KR960000881A - Novel pyridone carboxylic acid derivatives or esters and salts thereof and preparation method thereof - Google Patents

Novel pyridone carboxylic acid derivatives or esters and salts thereof and preparation method thereof Download PDF

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KR960000881A
KR960000881A KR1019940014230A KR19940014230A KR960000881A KR 960000881 A KR960000881 A KR 960000881A KR 1019940014230 A KR1019940014230 A KR 1019940014230A KR 19940014230 A KR19940014230 A KR 19940014230A KR 960000881 A KR960000881 A KR 960000881A
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group
lower alkyl
alkyl group
amino
hydrogen
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KR1019940014230A
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Korean (ko)
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KR100332527B1 (en
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김진웅
조일환
신명준
이재옥
윤용식
이기호
송석범
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김정순
제일제당 주식회사
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

1. 청구범위에 기재된 발명이 속하는 기술분야1. TECHNICAL FIELD OF THE INVENTION

약품화학.Pharmaceutical Chemistry.

2. 발명이 해결하고자 하는 기술적 과제2. Technical problem to be solved by the invention

신규한 피리돈 카르본산 유도체 및 그의 제조방법.Novel pyridone carboxylic acid derivatives and preparation methods thereof.

3. 발명의 해결방법의 요지3. Summary of Solution to Invention

본 발명은 다음 일반식(I)로 표시되는 피리돈 카르본산 화합물과 그의 염 및 이를 함유시켜서 된 항균제 조성물에 관한 것이다.The present invention relates to a pyridone carboxylic acid compound represented by the following general formula (I), a salt thereof and an antimicrobial composition containing the same.

4. 발명의 중요한 용도4. Important uses of the invention

항균제Antibacterial agents

Description

신규한 피리돈 카르본산 유도체 또는 그의 에스테르 및 염 및 그의 제조방법Novel pyridone carboxylic acid derivatives or esters and salts thereof and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (5)

일반식(I)로 표시되는 피리돈 카르본산 유도체 또는 그의 에스테르 및 염:Pyridone carboxylic acid derivative represented by general formula (I) or its ester and salt: 상기식에서, R1은 저급알킬기, 할로겐 치환된 저급알킬기, 저급알케닐기, 사이클로알킬기 또는 치환되었거나 치환되지 않은 페닐기를 의미하고; R2는 수소, 저급알킬기, 히드록시기, 알콜시기 또는 아미노기를 의미하며; A는 질소 또는 C-X(여기에서 X는 수소, 할로겐, 저급알킬기 또는 알콕시기를 의미한다)를 의미하고; Z는 하기 일반식으로 표시되며;Wherein R 1 represents a lower alkyl group, a halogen substituted lower alkyl group, a lower alkenyl group, a cycloalkyl group or a substituted or unsubstituted phenyl group; R 2 means hydrogen, lower alkyl group, hydroxy group, alcohol group or amino group; A means nitrogen or CX, where X means hydrogen, halogen, lower alkyl group or alkoxy group; Z is represented by the following general formula; 여기서, R3,R4및 R5는 각각 수소 도는 저급알킬기를 의미하고, B는 히드록시, 알콕시, 아미노 또는 저급알킬기로 치환된 아미노기를 의미한다.Wherein R 3 , R 4 and R 5 each represent a hydrogen or lower alkyl group and B means an amino group substituted with a hydroxy, alkoxy, amino or lower alkyl group. 일반식(Ⅲ)으로 표시되는 화합물:Compound represented by general formula (III): Z-H (Ⅲ)Z-H (Ⅲ) 상기식에서, Z는 하기 일반식으로 표시되고,In the formula, Z is represented by the following general formula, 여기에서,R3,R4및 R5는 각각 수소 도는 저급알킬기를 의미하고, B는 히드록시, 알콕시, 아미노 또는 저급알킬기로 치환된 아미노기를 의미한다.Here, R 3 , R 4 and R 5 each represent a hydrogen or lower alkyl group and B means an amino group substituted with a hydroxy, alkoxy, amino or lower alkyl group. R6이 수소인 일반식(Ⅱ)로 표시되는 화합물과 일반식(Ⅲ)으로 표시되는 화합물 또는 그의 산부가염을 불활성 유기용매중에서 축합 반응시킴을 특징으로 하며, 일반식(I)로 표시되는 피리돈 카르본산 유도체 도는 그의 에스테르 및 염을 제조하는 방법:A condensation reaction between a compound represented by formula (II) wherein R 6 is hydrogen and a compound represented by formula (III) or an acid addition salt thereof in an inert organic solvent; Processes for preparing don carboxylic acid derivatives or esters and salts thereof: 상기식(I)에서, R1은 저급알킬기, 할로겐 치환된 저급알킬기, 저급알케닐기, 사이클로알킬기 또는 치환되었거나 치환되지 않은 페닐기를 의미하고; R2는 수소, 저급알킬기, 히드록시기, 알콕시기 또는 아미노기를 의미하며; A는 질소 또는 C-X(여기에서 X는 수소, 할로겐, 저급 알킬기 또는 알콕시기를 의미한다)를 의마하고; Z는 하기 일반식으로 표시되며;In formula (I), R 1 means lower alkyl group, halogen substituted lower alkyl group, lower alkenyl group, cycloalkyl group or substituted or unsubstituted phenyl group; R 2 means hydrogen, lower alkyl group, hydroxy group, alkoxy group or amino group; A is nitrogen or CX, where X means hydrogen, halogen, lower alkyl group or alkoxy group; Z is represented by the following general formula; 여기에서, R3,R4및 R5는 각각 수소 또는 저급알킬기를 의미하고, B는 히드록시, 알콕시, 아미노 또는 저급알킬기로 치환된 아미노기를 의미한다.Here, R 3 , R 4 and R 5 each represent hydrogen or a lower alkyl group, and B means an amino group substituted with a hydroxy, alkoxy, amino or lower alkyl group. R6이 저급알킬인 일반식(Ⅱ)로 표시되는 화합물과 일반식(Ⅲ)으로 표시되는 화합물 또는 그의 산부가염을 불활성 유기용매 중에서 축합반응시킨 후 가수분해시킴을 특징으로 하며, 일반식(I)로 표시되는 피리돈 카르본산 유도체 또는 그의 에스테르 및 염을 제조하는 방법 :A compound represented by formula (II) wherein R 6 is lower alkyl and a compound represented by formula (III) or an acid addition salt thereof are subjected to condensation reaction in an inert organic solvent, followed by hydrolysis. Method for preparing pyridone carboxylic acid derivative or ester and salt thereof represented by: 상기식(I)에서, R1은 저급알킬기, 할로겐 치환된 저급알킬기, 저급알케닐기, 사이클로알킬기 또는 치환되었거나 치환되지 않은 페닐기를 의미하고; R2는 수소, 저급알킬기, 히드록시키, 알콕시키 또는 아미노기를 의미하며; A는 질소 또는 C-X(여기에서 X는 수소, 할로겐, 저급 알킬기 또는 알콕시기를 의마한다)를 의미하고; Z는 하기 일반식으로 표시되며;In formula (I), R 1 means lower alkyl group, halogen substituted lower alkyl group, lower alkenyl group, cycloalkyl group or substituted or unsubstituted phenyl group; R 2 means hydrogen, lower alkyl group, hydroxy key, alkoxy key or amino group; A means nitrogen or CX, where X stands for hydrogen, halogen, lower alkyl group or alkoxy group; Z is represented by the following general formula; 여기에서,R3,R4및 R5는 각각 수소 또는 저급알킬기를 의미하고, B는 히드록시, 알콕시, 아미노 또는 저급알킬기로 치환된 아미노기를 의미한다.Here, R 3 , R 4 and R 5 each represent hydrogen or a lower alkyl group, and B means an amino group substituted with a hydroxy, alkoxy, amino or lower alkyl group. 제1항에 따른 일반식(I)의 화합물과 약제학적으로 허용되는 담체를 함유한 항균제 조성물 ;An antimicrobial composition comprising a compound of formula (I) according to claim 1 and a pharmaceutically acceptable carrier; 상기식(I)에서, R1은 저급알킬기, 할로겐 치환된 저급알킬기, 저급알케닐기, 사이클로알킬기 또는 치환되었거나 치환되지 않은 페닐기를 의미하고; R2는 수소, 저급알킬기, 히드록시키, 알콕시키 또는 아미노기를 의미하며; A는 질소 또는 C-X(여기에서 X는 수소, 할로겐, 저급 알킬기 또는 알콕시기를 의마한다)를 의미하고; Z는 하기 일반식으로 표시되며;In formula (I), R 1 means lower alkyl group, halogen substituted lower alkyl group, lower alkenyl group, cycloalkyl group or substituted or unsubstituted phenyl group; R 2 means hydrogen, lower alkyl group, hydroxy key, alkoxy key or amino group; A means nitrogen or CX, where X stands for hydrogen, halogen, lower alkyl group or alkoxy group; Z is represented by the following general formula; 여기에서,R3,R4및 R5는 각각 수소 또는 저급알킬기를 의미하고, B는 히드록시, 알콕시, 아미노 또는 저급알킬기로 치환된 아미노기를 의미한다.Here, R 3 , R 4 and R 5 each represent hydrogen or a lower alkyl group, and B means an amino group substituted with a hydroxy, alkoxy, amino or lower alkyl group. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940014230A 1994-06-22 1994-06-22 Pyridon carbonate derivative, salt thereof and method for manufacturing the same KR100332527B1 (en)

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