KR960705565A - 테르페나딘과 이부프로펜의 안정한 약제학적 조성물(A stable pharmaceuitical composition of terfenadine and ibuprofen) - Google Patents
테르페나딘과 이부프로펜의 안정한 약제학적 조성물(A stable pharmaceuitical composition of terfenadine and ibuprofen)Info
- Publication number
- KR960705565A KR960705565A KR1019960702078A KR19960702078A KR960705565A KR 960705565 A KR960705565 A KR 960705565A KR 1019960702078 A KR1019960702078 A KR 1019960702078A KR 19960702078 A KR19960702078 A KR 19960702078A KR 960705565 A KR960705565 A KR 960705565A
- Authority
- KR
- South Korea
- Prior art keywords
- terfenadine
- pharmaceutical composition
- pct
- ibuprofen
- carboxylic acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
Abstract
본 발명은 테르페나딘과 함께 이부프로펜을 함유하고, 테르페나딘이 테르페나돈으로 산화되는 것은 조성물 내에 α-하이드록시 카복실산이 존재함으로써 방지되는, 화학적으로 안정한 약제학적 조성물에 관한 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- a) 진통제로서 치료학적으로 유효한 양의 이부프로펜 또는 약제학적으로 허용되는 이의 염; b) 항히스타민제로서 치료학적으로 유효한 양의 테르페나딘 또는 약제학적으로 허용되는 이의 염; 및 c) α-하이드록시 카복실산을 함유하는 화학적으로 안정한 약제학적 조성물.
- 제1항에 있어서, 카복실산이 디카복실산인 약제학적 조성물.
- 제1항에 있어서, 카복실산이 타르타르산인 약제학적 조성물.
- 제1항에 있어서, 카복실산이 타르트론산인 약제학적 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14252893A | 1993-10-25 | 1993-10-25 | |
US08/142,528 | 1993-10-25 | ||
US08/142528 | 1993-10-25 | ||
PCT/US1994/010972 WO1995011677A1 (en) | 1993-10-25 | 1994-09-28 | A stable pharmaceutical composition of terfenadine and ibuprofen |
Publications (2)
Publication Number | Publication Date |
---|---|
KR960705565A true KR960705565A (ko) | 1996-11-08 |
KR100338877B1 KR100338877B1 (ko) | 2002-12-05 |
Family
ID=22500192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019960702078A KR100338877B1 (ko) | 1993-10-25 | 1994-09-28 | 테르페나딘과이부프로펜의안정한약제학적조성물 |
Country Status (18)
Country | Link |
---|---|
US (1) | US5691352A (ko) |
EP (1) | EP0725639B1 (ko) |
JP (1) | JPH09509138A (ko) |
KR (1) | KR100338877B1 (ko) |
CN (1) | CN1060040C (ko) |
AT (1) | ATE197544T1 (ko) |
AU (1) | AU683093B2 (ko) |
CA (1) | CA2173467A1 (ko) |
DE (1) | DE69426306T2 (ko) |
DK (1) | DK0725639T3 (ko) |
ES (1) | ES2153863T3 (ko) |
FI (1) | FI117000B (ko) |
GR (1) | GR3035384T3 (ko) |
HU (1) | HU222887B1 (ko) |
NO (1) | NO308773B1 (ko) |
NZ (1) | NZ274423A (ko) |
PT (1) | PT725639E (ko) |
WO (1) | WO1995011677A1 (ko) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2134743B1 (es) * | 1998-02-06 | 2000-05-01 | Biocosmetics Sl | Composicion para el tratamiento de la halitosis. |
US5962488A (en) * | 1998-04-08 | 1999-10-05 | Roberts Laboratories, Inc. | Stable pharmaceutical formulations for treating internal bowel syndrome containing isoxazole derivatives |
CL2003002653A1 (es) * | 2002-12-18 | 2005-04-22 | Wyeth Corp | Composicion farmaceutica que comprende (a) un antiinflamatorio no esteroidal (nsaid), preferentemente ibuprofeno, (b) un descongestionante, preferentemente pseudoefedrina y (c) un antihistaminico, preferentemente clorfeniramina; metodo para su prepar |
CN101417131B (zh) * | 2007-10-22 | 2010-11-10 | 鲁南制药集团股份有限公司 | 一种用于治疗皮肤过敏性疾病的外用药物组合物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4285957A (en) * | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof |
US4254129A (en) * | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
US4783465A (en) * | 1984-04-09 | 1988-11-08 | Analgesic Associates | Cough/cold mixtures comprising non-sedating antihistamine drugs |
US4999226A (en) * | 1988-06-01 | 1991-03-12 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical compositions for piperidinoalkanol-ibuprofen combination |
CA2092566A1 (en) * | 1990-09-28 | 1992-03-29 | Thomas N. Gates | Ibuprofen-antihistamine combinations |
US5512300A (en) * | 1992-09-15 | 1996-04-30 | Warner-Lambert Company | Prevention of ibuprofen from forming low melting eutectics with other therapeutic agents in solid dosage forms |
-
1994
- 1994-09-28 EP EP94929374A patent/EP0725639B1/en not_active Expired - Lifetime
- 1994-09-28 DE DE69426306T patent/DE69426306T2/de not_active Expired - Lifetime
- 1994-09-28 ES ES94929374T patent/ES2153863T3/es not_active Expired - Lifetime
- 1994-09-28 NZ NZ274423A patent/NZ274423A/en not_active IP Right Cessation
- 1994-09-28 US US08/624,362 patent/US5691352A/en not_active Expired - Lifetime
- 1994-09-28 KR KR1019960702078A patent/KR100338877B1/ko not_active IP Right Cessation
- 1994-09-28 CA CA002173467A patent/CA2173467A1/en not_active Withdrawn
- 1994-09-28 WO PCT/US1994/010972 patent/WO1995011677A1/en active IP Right Grant
- 1994-09-28 DK DK94929374T patent/DK0725639T3/da active
- 1994-09-28 AT AT94929374T patent/ATE197544T1/de active
- 1994-09-28 CN CN94193911A patent/CN1060040C/zh not_active Expired - Lifetime
- 1994-09-28 AU AU78456/94A patent/AU683093B2/en not_active Expired
- 1994-09-28 PT PT94929374T patent/PT725639E/pt unknown
- 1994-09-28 HU HU9601074A patent/HU222887B1/hu active IP Right Grant
- 1994-09-28 JP JP7512634A patent/JPH09509138A/ja not_active Ceased
-
1996
- 1996-04-24 NO NO961640A patent/NO308773B1/no not_active IP Right Cessation
- 1996-04-24 FI FI961756A patent/FI117000B/fi not_active IP Right Cessation
-
2001
- 2001-02-07 GR GR20010400211T patent/GR3035384T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE197544T1 (de) | 2000-12-15 |
CN1060040C (zh) | 2001-01-03 |
PT725639E (pt) | 2001-02-28 |
HU222887B1 (hu) | 2003-12-29 |
HUT74577A (en) | 1997-01-28 |
NZ274423A (en) | 1997-10-24 |
AU7845694A (en) | 1995-05-22 |
WO1995011677A1 (en) | 1995-05-04 |
JPH09509138A (ja) | 1997-09-16 |
CA2173467A1 (en) | 1995-05-04 |
DK0725639T3 (da) | 2000-12-11 |
HU9601074D0 (en) | 1996-06-28 |
DE69426306T2 (de) | 2001-06-07 |
ES2153863T3 (es) | 2001-03-16 |
CN1133560A (zh) | 1996-10-16 |
US5691352A (en) | 1997-11-25 |
FI961756A (fi) | 1996-04-24 |
KR100338877B1 (ko) | 2002-12-05 |
FI961756A0 (fi) | 1996-04-24 |
EP0725639B1 (en) | 2000-11-15 |
NO961640D0 (no) | 1996-04-24 |
NO961640L (no) | 1996-04-24 |
NO308773B1 (no) | 2000-10-30 |
EP0725639A1 (en) | 1996-08-14 |
DE69426306D1 (de) | 2000-12-21 |
GR3035384T3 (en) | 2001-05-31 |
AU683093B2 (en) | 1997-10-30 |
FI117000B (fi) | 2006-05-15 |
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