KR950013519A - 골절 예방 및 치료용 약제 - Google Patents

골절 예방 및 치료용 약제 Download PDF

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Publication number
KR950013519A
KR950013519A KR1019940028717A KR19940028717A KR950013519A KR 950013519 A KR950013519 A KR 950013519A KR 1019940028717 A KR1019940028717 A KR 1019940028717A KR 19940028717 A KR19940028717 A KR 19940028717A KR 950013519 A KR950013519 A KR 950013519A
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KR
South Korea
Prior art keywords
platelet factor
preventing
pharmaceutical composition
medicines
fracture
Prior art date
Application number
KR1019940028717A
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English (en)
Other versions
KR100313980B1 (ko
Inventor
마사요시 고야마
미키코 다카하시
가즈유키 도이
Original Assignee
사토 미쓰아키
훽스트 저팬 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 사토 미쓰아키, 훽스트 저팬 리미티드 filed Critical 사토 미쓰아키
Publication of KR950013519A publication Critical patent/KR950013519A/ko
Application granted granted Critical
Publication of KR100313980B1 publication Critical patent/KR100313980B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

본 발명은, 활성 성분으로서 혈소판 인자 4를 포함하는 골절 예방 또는 치료용 약제학적 조성물에 관한 것이다.
본 조성물은 조골세포의 분화를 촉진함으로써 골절등과 같이 골 분화 및 중식을 필요로 하는 질환의 예방 및 치료에 효과적이 되도록 한다.

Description

골절 예방 및 치료용 약제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 헤파린 친화 크로마토그래피에 결합되어 용출된 분획을 역상 HPLC로 좀 더 전개시킨 패턴을 나타내며, 이때 화살표는 소 PF 4를 함유하는 활성 분획(피크 1)을 나타낸다.
제2도는 부분 정제된 사람 PF 4가 역상 HPLC로 전개되는 패턴을 나타내며, 이때 화살표는 사람 PF 4를 함유하는 활성 분획(피크 1)을 나타낸다.

Claims (5)

  1. 유효량의 혈소판 인자 4가 약제학적으로 허용되는 담체 또는 부형제와 함께 혼합되어 포함된, 골절 예방 또는 치료용 약제학적 조성물.
  2. 제1항에 있어서, 혈소판 인자 4가 사람 혈소판 인자 4인 약제학적 조성물.
  3. 제 1항에 있어서, 혈소판 인자 4가 소 혈소판 인자 4가 소 혈소판 인자 4인 약제학적 조성물.
  4. 골절을 앓는 대상체에게 유효량의 혈소판 인자 4를 투여함을 포함하여, 골절을 예방하거나 치료하는 방법.
  5. 골절 예방 또는 치료제로서의 혈소판 인자 4의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940028717A 1993-11-05 1994-11-03 골절예방및치료용약제 KR100313980B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP93-276473 1993-11-05
JP5276473A JPH07126181A (ja) 1993-11-05 1993-11-05 骨折の予防および治療剤

Publications (2)

Publication Number Publication Date
KR950013519A true KR950013519A (ko) 1995-06-15
KR100313980B1 KR100313980B1 (ko) 2002-02-19

Family

ID=17569945

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940028717A KR100313980B1 (ko) 1993-11-05 1994-11-03 골절예방및치료용약제

Country Status (12)

Country Link
US (1) US5622935A (ko)
EP (1) EP0655251B1 (ko)
JP (1) JPH07126181A (ko)
KR (1) KR100313980B1 (ko)
AT (1) ATE193450T1 (ko)
AU (1) AU7762594A (ko)
CA (1) CA2135123A1 (ko)
DE (1) DE69424747T2 (ko)
DK (1) DK0655251T3 (ko)
ES (1) ES2148268T3 (ko)
GR (1) GR3034161T3 (ko)
PT (1) PT655251E (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU726538B2 (en) * 1993-11-05 2000-11-09 Hoechst Japan Limited Pharmaceutical composition for increasing differentiation of osteoblasts
CN1108169C (zh) * 1999-06-24 2003-05-14 中国医学科学院血液学研究所 一种用于辐射损伤治疗的多肽类药物组合物
CN1196480C (zh) * 2001-07-03 2005-04-13 北京巨能亚太生命科学研究中心 L－苏糖酸钙在制备预防或治疗骨折的药物中的用途
WO2005065704A1 (ja) * 2004-01-09 2005-07-21 Saitama Medical School 骨疾患の予防および治療剤
JP2008239488A (ja) * 2005-07-07 2008-10-09 Saitama Medical Univ 動脈硬化の治療剤
US8367112B2 (en) * 2006-02-28 2013-02-05 Alkermes Pharma Ireland Limited Nanoparticulate carverdilol formulations
JP7071724B2 (ja) * 2017-08-24 2022-05-19 国立大学法人大阪大学 骨配向化用薬剤組成物、及び骨疾患治療薬

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0564502B1 (en) * 1990-11-27 2002-01-30 The American National Red Cross Tissue sealant and growth factor containing compositions that promote accelerated wound healing
US5304542A (en) * 1992-08-28 1994-04-19 University Of Louisville Research Foundation, Inc. Use of platelet factor 4 to inhibit osteoblast proliferation

Also Published As

Publication number Publication date
DK0655251T3 (da) 2000-10-09
EP0655251A1 (en) 1995-05-31
AU7762594A (en) 1995-05-18
DE69424747D1 (de) 2000-07-06
EP0655251B1 (en) 2000-05-31
GR3034161T3 (en) 2000-11-30
JPH07126181A (ja) 1995-05-16
ES2148268T3 (es) 2000-10-16
KR100313980B1 (ko) 2002-02-19
PT655251E (pt) 2000-10-31
DE69424747T2 (de) 2000-11-09
US5622935A (en) 1997-04-22
CA2135123A1 (en) 1995-05-06
ATE193450T1 (de) 2000-06-15

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