KR970706238A - 양이온성 운반 시약(cationic transport reagents) - Google Patents
양이온성 운반 시약(cationic transport reagents)Info
- Publication number
- KR970706238A KR970706238A KR1019970702060A KR19970702060A KR970706238A KR 970706238 A KR970706238 A KR 970706238A KR 1019970702060 A KR1019970702060 A KR 1019970702060A KR 19970702060 A KR19970702060 A KR 19970702060A KR 970706238 A KR970706238 A KR 970706238A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- alkyl
- alkenyl
- composition
- alkenyl group
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 59
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 57
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract 14
- 125000002252 acyl group Chemical group 0.000 claims abstract 14
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 10
- 239000001257 hydrogen Substances 0.000 claims abstract 10
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract 10
- 150000001450 anions Chemical class 0.000 claims abstract 9
- -1 diamine compounds Chemical class 0.000 claims abstract 3
- 125000002091 cationic group Chemical group 0.000 claims abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 15
- 125000004432 carbon atom Chemical group C* 0.000 claims 10
- 239000000126 substance Substances 0.000 claims 5
- 150000002632 lipids Chemical class 0.000 claims 4
- 150000004820 halides Chemical class 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000004985 diamines Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000005741 alkyl alkenyl group Chemical group 0.000 claims 1
- 125000003977 lipoyl group Chemical group S1SC(C([H])([H])C(C(C(C(=O)[*])([H])[H])([H])[H])([H])[H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 230000008384 membrane barrier Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
- C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/08—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of an acyclic unsaturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/40—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the same carbon atom of the carbon skeleton, e.g. amino-ketals, ortho esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/06—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Abstract
생물학적 활성종을 막 배리어 속으로 통과시켜 운반하는데 사용하기 위하여, 양이온성 대칭 디아민 화합물이 일반적 구조(Ⅰ)를 갖는다.
[식 중, m=1-10이고; R1은 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기, 또는 에테르 함유 알킬 또는 알케닐기이고; R2는 알킬기, 알케닐기, 또는 알킬 또는 알케닐 함유 아실기이고; R3는 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기, 또는 에테르 함유 알킬 또는 알케닐기이고; R4는 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기, 또는 에테르 함유 알킬 또는 알케닐기이고; 및 X-는 음이온이다.]
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (21)
- 알킬 사슬, 알케닐 사슬, 및 알킬 또는 알케닐 함유 아실 사슬로 구성된 군으로부터 선택한 한쌍 이상의 동일한 리포일 부분 및 히드록시기로 끝나는 알킬 사슬 또는 알케닐 사슬 또는 에테르를 함유하는 알킬 사슬 또는 알케닐 사슬로 구성된 군으로부터 선택한 한쌍 이상의 동일한 히드록시 또는 알콕시 함유 부분을 갖는 양이온성 대칭 디아민을 포함하는 물질의 조성물.
- 제1항에 있어서, 디아민이 4차화된 조성물.
- 다음 구조를 갖는 물질의 조성물 ;[식 중, m=1-10이고; R1은 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기, 또는 에테르 함유 알킬 또는 알케닐기이고; R2는 알킬기, 알케닐기, 또는 알킬 또는 알케닐 함유 아실기이고; R3는 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기, 또는 에테르 함유 알킬 또는 알케닐기이고; R4는 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기, 또는 에테르 함유 알킬 또는 알케닐기이고; 및 X-는 음이온이다.]
- 다음 구조를 갖는 물질의 조성물 :〔식 중, n=0-10이고; R2는 알킬기, 알케닐기, 또는 일킬 또는 알케닐 함유 아실기이고; R3는 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기이고; 및 X-는 음이온이다〕.
- 제4항에 있어서, n=0-3이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3는 탄소수 1-10의 알킬기인 조성물.
- 제4항에 있어서, n=0-3이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3메탈기인 조성물.
- 다음 구조를 갖는 물질의 조성물 :[식 중, n=1-10이고; R1은 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기이고; R2는 알킬기, 알케닐기, 또는 알킬 또는 알케닐 함유 아실기이고; R3는 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기이고; R5는 탄소수 1-10의 알킬 알케닐기, 바람직하게는 메틸기이고; 및 X-는 음이온이다].
- 제7항에 있어서, n=0-3이고, R1는 탄소수 1-10의 알킬기이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3는 탄소수 1-10의 알킬기이고, 및 R5는 탄소수 1-10의 알킬 또는 알케닐기인 조성물.
- 제7항에 있어서, n=0-3이고, R1는 메틸기이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3는 메틸기이고, 및 R5는 메틸기인 조성물.
- 제7항에 있어서, n=1이고, R2는 메틸기이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3는 메틸기이고, 및 R5는 메틸기인 조성물.
- 다음 구조를 갖는 물질의 조성물 :[식 중, n=0-10이고; R2는 알킬기, 알케닐기, 또는 알킬 또는 알케닐 함유 아실기이고; R3는 수소, 알킬기, 알케닐기, 히드록시화 알킬 또는 알케닐기이고; R5는 탄소수 1-10의 알킬 또는 알케닐기, 바람직하게는 메틸기이고; R6는 탄소수 1-10의 알킬 또는 알케닐기, 바람직하게는 메틸기이고; 및 X-는 음이온이다].
- 제11항에 있어서, n=0-3이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3는 탄소수 1-10의 알킬기이고, 및 R5는 탄소수 1-10의 알킬 또는 알케닐이고, 및 R6는 탄소수 1-10의 알킬 또는 알케닐기인 조성물.
- 제11항에 있어서, n=3이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3는 메틸기이고, R5는 메틸기이고, 및 R6은 메틸기인 조성물.
- 제11항에 있어서, n=1이고, R2는 알킬 또는 알케닐 함유 아실기이고, R3는 메틸기이고, R5는 메틸기이고, R6는 메틸기인 조성물.
- 다음 구조를 갖는 물질의 조성물.[식 중, R은 알킬 또는 알케닐기이고 및 X_는 음이온이다].
- 제15항에 있어서, X_는 할라이드인 조성물.
- 다음 구조를 갖는 물질의 조성물 :[식 중, R은 알킬 또는 알케닐기이고 및 X_는 음이온이다].
- 제17항에 있어서, X_는 할라이드인 조성물.
- 다음 구조를 갖는 물질의 조성물 :[식 중, R은 알킬 또는 알케닐기이고 및 X_는 음이온이다].
- 제19항에 있어서, X_는 할라이드인 조성물.
- 다음 단계들을 특징으로 하는, 생물학적 활성종으로 세포들을 트란스펙션시키는 방법 : a) 다음 구조들을 갖는 한 군으로부터 양이온성 디아민 조성물을 선택하여, 생물학적 활성종, 지질, 및 양이온성 디아민 조성물을 함유하는 지질 소포를 형성하고 :[식 중, R은 알킬 또는 알케닐기이고 및 X_는 음이온이다]; b) 생물학적 활성종과 지질 소포로 복합체를 형성하고; 및 c) 트란스펙션되는 세포에 지질 소포를 접촉시킨다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/316,719 US5527928A (en) | 1994-09-30 | 1994-09-30 | Cationic transport reagents |
US08/316,719 | 1994-09-30 | ||
US08/528,733 US5892071A (en) | 1994-09-30 | 1995-09-15 | Cationic transport reagents |
Publications (1)
Publication Number | Publication Date |
---|---|
KR970706238A true KR970706238A (ko) | 1997-11-03 |
Family
ID=26980557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019970702060A KR970706238A (ko) | 1994-09-15 | 1995-09-21 | 양이온성 운반 시약(cationic transport reagents) |
Country Status (7)
Country | Link |
---|---|
US (1) | US5892071A (ko) |
EP (1) | EP0783482B1 (ko) |
JP (1) | JP4008491B2 (ko) |
KR (1) | KR970706238A (ko) |
AT (1) | ATE246168T1 (ko) |
AU (1) | AU704189B2 (ko) |
DE (1) | DE69531402T2 (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6090619A (en) * | 1997-09-08 | 2000-07-18 | University Of Florida | Materials and methods for intracellular delivery of biologically active molecules |
WO2000027795A1 (en) | 1998-11-12 | 2000-05-18 | Invitrogen Corporation | Transfection reagents |
US6514762B1 (en) | 1999-04-23 | 2003-02-04 | New Mexico State University Technology Transfer Corporation | Delivery of nucleotides by electrochemical release |
WO2001051454A1 (en) * | 2000-01-13 | 2001-07-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
WO2007070705A2 (en) * | 2005-12-15 | 2007-06-21 | The Trustees Of The University Of Pennsylvania | Cationic lipid-mediated vectors |
CA3039251C (en) | 2008-11-10 | 2024-01-09 | Arbutus Biopharma Corporation | Novel lipids and compositions for the delivery of therapeutics |
EP3169310A1 (en) | 2014-07-15 | 2017-05-24 | Life Technologies Corporation | Compositions with lipid aggregates and methods for efficient delivery of molecules to cells |
EP4228610A1 (en) | 2020-10-13 | 2023-08-23 | Kriya Therapeutics, Inc. | Viral vector constructs for delivery of nucleic acids encoding cytokines and uses thereof for treating cancer |
WO2022164923A1 (en) | 2021-01-26 | 2022-08-04 | Kriya Therapeutics, Inc. | Vector constructs for delivery of nucleic acids encoding therapeutic anti-tnf antibodies and methods of using the same |
WO2022187679A1 (en) | 2021-03-04 | 2022-09-09 | Kriya Therapeutics, Inc. | Viral vector constructs incorporating dna for inhibiting toll like receptors and methods of using the same |
WO2023133561A1 (en) | 2022-01-09 | 2023-07-13 | Kriya Therapeutics, Inc. | Vector constructs for delivery of nucleic acids encoding therapeutic anti-igf-1r antibodies and methods of using the same |
WO2024054993A1 (en) | 2022-09-09 | 2024-03-14 | Kriya Therapeutics, Inc. | Vector constructs for delivery of nucleic acids encoding therapeutic anti-ctla4 antibodies and methods of using the same |
WO2024130007A2 (en) | 2022-12-16 | 2024-06-20 | Kriya Therapeutics, Inc. | Synthetic htert promoters and uses thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3135014A1 (de) * | 1981-09-04 | 1983-03-24 | Hoechst Ag, 6000 Frankfurt | Waescheweichspuelmittel |
US5208036A (en) * | 1985-01-07 | 1993-05-04 | Syntex (U.S.A.) Inc. | N-(ω, (ω-1)-dialkyloxy)- and N-(ω, (ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4812449A (en) * | 1986-07-03 | 1989-03-14 | Scripps Clinic And Research Foundation | In situ active compound assembly |
FR2645866B1 (fr) * | 1989-04-17 | 1991-07-05 | Centre Nat Rech Scient | Nouvelles lipopolyamines, leur preparation et leur emploi |
DE3930674A1 (de) * | 1989-09-11 | 1991-03-21 | Diagnostikforschung Inst | Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie |
US5279833A (en) * | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
US5186923A (en) * | 1990-10-10 | 1993-02-16 | Brigham And Womens Hospital | Enhancement of cellular accumulation of lipophilic cationic organometallic compounds by reduction of intramembrane potential |
US5334761A (en) * | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
US5674908A (en) * | 1993-12-20 | 1997-10-07 | Life Technologies, Inc. | Highly packed polycationic ammonium, sulfonium and phosphonium lipids |
US5527928A (en) * | 1994-09-30 | 1996-06-18 | Nantz; Michael H. | Cationic transport reagents |
-
1995
- 1995-09-15 US US08/528,733 patent/US5892071A/en not_active Expired - Lifetime
- 1995-09-21 DE DE69531402T patent/DE69531402T2/de not_active Expired - Lifetime
- 1995-09-21 JP JP51188396A patent/JP4008491B2/ja not_active Expired - Fee Related
- 1995-09-21 AT AT95935042T patent/ATE246168T1/de not_active IP Right Cessation
- 1995-09-21 KR KR1019970702060A patent/KR970706238A/ko not_active Application Discontinuation
- 1995-09-21 AU AU37210/95A patent/AU704189B2/en not_active Ceased
- 1995-09-21 EP EP95935042A patent/EP0783482B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0783482A4 (en) | 1999-08-25 |
DE69531402T2 (de) | 2004-04-15 |
EP0783482B1 (en) | 2003-07-30 |
JP4008491B2 (ja) | 2007-11-14 |
EP0783482A1 (en) | 1997-07-16 |
DE69531402D1 (de) | 2003-09-04 |
US5892071A (en) | 1999-04-06 |
AU3721095A (en) | 1996-04-26 |
AU704189B2 (en) | 1999-04-15 |
JP2002515006A (ja) | 2002-05-21 |
ATE246168T1 (de) | 2003-08-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2200695A1 (en) | Cationic transport reagents | |
KR970706238A (ko) | 양이온성 운반 시약(cationic transport reagents) | |
KR860000065A (ko) | 국부적이고 계통적인 약물의 경피 및 전위막 침투를 증강시키는 조성물 및 방법 | |
KR840005340A (ko) | 국소용 소염조성물의 제조방법 | |
KR920001659A (ko) | 알루미늄 배선기판의 표면 처리제 | |
KR970704415A (ko) | 생분해성 4급 모발 및 피부 컨디셔너(Biodegradable Quaternary Hair and Skin Conditioners) | |
KR950005932A (ko) | 폴리 이미드 와니스 | |
KR850001801A (ko) | 안정한 액체 세제의 조성물 | |
ES2091012T3 (es) | Preparacion y utilizacion de nuevos sistemas coloidales dispersables a base de ciclodextrina, en forma de nanoesferas. | |
ES2161851T3 (es) | Formulacion de agente blanqueador fluorescente. | |
KR890017338A (ko) | 토양의 표면처리용 조성물의 용도 | |
BR9909636A (pt) | Processo para a preparação de uma formulação, e, formulação | |
KR870008906A (ko) | 마크로라이드 유도체의 제조방법 | |
KR880014090A (ko) | 연성세제 조성물 | |
KR970706732A (ko) | 엘레우테로빈 및 그의 유사체(ELEUTHEROBlN AND ANALOGS THEREOF) | |
ES2092116T3 (es) | Policarbonatos y sus usos para la preparacion de matrices bioerosionables. | |
KR870010421A (ko) | 정전하상 현상용 토우너 및 그 제조방법 | |
KR930000128A (ko) | 공기 청정제 조성물 | |
KR920702853A (ko) | 신규 글루코사민 유도체 및 이것을 막 구성성분으로서 함유한 리포솜 | |
KR920703912A (ko) | 직물처리용 활성물질의 조합 | |
KR900006355A (ko) | 신규 페로센 유도체, 그것을 함유한 계면활성제 및 유기박막의 제조방법 | |
KR960037871A (ko) | 오염물 피막을 금속 표면으로부터 제거하는 방법 | |
JPS6485941A (en) | Alcohol and ether having 3-methylbenzyl group or 3,5-dimethylbenzyl group, manufacture and perfume | |
ATE229100T1 (de) | Pellistor | |
KR850007582A (ko) | 모노아실 폴리알킬렌 폴리아민의 제조방법 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |