KR970027069A - Novel quinolone carboxylic acid derivatives and preparation method thereof - Google Patents

Novel quinolone carboxylic acid derivatives and preparation method thereof Download PDF

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Publication number
KR970027069A
KR970027069A KR1019950039732A KR19950039732A KR970027069A KR 970027069 A KR970027069 A KR 970027069A KR 1019950039732 A KR1019950039732 A KR 1019950039732A KR 19950039732 A KR19950039732 A KR 19950039732A KR 970027069 A KR970027069 A KR 970027069A
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South Korea
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oxo
group
atom
oxygen
lower alkyl
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KR1019950039732A
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Korean (ko)
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KR100198489B1 (en
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박상후
조성민
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이웅열
주식회사 코오롱
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

본 발명은 다음의 일반 구조식(Ⅰ)로 표시되는 신규 퀴놀론 카르복실산 유도체 및 그 약학적으로 허용되는 염, 및 그 제조방법에 관한 것이다.The present invention relates to a novel quinolone carboxylic acid derivative represented by the following general structural formula (I), a pharmaceutically acceptable salt thereof, and a preparation method thereof.

상기 식에서, R1은 메틸, 에틸, 시클로프로필 등의 탄소수 1-6의 저급알킬기 또는 3-옥소-2-프로파닐기를 표시하며, 다만 3-옥소-2-프로파닐기의 경우)를 표시하며, 다만 3-옥소-2-프로파닐기의 경우 R2에 3-옥소-2-프로파닐기의 산소가 결합되고 고리를 형성하며, R2는 수소원자 또는 할로겐 원자이거나 R1이 3-옥소-2-프로파닐기인 경우 그 산소원자와 또는 할로겐 원자이거나 R1이 3-옥소-2-프로파닐기인 경우 그 산소원자와 결합되어 고리를 형성하며, R3는 탄소수 1-3의 저급 알킬기를 나타내고, n은 1 또는 2의 정수이다.In the formula, R 1 is a lower alkyl group or 3-oxo-2-propanyl group having 1 to 6 carbon atoms such as methyl, ethyl, and cyclopropyl In the case of a 3-oxo-2-propaneyl group), but in the case of a 3-oxo-2-propaneyl group, the oxygen of the 3-oxo-2-propaneyl group is bonded to R 2 . Forms a ring and R 2 is a hydrogen atom or a halogen atom or R 1 is a 3-oxo-2-propanyl group or an oxygen atom thereof or a halogen atom or R 1 is a 3-oxo-2-propanyl group that oxygen thereof. It combines with an atom to form a ring, R 3 represents a lower alkyl group having 1 to 3 carbon atoms, and n is an integer of 1 or 2.

Description

신규 퀴놀론 카르복실산 유도체 및 그 제조방법Novel quinolone carboxylic acid derivatives and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (2)

다음의 일반구조식(Ⅰ)로 표시되는 퀴놀론카르복실산 유도체 및 그 약학적으로 허용되는 염.Quinolonecarboxylic acid derivative represented by the following general structural formula (I) and its pharmaceutically acceptable salt. 상기 식에서, R1은 메틸, 에틸, 시클로프로필 등의 탄소수 1-6의 저급알킬기 또는 3-옥소-2-프로파닐기를 표시하며, 다만 3-옥소-2-프로파닐기의 경우 R2에 3-옥소-2-프로파닐기의 산소가 결합되고 고리를 형성하며, R2는 수소원자 또는 할로겐 원자이거나 R1이 3-옥소-2-프로파닐기인 경우 그 산소원자와 또는 할로겐 원자이거나 R1이 3-옥소-2-프로파닐기인 경우 그 산소원자와 결합되어 고리를 형성하며, R3는 탄소수 1-3의 저급 알킬기를 나타내고, n은 1 또는 2의 정수이다.In the formula, R 1 is a lower alkyl group or 3-oxo-2-propanyl group having 1 to 6 carbon atoms such as methyl, ethyl, and cyclopropyl A display, and 3-oxo-but-2-profiles for group and the oxygen of the 3-oxo-2-profiles group bound to R 2 and form a ring, R 2 is hydrogen atom or halogen atom R 1 is when 3-oxo-2-propanil due to that when the oxygen atom with a halogen atom, or R 1 is 3-oxo-2-propanil group is combined with the oxygen atom to form a ring, R 3 is a carbon number of 1 to 3 Lower alkyl group is represented, n is an integer of 1 or 2. 다음 구조식(Ⅱ)로 표시되는 피롤리딘 유도체 또는 그 염을 다음 구조식(Ⅲ)으로 표시되는 퀴놀론 카르복실산 유도체와 용매 존재하에 염기를 사용하여 반응시켜 얻어지는 다음 일반구조식(Ⅰ)의 퀴놀론 카르복실산 유도체 및 그 약학적으로 허용되는 염을 제조하는 방법.Quinolone carboxyl of the general formula (I) A process for preparing acid derivatives and pharmaceutically acceptable salts thereof. 상기 식에서, n, R1, R2및 R3는 청구범위 제1항에서와 같으며, X는 불소 또는 염소원자이다.Wherein n, R 1 , R 2 and R 3 are as defined in claim 1 and X is a fluorine or chlorine atom. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950039732A 1995-11-04 1995-11-04 Novel quinolone carboxylic acid and their preparation method KR100198489B1 (en)

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KR100198489B1 KR100198489B1 (en) 1999-06-15

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DE102011009112A1 (en) * 2011-01-21 2012-07-26 Merck Patent Gmbh Chromen-4-one derivatives

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