KR970042509A - Method for preparing 2,6-dichloro-5-fluoronicotinic acid - Google Patents

Method for preparing 2,6-dichloro-5-fluoronicotinic acid Download PDF

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Publication number
KR970042509A
KR970042509A KR1019950058700A KR19950058700A KR970042509A KR 970042509 A KR970042509 A KR 970042509A KR 1019950058700 A KR1019950058700 A KR 1019950058700A KR 19950058700 A KR19950058700 A KR 19950058700A KR 970042509 A KR970042509 A KR 970042509A
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South Korea
Prior art keywords
compound
sulfuric acid
concentrated sulfuric
preparing
water
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KR1019950058700A
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Korean (ko)
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KR0177618B1 (en
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최훈
김세호
장재혁
남두현
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성재갑
주식회사 엘지화학(Chemical Ltd.)
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Priority to KR1019950058700A priority Critical patent/KR0177618B1/en
Publication of KR970042509A publication Critical patent/KR970042509A/en
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Publication of KR0177618B1 publication Critical patent/KR0177618B1/en

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Abstract

본 발명은 구조식(1)의 화합물을 진한 황산과 물로 처리하여 가수분해시킴을 특징으로 하여 1,8-나프티리딘퀴놀론계 항생제의 제조시에 중간체로 유용한 구조식(2)의 화합물을 간편하게 부산물이 없이 고수율로 제조하는 방법에 관한 것이다.The present invention is characterized in that the compound of formula (1) is hydrolyzed by treatment with concentrated sulfuric acid and water, so that the compound of formula (2), which is useful as an intermediate in the preparation of 1,8-naphthyridinequinolone antibiotics, is simply free of by-products. It relates to a process for producing in high yield.

Description

2, 6-디클로로-5-플루오로니코틴산의 제조방법Method for preparing 2,6-dichloro-5-fluoronicotinic acid

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

구조식(1)의 화합물을 진한 황산과 물로 처리하여 가수분해시킴을 특징으로 하여 구조식(2)의 화합물을 제조하는 방법 :Process for preparing a compound of formula (2) characterized in that the compound of formula (1) is hydrolyzed by treatment with concentrated sulfuric acid and water: 제1항에 있어서, 진한 황산을 화합물(1) 1 당량에 대해 3 내지 4 당량의 비로 사용하고, 물은 진한 황산에 대해 부피를 기준으로 1 내지 3배의 양으로 사용함을 특징으로 하는 방법.The method of claim 1, wherein concentrated sulfuric acid is used in a ratio of 3 to 4 equivalents to 1 equivalent of compound (1), and water is used in an amount of 1 to 3 times by volume based on the volume of concentrated sulfuric acid. 제2항에 있어서, 진한 황산을 화합물(1) 1 당량에 대해 3 내지 4 당량의 비로 사용하고, 물은 진한 황산에 대해 부피를 기준으로 1.5 내지 2 배의 양으로 사용함을 특징으로 하는 방법.3. The process of claim 2, wherein concentrated sulfuric acid is used in a ratio of 3 to 4 equivalents to 1 equivalent of compound (1), and water is used in an amount of 1.5 to 2 times by volume relative to concentrated sulfuric acid. 제1항에 있어서, 물의 첨가시 반응용액의 내부온도를 30 내지 70℃로 유지시킴을 특징으로 하는 방법.The method of claim 1, wherein the internal temperature of the reaction solution is maintained at 30 to 70 ° C. upon addition of water.
KR1019950058700A 1995-12-27 1995-12-27 Process for preparation of 2,6-dichloro-5-fluoronicotinic acid KR0177618B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950058700A KR0177618B1 (en) 1995-12-27 1995-12-27 Process for preparation of 2,6-dichloro-5-fluoronicotinic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950058700A KR0177618B1 (en) 1995-12-27 1995-12-27 Process for preparation of 2,6-dichloro-5-fluoronicotinic acid

Publications (2)

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KR970042509A true KR970042509A (en) 1997-07-24
KR0177618B1 KR0177618B1 (en) 1999-03-20

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KR1019950058700A KR0177618B1 (en) 1995-12-27 1995-12-27 Process for preparation of 2,6-dichloro-5-fluoronicotinic acid

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KR0177618B1 (en) 1999-03-20

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