KR960703927A - It-62-b 물질 및 이를 함유하는 의약조성물 - Google Patents

It-62-b 물질 및 이를 함유하는 의약조성물

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Publication number
KR960703927A
KR960703927A KR1019960700855A KR19960700855A KR960703927A KR 960703927 A KR960703927 A KR 960703927A KR 1019960700855 A KR1019960700855 A KR 1019960700855A KR 19960700855 A KR19960700855 A KR 19960700855A KR 960703927 A KR960703927 A KR 960703927A
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KR
South Korea
Prior art keywords
substance
same
medicament
effective amount
administering
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KR1019960700855A
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English (en)
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KR0173195B1 (ko
Inventor
타카시 가와우치
토루 사사키
히로시 마츠모토
토시오 오타니
루시안 첸
밍유 황
켄이치로 요시다
Original Assignee
고바야시 유키오
다이호 야쿠힌 고교 가부시키가이샤
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Publication of KR960703927A publication Critical patent/KR960703927A/ko
Application granted granted Critical
Publication of KR0173195B1 publication Critical patent/KR0173195B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

하기 식(Ⅰ)
로 표시되는 IT-62-B 물질, 그의 생상 방법, 이 물질을 유효성분으로 함유하는 의약조성물, 이와 같은 물질을 투여함으로써 박테리아 원인 전염병 및 종양의 치료방법.
본 발명에 따른 화합물은 그램양성균 및 일부의 그램음성균에 대해 양호한 항균작용을 가지며, 사람 비인강암과 같은 종양에 대해 우수한 항종양 작용을 가지므로 의약으로서 유용하다.

Description

IT-62-B 물질 및 이를 함유하는 의약조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 하기 식(Ⅰ)으로 표시되는 IT-62-B 물질
  2. IT-62주 또는 변이주 등의스트렙토마이세스속에 속하고, 제 1항 기재의 IT-62-B 물질 생산능을 갖는 미생물을 배지에서 배양하여 배양액에 제 1항에 따른 IT-62-B 물질을 축적하고, IT-62-B 물질을 분리함을 특징으로 하는 제 1항 기재의 IT-62-B 물질의 생산방법.
  3. IT-62-B 물질을 제조하는 제 2항에 있어서, 미생물이스트렙토마이세스에스 피. IT-62주 또는 그의 변이주인 것이 특징인 방법.
  4. IT-62-B 물질을 유효성분으로 함유하는 약제.
  5. 제 4항에 있어서, 약제가 박테리아 감염증 또는 종양 치료제인 약제.
  6. 제 1항의 IT-62-B 물질의 유효량과 약학적으로 허용되는 담체로 구성된 의약 조성물.
  7. 제 6항에 있어서, 박테리아 감염증 및 종양의 치료에 사용되기에 적합한 의약 조성물.
  8. 제 1항의 IT-62-B 물질의 유효량을 환자에게 투여함을 특징으로 하는 박테리아 감염증의 치료방법.
  9. 제 1항의 IT-62-B 물질의 유효량을 환자에게 투여함을 특징으로 하는 종양의 치료방법.
  10. 제 1항의 IT-62-B 물질의 약제로서의 사용.
  11. 제10항에 있어서, 약제가 박테리아 감염증 또는 종양 치료제인 것이 특징인 약제로서의 사용.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960700855A 1994-07-14 1995-07-12 It-62-b 물질 및 이를 함유하는 의약조성물 KR0173195B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP16203794 1994-07-14
JP162037/1994 1994-07-14
PCT/JP1995/001384 WO1996002659A1 (fr) 1994-07-14 1995-07-12 Substance it-62-b et composition medicinale la contenant

Publications (2)

Publication Number Publication Date
KR960703927A true KR960703927A (ko) 1996-08-31
KR0173195B1 KR0173195B1 (ko) 1999-02-01

Family

ID=15746887

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960700855A KR0173195B1 (ko) 1994-07-14 1995-07-12 It-62-b 물질 및 이를 함유하는 의약조성물

Country Status (10)

Country Link
US (1) US5698528A (ko)
EP (1) EP0721985B1 (ko)
JP (1) JP2748048B2 (ko)
KR (1) KR0173195B1 (ko)
CN (1) CN1059678C (ko)
AT (1) ATE196929T1 (ko)
AU (1) AU674115B2 (ko)
CA (1) CA2171116C (ko)
DE (1) DE69519084T2 (ko)
WO (1) WO1996002659A1 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69636652T2 (de) * 1995-02-14 2007-10-04 Kao Corp. Die verwendung von biologisch abbaubaren schmier-grundöl
AU2343900A (en) 1998-11-02 2000-05-22 Board Of Regents, The University Of Texas System Methods and compositions for the manufacture of highly potent anthracycline-based antitumor agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6133194A (ja) * 1984-07-25 1986-02-17 Sanraku Inc 新規アントラサイクリン抗生物質
JPS62238298A (ja) * 1986-04-08 1987-10-19 Sanraku Inc 新規アントラサイクリン抗生物質ｄｃｐ−１及び２
JP2779652B2 (ja) * 1988-12-27 1998-07-23 武田薬品工業株式会社 生理活性物質ｔａｎ―１１２０，その還元体，それらの製造法および用途ならびに微生物

Also Published As

Publication number Publication date
WO1996002659A1 (fr) 1996-02-01
KR0173195B1 (ko) 1999-02-01
JP2748048B2 (ja) 1998-05-06
EP0721985A4 (en) 1998-08-26
AU674115B2 (en) 1996-12-05
ATE196929T1 (de) 2000-10-15
DE69519084D1 (de) 2000-11-16
CA2171116C (en) 1999-02-23
EP0721985A1 (en) 1996-07-17
US5698528A (en) 1997-12-16
DE69519084T2 (de) 2001-05-10
CN1127300A (zh) 1996-07-24
CA2171116A1 (en) 1996-02-01
AU2935995A (en) 1996-02-16
CN1059678C (zh) 2000-12-20
EP0721985B1 (en) 2000-10-11

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