KR960000882A - Novel pyridone carboxylic acid derivatives and preparation method thereof - Google Patents

Novel pyridone carboxylic acid derivatives and preparation method thereof Download PDF

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KR960000882A
KR960000882A KR1019940014451A KR19940014451A KR960000882A KR 960000882 A KR960000882 A KR 960000882A KR 1019940014451 A KR1019940014451 A KR 1019940014451A KR 19940014451 A KR19940014451 A KR 19940014451A KR 960000882 A KR960000882 A KR 960000882A
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South Korea
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group
hydrogen
following general
general formula
carboxylic acid
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KR1019940014451A
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Korean (ko)
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KR0139946B1 (en
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김진웅
조일환
이재목
신영준
윤용식
이기호
송석범
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김정순
제일제당 주식회사
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

본 발명은 다음 일반식(I)로 표시되는 피리돈 카르본산 화합물과 그의 염 및 이를 함유시켜서 된 항균제 조성물에 관한 것이다.The present invention relates to a pyridone carboxylic acid compound represented by the following general formula (I), a salt thereof and an antimicrobial composition containing the same.

상기 식(I)에서, R1은 메틸, 에틸, 플루오르에틸, 디플루오로에틸, 트리플루오로에틸, 플루오로이소프로필기를 의미하고, A는 질소원자 또는 C-H를 의미하며, Z는 다음식으로 표시되는 기를 나타낸다.In formula (I), R 1 means methyl, ethyl, fluoroethyl, difluoroethyl, trifluoroethyl, fluoroisopropyl group, A means nitrogen atom or CH, and Z represents The group displayed is shown.

(여기서, R2,R3는 수소원자 또는 메틸기를 의미하는 데 둘중 하나는 수소를 의미하고, R4,R5중의 하나는 히드록시, 알콜시, 아미노기를 의미하고, 나머지 하나는 수소를 의미한다.)(Wherein R 2 , R 3 means a hydrogen atom or a methyl group, one of them means hydrogen, one of R 4 , R 5 means a hydroxy, alcohol, amino group, the other means hydrogen do.)

Description

신규한 피리돈 카르본산 유도체 및 그의 제조방법Novel pyridone carboxylic acid derivatives and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (3)

다음 일반식(I)로 표시되는 피리돈 카르본산 유도체와 그의 에스테르 및 그의 염.Pyridone carboxylic acid derivative represented by the following general formula (I), its ester, and its salt. 상기 일반식(I)에서 R1은 메틸, 에틸, 플루오르에틸, 디플루오로에틸, 트리플루오로에틸, 플루오로이소프로필기를 의미하고, A는 질소원자 도는 C-H를 의미하며, Z는 다음식으로 표시되는 기를 의미한다.In Formula (I), R 1 represents methyl, ethyl, fluoroethyl, difluoroethyl, trifluoroethyl, fluoroisopropyl group, A means nitrogen atom or CH, and Z represents It means the group displayed. (여기서, R2,R3는 수소원자 또는 메틸기를 의미하는 데 둘중 하나는 수소를 의미하고, R4,R5중의 하나는 히드록시, 알콜시, 아미노기를 의미하고 나머지 하나는 수소를 의미한다).(Wherein R 2 , R 3 means a hydrogen atom or a methyl group, one of which means hydrogen, one of R 4 , R 5 means a hydroxy, alcohol, amino group and the other means hydrogen) ). 다음 일반식(Ⅱ)로 표시되는 화합물과 다음 일반식Ⅲ)으로 표시되는 화합물 또는 그의 산부가염을 불활성 유기용매 중에서 축합반응시키거나, R6가 저급알킬인 경우 다음 일반식(Ⅱ)로 표시되는 화합물과 다음 일반식(Ⅲ)으로 표시되는 화합물 또는 그의 산부가염을 불활성 유기용매 중에서 축합반응시킨 후 가수분해시켜 다음 일반식(I)로 표시되는 피리돈 카르본산 유도체를 제조하는 방법.The compound represented by the following general formula (II) and the compound represented by the following general formula (III) or an acid addition salt thereof are condensed in an inert organic solvent, or when R 6 is lower alkyl, represented by the following general formula (II) A method for producing a pyridone carboxylic acid derivative represented by the following general formula (I) by condensation reaction of the compound and a compound represented by the following general formula (III) or an acid addition salt thereof in an inert organic solvent followed by hydrolysis. 상기 일반식(I),(Ⅱ)및 (Ⅲ)에서 R1은 메틸, 에틸, 플루오르에틸, 디플루오로에틸, 트리플루오로에틸, 플루오로이소프로필기를 의미하고, A는 질소원자 도는 C-H를 의미하며, R6는 수소 도는 저급알킬기를 의미하며, Y는 할로겐 원자를 의미하고, Z는 다음식으로 표시되는 기를 의미한다.In Formulas (I), (II) and (III), R 1 represents methyl, ethyl, fluoroethyl, difluoroethyl, trifluoroethyl, and fluoroisopropyl groups, and A represents a nitrogen atom or CH. R 6 means hydrogen or a lower alkyl group, Y means a halogen atom, and Z means a group represented by the following formula. (여기서, R2,R3는 수소원자 또는 메틸기를 의미하는 데 둘중 하나는 수소를 의미하고, R4,R5중의 하나는 히드록시, 알콜시, 아미노기를 의미하고 나머지 하나는 수소를 의미한다).(Wherein R 2 , R 3 means a hydrogen atom or a methyl group, one of which means hydrogen, one of R 4 , R 5 means a hydroxy, alcohol, amino group and the other means hydrogen) ). 다음 일반식(I)로 표시되는 피리돈 카르본산 유도체를 유효성분으로서 적어도 1종 이상 함유시켜서 된것임을 특징으로 하는 항균제 조성물.An antimicrobial composition comprising at least one pyridon carboxylic acid derivative represented by the following general formula (I) as an active ingredient. 상기 일반식(I)에서 R1은 메틸, 에틸, 플루오르에틸, 디플루오로에틸, 트리플루오로에틸, 플루오로이소프로필기를 의미하고, A는 질소원자 도는 C-H를 의미하며, Z는 다음식으로 표시되는 기를 의미한다.In Formula (I), R 1 represents methyl, ethyl, fluoroethyl, difluoroethyl, trifluoroethyl, fluoroisopropyl group, A means nitrogen atom or CH, and Z represents It means the group displayed. (여기서, R2,R3는 수소원자 또는 메틸기를 의미하는 데 둘중 하나는 수소를 의미하고, R4,R5중의 하나는 히드록시, 알콜시, 아미노기를 의미하고 나머지 하나는 수소를 의미한다).(Wherein R 2 , R 3 means a hydrogen atom or a methyl group, one of which means hydrogen, one of R 4 , R 5 means a hydroxy, alcohol, amino group and the other means hydrogen) ). ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940014451A 1994-06-23 1994-06-23 Pyridone carboxylic acid derivatives and method of production thereof KR0139946B1 (en)

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