KR960705565A - 테르페나딘과 이부프로펜의 안정한 약제학적 조성물(A stable pharmaceuitical composition of terfenadine and ibuprofen) - Google Patents

테르페나딘과 이부프로펜의 안정한 약제학적 조성물(A stable pharmaceuitical composition of terfenadine and ibuprofen)

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Publication number
KR960705565A
KR960705565A KR1019960702078A KR19960702078A KR960705565A KR 960705565 A KR960705565 A KR 960705565A KR 1019960702078 A KR1019960702078 A KR 1019960702078A KR 19960702078 A KR19960702078 A KR 19960702078A KR 960705565 A KR960705565 A KR 960705565A
Authority
KR
South Korea
Prior art keywords
terfenadine
pharmaceutical composition
pct
ibuprofen
carboxylic acid
Prior art date
Application number
KR1019960702078A
Other languages
English (en)
Other versions
KR100338877B1 (ko
Inventor
디. 어텔 케이쓰
롱 데이빗 에프
Original Assignee
게리 디. 스트리트
메렐 파마슈티칼즈 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 게리 디. 스트리트, 메렐 파마슈티칼즈 인코포레이티드 filed Critical 게리 디. 스트리트
Publication of KR960705565A publication Critical patent/KR960705565A/ko
Application granted granted Critical
Publication of KR100338877B1 publication Critical patent/KR100338877B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)

Abstract

본 발명은 테르페나딘과 함께 이부프로펜을 함유하고, 테르페나딘이 테르페나돈으로 산화되는 것은 조성물 내에 α-하이드록시 카복실산이 존재함으로써 방지되는, 화학적으로 안정한 약제학적 조성물에 관한 것이다.

Description

테르페나딘과 이부프로펜의 안정한 약제학적 조성물(A stable pharmaceutical composition of terfenadine and ibuprofen)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. a) 진통제로서 치료학적으로 유효한 양의 이부프로펜 또는 약제학적으로 허용되는 이의 염; b) 항히스타민제로서 치료학적으로 유효한 양의 테르페나딘 또는 약제학적으로 허용되는 이의 염; 및 c) α-하이드록시 카복실산을 함유하는 화학적으로 안정한 약제학적 조성물.
  2. 제1항에 있어서, 카복실산이 디카복실산인 약제학적 조성물.
  3. 제1항에 있어서, 카복실산이 타르타르산인 약제학적 조성물.
  4. 제1항에 있어서, 카복실산이 타르트론산인 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960702078A 1993-10-25 1994-09-28 테르페나딘과이부프로펜의안정한약제학적조성물 KR100338877B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14252893A 1993-10-25 1993-10-25
US08/142,528 1993-10-25
US08/142528 1993-10-25
PCT/US1994/010972 WO1995011677A1 (en) 1993-10-25 1994-09-28 A stable pharmaceutical composition of terfenadine and ibuprofen

Publications (2)

Publication Number Publication Date
KR960705565A true KR960705565A (ko) 1996-11-08
KR100338877B1 KR100338877B1 (ko) 2002-12-05

Family

ID=22500192

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960702078A KR100338877B1 (ko) 1993-10-25 1994-09-28 테르페나딘과이부프로펜의안정한약제학적조성물

Country Status (18)

Country Link
US (1) US5691352A (ko)
EP (1) EP0725639B1 (ko)
JP (1) JPH09509138A (ko)
KR (1) KR100338877B1 (ko)
CN (1) CN1060040C (ko)
AT (1) ATE197544T1 (ko)
AU (1) AU683093B2 (ko)
CA (1) CA2173467A1 (ko)
DE (1) DE69426306T2 (ko)
DK (1) DK0725639T3 (ko)
ES (1) ES2153863T3 (ko)
FI (1) FI117000B (ko)
GR (1) GR3035384T3 (ko)
HU (1) HU222887B1 (ko)
NO (1) NO308773B1 (ko)
NZ (1) NZ274423A (ko)
PT (1) PT725639E (ko)
WO (1) WO1995011677A1 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2134743B1 (es) * 1998-02-06 2000-05-01 Biocosmetics Sl Composicion para el tratamiento de la halitosis.
US5962488A (en) * 1998-04-08 1999-10-05 Roberts Laboratories, Inc. Stable pharmaceutical formulations for treating internal bowel syndrome containing isoxazole derivatives
CL2003002653A1 (es) * 2002-12-18 2005-04-22 Wyeth Corp Composicion farmaceutica que comprende (a) un antiinflamatorio no esteroidal (nsaid), preferentemente ibuprofeno, (b) un descongestionante, preferentemente pseudoefedrina y (c) un antihistaminico, preferentemente clorfeniramina; metodo para su prepar
CN101417131B (zh) * 2007-10-22 2010-11-10 鲁南制药集团股份有限公司 一种用于治疗皮肤过敏性疾病的外用药物组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4285957A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4783465A (en) * 1984-04-09 1988-11-08 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
US4999226A (en) * 1988-06-01 1991-03-12 Merrell Dow Pharmaceuticals Inc. Pharmaceutical compositions for piperidinoalkanol-ibuprofen combination
CA2092566A1 (en) * 1990-09-28 1992-03-29 Thomas N. Gates Ibuprofen-antihistamine combinations
US5512300A (en) * 1992-09-15 1996-04-30 Warner-Lambert Company Prevention of ibuprofen from forming low melting eutectics with other therapeutic agents in solid dosage forms

Also Published As

Publication number Publication date
ATE197544T1 (de) 2000-12-15
CN1060040C (zh) 2001-01-03
PT725639E (pt) 2001-02-28
HU222887B1 (hu) 2003-12-29
HUT74577A (en) 1997-01-28
NZ274423A (en) 1997-10-24
AU7845694A (en) 1995-05-22
WO1995011677A1 (en) 1995-05-04
JPH09509138A (ja) 1997-09-16
CA2173467A1 (en) 1995-05-04
DK0725639T3 (da) 2000-12-11
HU9601074D0 (en) 1996-06-28
DE69426306T2 (de) 2001-06-07
ES2153863T3 (es) 2001-03-16
CN1133560A (zh) 1996-10-16
US5691352A (en) 1997-11-25
FI961756A (fi) 1996-04-24
KR100338877B1 (ko) 2002-12-05
FI961756A0 (fi) 1996-04-24
EP0725639B1 (en) 2000-11-15
NO961640D0 (no) 1996-04-24
NO961640L (no) 1996-04-24
NO308773B1 (no) 2000-10-30
EP0725639A1 (en) 1996-08-14
DE69426306D1 (de) 2000-12-21
GR3035384T3 (en) 2001-05-31
AU683093B2 (en) 1997-10-30
FI117000B (fi) 2006-05-15

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