KR970703769A - 모르핀, 폴리피롤리돈 및 폴리알킬렌옥사이드를 함유하는 조성물(Composition Comprising Morphine,Polypyrrolidone and a Polyalkyleneoxide) - Google Patents

모르핀, 폴리피롤리돈 및 폴리알킬렌옥사이드를 함유하는 조성물(Composition Comprising Morphine,Polypyrrolidone and a Polyalkyleneoxide)

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Publication number
KR970703769A
KR970703769A KR1019960707439A KR19960707439A KR970703769A KR 970703769 A KR970703769 A KR 970703769A KR 1019960707439 A KR1019960707439 A KR 1019960707439A KR 19960707439 A KR19960707439 A KR 19960707439A KR 970703769 A KR970703769 A KR 970703769A
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South Korea
Prior art keywords
morphine
ratio
weight
composition
poly
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KR1019960707439A
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English (en)
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KR100388880B1 (ko
Inventor
소냐 메릴
아툴 데브다트 아예르
폴 황
안토니 엘. 쿠친스키
Original Assignee
스티븐 에프. 스톤
앨자 코포레이션
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Publication of KR970703769A publication Critical patent/KR970703769A/ko
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Publication of KR100388880B1 publication Critical patent/KR100388880B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

모르핀 치료용으로 모르핀 함유 조성물, 및 모르핀 함유 투여형이 개시된다. 또한 모르핀 치료용으로 이들 조성물 및 투여형의 사용 방법이 개시되고 제시된다.

Description

모르핀, 폴리피롤리돈 및 폴리알킬렌옥사이드를 함유하는 조성물(Composition Comprising Morphine,Polypyrrolidone and a Polyalkyleneoxi-de)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 모르핀 50ng내지 1,200mg,분자량 100,000내지 650,000의 폴리(알킬렌 옥사이드)5mg내지 750mg;분자량 3,000내지 350,000 의 폴리(비닐 피롤리돈)0.5mg내지 80mg;및 윤활제 0내지 7.5mg을 함유하는 치료 조성물.
  2. 제1항에 있어서, 모르핀이 모르핀 히드로브로마이드, 모르핀 히드로클로라이드, 모르핀 뮤케이트, 모르핀 메틸브로마이드, 모르핀 올레에이트, 모르핀 N- 옥사이드, 모르핀 슬페이트, 모르핀 아세테이트, 모르핀 일염기성 포스페이트, 모르핀 아세테이트 트리히드레이트, 모르핀 비(헵타플루오로부티레이트),모르핀 비(메틸카르바메이트), 모르핀 비(펜타플루오로프로피오네이트), 모르핀비(피리딘 3-카르복실레이트), 모르핀 비(트리플루오로아세테이트), 모르핀 비타르트레이트, 모르핀 클로르히드레이트, 모르핀 슬페이트 펜타히드레이트, 및 모르핀 염기로 이루어진 군으로부터 선택된 성분인 치료 조성물.
  3. 제1항에 있어서, 1/2내지 25톤의 압착력 하에서 압착된 모르핀 함유 치료 조성물.
  4. 제1항에 있어서, 중합체에 의하여 둘러 쌓인 모르핀 함유 치료 조성물.
  5. 모르핀 10내지 98중량%, 분자량 100,000내지 650,000의 폴리(알킬렌 옥사이드)10내지 80중량%, 및 폴리(비닐 피롤리돈)1내지 20중량%를 함유하는 모르핀 조성물; 및 분자량 3,000,000내지 7,500,000의 폴리(알킬렌 옥사이드)40내지 99중량%, 삼투제 0내지 80중량%, 및 분자량 7,500내지 75,000의 히드록시알킬셀룰로스 0.25 내지 25중량%를 함유하는 팽창성 조성물로 이루어진 투여형.
  6. 제5항에 있어서, 모르핀 조성물 및 팽창성 조성물이 중합체에 의해 둘러 쌓인 투여형.
  7. 제5항에 있어서, 투여형이 투여형으로부터 모르핀 조성물을 방출하는 수단을 포함하는 투여형.
  8. 제5항에 있어서, 모르핀이 모르핀 슬페이트 펜타히드레이드,모르핀 염기, 모르핀 클로르히드레이트,모르핀 비타르트레이트, 모르핀 비(트리플루오로아세테이트), 모르핀 비(펜타플루오로프로피오네이트), 모르핀 비(메틸카르보네이트), 모르핀 비(헵타플루오로부티레이트), 모르핀염, 모르핀 아세테이트 트리히드레이트, 모르핀 일염기성 포스페이트, 모르핀 아세테이트, 모르핀 N-옥사이드, 모르핀 술페이트, 모르핀 N-옥사이드, 모르핀 슬페이트, 모르핀 올레에이트, 모르핀 메틸비오마이드, 모르핀 뮤테이트, 모르핀 히드로클로라이드, 및 모르핀 히드로브로마이드로 이루어진 군으로부터 선택된 성분인 투여형.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960707439A 1994-06-27 1995-06-14 모르핀,폴리피롤리돈및폴리알킬렌옥사이드를포함하는조성물 KR100388880B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/266,075 US5460826A (en) 1994-06-27 1994-06-27 Morphine therapy
US266,075 1994-06-27

Publications (2)

Publication Number Publication Date
KR970703769A true KR970703769A (ko) 1997-08-09
KR100388880B1 KR100388880B1 (ko) 2003-09-19

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Country Status (14)

Country Link
US (3) US5460826A (ko)
EP (1) EP0767663B1 (ko)
JP (1) JPH10502086A (ko)
KR (1) KR100388880B1 (ko)
AT (1) ATE215372T1 (ko)
AU (1) AU688524B2 (ko)
CA (1) CA2186260C (ko)
DE (1) DE69526225T2 (ko)
ES (1) ES2172587T3 (ko)
FI (1) FI965203A0 (ko)
MX (1) MX9700082A (ko)
NO (1) NO311326B1 (ko)
NZ (1) NZ288509A (ko)
WO (1) WO1996000066A1 (ko)

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FI965203A (fi) 1996-12-23
NO965540L (no) 1996-12-27
FI965203A0 (fi) 1996-12-23
NO311326B1 (no) 2001-11-19
US5593695A (en) 1997-01-14
WO1996000066A1 (en) 1996-01-04
KR100388880B1 (ko) 2003-09-19
DE69526225T2 (de) 2003-01-09
US5460826A (en) 1995-10-24
AU688524B2 (en) 1998-03-12
MX9700082A (es) 1997-04-30
JPH10502086A (ja) 1998-02-24
EP0767663B1 (en) 2002-04-03
ES2172587T3 (es) 2002-10-01
NO965540D0 (no) 1996-12-23
CA2186260A1 (en) 1996-01-04
DE69526225D1 (de) 2002-05-08
CA2186260C (en) 2007-07-31
AU2776195A (en) 1996-01-19
US5667805A (en) 1997-09-16
NZ288509A (en) 1998-07-28
ATE215372T1 (de) 2002-04-15

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