KR960008669B1 - 1-β-D-아라비노푸라노실-(E)-5-(2-할로게노비닐) 우라실 유도체 - Google Patents

1-β-D-아라비노푸라노실-(E)-5-(2-할로게노비닐) 우라실 유도체 Download PDF

Info

Publication number
KR960008669B1
KR960008669B1 KR1019920703320A KR920703320A KR960008669B1 KR 960008669 B1 KR960008669 B1 KR 960008669B1 KR 1019920703320 A KR1019920703320 A KR 1019920703320A KR 920703320 A KR920703320 A KR 920703320A KR 960008669 B1 KR960008669 B1 KR 960008669B1
Authority
KR
South Korea
Prior art keywords
compound
mmol
arabinofuranosyl
group
uracil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019920703320A
Other languages
English (en)
Korean (ko)
Inventor
신지 사까따
하루히꼬 마찌다
가쓰시 이지찌
후미다까 가노오
Original Assignee
야마사 쇼오유 가부시끼가이샤
하마구찌 미찌오
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 야마사 쇼오유 가부시끼가이샤, 하마구찌 미찌오 filed Critical 야마사 쇼오유 가부시끼가이샤
Application granted granted Critical
Publication of KR960008669B1 publication Critical patent/KR960008669B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019920703320A 1991-04-24 1992-04-23 1-β-D-아라비노푸라노실-(E)-5-(2-할로게노비닐) 우라실 유도체 Expired - Fee Related KR960008669B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9447091 1991-04-24
JP91/94470 1991-04-24
PCT/JP1992/000527 WO1992019638A1 (fr) 1991-04-24 1992-04-23 DERIVE DE 1-β-D-ARABINOFURANOSYL-(E)-5-(2-HALOGENOVINYL)-URACILE

Publications (1)

Publication Number Publication Date
KR960008669B1 true KR960008669B1 (ko) 1996-06-28

Family

ID=14111174

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920703320A Expired - Fee Related KR960008669B1 (ko) 1991-04-24 1992-04-23 1-β-D-아라비노푸라노실-(E)-5-(2-할로게노비닐) 우라실 유도체

Country Status (5)

Country Link
EP (1) EP0572669A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR960008669B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU645422B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2085994A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1992019638A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653318B1 (en) * 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
JP4964473B2 (ja) * 2006-02-10 2012-06-27 アリジェン製薬株式会社 ピリミジンヌクレオシド誘導体及びその塩
US8076302B2 (en) 2007-02-15 2011-12-13 Arigen Pharmaceuticals, Inc. Pyrimidine nucleoside derivatives and salts thereof
WO2018049145A1 (en) 2016-09-09 2018-03-15 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
NZ754171A (en) 2016-12-22 2022-12-23 Calithera Biosciences Inc Ectonucleotidase inhibitors and methods of use thereof
NZ771648A (en) 2018-06-21 2025-08-29 Antengene Therapeutics Ltd Ectonucleotidase inhibitors and methods of use thereof
US12116382B2 (en) 2022-11-28 2024-10-15 Hongene Biotech Corporation Functionalized N-acetylgalactosamine analogs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5687599A (en) * 1979-12-19 1981-07-16 Yamasa Shoyu Co Ltd E 55 22halogenovinyl arabinofuranosyluracil and its preparation
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
JPS58225097A (ja) * 1982-06-23 1983-12-27 Yamasa Shoyu Co Ltd ヌクレオシド５′−アルキルもしくはアルケニルりん酸
GB8912972D0 (en) * 1989-06-06 1989-07-26 Wellcome Found Therapeutic nucleosides

Also Published As

Publication number Publication date
EP0572669A1 (en) 1993-12-08
EP0572669A4 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1994-02-23
WO1992019638A1 (fr) 1992-11-12
CA2085994A1 (en) 1992-10-25
AU1673192A (en) 1992-12-21
AU645422B2 (en) 1994-01-13

Similar Documents

Publication Publication Date Title
JPS61148193A (ja) 腫瘍治療剤
JPH0723394B2 (ja) 新規アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
KR920004486B1 (ko) 시토신 누클레오시드의 제조방법
JPS5924999B2 (ja) 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体の製造法
KR960008669B1 (ko) 1-β-D-아라비노푸라노실-(E)-5-(2-할로게노비닐) 우라실 유도체
JPH06228186A (ja) ２’−デオキシ−（２’ｓ）−アルキルピリミジンヌクレオシド誘導体
US5446031A (en) 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil derivatives
KR0136869B1 (ko) 2'-메틸리덴피리미딘 뉴클레오시드 화합물, 그의 용도 및 제조방법
JPH0243749B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JPH0340034B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP3026861B2 (ja) デオキシヌクレオシド類の製造方法
JP3025557B2 (ja) ２‐アルキニルアデノシン誘導体
JP3041047B2 (ja) １―β―Ｄ―アラビノフラノシル―（Ｅ）―５―（２―ハロゲノビニル）ウラシル誘導体
WO1991006555A1 (en) Nucleoside derivative
JPH0340039B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP2664837B2 (ja) トリフルオロチミジン誘導体、その製造法およびそれを有効成分とする制ガン剤
JP3195002B2 (ja) 新規なプロスタグランジン誘導体
JPS6152839B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JPH0340036B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JPS6160695A (ja) 新規なｎ↑６−置換アデノシン誘導体及びその製造法並びにそれを有効成分とする降圧薬
US5420117A (en) 5-substituted uridine derivatives
JPH0564123B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JPS6312477B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP2634013B2 (ja) ３’−ｏ−プロパルギル−トリフルオロチミジン誘導体、その製造法およびそれを有効成分とする制癌剤
US3492288A (en) Adenosine acetals

Legal Events

Date Code Title Description
A201 Request for examination
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19990629

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19990629