KR960007540A - 아릴벤조일구아니딘 유도체 - Google Patents
아릴벤조일구아니딘 유도체 Download PDFInfo
- Publication number
- KR960007540A KR960007540A KR1019950026799A KR19950026799A KR960007540A KR 960007540 A KR960007540 A KR 960007540A KR 1019950026799 A KR1019950026799 A KR 1019950026799A KR 19950026799 A KR19950026799 A KR 19950026799A KR 960007540 A KR960007540 A KR 960007540A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- carbon atoms
- compound
- diaminomethylene
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 claims abstract 10
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 9
- 150000003839 salts Chemical class 0.000 claims abstract 8
- 125000002947 alkylene group Chemical group 0.000 claims abstract 5
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 4
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 4
- -1 biphenylyl Chemical group 0.000 claims abstract 3
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 2
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims abstract 2
- 125000001624 naphthyl group Chemical group 0.000 claims abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 2
- 238000004519 manufacturing process Methods 0.000 claims 4
- 238000011282 treatment Methods 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010061216 Infarction Diseases 0.000 claims 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 150000007514 bases Chemical class 0.000 claims 1
- 239000012876 carrier material Substances 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000007574 infarction Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- FJOOYRCQANEWMT-UHFFFAOYSA-N n-(diaminomethylidene)-2-ethyl-3-methylsulfonyl-4-phenylbenzamide Chemical compound CCC1=C(C(=O)N=C(N)N)C=CC(C=2C=CC=CC=2)=C1S(C)(=O)=O FJOOYRCQANEWMT-UHFFFAOYSA-N 0.000 claims 1
- RCKAWQCNULZGJE-UHFFFAOYSA-N n-(diaminomethylidene)-2-ethyl-4-(4-methylphenyl)-5-methylsulfonylbenzamide Chemical compound C1=C(C(=O)N=C(N)N)C(CC)=CC(C=2C=CC(C)=CC=2)=C1S(C)(=O)=O RCKAWQCNULZGJE-UHFFFAOYSA-N 0.000 claims 1
- XQYPJPSITWOGIY-UHFFFAOYSA-N n-(diaminomethylidene)-2-methyl-4-(4-methylphenyl)-5-methylsulfonylbenzamide Chemical compound C1=CC(C)=CC=C1C1=CC(C)=C(C(=O)N=C(N)N)C=C1S(C)(=O)=O XQYPJPSITWOGIY-UHFFFAOYSA-N 0.000 claims 1
- GGSMVRMJSSOOLO-UHFFFAOYSA-N n-(diaminomethylidene)-2-methyl-5-methylsulfonyl-4-(4-phenylphenyl)benzamide Chemical compound C1=C(C(=O)N=C(N)N)C(C)=CC(C=2C=CC(=CC=2)C=2C=CC=CC=2)=C1S(C)(=O)=O GGSMVRMJSSOOLO-UHFFFAOYSA-N 0.000 claims 1
- AJDQRQQNNLZLPM-UHFFFAOYSA-N n-(diaminomethylidene)benzamide Chemical compound NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Electroluminescent Light Sources (AREA)
- Photoreceptors In Electrophotography (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4430213A DE4430213A1 (de) | 1994-08-28 | 1994-08-28 | Arylbenzoylguanidine |
| DEP4430213.4 | 1994-08-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR960007540A true KR960007540A (ko) | 1996-03-22 |
Family
ID=6526570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019950026799A Abandoned KR960007540A (ko) | 1994-08-28 | 1995-08-28 | 아릴벤조일구아니딘 유도체 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5807896A (enExample) |
| EP (1) | EP0699660B1 (enExample) |
| JP (1) | JPH0859598A (enExample) |
| KR (1) | KR960007540A (enExample) |
| CN (1) | CN1055919C (enExample) |
| AT (1) | ATE172716T1 (enExample) |
| AU (1) | AU704630B2 (enExample) |
| BR (1) | BR9503810A (enExample) |
| CA (1) | CA2156960A1 (enExample) |
| CZ (1) | CZ289058B6 (enExample) |
| DE (2) | DE4430213A1 (enExample) |
| ES (1) | ES2125537T3 (enExample) |
| HU (1) | HU216833B (enExample) |
| NO (1) | NO305242B1 (enExample) |
| PL (1) | PL180872B1 (enExample) |
| RU (1) | RU2153490C2 (enExample) |
| SK (1) | SK281135B6 (enExample) |
| TW (1) | TW386988B (enExample) |
| UA (1) | UA44237C2 (enExample) |
| ZA (1) | ZA957163B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4328352A1 (de) | 1993-08-24 | 1995-03-02 | Hoechst Ag | Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| CA2195697A1 (en) * | 1996-02-02 | 1997-08-03 | Masahumi Kitano | Novel substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof |
| DE19608161A1 (de) * | 1996-03-04 | 1997-09-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19624178A1 (de) * | 1996-06-18 | 1998-01-08 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19819548A1 (de) * | 1998-04-30 | 1999-11-04 | Merck Patent Gmbh | Biphenylderivate |
| DE19833118C2 (de) * | 1998-07-23 | 2000-07-27 | Merck Patent Gmbh | Verfahren zur Herstellung von orthoalkylierten Benzoesäurederivaten |
| GB0225548D0 (en) * | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
| ATE440827T1 (de) * | 2002-12-04 | 2009-09-15 | Ore Pharmaceuticals Inc | Melanocortin-rezeptormodulatoren |
| GB0323581D0 (en) * | 2003-10-08 | 2003-11-12 | Glaxo Group Ltd | Novel compounds |
| GB0323584D0 (en) * | 2003-10-08 | 2003-11-12 | Glaxo Group Ltd | Compounds |
| GB0323585D0 (en) * | 2003-10-08 | 2003-11-12 | Glaxo Group Ltd | Compounds |
| GB0410121D0 (en) * | 2004-05-06 | 2004-06-09 | Glaxo Group Ltd | Compounds |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3420874A (en) * | 1962-09-28 | 1969-01-07 | Standard Oil Co | Amine addition salts of nitro-carboxyalkali metal phenolates |
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| EP0556674B1 (de) * | 1992-02-15 | 1996-06-19 | Hoechst Aktiengesellschaft | 3,5-Substituierte Benzoylguanidine, mit antiarrythmischer Wirkung und inhibierender Wirkung auf die Proliferationen von Zellen |
| CZ284456B6 (cs) * | 1992-02-15 | 1998-12-16 | Hoechst Aktiengesellschaft | Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje |
| ATE158278T1 (de) * | 1992-02-15 | 1997-10-15 | Hoechst Ag | Ortho-substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament |
| DK0577024T3 (enExample) * | 1992-07-01 | 1997-02-24 | Hoechst Ag | |
| TW250477B (enExample) * | 1992-12-15 | 1995-07-01 | Hoechst Ag | |
| ES2100435T3 (es) * | 1992-12-16 | 1997-06-16 | Hoechst Ag | Aminobenzoilguanidinas 3,5-sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene. |
| EP0604852A1 (de) * | 1992-12-28 | 1994-07-06 | Hoechst Aktiengesellschaft | 2,4-Substituierte 5-(N-substituierte-Sulfamoyl)-Benzoylguanidine, als Antiarrythmika, Inhibitoren der Proliferationen von Zellen, und Inhibitoren des Natrium-Protonen-Antiporters |
| DE59403818D1 (de) * | 1993-02-20 | 1997-10-02 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament |
| DE4318756A1 (de) * | 1993-06-05 | 1994-12-08 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1994
- 1994-08-28 DE DE4430213A patent/DE4430213A1/de not_active Withdrawn
-
1995
- 1995-07-21 TW TW084107589A patent/TW386988B/zh active
- 1995-08-21 AT AT95113105T patent/ATE172716T1/de not_active IP Right Cessation
- 1995-08-21 ES ES95113105T patent/ES2125537T3/es not_active Expired - Lifetime
- 1995-08-21 EP EP95113105A patent/EP0699660B1/de not_active Expired - Lifetime
- 1995-08-21 DE DE59504053T patent/DE59504053D1/de not_active Expired - Fee Related
- 1995-08-21 AU AU30144/95A patent/AU704630B2/en not_active Ceased
- 1995-08-23 UA UA95083913A patent/UA44237C2/uk unknown
- 1995-08-25 PL PL95310193A patent/PL180872B1/pl not_active IP Right Cessation
- 1995-08-25 SK SK1053-95A patent/SK281135B6/sk unknown
- 1995-08-25 RU RU95114440/04A patent/RU2153490C2/ru not_active IP Right Cessation
- 1995-08-25 CN CN95116621A patent/CN1055919C/zh not_active Expired - Fee Related
- 1995-08-25 CA CA002156960A patent/CA2156960A1/en not_active Abandoned
- 1995-08-25 BR BR9503810A patent/BR9503810A/pt not_active Application Discontinuation
- 1995-08-25 CZ CZ19952182A patent/CZ289058B6/cs not_active IP Right Cessation
- 1995-08-25 ZA ZA957163A patent/ZA957163B/xx unknown
- 1995-08-25 US US08/519,182 patent/US5807896A/en not_active Expired - Fee Related
- 1995-08-25 NO NO953351A patent/NO305242B1/no not_active IP Right Cessation
- 1995-08-28 KR KR1019950026799A patent/KR960007540A/ko not_active Abandoned
- 1995-08-28 JP JP7240499A patent/JPH0859598A/ja active Pending
- 1995-08-28 HU HU9502516A patent/HU216833B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2153490C2 (ru) | 2000-07-27 |
| UA44237C2 (uk) | 2002-02-15 |
| HU216833B (hu) | 1999-09-28 |
| US5807896A (en) | 1998-09-15 |
| CZ289058B6 (cs) | 2001-10-17 |
| PL310193A1 (en) | 1996-03-04 |
| JPH0859598A (ja) | 1996-03-05 |
| DE59504053D1 (de) | 1998-12-03 |
| CN1117962A (zh) | 1996-03-06 |
| EP0699660A3 (enExample) | 1996-03-20 |
| NO305242B1 (no) | 1999-04-26 |
| SK105395A3 (en) | 1996-03-06 |
| TW386988B (en) | 2000-04-11 |
| ES2125537T3 (es) | 1999-03-01 |
| CZ218295A3 (en) | 1996-03-13 |
| ZA957163B (en) | 1996-04-17 |
| CA2156960A1 (en) | 1996-03-01 |
| DE4430213A1 (de) | 1996-02-29 |
| EP0699660B1 (de) | 1998-10-28 |
| PL180872B1 (pl) | 2001-04-30 |
| HU9502516D0 (en) | 1995-10-30 |
| AU704630B2 (en) | 1999-04-29 |
| NO953351L (no) | 1996-02-29 |
| BR9503810A (pt) | 1996-04-16 |
| HUT72303A (en) | 1996-04-29 |
| SK281135B6 (sk) | 2000-12-11 |
| NO953351D0 (no) | 1995-08-25 |
| CN1055919C (zh) | 2000-08-30 |
| EP0699660A2 (de) | 1996-03-06 |
| AU3014495A (en) | 1996-03-14 |
| ATE172716T1 (de) | 1998-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19950828 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20000823 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19950828 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20021031 Patent event code: PE09021S01D |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20031013 |
|
| NORF | Unpaid initial registration fee | ||
| PC1904 | Unpaid initial registration fee |