KR960029790A - 면역크로마토그래피 스트립 상에서의 분석물의 정량적 측정방법 - Google Patents

면역크로마토그래피 스트립 상에서의 분석물의 정량적 측정방법 Download PDF

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KR960029790A
KR960029790A KR1019960001777A KR19960001777A KR960029790A KR 960029790 A KR960029790 A KR 960029790A KR 1019960001777 A KR1019960001777 A KR 1019960001777A KR 19960001777 A KR19960001777 A KR 19960001777A KR 960029790 A KR960029790 A KR 960029790A
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지. 솜머 로날드
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프랭클린 이. 브렉켄릿지
바이엘 코포레이션
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
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Abstract

포획된 분석물／표지된 결합 파트너 복합체로부터의 시그날을 장치적 수단, 예를 들면, 방사 분광광도계에 의해 정량적으로 측정함을 포함하여, 면역크로마토그래피 기술에 의해 시험 유체중의 분석물 농도를 측정하는 개선된 방법이 기술되어 있다. 바람직한 양태에 있어, 반사 판독은 면역크로마토그래피 스트립의 별개 영역중에 포획된 비복합체화된 표지된 결합 파트너와 포획된 복합체에 대해 측정하고, 이들 반사치의 비를 사용하여 검정 방법에 대해 부가적 정량화가 이루어진다.

Description

면역크로마토그래피 스트립 상에서의 분석물의 정량적 측정방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제3도는 본 발명의 또다른 양태의 면역크로마토그래피 스트립을 나타내는 도면이다.

Claims (17)

  1. 검출영역에서 스그날을 측정할 수 있는 검출기가 있는 장치를 사용하여 표지로부터의 시그날을 측정함을 특징으로 하여, 유체를 면역크로마토그래피 매트릭스[여기서, 매트릭스는 분석물에 대한 표지된 결합 파트너를 함유하고, 표지된 결합 파트너가 함유하고 있는 표지를 검출함으로써 분석물이 검출되는 검출영역 하나 이상을 함유한다]에 적용시킴으로써 유체 시험 샘플이 모세관 현상에 의해 매트릭스를 따라 흐르게 하여 유체 시험 샘플중의 분석물을 측정하는 방법.
  2. a) 검출가능한 표지를 함유하고 분석물과 반응함으로써 분석물／표지된 결합 파트너 복합체를 형성할 수 있는, 분석물에 대한 이동성 특이적 결합 파트너를 함유하는 제1영역과, 고정된 분석물 또는 이의 동족체를 함유하는 하나 이상의 제2영역으로 이루어지는, 모세관 현상에 의해 유체 시험 샘플이 흐를 수 있는 매트릭스를 포함하는 시험 스트립을 제공하는 단계; b) 분석물을 함유하는 것으로 추정되는 유체 시험 샘플을 스트립에 적용시킴으로써 분석물이 이에 대한 이동성, 표지된 특이적 결합 파트너와 접촉하게 하여 유체 시험 샘플 중에 존재하는 분석물이 좀더 반응할 수 있는 과량의 비반응된 결합 파트너를 남겨 둔채 표지된 특이적 결합 파트너와 결합하여 복합체를 형성시키고, 유체 시험 샘플이 분석물／표지된 결합 파트너 복합체와 비반응된 표지된 결합 파트너를 모세관 현상에 의해 고정된 분석물 또는 이의 동족체를 함유하는 제2영역으로 스트립을 따라 운반시켜 여기서 비반응된 표지된 결합 파트너가 고정된 분석물과 유체 시험 샘플 중의 분석물 농도까지 역관계로 결합하도록 스트립을 전개시키는 단계; c) 검출가능한 표지로부터의 시그날을 측정할 수 있는 검출기를 갖는 장치 상에서 전개된 스트립을 판독하여 제2영역중의 표지된 결합 파트너의 농도를 측정하는 단계; 및 d) 단계 c)에서 측정된 검출가능한 표지로부터의 시그날을 공지된 농도의 분석물을 함유하는 유체 샘플을 사용하여 유사한 방식으로 작성된 시그날 측정치와 비교함으로써 유체 시험 샘플중의 분석물 농도를 측정하는 단계들을 포함하여, 유체 시험 샘플중의 분석물 하나 이상의 농도를 측정하는 방법.
  3. 제2항에 있어서, 분석물과 표지된 결합 파트너 사이에 형성된 복합체를 고정화시키고 제3영역내에 고정된 검출가능한 표지로부터의 시그날을 측정하기 위한 수단을 함유하는 스트립의 제3영역이 존재하여, 제2영역중에 고정화된 표지된 결합 파트너와 제3영역중에 고정된 복합체로부터의 시그날의 비를 측정하는 방법.
  4. 제2항에 있어서, 장치가 스트립 또는 검출기를 서로에 대해 이동시키기 위한 수단을 함유하여, 장치상에 정밀하게 위치하지 않을 수 있는 영역에 대해 정확한 정량화가 이루어지게 하는 방법.
  5. 제2항에 있어서, 스트립 상의 동일하거나 상이한 영역내에 둘 이상의 이동성 표지된 결합 파트너 및 고정된 분석물 또는 이의 동촉체를 함유하는 둘 이상의 영역의 존재함으로써, 둘 이상의 분석물이 단일 시험으로 측정될 수 있는 방법.
  6. 제2항에 있어서, 장치가 반사 분광광도계인 방법.
  7. 제2항에 있어서, 매트릭스가 비－흡수성 측위 유동성인 재료 또는 흡수성 재료로 구성되는 방법.
  8. 제2항에 있어서, 분석물이 사람 혈청 알부민(HSA)인 방법.
  9. 제2항에 있어서, 검출 가능한 표지가 발색중인 방법.
  10. 제9항에 있어서, 발색종이 골드 졸인 방법.
  11. 제2항에 있어서, 표지된 결합 파트너가 항체인 방법.
  12. a) 검출가능한 표지를 함유하고 분석물과 반응함으로써 분석물／표지된 결합 파트너 복합체를 형성할 수 있는, 분석물에 대한 이동성 특이적 결합 파트너를 함유하는 제1영역과, 고정된 분성물 또는 이의 동족체를 함유하는 하나 이상의 제2영역 및 분석물과 표지된 결합 파트너 사이에 형성된 복합체를 고정화시키기 위한 수단을 함유하는 하나 이상의 제3영역으로 이루어지는, 모세관 현상에 의해 유체 시험 샘플이 흐를 수 있는 매트릭스를 포함하는 시험 스트립을 제공하는 단계; b) 분석물을 함유하는 것으로 추정되는 유체 시험 샘플을 스트립에 적용시킴으로써 분석물이 이에 대한 이동성, 특이적 결합 파트너와 접촉하게 하여 유체 시험 샘플 중에 존재하는 분석물이 좀더 반응할 수 있는 과량의 비반응된 결합 파트너를 남겨 둔채 표지된 특이적 결합 파트너와 결합하여 복합체를 형성시키고, 유체 시험 샘플이 분석물／표지된 결합 파트너 복합체와 비반응된 표지된 결합 파트너를 모세관 현상에 의해 스트립을 따라 고정된 분석물 또는 이의 동족체를 함유하는 제2영역으로 운반시켜 여기서 비반응된 표지된 결합 파트너를 고정된 분석물과 유체 시험 샘플 중의 분석물 농도까지 역관계로 결합시키고, 분석물／표지된 결합 파트너 복합체를 모세관 현상에 의해 제3영역까지 운반시켜 여기서 고정화 수단에 의해 포획될 수 있도록 스트립을 전개시키는 단계; c) 검출가능한 표지로부터의 시그날을 측정할 수 있는 검출기를 갖는 장치 상에서 전개된 스트립의 제2영역을 판독하여 제2영역중의 표지된 결합 파트너의 농도를 측정하고 유사한 방식으로 전개된 스트립의 제3영역을 판독하여 스트립의 제3영역중의 표지된 결합 파트너로부터의 시그날을 측정하는 단계; 및 d) 제2영역중에 고정된 표지된 결합 파트너로부터의 시그날과 제3영역중의 표지된 결합 파트너로부터의 시그날의 비를 측정하는 단계; 및 e) 단계 c)에서 측정된 스그날과 공지된 농도의 분석물을 함유하는 유체 샘플을 사용하여 유사한 방식으로 측정된 스그날비의 측정치를 비교함으로써 유체 시험 샘플중의 분석물 농도를 측정하는 단계들을 포함하여, 유체 시험 샘플중의 분석물 하나 이상의 농도를 정량적으로 측정하는 방법.
  13. 제12항에 있어서, 측정 장치가 반사 분광광도계인 방법.
  14. 제12항에 있어서, 매트릭스가 비－흡수성 측위 유동성인 재료 또는 흡수성 재료로 구성되는 방법.
  15. 제12항에 있어서, 분석물이 사람 혈청 알부민(HSA)인 방법.
  16. 제12항에 있어서, 검출 가능한 표지가 골드 졸인 방법.
  17. 제12항에 있어서, 표지된 결합 파트너가 항체인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960001777A 1995-01-30 1996-01-27 면역크로마토그래피 스트립 상에서의 분석물의 정량적 측정방법 KR960029790A (ko)

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US08/380,119 US5569608A (en) 1995-01-30 1995-01-30 Quantitative detection of analytes on immunochromatographic strips
US08/380,119 1995-01-30

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KR960029790A true KR960029790A (ko) 1996-08-17

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US (1) US5569608A (ko)
EP (1) EP0724157A2 (ko)
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CN (1) CN1146557A (ko)
AU (1) AU4222696A (ko)
CA (1) CA2166913A1 (ko)
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Families Citing this family (136)

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Publication number Priority date Publication date Assignee Title
DE69219686T2 (de) * 1991-07-29 1997-09-11 Mochida Pharm Co Ltd Verfahren und Vorrichtung zur Verwendung in spezifischen Bindungstests
US7635597B2 (en) * 1995-08-09 2009-12-22 Bayer Healthcare Llc Dry reagent particle assay and device having multiple test zones and method therefor
US5945345A (en) * 1996-08-27 1999-08-31 Metrika, Inc. Device for preventing assay interference using silver or lead to remove the interferant
US6001658A (en) * 1996-09-13 1999-12-14 Diagnostic Chemicals Limited Test strip apparatus and method for determining presence of analyte in a fluid sample
US6194221B1 (en) * 1996-11-19 2001-02-27 Wyntek Diagnostics, Inc. Hybrid one-step immunochromatographic device and method of use
US5879951A (en) 1997-01-29 1999-03-09 Smithkline Diagnostics, Inc. Opposable-element assay device employing unidirectional flow
US5939252A (en) 1997-05-09 1999-08-17 Lennon; Donald J. Detachable-element assay device
EP1473565B1 (en) * 1997-07-16 2010-08-25 Charm Sciences Inc. A test device and method for detecting the presence of a residue analyte in a sample
US6436721B1 (en) * 1997-07-25 2002-08-20 Bayer Corporation Device and method for obtaining clinically significant analyte ratios
US6437563B1 (en) * 1997-11-21 2002-08-20 Quantum Design, Inc. Method and apparatus for making measurements of accumulations of magnetically susceptible particles combined with analytes
US8071384B2 (en) 1997-12-22 2011-12-06 Roche Diagnostics Operations, Inc. Control and calibration solutions and methods for their use
US7713703B1 (en) 2000-11-13 2010-05-11 Biosite, Inc. Methods for monitoring the status of assays and immunoassays
US6194222B1 (en) * 1998-01-05 2001-02-27 Biosite Diagnostics, Inc. Methods for monitoring the status of assays and immunoassays
EP1086372B1 (en) 1998-03-30 2006-05-31 OraSure Technologies, Inc. Collection device for single step assay of oral fluids
US8062908B2 (en) * 1999-03-29 2011-11-22 Orasure Technologies, Inc. Device for collection and assay of oral fluids
US6303081B1 (en) * 1998-03-30 2001-10-16 Orasure Technologies, Inc. Device for collection and assay of oral fluids
US6183972B1 (en) * 1998-07-27 2001-02-06 Bayer Corporation Method for the determination of analyte concentration in a lateral flow sandwich immunoassay exhibiting high-dose hook effect
US6475743B1 (en) 1998-10-02 2002-11-05 Ischemia Technologies, Inc. Marker useful for detection and measurement of free radical damage and method
US7070937B1 (en) 1998-10-02 2006-07-04 Ischemia Technologies, Inc. Marker useful for detection and measurement of free radical damage and method
US20030215952A1 (en) * 1998-10-02 2003-11-20 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US20030215359A1 (en) * 1998-10-02 2003-11-20 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US20050142613A1 (en) * 1998-10-02 2005-06-30 David Bar-Or Test for the rapid evaluation of ischemic states and kits
US7449338B2 (en) * 1998-10-02 2008-11-11 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
AUPP713498A0 (en) * 1998-11-17 1998-12-10 Chandler, Howard Milne A method of detecting blood
US6136610A (en) 1998-11-23 2000-10-24 Praxsys Biosystems, Inc. Method and apparatus for performing a lateral flow assay
US6773671B1 (en) 1998-11-30 2004-08-10 Abbott Laboratories Multichemistry measuring device and test strips
WO2000033072A2 (en) 1998-11-30 2000-06-08 Abbott Laboratories Analyte test instrument having improved calibration and communication processes
US7148016B1 (en) * 1999-01-14 2006-12-12 Ca*Tx Inc. Immunoassays to detect diseases or disease susceptibility traits
FR2788856B1 (fr) * 1999-01-21 2001-07-13 Adiatec Sa Dispositif de test et procede pour la quantification de resultats obtenus par des methodes immunochromatographiques
JP2000321277A (ja) * 1999-05-13 2000-11-24 Matsushita Electric Ind Co Ltd クロマト定量測定装置
JP4402263B2 (ja) 1999-06-21 2010-01-20 パナソニック株式会社 クロマトグラフィー定量測定装置
US20050103624A1 (en) 1999-10-04 2005-05-19 Bhullar Raghbir S. Biosensor and method of making
JP4223163B2 (ja) * 1999-10-25 2009-02-12 パナソニック株式会社 免疫クロマトグラフィー試験片、及びクロマトグラフ分析方法
US6509196B1 (en) 2000-01-04 2003-01-21 Response Biomedical Corp. Compensation for non-specific signals in quantitative immunoassays
DE10003734A1 (de) * 2000-01-28 2001-08-02 Bosch Gmbh Robert Detektionsverfahren und -vorrichtung
US20020004246A1 (en) * 2000-02-07 2002-01-10 Daniels Robert H. Immunochromatographic methods for detecting an analyte in a sample which employ semiconductor nanocrystals as detectable labels
US6998273B1 (en) * 2000-02-09 2006-02-14 A-Fem Medical Corporation Collection device for lateral flow chromatography
US6365417B1 (en) 2000-02-09 2002-04-02 A-Fem Medical Corporation Collection device for lateral flow chromatography
US6699722B2 (en) 2000-04-14 2004-03-02 A-Fem Medical Corporation Positive detection lateral-flow apparatus and method for small and large analytes
JP4562854B2 (ja) * 2000-05-08 2010-10-13 パナソニック株式会社 クロマトグラフィー測定方法
KR100505803B1 (ko) * 2000-05-26 2005-08-04 마츠시타 덴끼 산교 가부시키가이샤 바이오센서
CN1287140C (zh) * 2000-09-25 2006-11-29 松下电器产业株式会社 色层分析定量测量装置
US6777198B2 (en) * 2000-10-11 2004-08-17 Pharmacia Diagnostics Ab Assay method and kit therefor
US20030100128A1 (en) * 2000-12-26 2003-05-29 Noriko Kenjyou Specific bonding analysis method and specific bonding analysis device using it
US6600057B2 (en) 2000-12-29 2003-07-29 Kimberly-Clark Worldwide, Inc. Matrix metalloproteinase inhibitors
US7041787B2 (en) * 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
US20030162236A1 (en) * 2001-03-26 2003-08-28 Response Biomedical Corporation Compensation for variability in specific binding in quantitative assays
US6770487B2 (en) * 2001-05-01 2004-08-03 Ischemia Technologies, Inc. Bar code readable diagnostic strip test
KR100550707B1 (ko) * 2001-08-09 2006-02-08 마츠시타 덴끼 산교 가부시키가이샤 바이오센서 및 측정방법
US7537731B2 (en) 2001-10-19 2009-05-26 Panasonic Corporation Specific binding analysis device
US7102752B2 (en) * 2001-12-11 2006-09-05 Kimberly-Clark Worldwide, Inc. Systems to view and analyze the results from diffraction-based diagnostics
US20030119073A1 (en) * 2001-12-21 2003-06-26 Stephen Quirk Sensors and methods of detection for proteinase enzymes
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US6837171B1 (en) 2002-04-29 2005-01-04 Palmer/Snyder Furniture Company Lightweight table with unitized table top
US7175992B2 (en) * 2002-04-10 2007-02-13 Response Biomedical Corporation Sensitive immunochromatographic assay
CA2480833C (en) * 2002-04-10 2011-09-13 Response Biomedical Corporation Sensitive immunochromatographic assay
US7214530B2 (en) 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
US7771922B2 (en) 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7108993B2 (en) * 2002-07-19 2006-09-19 Bayer Healthcare Llc Use of dual conjugated labels in the elimination of serum interference in immunochromatographic assays
US20040018576A1 (en) * 2002-07-24 2004-01-29 Dematteo Todd M. Bence Jones protein testing cassette
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
JP4694840B2 (ja) 2002-09-09 2011-06-08 アルボー ビータ コーポレーション 子宮頸部癌を検査する方法
US7781172B2 (en) 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US7247500B2 (en) 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
FI20030463A0 (fi) * 2003-03-28 2003-03-28 Ani Biotech Oy Monikanavainen testiväline, menetelmä sen valmistamiseksi ja sen käyttö
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US7074194B2 (en) * 2003-05-19 2006-07-11 Ischemia Technologies, Inc. Apparatus and method for risk stratification of patients with chest pain of suspected cardiac origin
US8101429B2 (en) * 2003-06-03 2012-01-24 Siemens Healthcare Diagnostics Inc. Native analyte as a reference in lateral flow assays
US7645421B2 (en) 2003-06-20 2010-01-12 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
EP1639353B8 (en) 2003-06-20 2018-07-25 Roche Diabetes Care GmbH Test strip with flared sample receiving chamber
US7718439B2 (en) 2003-06-20 2010-05-18 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7452457B2 (en) 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
US8148164B2 (en) 2003-06-20 2012-04-03 Roche Diagnostics Operations, Inc. System and method for determining the concentration of an analyte in a sample fluid
US8071030B2 (en) 2003-06-20 2011-12-06 Roche Diagnostics Operations, Inc. Test strip with flared sample receiving chamber
US8058077B2 (en) 2003-06-20 2011-11-15 Roche Diagnostics Operations, Inc. Method for coding information on a biosensor test strip
US7488601B2 (en) 2003-06-20 2009-02-10 Roche Diagnostic Operations, Inc. System and method for determining an abused sensor during analyte measurement
US7645373B2 (en) 2003-06-20 2010-01-12 Roche Diagnostic Operations, Inc. System and method for coding information on a biosensor test strip
US8206565B2 (en) 2003-06-20 2012-06-26 Roche Diagnostics Operation, Inc. System and method for coding information on a biosensor test strip
US8679853B2 (en) 2003-06-20 2014-03-25 Roche Diagnostics Operations, Inc. Biosensor with laser-sealed capillary space and method of making
US7659107B2 (en) 2003-09-23 2010-02-09 Epinex Diagnostics, Inc. Rapid test for glycated albumin
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
CN1914331A (zh) 2004-02-06 2007-02-14 拜尔健康护理有限责任公司 作为生物传感器的内部参照的可氧化种类和使用方法
CN102768273B (zh) * 2004-03-30 2015-08-26 通用电气医疗集团生物科学公司 侧流格式、材料和方法
US7319032B2 (en) 2004-04-22 2008-01-15 Medtox Non-sugar sweeteners for use in test devices
DE102004023402A1 (de) * 2004-05-12 2005-12-08 Roche Diagnostics Gmbh Verfahren zur Erhöhung des dynamischen Messbereichs von auf spezifischen Bindereaktionen basierenden, insbesondere immunologischen Testelementen
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US7442557B1 (en) 2004-10-22 2008-10-28 Idexx Laboratories, Inc. Bi-directional flow assay device with reagent bridge
FR2881828B1 (fr) * 2005-02-04 2007-11-30 Diagnostica Stago Soc Par Acti Methode de mesure quantitative par immunochromatographie, d'analytes dans un echantillon liquide
WO2006082318A1 (fr) * 2005-02-04 2006-08-10 Diagnostica Stago Methode de mesure quantitative par immunochromatographie, d’analytes dans un echantillon liquide
US8709792B2 (en) * 2005-02-18 2014-04-29 Charm Sciences, Inc. Lateral flow test kit and method for detecting an analyte
ES2580107T3 (es) * 2005-02-18 2016-08-19 Charm Sciences, Inc. Kit de ensayo de flujo lateral y método para detectar un analito
US20060246513A1 (en) * 2005-05-02 2006-11-02 Bohannon Robert C Method and device to detect the presence of analytes in a sample
JP5385607B2 (ja) 2005-07-20 2014-01-08 バイエル・ヘルスケア・エルエルシー ゲート化電流測定器
US8404100B2 (en) 2005-09-30 2013-03-26 Bayer Healthcare Llc Gated voltammetry
US7816122B2 (en) * 2005-10-18 2010-10-19 Idexx Laboratories, Inc. Lateral flow device with onboard reagents
US7935538B2 (en) 2006-12-15 2011-05-03 Kimberly-Clark Worldwide, Inc. Indicator immobilization on assay devices
JP2010515884A (ja) * 2007-01-08 2010-05-13 スリーエム イノベイティブ プロパティズ カンパニー 調理用油の品質認定装置及び方法
CA2677977C (en) * 2007-02-26 2015-03-31 Response Biomedical Corporation Comparative multiple analyte assay
US8865454B2 (en) * 2007-03-22 2014-10-21 Scandinavian Micro Biodevices Aps Flow through system, flow through device and a method of performing a test
WO2009076302A1 (en) 2007-12-10 2009-06-18 Bayer Healthcare Llc Control markers for auto-detection of control solution and methods of use
CA2717143A1 (en) * 2008-03-04 2009-09-11 3M Innovative Properties Company Methods and devices for monitoring of frying oil quality
CN102007406B (zh) * 2008-03-04 2013-08-21 3M创新有限公司 利用组合光学询问方法和装置监测炸油质量
WO2009112038A2 (en) 2008-03-14 2009-09-17 Scandinavian Micro Biodevices Aps A microfluidic system and a method of performing a test
US8962260B2 (en) 2008-05-20 2015-02-24 Rapid Pathogen Screening, Inc. Method and device for combined detection of viral and bacterial infections
US20130196310A1 (en) 2008-05-20 2013-08-01 Rapid Pathogen Screening, Inc. Method and Device for Combined Detection of Viral and Bacterial Infections
US9910036B2 (en) 2008-05-20 2018-03-06 Rapid Pathogen Screening, Inc. Method and device for combined detection of viral and bacterial infections
JP2011524983A (ja) * 2008-06-18 2011-09-08 マイーア・アクチボラゲット 分布決定
WO2010012281A1 (en) 2008-07-29 2010-02-04 Jacques Jonsmann A microfluidic device
US8446463B2 (en) 2008-08-22 2013-05-21 Genprime, Inc. Apparatus, method and article to perform assays using assay strips
WO2010040250A1 (zh) * 2008-10-09 2010-04-15 红电医学科技股份有限公司 流体检测方法
JP2012505417A (ja) 2008-10-17 2012-03-01 紅電醫學科技股▲分▼有限公司 体液試験ストリップ及びその方法
WO2010043075A1 (zh) 2008-10-17 2010-04-22 红电医学科技股份有限公司 流体检测试片及其测试方法
EP2413141A4 (en) 2009-03-23 2013-03-06 Actherm Inc FLUID TEST CHIP AND METHOD FOR PREPARING THE SAME
WO2010129302A1 (en) * 2009-04-28 2010-11-11 Innovative Laboratory Technologies, Inc. Lateral-flow immuno-chromatographic assay devices
WO2013096817A2 (en) 2011-12-23 2013-06-27 Abbott Point Of Care Inc Integrated test device for optical detection of microarrays
WO2013096804A2 (en) 2011-12-23 2013-06-27 Abbott Point Of Care Inc Optical assay device with pneumatic sample actuation
WO2013096801A1 (en) 2011-12-23 2013-06-27 Abbott Point Of Care Inc Reader devices for optical and electrochemical test devices
US9335290B2 (en) 2011-12-23 2016-05-10 Abbott Point Of Care, Inc. Integrated test device for optical and electrochemical assays
US20130280696A1 (en) 2012-04-23 2013-10-24 Elliott Millenson Devices and methods for detecting analyte in bodily fluid
US9285323B2 (en) 2012-08-08 2016-03-15 Scanadu Incorporated Quantifying color changes of chemical test pads induced concentrations of biological analytes under different lighting conditions
EP2883037B1 (en) 2012-08-08 2023-06-07 Healthy.io Ltd. Method and apparatus for performing and quantifying color changes induced by specific concentrations of biological analytes in an automatically calibrated environment
US9528941B2 (en) 2012-08-08 2016-12-27 Scanadu Incorporated Method and apparatus for determining analyte concentration by quantifying and interpreting color information captured in a continuous or periodic manner
CA2891509C (en) 2012-11-15 2021-05-11 Ortho-Clinical Diagnostics, Inc. Calibrating assays using reaction time
US9360479B2 (en) 2012-11-15 2016-06-07 Daniel Wang Rapid lateral flow assay method for low quantity liquid or dry samples
JP6417725B2 (ja) * 2014-06-06 2018-11-07 凸版印刷株式会社 分析対象物の検出方法
US9863811B2 (en) 2014-08-15 2018-01-09 Scanadu Incorporated Precision luxmeter methods for digital cameras to quantify colors in uncontrolled lighting environments
US10808287B2 (en) 2015-10-23 2020-10-20 Rapid Pathogen Screening, Inc. Methods and devices for accurate diagnosis of infections
US10576475B2 (en) 2016-09-15 2020-03-03 Genprime, Inc. Diagnostic assay strip cassette
US20210389318A1 (en) 2018-10-24 2021-12-16 Orasure Technologies, Inc. Lateral flow assays for differential isotype detection
US11878297B2 (en) 2019-06-04 2024-01-23 Abbott Toxicology Limited Fluid specimen testing

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE388694B (sv) * 1975-01-27 1976-10-11 Kabi Ab Sett att pavisa ett antigen exv i prov av kroppvetskor, med utnyttjande av till porost berarmaterial bundna eller adsorberande antikroppar
NL7807532A (nl) * 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4446232A (en) * 1981-10-13 1984-05-01 Liotta Lance A Enzyme immunoassay with two-zoned device having bound antigens
US4868108A (en) * 1985-12-12 1989-09-19 Hygeia Sciences, Incorporated Multiple-antibody detection of antigen
US4772561A (en) * 1985-12-23 1988-09-20 Miles Inc. Test device and method of determining concentration of a sample component
EP0231951B1 (en) * 1986-02-07 1993-06-09 Fuji Photo Film Co., Ltd. Chemical analysis apparatus
ATE225509T1 (de) * 1987-04-27 2002-10-15 Inverness Medical Switzerland Testgerät zur durchführung von spezifischen bindungsprüfungen
US4943522A (en) * 1987-06-01 1990-07-24 Quidel Lateral flow, non-bibulous membrane assay protocols
US5120643A (en) * 1987-07-13 1992-06-09 Abbott Laboratories Process for immunochromatography with colloidal particles
US4833088A (en) * 1987-09-25 1989-05-23 Miles Inc. Reagent strip handling mechanism
US4859612A (en) * 1987-10-07 1989-08-22 Hygeia Sciences, Inc. Metal sol capture immunoassay procedure, kit for use therewith and captured metal containing composite
DE3826057A1 (de) * 1988-07-30 1990-02-01 Boehringer Mannheim Gmbh Testtraeger zur analytischen bestimmung eines bestandteils einer fluessigen probe
US5141850A (en) * 1990-02-07 1992-08-25 Hygeia Sciences, Inc. Porous strip form assay device method
US5308775A (en) * 1992-09-15 1994-05-03 Abbott Laboratories Assay devices for concurrently detecting an analyte and confirming the test result

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