KR940019671A - 프로판올아민 유도체 - Google Patents

프로판올아민 유도체 Download PDF

Info

Publication number
KR940019671A
KR940019671A KR1019940002610A KR19940002610A KR940019671A KR 940019671 A KR940019671 A KR 940019671A KR 1019940002610 A KR1019940002610 A KR 1019940002610A KR 19940002610 A KR19940002610 A KR 19940002610A KR 940019671 A KR940019671 A KR 940019671A
Authority
KR
South Korea
Prior art keywords
tert
butyl
chemical name
compound
piperazinyl
Prior art date
Application number
KR1019940002610A
Other languages
English (en)
Inventor
가즈미 오가따
다까히로 사까우에
유우이찌 이소와끼
다까아끼 데구찌
Original Assignee
요시다 쇼오지
센쥬 세이야꾸 가부시기 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 요시다 쇼오지, 센쥬 세이야꾸 가부시기 가이샤 filed Critical 요시다 쇼오지
Publication of KR940019671A publication Critical patent/KR940019671A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

아래의 일반 구조식으로 나타내어지는 화합물 또는 약리학적으로 허용되는 그 염을 함유하는 혈압 강하제 및 항녹내장제.
(위에 식에서 R1은 수소 또는 저급 알킬 또는 저급 알콕시 그룹, R2는 이소프로필아미노, tert-부틸아미노, 2-(2-메톡시페닐)에틸-1-아미노, 4-(2-메톡시 페닐)-1-피페라지닐 또는 4-피페로닐-1-피페라지닐 그룹이고, 단 r1이 수소인 경우에는 R2는 이소프로필아미노 또는 tert-부틸아미노 그룹이 아님).

Description

프로판올아민 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 실시예 1에서 합성한 화합물의 적외선 흡수 스팩트럼.

Claims (18)

  1. 아래의 일반 구조식(A)으로 나타내어지는 화합물 또는 약리적으로 허용되는 그 염.
    (위에 식에서 R1은 수소 또는 저급 알킬 또는 저급 알콕시 그룹, R2는 이소프로필아미노, tert-부틸아미노, 2-(2-메톡시페닐)에틸-1-아미노, 4-(2-메톡시 페닐)-1-피페라지닐 또는 4-피레로닐-1-피페라지닐 그룹이고, 단 R1이 수소인 경우에는 R2는 이소프로필아미노 또는 tert-부틸아미노 그룹이 아니며, R1이 메틸 그룹인 경우에는 R2는 이소프로필 그룹이 아님).
  2. 제1항에 있어서, 화학 명칭이 1-(2-tert-부틸-4-메톡시페녹시)-3-tert-부틸 아미노-2-프로판올 염산염인 화합물.
  3. 제1항에 있어서, 화학 명칭이 1-(2-tert-부틸-4-메톡시페녹시)-3-이소프로필 아니모-2-프로판올 염산염인 화합물.
  4. 제1항에 있어서, 화학 명칭이 1-(2-tert-부틸-4-베톡시페녹시)3-[4-(2-메톡시페닐)-1-피페라지닐]-2-프로판올 염산염인 화합물.
  5. 제1항에 있어서, 화학 명칭이 1-(2-tert-부틸-4-메톡시페녹시)-3-[2-(메톡시페닐에틸)-1-아미노]-2-프로판올 염산염인 화합물.
  6. 제1항에 있어서 화학 명칭이 1-(2-tert-부틸-4-메톡시페녹시)3-(4-피페로닐-1-피페라지닐)-2-프로판올 염산염인 화합물.
  7. 제1항에 있어서, 화학 명칭이 1-(2-tert-부틸페녹시)-3-[4-(2-메톡시페닐)-1-피페라지닐]-2-프포판올 염산염인 화합물.
  8. 2-tert-부틸페놀, 2-tert-부틸-4-알콕시페놀 또는 2-tert-부틸-4-알킬페놀과 에피클로로히드린을 알칼리 존재하에 반응시켜 각각 1-(2,3-에폭시프로폭시)-2-tert-부틸벤젠, 1-(2,3-에폭시프로폭시)-2-tert-부틸-4-알콕시벤젠 또는 1-(2,3-에폭시프로폭시)-2-tert-부틸-4-알킬벤젠을 제조한 다음 이들의 상응한 아민을 첨가하는 공정을 특징으로 하는 제1항 기재의 화합물의 제조방법.
  9. 제1항 기재의 화합물 또는 약리학적으로 허용되는 그 염을 함유하는 혈압강하제.
  10. 제9항에 있어서, 화학 명칭이 1-(2-tert-부틸-4-메톡시페녹시)-3-tert-부틸아미노-2-프로판올 염산염인 화합물을 함유하는 혈압 강하제.
  11. 제9항에 있어서, 화학 명칭이 1-(2-tert-부틸-4-메톡시페녹시)-3-[4-(2-메톡시페닐)-1-피페라지닐[-2-프로판올 염산염인 화합물을 함유하는 혈압강하제.
  12. 아래의 일반 구조식(A-1)으로 나타내어지는 화합물 또는 약리학적으로 허용되는 그 염을 함유하는 항녹내장제.
    (위에 식에서 R1은 수소 또는 저급 알킬 또는 저급 알콕시 그룹, R2는 이소프로필아미노, tert-부틸아미노, 2-(2-메톡시페닐)에틸-1-아미노, 4-(2-메톡시 페닐)-1-피페라지닐 또는 4-피레로닐-1-피페라지닐 그룹이고, 단 R1이 수소인 경우에는 R2는 이소프로필아미노 또는 tert-부틸아미노 그룹이 아님).
  13. 제12항에 있어서, 화학 명칭이 화학 명칭이 1-(2-tert-부틸-4-메톡시페녹시)-3-tert-부틸 아미노-2-프로판올 염산염인 화합물을 함유하는 항녹내장제.
  14. 제12항에 있어서, 화학 명칭이 1-(2-tert-부틸-4-메톡시페녹시)-3-[4-(2-메톡시페닐)-1-피페라지닐]-2-프로판올 염산염인 화합물을 함유하는 항녹내장제.
  15. 제12항에 있어서, 화학 명칭이 1-(2-TERT-부틸-4-메톡시페녹시)-3-[2-(2-메톡시페닐)에틸-1-아미노]-2-프로판올 염산염인 화합물을 함유하는 항녹내장제.
  16. 제12항에 있어서, 화학 명칭이 1-(2-TERT-부틸-4-메톡시페녹시)-3-(4-피페로닐-1-피페라지닐)-2-프로판올 염산염인 화합물을 함유하는 항녹내장제.
  17. 제12항에 있어서, 화학 명칭이 1-(2-TERT-부틸페녹시)-3-[4-(2-메톡시페닐)-1-피페라지닐]-2-프로판올 염산염인 화합물을 함유하는 항녹내장제.
  18. 제12항에 있어서, 화학 명칭이 1-(2-TERT-부틸-4-메틸페녹시)-3-이소프로필 아미노-2-프로판올 염산염인 화합물을 함유하는 항녹내장제.
    ※ 참고사항 ; 최초출원 내용에 의하여 공개하는 것임.
KR1019940002610A 1993-02-15 1994-02-15 프로판올아민 유도체 KR940019671A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP93-25361 1993-02-15
JP2536193 1993-02-15
JP93-256739 1993-10-14
JP25673993 1993-10-14

Publications (1)

Publication Number Publication Date
KR940019671A true KR940019671A (ko) 1994-09-14

Family

ID=26362958

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940002610A KR940019671A (ko) 1993-02-15 1994-02-15 프로판올아민 유도체

Country Status (5)

Country Link
US (1) US5504087A (ko)
EP (1) EP0611748A1 (ko)
KR (1) KR940019671A (ko)
CA (1) CA2115332A1 (ko)
TW (1) TW275614B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2172183A1 (en) * 1995-03-29 1996-09-30 Kazumi Ogata Piperazine derivative
KR20000070507A (ko) * 1997-01-30 2000-11-25 요시다 쇼지 하이드로퀴논 유도체
PT958280E (pt) * 1997-10-31 2005-09-30 Daiichi Suntory Pharma Co Ltd Derivados de arilpiperidinopropanol e arilpiperazinopropanol e farmacos contendo os mesmos

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1236523C2 (de) * 1962-02-15 1975-06-12 Sanol-Arzneimittel Dr. Schwarz Gmbh, 4019 Monheim Verfahren zur herstellung von basischen phenylaethern und deren salzen
GB1123258A (en) * 1965-09-15 1968-08-14 Ici Ltd Alkanolamine derivatives
NL301580A (ko) * 1962-12-11
US3211735A (en) * 1963-01-14 1965-10-12 Ciba Geigy Corp N-aryl-n'-oxyalkyldiazacycloalkanes
GB1069345A (en) * 1963-07-19 1967-05-17 Ici Ltd New alkanolamine derivatives
GB2044251B (en) * 1978-12-01 1983-03-23 Bristol Myers Co Phenoxypropanolamine derivatives
JPS58164583A (ja) * 1982-03-18 1983-09-29 Nippon Shinyaku Co Ltd フエノキシプロパノ−ルアミン誘導体
US4652584A (en) * 1984-07-13 1987-03-24 Mcneilab, Inc. Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension
ES8609190A1 (es) * 1985-02-07 1986-07-16 Pharma Investi S A Un procedimiento para preparar eteres fenolicos
US4665094A (en) * 1985-08-29 1987-05-12 Merck & Co., Inc. Oculoselective beta-blockers for treatment of elevated intraocular pressure
FR2672594B1 (fr) * 1991-02-08 1994-07-01 Synthelabo Derives d'ethers de phenols, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
EP0611748A1 (en) 1994-08-24
TW275614B (ko) 1996-05-11
US5504087A (en) 1996-04-02
CA2115332A1 (en) 1994-08-16

Similar Documents

Publication Publication Date Title
RU2225400C2 (ru) Фторпиразолбифениламидные фунгициды
RU2201924C2 (ru) Морфолиновое производное и фармацевтическая композиция на его основе
KR950014084A (ko) O-하이드록시페닐-s-트리아진
NO964813D0 (no) Fremgangsmåte for stabilisering av duocarmycinderivater
KR920701153A (ko) 옥시인돌 유도체
BR8305546A (pt) Processo para a preparacao de derivados substituidos de 1-hidroxietil-triazolilo, composicoes de protecao as plantas e fungicidas e processos para o combate a fungos, para a protecao de plantas e para a preparacao de composicoes
ATE196293T1 (de) Triazole enthaltende antifungizide mittel
KR970027071A (ko) 피롤릴벤즈이미다졸유도체
KR890014520A (ko) 이소인돌리논 유도체, 그 제조방법 및 이를 함유한 약품
KR910009672A (ko) 피리다진 유도체, 이의 제조방법 및 이것을 함유하는 약학 조성물
AU2001269540A1 (en) Serotonin reuptake inhibitors
KR940019671A (ko) 프로판올아민 유도체
DE69407807D1 (de) Indolin verbindungen und sie als aktivbestandteil enthaltende 5-ht3-antagonisten
ES2060608T3 (es) 1h-imidazoles sustituidos.
KR910020007A (ko) 3-[1-티아졸리디닐부틸-4-피페라지닐]-1h-인다졸, 이의 제조방법 및 이의 약제로서의 용도
RU2203281C2 (ru) Производные 8-азабицикло[3.2.1] октан-3-метанамина в качестве лигандов рецепторов дофамина d2 и d3 и рецепторов серотонина 5ht1a и 5ht2 и содержащее их лекарство и фармацевтическая композиция
KR960702456A (ko) 4-(p-플로오로페닐)-3-[(3,4-(메틸렌디옥시)페녹시)메틸]피페리딘의 n-p-할로벤조일메틸 유도체(n-p-halobenzoylmethyl derivatives of 4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl]piperidine)
DK432086D0 (da) Fremgangsmaade til fremstilling af beta-lactamforbindelser eller saltederaf
KR880007491A (ko) Paf-길항물질인피페라진화합물
KR930004234A (ko) 메타노안트라센 화합물
EP1193548A3 (en) Silver halide color photographic light-sensitive material, pyrrolotriazole compound, and dye-forming compound
KR880007480A (ko) 이미다졸 유도체, 이의 제조방법 및 이를 함유한 살균제
KR950704335A (ko) 포스폰산 디에스테르 유도체(phosphonic diester derivative)
KR950025029A (ko) N-[1-(벤조트리아졸-1-일)]아릴아민 유도체
KR960022511A (ko) 2-(4'-티아졸릴)벤즈이미다졸의 제조방법

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid