; R3는 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기이고; 및 X-는 음이온이다〕.
  5. 제4항에 있어서, n=0-3이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3는 탄소수 1-10의 알킬기인 조성물.
  6. 제4항에 있어서, n=0-3이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3메탈기인 조성물.
  7. 다음 구조를 갖는 물질의 조성물 :
    [식 중, n=1-10이고; R1은 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기이고; R2는 알킬기, 알케닐기, 또는 알킬 또는 알케닐 함유 아실기이고; R3는 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기이고; R5는 탄소수 1-10의 알킬 알케닐기, 바람직하게는 메틸기이고; 및 X-는 음이온이다].
  8. 제7항에 있어서, n=0-3이고, R1는 탄소수 1-10의 알킬기이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3는 탄소수 1-10의 알킬기이고, 및 R5는 탄소수 1-10의 알킬 또는 알케닐기인 조성물.
  9. 제7항에 있어서, n=0-3이고, R1는 메틸기이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3는 메틸기이고, 및 R5는 메틸기인 조성물.
  10. 제7항에 있어서, n=1이고, R2는 메틸기이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3는 메틸기이고, 및 R5는 메틸기인 조성물.
  11. 다음 구조를 갖는 물질의 조성물 :
    [식 중, n=0-10이고; R2는 알킬기, 알케닐기, 또는 알킬 또는 알케닐 함유 아실기이고; R3는 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기이고; R5는 탄소수 1-10의 알킬 또는 알케닐기, 바람직하게는 메틸기이고; R6는 탄소수 1-10의 알킬 또는 알케닐기, 바람직하게는 메틸기이고; 및 X-는 음이온이다].
  12. 제11항에 있어서, n=0-3이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3는 탄소수 1-10의 알킬기이고, 및 R5는 탄소수 1-10의 알킬 또는 알케닐이고, 및 R6는 탄소수 1-10의 알킬 또는 알케닐기인 조성물.
  13. 제11항에 있어서, n=3이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3는 메틸기이고, R5는 메틸기이고, 및 R6은 메틸기인 조성물.
  14. 제11항에 있어서, n=1이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3는 메틸기이고, R5는 메틸기이고, R6는 메틸기인 조성물.
  15. 다음 구조를 갖는 물질의 조성물.
    [식 중, R은 알킬 또는 알케닐기이고 및 X_는 음이온이다].
  16. 제15항에 있어서, X_는 할라이드인 조성물.
  17. 다음 구조를 갖는 물질의 조성물 :
    [식 중, R은 알킬 또는 알케닐기이고 및 X_는 음이온이다].
  18. 제17항에 있어서, X_는 할라이드인 조성물.
  19. 다음 구조를 갖는 물질의 조성물 :
    [식 중, R은 알킬 또는 알케닐기이고 및 X_는 음이온이다].
  20. 제19항에 있어서, X_는 할라이드인 조성물.
  21. 다음 단계들을 특징으로 하는, 생물학적 활성종으로 세포들을 트란스펙션시키는 방법 : a) 다음 구조들을 갖는 한 군으로부터 양이온성 디아민 조성물을 선택하여, 생물학적 활성종, 지질, 및 양이온성 디아민 조성물을 함유하는 지질 소포를 형성하고 :
    [식 중, R은 알킬 또는 알케닐기이고 및 X_는 음이온이다]; b) 생물학적 활성종과 지질 소포로 복합체를 형성하고; 및 c) 트란스펙션되는 세포에 지질 소포를 접촉시킨다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970702060A 1994-09-15 1995-09-21 양이온성 운반 시약(cationic transport reagents) KR970706238A (ko)

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US08/316,719 US5527928A (en) 1994-09-30 1994-09-30 Cationic transport reagents
US08/316,719 1994-09-30
US08/528,733 US5892071A (en) 1994-09-30 1995-09-15 Cationic transport reagents

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EP0783482A4 (en) 1999-08-25
DE69531402T2 (de) 2004-04-15
EP0783482B1 (en) 2003-07-30
JP4008491B2 (ja) 2007-11-14
EP0783482A1 (en) 1997-07-16
DE69531402D1 (de) 2003-09-04
US5892071A (en) 1999-04-06
AU3721095A (en) 1996-04-26
AU704189B2 (en) 1999-04-15
JP2002515006A (ja) 2002-05-21
ATE246168T1 (de) 2003-08-15

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