KR910016737A - Quinoline derivatives and preparation method thereof - Google Patents

Quinoline derivatives and preparation method thereof Download PDF

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Publication number
KR910016737A
KR910016737A KR1019900004222A KR900004222A KR910016737A KR 910016737 A KR910016737 A KR 910016737A KR 1019900004222 A KR1019900004222 A KR 1019900004222A KR 900004222 A KR900004222 A KR 900004222A KR 910016737 A KR910016737 A KR 910016737A
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South Korea
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lower alkyl
hydrogen
structural formula
following structural
halogen
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KR1019900004222A
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Korean (ko)
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KR920003606B1 (en
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김완주
이태석
박태호
김봉진
조귀웅
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채영복
재단법인 한국화학연구소
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음No content

Description

퀴놀린계 유도체와 그의 제조방법Quinoline derivatives and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

다음 구조식(I)로 표시되는 퀴놀린계 유도체와 그의 약제학적으로 허용가능한 산 첨가염.A quinoline derivative and the pharmaceutically acceptable acid addition salt thereof represented by the following structural formula (I). 상기 식에서, R1은 탄소원자수 1내지 3인 사슬형 또는 고리형 저급알킬기이고, R2와 R3는 각각 수소원자 또는 저급알킬이며, X는 N,C-H 또는 C-할로겐이고, Y는 수소원자, 할로겐원자 또는 아미노기 등이다.Wherein R 1 is a chain or cyclic lower alkyl group having 1 to 3 carbon atoms, R 2 and R 3 are each hydrogen or lower alkyl, X is N, CH or C-halogen, and Y is hydrogen And a halogen atom or an amino group. 다음 구조식(Ⅱ)로 표시되는 카르복실산 유도체와 다음 구조식(Ⅲ)로 표시되는 화합물을 상온 내지 200℃의 온도에서 1내지 8시간 동안 축합반응시켜서 되는 것임을 특징으로 하는 다음 구조식(I)로 표시되는 퀴놀린계 유도체의 제조방법.It is represented by the following structural formula (I) characterized in that the carboxylic acid derivative represented by the following structural formula (II) and the compound represented by the following structural formula (III) are condensation reaction for 1 to 8 hours at a temperature of room temperature to 200 ℃ Method for producing a quinoline derivative. 윗 식에서, R1은 탄소원자수 1 내지 3인 사슬형 또는 고리형 저급알킬기이고, R2와 R3는 각각 수소원자 또는 저급알킬기이며, X는 N,C-H 또는 C-할로겐이고, Y는 수소원자, 할로겐원자 또는 아미노기 등이며, Z는 할로겐원자이다.Wherein R 1 is a chain or cyclic lower alkyl group having 1 to 3 carbon atoms, R 2 and R 3 are each hydrogen or lower alkyl, X is N, CH or C-halogen, and Y is hydrogen And a halogen atom or an amino group, and Z is a halogen atom. 다음 구조식(Ⅳ)로 표시되는 퀴롤린계 유도체와 릴퍼옥사이드를 반응시켜 아민을 벤조일록실하여 다음 구조식(Ⅴ)으로 표시되는 화합물을 제조한후, 상기 화합물을 가수분해하여 아민을 히드록실화시켜서 되는 것임을 특징으로 하는 구조식(I-I)로 표시되는 퀴놀린계 유도체의 제조방법.The reaction of the quinolyl derivative represented by the following structural formula (IV) and the reel peroxide to benzoyloxy amine to prepare the compound represented by the following structural formula (V), and then the compound is hydrolyzed to hydroxylate the amine. Method for producing a quinoline derivative represented by formula (II) characterized in that. 윗 식에서, R1은 탄소원자수 1 내지 3인 사슬형 또는 고리형 저급알킬기이고, R3는 각각 수소원자 또는 저급알킬기이며, X는 N,C-H 또는 C-할로겐이고, Y는 수소원자, 할로겐원자 또는 아미노기 등이며, R은 수소, 저급알킬기 또는 일반적인 유기산 보호기이다.Wherein R 1 is a chain or cyclic lower alkyl group having 1 to 3 carbon atoms, R 3 is each a hydrogen atom or a lower alkyl group, X is N, CH or C-halogen, Y is a hydrogen atom or a halogen atom Or an amino group and the like, and R is hydrogen, a lower alkyl group or a general organic acid protecting group. 다음 구조식(I)로 표시되는 퀴놀린게 유도체를 유효성분으로 하는 것임을 특징으로 하는 항균제.An antibacterial agent characterized in that a quinolinge derivative represented by the following structural formula (I) is used as an active ingredient. 윗 식에서, R1은 탄소원자수 1 내지 3인 사슬형 또는 고리형 저급알킬기이고, R2와 R3는 각각 수소원자 또는 저급알킬기이며, X는 N,C-H 또는 C-할로겐이고, Y는 수소원자,할로겐원자 또는 아미노기 등이다.Wherein R 1 is a chain or cyclic lower alkyl group having 1 to 3 carbon atoms, R 2 and R 3 are each hydrogen or lower alkyl, X is N, CH or C-halogen, and Y is hydrogen And a halogen atom or an amino group. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019900004222A 1990-03-29 1990-03-29 Quinoline derivatives and its preparation process KR920003606B1 (en)

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KR920003606B1 KR920003606B1 (en) 1992-05-04

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19980015377A (en) * 1996-08-21 1998-05-25 이웅열 New quinolone carboxylic acid compounds and methods for their preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19980015377A (en) * 1996-08-21 1998-05-25 이웅열 New quinolone carboxylic acid compounds and methods for their preparation

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