KR960017657A - New quinolinecarboxylic acid derivatives and preparation method thereof - Google Patents

New quinolinecarboxylic acid derivatives and preparation method thereof Download PDF

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Publication number
KR960017657A
KR960017657A KR1019940029177A KR19940029177A KR960017657A KR 960017657 A KR960017657 A KR 960017657A KR 1019940029177 A KR1019940029177 A KR 1019940029177A KR 19940029177 A KR19940029177 A KR 19940029177A KR 960017657 A KR960017657 A KR 960017657A
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KR
South Korea
Prior art keywords
general formula
hydrogen atom
quinolinecarboxylic acid
halogen atom
preparation
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KR1019940029177A
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Korean (ko)
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KR100198488B1 (en
Inventor
조성민
박상후
이경주
Original Assignee
이웅열
주식회사 코오롱
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Priority to KR1019940029177A priority Critical patent/KR100198488B1/en
Publication of KR960017657A publication Critical patent/KR960017657A/en
Application granted granted Critical
Publication of KR100198488B1 publication Critical patent/KR100198488B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/12—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

본 발명은 탁월한 항균능력을 가지며, 특히, 그람양성균에서도 탁월한 효능을 가지며, 항균제로 이용될 수 있는 다음 일반구조식(Ⅰ)의 신규의 퀴놀린카르복실산 유도체 및 그 약학적으로 허용되는 염에 관한 것이다.The present invention relates to novel quinolinecarboxylic acid derivatives of the following general formula (I) and pharmaceutically acceptable salts thereof, which have excellent antibacterial ability, in particular excellent efficacy in Gram-positive bacteria, and which can be used as antibacterial agents. .

상기식에서 X는 할로겐원자를 나타내며, M은 할로겐원자, -OR1또는 -SR2를 나타내며(여기에서 R1및 R2는 각각 같거나 다르며 수소원자 또는 탄소수 1∼3의 저급알킬을 나타낸다.), R은 수소원자 또는 카르복실보호기이며, n은 1 또는 2의 정수를 나타낸다.Wherein X represents a halogen atom, M represents a halogen atom, -OR 1 or -SR 2 (wherein R 1 and R 2 are the same or different and represent a hydrogen atom or lower alkyl of 1 to 3 carbon atoms). , R is a hydrogen atom or a carboxyl protecting group, n represents an integer of 1 or 2.

본 발명은 또한 상기 일반구조식 (Ⅰ)의 화합물의 제조방법을 제공한다.The present invention also provides a process for the preparation of the compound of general formula (I).

Description

신규 퀴놀린카르복실산 유도체 및 그 제조방법New quinolinecarboxylic acid derivatives and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (2)

다음 일반구조식 (Ⅰ)로 표시되는 퀴놀린카르복실산 유도체 및 그 약학적으로 허용되는 염.A quinolinecarboxylic acid derivative represented by the following general formula (I) and a pharmaceutically acceptable salt thereof. 상기식에서 X는 할로겐원자를 나타내며, M은 할로겐, -OR1또는 -SR2를 나타내며(여기에서 R1및 R2는 각각 같거나 다르며 수소원자 또는 탄소수 1∼3의 저급알킬을 나타낸다.), R은 수소원자 또는 카르복실보호기이며, n은 1 또는 2의 정수를 나타낸다.Wherein X represents a halogen atom, M represents halogen, -OR 1 or -SR 2 (wherein R 1 and R 2 are the same or different and represent a hydrogen atom or lower alkyl of 1 to 3 carbon atoms), R is a hydrogen atom or a carboxyl protecting group, n represents an integer of 1 or 2. 다음 일반구조식 (Ⅱ)의 화합물을 다음 일반구조식 (Ⅲ)의 화합물과 반응시켜서 다음 일반구조식(Ⅰ)의 귀놀린카르복실산 유도체 및 그 약학적으로 허용되는 염을 제조하는 방법.A method for preparing a guinolinecarboxylic acid derivative of the general formula (I) and a pharmaceutically acceptable salt thereof by reacting a compound of the following general formula (II) with a compound of the following general formula (III). 상기식에서 X는 할로겐원자를 나타내며, M은 할로겐원자, -OR1또는 -SR2를 나타내며(여기에서 R1및 R2는 각각 같거나 다르며 수소원자 또는 탄소수 1∼3의 저급알킬을 나타낸다.), R은 수소원자 또는 카르복실보호기이며, n은 1 또는 2의 정수를 나타낸다.Wherein X represents a halogen atom, M represents a halogen atom, -OR 1 or -SR 2 (wherein R 1 and R 2 are the same or different and represent a hydrogen atom or lower alkyl of 1 to 3 carbon atoms). , R is a hydrogen atom or a carboxyl protecting group, n represents an integer of 1 or 2. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940029177A 1994-11-08 1994-11-08 Novel quinoline carboxylic acid derivatives and their preparation method KR100198488B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019940029177A KR100198488B1 (en) 1994-11-08 1994-11-08 Novel quinoline carboxylic acid derivatives and their preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019940029177A KR100198488B1 (en) 1994-11-08 1994-11-08 Novel quinoline carboxylic acid derivatives and their preparation method

Publications (2)

Publication Number Publication Date
KR960017657A true KR960017657A (en) 1996-06-17
KR100198488B1 KR100198488B1 (en) 1999-06-15

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19980066915A (en) * 1997-01-29 1998-10-15 이웅열 Novel quinolone carboxylic acid derivatives and preparation method thereof

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