DE69407807D1 - Indolin verbindungen und sie als aktivbestandteil enthaltende 5-ht3-antagonisten - Google Patents

Indolin verbindungen und sie als aktivbestandteil enthaltende 5-ht3-antagonisten

Info

Publication number
DE69407807D1
DE69407807D1 DE69407807T DE69407807T DE69407807D1 DE 69407807 D1 DE69407807 D1 DE 69407807D1 DE 69407807 T DE69407807 T DE 69407807T DE 69407807 T DE69407807 T DE 69407807T DE 69407807 D1 DE69407807 D1 DE 69407807D1
Authority
DE
Germany
Prior art keywords
group
chem
receptor antagonists
indolin
connections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69407807T
Other languages
English (en)
Other versions
DE69407807T2 (de
Inventor
Shinji Tokyo Tanabe C Tsuchiya
Nobuyuki Tokyo Tanabe C Yasuda
Atsushi Tokyo Tanabe Fukuzaki
Koichi Tokyo Tanabe Com Kazama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tokyo Pharmaceuticals Inc
Original Assignee
Tokyo Tanabe Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo Tanabe Co Ltd filed Critical Tokyo Tanabe Co Ltd
Priority claimed from PCT/JP1994/001641 external-priority patent/WO1995009168A1/ja
Publication of DE69407807D1 publication Critical patent/DE69407807D1/de
Application granted granted Critical
Publication of DE69407807T2 publication Critical patent/DE69407807T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DE69407807T 1993-09-30 1994-09-30 Indolin verbindungen und sie als aktivbestandteil enthaltende 5-ht3-antagonisten Expired - Fee Related DE69407807T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP24577893 1993-09-30
JP6272894 1994-03-31
PCT/JP1994/001622 WO1995009167A1 (fr) 1993-09-30 1994-09-29 Derive d'indoline et antagoniste du recepteur 5-ht3 contenant ce derive et utilise comme ingredient actif
PCT/JP1994/001641 WO1995009168A1 (fr) 1993-09-30 1994-09-30 Compose d'indoline et antagoniste des recepteurs de 5-ht3 contenant ce compose comme principe actif

Publications (2)

Publication Number Publication Date
DE69407807D1 true DE69407807D1 (de) 1998-02-12
DE69407807T2 DE69407807T2 (de) 1998-05-20

Family

ID=26403780

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69407807T Expired - Fee Related DE69407807T2 (de) 1993-09-30 1994-09-30 Indolin verbindungen und sie als aktivbestandteil enthaltende 5-ht3-antagonisten

Country Status (8)

Country Link
US (1) US5677326A (de)
EP (1) EP0721949B1 (de)
KR (1) KR960704881A (de)
AT (1) ATE161842T1 (de)
AU (2) AU7707994A (de)
CA (1) CA2173155A1 (de)
DE (1) DE69407807T2 (de)
WO (1) WO1995009167A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521183A (en) * 1994-08-30 1996-05-28 Allergan Use of 5-HT ligands as anti-pruritic agents
WO1996025396A1 (fr) * 1995-02-17 1996-08-22 Tokyo Tanabe Company Limited Procede de preparation de composes indoline et intermediaires de cette preparation
KR19980702282A (ko) * 1995-02-17 1998-07-15 아사이 이뻬이 인돌린 화합물의 제조 방법 및 이의 제조용 중간체
US6562629B1 (en) 1999-08-11 2003-05-13 Cedars-Sinai Medical Center Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum
US7048906B2 (en) * 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
FR2744452B1 (fr) * 1996-02-06 1998-03-06 Cird Galderma Composes biaryles heterocycliques, compositions pharmaceutiques et cosmetiques les contenant et utilisations
US6437147B1 (en) 2000-03-17 2002-08-20 Novo Nordisk Imidazole compounds
WO2001068652A1 (en) * 2000-03-17 2001-09-20 Novo Nordisk A/S Condensed imidazoles as histamine h3 receptor ligands
AU2003301184A1 (en) * 2002-12-20 2004-07-22 Dynogen Pharmaceuticals Inc METHODS OF TREATING NON-PAINFUL BLADDER DISORDERS USING Alpha2Delta SUBUNIT CALCIUM CHANNEL MODULATORS
DE602004003172T2 (de) * 2003-03-21 2007-09-27 Dynogen Pharmaceuticals Inc., Waltham Verfahren zur behandlung von erkrankungen der unteren harnwege mit antimuskarinika und mit modulatoren der alpha-2-delta untereinheit des kalziumkanals
ES2432618T3 (es) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular
DK2432467T3 (en) 2009-05-20 2018-04-16 Inst Nat Sante Rech Med SEROTONIN 5-HT3 RECEPTOR ANTAGONISTS FOR USE IN TREATMENT OF VESTIBULAR DAMAGE LESSONS

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3401173A (en) * 1966-04-05 1968-09-10 Smith Kline French Lab Heterocyclic acylaminobenzimidazoles
CH528514A (de) * 1969-05-22 1972-09-30 Bayer Ag Verfahren zur Herstellung von Acylimidazolen
US4080330A (en) * 1975-06-23 1978-03-21 Delmar Chemicals Limited Phenylindolines and process for their production
SU786266A1 (ru) * 1978-12-04 1982-05-07 Ростовский Ордена Трудового Красного Знамени Государственный Университет Способ получени 2-бензимидазолиларилкетонов
DE3708292A1 (de) * 1987-03-14 1988-09-29 Basf Ag Gegen einwirkung von licht stabilisierte polymere sowie neue imidazol-2-carbonsaeureanilide
DE69028934T2 (de) * 1989-02-02 1997-03-20 Yamanouchi Pharma Co Ltd Tetrahydrobenzimidazol-Derivate
US5344927A (en) * 1989-02-02 1994-09-06 Yamanouchi Pharmaceutical Co., Ltd. Tetrahydrobenzimidazole derivatives and pharmaceutical compositions containing same

Also Published As

Publication number Publication date
AU678057B2 (en) 1997-05-15
WO1995009167A1 (fr) 1995-04-06
EP0721949A4 (de) 1996-08-28
KR960704881A (ko) 1996-10-09
US5677326A (en) 1997-10-14
AU7707994A (en) 1995-04-18
AU7708394A (en) 1995-04-18
CA2173155A1 (en) 1995-04-06
EP0721949A1 (de) 1996-07-17
EP0721949B1 (de) 1998-01-07
DE69407807T2 (de) 1998-05-20
ATE161842T1 (de) 1998-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MITSUBISHI-TOKYO PHARMACEUTICALS, INC., TOKIO, JP

8339 Ceased/non-payment of the annual fee